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Entry version 128 (29 Sep 2021)
Sequence version 4 (27 Jul 2011)
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Protein

Dedicator of cytokinesis protein 6

Gene

Dock6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases (By similarity).

Through its activation of CDC42 and RAC1, regulates neurite outgrowth in an vitro differentiation system.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-9013148, CDC42 GTPase cycle
R-MMU-9013149, RAC1 GTPase cycle
R-MMU-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dedicator of cytokinesis protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dock6
Synonyms:Kiaa1395
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914789, Dock6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000032198

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001899941 – 2080Dedicator of cytokinesis protein 6Add BLAST2080

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei178PhosphoserineCombined sources1
Modified residuei863Omega-N-methylarginineCombined sources1
Modified residuei870PhosphoserineCombined sources1
Modified residuei878PhosphoserineCombined sources1
Modified residuei882PhosphoserineCombined sources1
Modified residuei1341PhosphoserineBy similarity1
Modified residuei2064PhosphothreonineCombined sources1
Modified residuei2065PhosphoserineCombined sources1
Modified residuei2069PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8VDR9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VDR9

PeptideAtlas

More...
PeptideAtlasi
Q8VDR9

PRoteomics IDEntifications database

More...
PRIDEi
Q8VDR9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
279755 [Q8VDR9-1]
279756 [Q8VDR9-2]
279757 [Q8VDR9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VDR9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VDR9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in lung and heart.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at 9.5 dpc in the growing edge of the limb buds and in the developing heart. At 10.5 dpc, strongly expressed at the edge of the limb buds, while expression in the heart maintained. At 11.5 dpc, detected in the apical ectodermal ridge of all 4 limbs, with higher expression in hindlimbs than in forelimbs. By 12.5 and 13.5 dpc, expression pattern more diffused in the limbs. At 13.5 dpc, clearly observed in the developing digits.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during differentiation of the N1E-115 neuroblastoma cell line.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8VDR9, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
235607, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000034728

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8VDR9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VDR9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini546 – 712C2 DOCK-typePROSITE-ProRule annotationAdd BLAST167
Domaini1620 – 2056DOCKERPROSITE-ProRule annotationAdd BLAST437

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 44DisorderedSequence analysisAdd BLAST25
Regioni156 – 189DisorderedSequence analysisAdd BLAST34
Regioni408 – 441DisorderedSequence analysisAdd BLAST34
Regioni1101 – 1123DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 34Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi160 – 177Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi408 – 435Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi1104 – 1123Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DOCKER domain may mediate some GEF activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1997, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159313

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VDR9

Database of Orthologous Groups

More...
OrthoDBi
20156at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08696, C2_Dock-C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037808, C2_Dock-C
IPR027007, C2_DOCK-type_domain
IPR027357, C2_DOCKER_dom
IPR035892, C2_domain_sf
IPR026791, DOCK
IPR010703, DOCK_C
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C

The PANTHER Classification System

More...
PANTHERi
PTHR23317, PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VDR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASERRAFA HKINRTVAAE VRKQVSRERS GSPHSSRRSS SSLGVPLTEV
60 70 80 90 100
IEPLDFEDVL LSRPPEVEPG PLRDLIEFPV DDLELLKQPR ECRTTESGVP
110 120 130 140 150
EDGQLDAQVR AAVEMYSEDW VIVRRRYQHL STAYSPITTE TQREWQKGLT
160 170 180 190 200
CQVFEQDTPG DERTGPEDVD DPQHCSGSPE DTPRSSGASG IFSLRNLAAD
210 220 230 240 250
SLLPTLLEQA APEDVDRRNE ALRRQHRAPT LLTLYPAPDE DEAVERCSRP
260 270 280 290 300
EPPREHFGQR ILVKCLSLKF EIEIEPIFGT LALYDVREKK KISENFYFDL
310 320 330 340 350
NSDSVKGLLR AHGTHPAIST LARSAIFSVT YPSPDIFLVV KLEKVLQQGD
360 370 380 390 400
ISECCEPYMV MKEADTAKNK EKLEKLRLAA EQFCTRLGRY RMPFAWTAVH
410 420 430 440 450
LANIVSRPQD RDSDSEGERR PTWAERRRRG PQDRGYSGDD ACSFSSFRPA
460 470 480 490 500
TLTVTNFFKQ EAERLSDEDL FKFLADMRRP SSLLRRLRPV TAQLKLDISP
510 520 530 540 550
APENLHFCLS PDLLHVKPYP DPRGRPTKEI LEFPAREVYA PHSCYRNLLF
560 570 580 590 600
VYPHSLNFSS RQGSVRNLAV RIQYMAGEDQ SQALPVIFGK SSCSEFTREA
610 620 630 640 650
FTPVVYHNKS PEFYEEFKLR LPACVTENHH LFFTFYHVSC QPRPGTALET
660 670 680 690 700
PVGFTWIPLL QHGRLRTGPF CLPVSVDQPP PSYSVLTPDV ALPGMRWVDG
710 720 730 740 750
HKGVFSVELT AVSSVHPQDP HLDKFFTLVH VLEEGIFPFR LKETVLSEGT
760 770 780 790 800
MEQELRASLA ALRLASPEPL VAFSHLVLDK LVRLVVRPPI ICGQMVNLGR
810 820 830 840 850
GAFEAMAHVA SLVHRNLEAV QDSRGHCPLL ASYVHYAFRL PGGDLSLPGE
860 870 880 890 900
APPATVQAAT LARGSGRPAS LYLARSKSIS SSNPDLAVVP GSVDDEVSRI
910 920 930 940 950
LASKGVDRSH SWVNSAYAPG GSKAVLRRVP PYCGADPRQL LHEELALQWV
960 970 980 990 1000
VSGSAVRELV LQHAWFFFQL MVKSMELHLL LGQRLDTPRK LRFPGRFLDD
1010 1020 1030 1040 1050
IAALVASVGL EVITRVHKDM KLAERLNASL AFFLSDLLSI ADRGYIFSLV
1060 1070 1080 1090 1100
RAHYKQVATR LQSAPNPTAL LTLRMDFTRI LCSHEHYVTL NLPCCPLSPP
1110 1120 1130 1140 1150
ASPSPSVSST TSQSSTFSSQ APDPKVTSMF ELSGPFRQQH FLSGLLLTEL
1160 1170 1180 1190 1200
ALALDPEAEG ASLLHKKAIS AVHSLLCSHD VDSRYAEATV KAKVAELYLP
1210 1220 1230 1240 1250
LLSLARDTLP QLHGFAEGSG QRSRLASMLD SDTEGEGDIG STINPSVAMA
1260 1270 1280 1290 1300
IAGGPLAPGS RTSISQGPST AARSGCPLSA ESSRTLLVCV LWVLKNAEPT
1310 1320 1330 1340 1350
LLQRWAADLA LPQLGRLLDL LYLCLAAFEY KGKKAFERIN SLTFKKSLDM
1360 1370 1380 1390 1400
KARLEEAILG TIGARQEMVR RSRERSPFGN QENVRWRKSA THWRQTSDRV
1410 1420 1430 1440 1450
DKTKDEMEHE ALVDGNLATE ASLVVLDTLE TIVQTVMLSE ARESILSAVL
1460 1470 1480 1490 1500
KVVLYSLGSA QSALFLQHGL ATQRALVSKF PELLFEEDTE LCADLCLRLL
1510 1520 1530 1540 1550
RHCGSRISTI RMHASASLYL LMRQNFEIGH NFARVKMLVT MSLSSLVGTT
1560 1570 1580 1590 1600
QNFSEEHLRK SLKTILTYAE EDIGLRDSTF AEQVQDLMFN LHMILTDTVK
1610 1620 1630 1640 1650
MKEHQEDPEM LMDLMYRIAR GYQGSPDLRL TWLQNMAGKH AELGNHAEAA
1660 1670 1680 1690 1700
QCMVHAAALV AEYLALLEDS RHLPVGCVSF QNVSSNVLEE SAISDDILSP
1710 1720 1730 1740 1750
DEEGFCSGKN FTELGLVGLL EQAAGYFTMG GLYEAVNEVY KNLIPILEAH
1760 1770 1780 1790 1800
RDYKKLAAVH GKLQEAFTKI MHQSSGWERV FGTYFRVGFY GTRFGDLDEQ
1810 1820 1830 1840 1850
EFVYKEPSIT KLAEISHRLE EFYTERFGDD VVEIIKDSNP VDKSKLDPQK
1860 1870 1880 1890 1900
AYIQITYVEP HFDTYELKDR VTYFDRNYGL RAFLFCTPFT PDGRAHGELA
1910 1920 1930 1940 1950
EQHKRKTLLS TEHAFPYIKT RIRVCHREET VLTPVEVAIE DMQKKTRELA
1960 1970 1980 1990 2000
FATEQDPPDA KMLQMVLQGS VGPTVNQGPL EVAQVFLSEI PEDPKLFRHH
2010 2020 2030 2040 2050
NKLRLCFKDF CKKCEDALRK NKALIGPDQK EYHRELERHY SRLREALQPL
2060 2070 2080
LTQRLPQLLA PSSTSLRSSM NRSSFRKADL
Length:2,080
Mass (Da):233,267
Last modified:July 27, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC9541FB05DB78D0
GO
Isoform 2 (identifier: Q8VDR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     905-939: Missing.
     1019-1062: DMKLAERLNA...HYKQVATRLQ → VRKDSAQGCS...WPWLDVETQL
     1063-2080: Missing.

Show »
Length:1,027
Mass (Da):115,582
Checksum:i95426603C75A5DCF
GO
Isoform 3 (identifier: Q8VDR9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-244: DEAV → VGAY
     245-2080: Missing.

Show »
Length:244
Mass (Da):27,270
Checksum:i4F45CF7C640A6A83
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SQR4A0A1L1SQR4_MOUSE
Dedicator of cytokinesis protein 6
Dock6
2,111Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1STJ1A0A1L1STJ1_MOUSE
Dedicator of cytokinesis protein 6
Dock6
477Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1ST98A0A1L1ST98_MOUSE
Dedicator of cytokinesis protein 6
Dock6
577Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21414 differs from that shown. Contaminating sequence. Vector contamination at the N-terminus.Curated
The sequence AAH21414 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC37843 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti145W → R in BAE26239 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022257241 – 244DEAV → VGAY in isoform 3. 1 Publication4
Alternative sequenceiVSP_022258245 – 2080Missing in isoform 3. 1 PublicationAdd BLAST1836
Alternative sequenceiVSP_022259905 – 939Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0222601019 – 1062DMKLA…ATRLQ → VRKDSAQGCSVVRDPVCHVG LFIHGLFLEHLWFTWPWLDV ETQL in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_0222611063 – 2080Missing in isoform 2. 1 PublicationAdd BLAST1018

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK016777 mRNA Translation: BAB30423.2
AK080190 mRNA Translation: BAC37843.1 Frameshift.
AK145109 mRNA Translation: BAE26239.1
AC161371 Genomic DNA No translation available.
AC166992 Genomic DNA No translation available.
BC021414 mRNA Translation: AAH21414.1 Different initiation.
BC043042 mRNA Translation: AAH43042.1
BC057368 mRNA Translation: AAH57368.2

NCBI Reference Sequences

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RefSeqi
NP_796004.2, NM_177030.3
XP_011240856.1, XM_011242554.2 [Q8VDR9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000034728; ENSMUSP00000034728; ENSMUSG00000032198 [Q8VDR9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
319899

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:319899

UCSC genome browser

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UCSCi
uc009omn.1, mouse [Q8VDR9-1]
uc009omq.1, mouse [Q8VDR9-2]
uc009omt.1, mouse [Q8VDR9-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016777 mRNA Translation: BAB30423.2
AK080190 mRNA Translation: BAC37843.1 Frameshift.
AK145109 mRNA Translation: BAE26239.1
AC161371 Genomic DNA No translation available.
AC166992 Genomic DNA No translation available.
BC021414 mRNA Translation: AAH21414.1 Different initiation.
BC043042 mRNA Translation: AAH43042.1
BC057368 mRNA Translation: AAH57368.2
RefSeqiNP_796004.2, NM_177030.3
XP_011240856.1, XM_011242554.2 [Q8VDR9-1]

3D structure databases

SMRiQ8VDR9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi235607, 3 interactors
STRINGi10090.ENSMUSP00000034728

PTM databases

iPTMnetiQ8VDR9
PhosphoSitePlusiQ8VDR9

Proteomic databases

jPOSTiQ8VDR9
PaxDbiQ8VDR9
PeptideAtlasiQ8VDR9
PRIDEiQ8VDR9
ProteomicsDBi279755 [Q8VDR9-1]
279756 [Q8VDR9-2]
279757 [Q8VDR9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
69705, 41 antibodies

Genome annotation databases

EnsembliENSMUST00000034728; ENSMUSP00000034728; ENSMUSG00000032198 [Q8VDR9-1]
GeneIDi319899
KEGGimmu:319899
UCSCiuc009omn.1, mouse [Q8VDR9-1]
uc009omq.1, mouse [Q8VDR9-2]
uc009omt.1, mouse [Q8VDR9-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57572
MGIiMGI:1914789, Dock6
VEuPathDBiHostDB:ENSMUSG00000032198

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1997, Eukaryota
GeneTreeiENSGT00940000159313
InParanoidiQ8VDR9
OrthoDBi20156at2759

Enzyme and pathway databases

ReactomeiR-MMU-9013148, CDC42 GTPase cycle
R-MMU-9013149, RAC1 GTPase cycle
R-MMU-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
319899, 3 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Dock6, mouse

Protein Ontology

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PROi
PR:Q8VDR9
RNActiQ8VDR9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

ExpressionAtlasiQ8VDR9, baseline and differential

Family and domain databases

CDDicd08696, C2_Dock-C, 1 hit
Gene3Di1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR037808, C2_Dock-C
IPR027007, C2_DOCK-type_domain
IPR027357, C2_DOCKER_dom
IPR035892, C2_domain_sf
IPR026791, DOCK
IPR010703, DOCK_C
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
PANTHERiPTHR23317, PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit
PROSITEiView protein in PROSITE
PS51650, C2_DOCK, 1 hit
PS51651, DOCKER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOCK6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VDR9
Secondary accession number(s): E9QKQ0
, Q3UM59, Q6PFY0, Q8BJS1, Q9D461
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: July 27, 2011
Last modified: September 29, 2021
This is version 128 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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