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Entry version 139 (16 Oct 2019)
Sequence version 2 (22 Jul 2008)
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Protein

Prostaglandin reductase 2

Gene

Ptgr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=49.6 µM for 15-keto-PGE21 Publication
  2. KM=34.4 µM for 15-keto-PGE11 Publication
  3. KM=108.8 µM for 15-keto-PGF2-alpha1 Publication
  4. KM=59.2 µM for 15-keto-PGF2-beta1 Publication
  5. KM=94.6 µM for NADPH1 Publication
  1. Vmax=178.4 µmol/min/mg enzyme for 15-keto-PGE21 Publication
  2. Vmax=115.0 µmol/min/mg enzyme for 15-keto-PGE11 Publication
  3. Vmax=230.9 µmol/min/mg enzyme for 15-keto-PGF2-alpha1 Publication
  4. Vmax=206.4 µmol/min/mg enzyme for 15-keto-PGF2-beta1 Publication
  5. Vmax=144.7 µmol/min/mg enzyme for NADPH1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei192NADP1 Publication1
Binding sitei208NADP1 Publication1
Binding sitei231NADP1 Publication1
Binding sitei337NADP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi165 – 168NADP1 Publication4
Nucleotide bindingi253 – 259NADP1 Publication7
Nucleotide bindingi287 – 289NADP1 Publication3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.3.1.48 3474

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q8VDQ1

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001623

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostaglandin reductase 2 (EC:1.3.1.48)
Short name:
PRG-2
Alternative name(s):
15-oxoprostaglandin 13-reductase
Zinc-binding alcohol dehydrogenase domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ptgr2
Synonyms:Zadh1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916372 Ptgr2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi259Y → F: Significant reduction in catalytic efficiency. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002180711 – 351Prostaglandin reductase 2Add BLAST351

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8VDQ1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8VDQ1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VDQ1

PeptideAtlas

More...
PeptideAtlasi
Q8VDQ1

PRoteomics IDEntifications database

More...
PRIDEi
Q8VDQ1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VDQ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VDQ1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8VDQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in adipose tissues.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in the late phase of adipocyte differentiation (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000072946 Expressed in 267 organ(s), highest expression level in heart left ventricle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8VDQ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VDQ1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
218562, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8VDQ1, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8VDQ1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000115704

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1351
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VDQ1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8VDQ1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni99 – 100Substrate bindingBy similarity2
Regioni288 – 290Substrate bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1196 Eukaryota
COG2130 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156793

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294663

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VDQ1

KEGG Orthology (KO)

More...
KOi
K13949

Identification of Orthologs from Complete Genome Data

More...
OMAi
WMSDIPQ

Database of Orthologous Groups

More...
OrthoDBi
884151at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324201

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08293 PTGR2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013149 ADH_C
IPR041694 ADH_N_2
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR037399 PTGR2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16884 ADH_N_2, 1 hit
PF00107 ADH_zinc_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VDQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIIQRVVLNS RPGKNGNPVA ENFRVEEFSL PDALNEGQVQ VRTLYLSVDP
60 70 80 90 100
YMRCKMNEDT GTDYLAPWQL AQVADGGGIG VVEESKHQKL TKGDFVTSFY
110 120 130 140 150
WPWQTKAILD GNGLEKVDPQ LVDGHLSYFL GAIGMPGLTS LIGVQEKGHI
160 170 180 190 200
SAGSNQTMVV SGAAGACGSL AGQIGHLLGC SRVVGICGTQ EKCLFLTSEL
210 220 230 240 250
GFDAAVNYKT GNVAEQLREA CPGGVDVYFD NVGGDISNAV ISQMNENSHI
260 270 280 290 300
ILCGQISQYS NDVPYPPPLP PAVEAIRKER NITRERFTVL NYKDKFEPGI
310 320 330 340 350
LQLSQWFKEG KLKVKETMAK GLENMGVAFQ SMMTGGNVGK QIVCISEDSS

L
Length:351
Mass (Da):38,015
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2766871577A8022F
GO
Isoform 2 (identifier: Q8VDQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-316: VKE → FLF
     317-351: Missing.

Note: No experimental confirmation available.
Show »
Length:316
Mass (Da):34,449
Checksum:i7699BA248C3E09D0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TXN1Q3TXN1_MOUSE
Prostaglandin reductase 2
Ptgr2 Zadh1
315Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGL6D6RGL6_MOUSE
Prostaglandin reductase 2
Ptgr2
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18P → T in BAB32284 (PubMed:16141072).Curated1
Sequence conflicti31P → L in AAH21466 (PubMed:15489334).Curated1
Sequence conflicti81V → I in BAE26315 (PubMed:16141072).Curated1
Sequence conflicti81V → I in AAH21466 (PubMed:15489334).Curated1
Sequence conflicti91T → A in BAE26315 (PubMed:16141072).Curated1
Sequence conflicti91T → A in AAH21466 (PubMed:15489334).Curated1
Sequence conflicti239A → T in BAE26315 (PubMed:16141072).Curated1
Sequence conflicti239A → T in AAH21466 (PubMed:15489334).Curated1
Sequence conflicti260 – 261SN → NK in BAE26315 (PubMed:16141072).Curated2
Sequence conflicti260 – 261SN → NK in AAH21466 (PubMed:15489334).Curated2
Sequence conflicti318M → V in BAE26315 (PubMed:16141072).Curated1
Sequence conflicti318M → V in AAH21466 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013528314 – 316VKE → FLF in isoform 2. 1 Publication3
Alternative sequenceiVSP_013529317 – 351Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK036168 mRNA Translation: BAC29329.1
AK021033 mRNA Translation: BAB32284.1
AK145232 mRNA Translation: BAE26315.1
AK159932 mRNA Translation: BAE35493.1
AK168895 mRNA Translation: BAE40712.1
BC021466 mRNA Translation: AAH21466.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36490.1 [Q8VDQ1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001239554.1, NM_001252625.1 [Q8VDQ1-1]
NP_001239555.1, NM_001252626.1
NP_084156.2, NM_029880.3 [Q8VDQ1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000123614; ENSMUSP00000115704; ENSMUSG00000072946 [Q8VDQ1-1]
ENSMUST00000146377; ENSMUSP00000119981; ENSMUSG00000072946 [Q8VDQ1-1]
ENSMUST00000147363; ENSMUSP00000114766; ENSMUSG00000072946 [Q8VDQ1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
77219

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:77219

UCSC genome browser

More...
UCSCi
uc007oep.2 mouse [Q8VDQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036168 mRNA Translation: BAC29329.1
AK021033 mRNA Translation: BAB32284.1
AK145232 mRNA Translation: BAE26315.1
AK159932 mRNA Translation: BAE35493.1
AK168895 mRNA Translation: BAE40712.1
BC021466 mRNA Translation: AAH21466.1
CCDSiCCDS36490.1 [Q8VDQ1-1]
RefSeqiNP_001239554.1, NM_001252625.1 [Q8VDQ1-1]
NP_001239555.1, NM_001252626.1
NP_084156.2, NM_029880.3 [Q8VDQ1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VJ1X-ray2.10A1-351[»]
2ZB3X-ray2.00A1-351[»]
SMRiQ8VDQ1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi218562, 1 interactor
IntActiQ8VDQ1, 2 interactors
MINTiQ8VDQ1
STRINGi10090.ENSMUSP00000115704

Chemistry databases

SwissLipidsiSLP:000001623

PTM databases

iPTMnetiQ8VDQ1
PhosphoSitePlusiQ8VDQ1
SwissPalmiQ8VDQ1

Proteomic databases

EPDiQ8VDQ1
jPOSTiQ8VDQ1
PaxDbiQ8VDQ1
PeptideAtlasiQ8VDQ1
PRIDEiQ8VDQ1

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
77219

Genome annotation databases

EnsembliENSMUST00000123614; ENSMUSP00000115704; ENSMUSG00000072946 [Q8VDQ1-1]
ENSMUST00000146377; ENSMUSP00000119981; ENSMUSG00000072946 [Q8VDQ1-1]
ENSMUST00000147363; ENSMUSP00000114766; ENSMUSG00000072946 [Q8VDQ1-2]
GeneIDi77219
KEGGimmu:77219
UCSCiuc007oep.2 mouse [Q8VDQ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
145482
MGIiMGI:1916372 Ptgr2

Phylogenomic databases

eggNOGiKOG1196 Eukaryota
COG2130 LUCA
GeneTreeiENSGT00940000156793
HOGENOMiHOG000294663
InParanoidiQ8VDQ1
KOiK13949
OMAiWMSDIPQ
OrthoDBi884151at2759
TreeFamiTF324201

Enzyme and pathway databases

BRENDAi1.3.1.48 3474
SABIO-RKiQ8VDQ1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ptgr2 mouse
EvolutionaryTraceiQ8VDQ1

Protein Ontology

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PROi
PR:Q8VDQ1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000072946 Expressed in 267 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiQ8VDQ1 baseline and differential
GenevisibleiQ8VDQ1 MM

Family and domain databases

CDDicd08293 PTGR2, 1 hit
InterProiView protein in InterPro
IPR013149 ADH_C
IPR041694 ADH_N_2
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR037399 PTGR2
PfamiView protein in Pfam
PF16884 ADH_N_2, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTGR2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VDQ1
Secondary accession number(s): Q3TG36
, Q3ULY3, Q8BZA2, Q9D1W8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 22, 2008
Last modified: October 16, 2019
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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