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Protein

Heterogeneous nuclear ribonucleoprotein U-like protein 1

Gene

Hnrnpul1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor, Ribonucleoprotein, RNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein U-like protein 1
Gene namesi
Name:Hnrnpul1
Synonyms:Hnrpul1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2443517 Hnrnpul1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275561 – 859Heterogeneous nuclear ribonucleoprotein U-like protein 1Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki143Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki143Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei195PhosphoserineCombined sources1
Modified residuei210PhosphothreonineCombined sources1
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki450Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei513PhosphoserineBy similarity1
Cross-linki540Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei639Asymmetric dimethylarginineCombined sources1
Modified residuei645Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei645Omega-N-methylarginine; alternateCombined sources1
Modified residuei659Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei659Omega-N-methylarginine; alternateCombined sources1
Modified residuei664Omega-N-methylarginineCombined sources1
Modified residuei674Omega-N-methylarginineBy similarity1
Modified residuei721PhosphoserineBy similarity1

Post-translational modificationi

Methylated.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8VDM6
PaxDbiQ8VDM6
PeptideAtlasiQ8VDM6
PRIDEiQ8VDM6

PTM databases

iPTMnetiQ8VDM6
PhosphoSitePlusiQ8VDM6

Expressioni

Gene expression databases

BgeeiENSMUSG00000040725 Expressed in 274 organ(s), highest expression level in humerus cartilage element
GenevisibleiQ8VDM6 MM

Interactioni

Subunit structurei

Interacts with BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231344, 2 interactors
IntActiQ8VDM6, 4 interactors
MINTiQ8VDM6
STRINGi10090.ENSMUSP00000037268

Structurei

3D structure databases

ProteinModelPortaliQ8VDM6
SMRiQ8VDM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 37SAPPROSITE-ProRule annotationAdd BLAST35
Domaini192 – 389B30.2/SPRYPROSITE-ProRule annotationAdd BLAST198
Repeati613 – 6151-13
Repeati620 – 6221-23
Repeati639 – 6411-33
Repeati645 – 6471-43
Repeati659 – 6611-53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 103Necessary for interaction with HRMT1L1By similarityAdd BLAST103
Regioni214 – 859Necessary for interaction with TP53By similarityAdd BLAST646
Regioni457 – 595Necessary for interaction with BRD7 and transcriptional activationBy similarityAdd BLAST139
Regioni613 – 6615 X 3 AA repeats of R-G-GAdd BLAST49
Regioni613 – 661Necessary for transcription repressionBy similarityAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi614 – 669Gly-richAdd BLAST56
Compositional biasi671 – 692Asn-richAdd BLAST22
Compositional biasi695 – 814Pro-richAdd BLAST120
Compositional biasi760 – 848Tyr-richAdd BLAST89
Compositional biasi809 – 835Gln-richAdd BLAST27

Domaini

The RGG-box domain is methylated.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2242 Eukaryota
ENOG410XSBV LUCA
GeneTreeiENSGT00390000020210
HOGENOMiHOG000253920
HOVERGENiHBG061101
InParanoidiQ8VDM6
KOiK15047
OrthoDBiEOG091G041T
PhylomeDBiQ8VDM6
TreeFamiTF317301

Family and domain databases

CDDicd12884 SPRY_hnRNP, 1 hit
Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR027025 hnRNP_U-like_1
IPR027417 P-loop_NTPase
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR003877 SPRY_dom
IPR035778 SPRY_hnRNP_U
PANTHERiPTHR12381:SF41 PTHR12381:SF41, 1 hit
PfamiView protein in Pfam
PF02037 SAP, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 1 hit
SSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50800 SAP, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8VDM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVRRLKVNE LREELQRRGL DTRGLKAELA ERLLAALEAE EPEDERELEA
60 70 80 90 100
DDDPGLPGHN NEEVETEGGS ELEGTAQPPP PGLQPHPEPG GYSGPDGHYV
110 120 130 140 150
MDNITRQNQF YETPVIKQEN ESSYDRRPLD MEPQQQVYHP ELKTEMKQEA
160 170 180 190 200
PPSFLPPEAS QLKTDRPQFQ NRKRPFEENR GRGYFEHRED RRGRSPQPPA
210 220 230 240 250
EEDEDDFDDT LVAIDTYNCD LHFKVARDRS SGYPLTIEGF AYLWSGARAS
260 270 280 290 300
YGVRRGRVCF EMKINEEISV KHLPSTEPDP HVVRIGWSLD SCSTQLGEEP
310 320 330 340 350
FSYGYGGTGK KSTNSRFENY GDKFAENDVI GCFADFECGN DVELSFTKNG
360 370 380 390 400
KWMGIAFRIQ KEALGGQALY PHVLVKNCAV EFNFGQRAEP YCSVLPGFTF
410 420 430 440 450
IQHLPLSERI RGTIGPKSKA ECEILMMVGL PAAGKTTWAI KHAASNPSKK
460 470 480 490 500
YNILGTNAIM DKMRVMGLRR QRNYAGRWDV LIQQATQCLN RLIQIAARKK
510 520 530 540 550
RNYILDQTNV YGSAQRRKMR PFEGFQRKAI VICPTDEDLK DRTVKRTDEE
560 570 580 590 600
GKDVPDHAVL EMKANFTLPD VGDFLDEVLF IELQREEADK LVRQYNEEGR
610 620 630 640 650
KAGPPPEKRF DSRGGGFRGR GGGGGFQRYD NRGPPGGNRG GFQNRGGGGG
660 670 680 690 700
SGGGGGNYRG GFNRSGGGGY NQNRWGNNNR DNNNSNNRGN YNRAPQQQPP
710 720 730 740 750
PQQPPPPQPP PQQPPPPPSY SPARNPPGAS SYNKNSNIPG SSANTSTPTV
760 770 780 790 800
SSYTPPQPSY SQPPYNQGGY TQGYTAPPPP PPPPPAYNYG SYGPYNPAPY
810 820 830 840 850
TPPPPPTAQT YPQPSYNQYQ QYAQQWSQYY QNQSQWPPYY GNYDYGGYSG

STQGGTSTQ
Length:859
Mass (Da):96,002
Last modified:March 1, 2002 - v1
Checksum:i197328B681DF260E
GO
Isoform 2 (identifier: Q8VDM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Show »
Length:759
Mass (Da):85,046
Checksum:i7DB36055FFEE4BF0
GO
Isoform 3 (identifier: Q8VDM6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-340: DFECGN → VLELQV
     341-859: Missing.

Show »
Length:340
Mass (Da):38,733
Checksum:i78013360382D09E2
GO

Sequence cautioni

The sequence AAH27844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti657N → Y in BAE33342 (PubMed:16141072).Curated1
Sequence conflicti665S → T in BAE33342 (PubMed:16141072).Curated1
Sequence conflicti672Q → L in BAE33342 (PubMed:16141072).Curated1
Sequence conflicti686N → Y in BAE33342 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0175531 – 100Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_017554335 – 340DFECGN → VLELQV in isoform 3. 1 Publication6
Alternative sequenceiVSP_017555341 – 859Missing in isoform 3. 1 PublicationAdd BLAST519

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042090 mRNA Translation: BAC31161.1
AK143666 mRNA Translation: BAE25486.1
AK155604 mRNA Translation: BAE33342.1
BC021506 mRNA Translation: AAH21506.1
BC027844 mRNA Translation: AAH27844.1 Different initiation.
BC078642 mRNA Translation: AAH78642.1
CCDSiCCDS20995.1 [Q8VDM6-1]
CCDS39841.1 [Q8VDM6-3]
RefSeqiNP_659171.1, NM_144922.2 [Q8VDM6-1]
NP_835190.1, NM_178089.2 [Q8VDM6-3]
XP_006539918.1, XM_006539855.3 [Q8VDM6-2]
XP_006539919.1, XM_006539856.2 [Q8VDM6-2]
UniGeneiMm.254223

Genome annotation databases

EnsembliENSMUST00000043765; ENSMUSP00000037268; ENSMUSG00000040725 [Q8VDM6-2]
ENSMUST00000108401; ENSMUSP00000104038; ENSMUSG00000040725 [Q8VDM6-3]
ENSMUST00000206832; ENSMUSP00000146263; ENSMUSG00000040725 [Q8VDM6-1]
GeneIDi232989
KEGGimmu:232989
UCSCiuc009ftu.1 mouse [Q8VDM6-1]
uc009ftw.1 mouse [Q8VDM6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042090 mRNA Translation: BAC31161.1
AK143666 mRNA Translation: BAE25486.1
AK155604 mRNA Translation: BAE33342.1
BC021506 mRNA Translation: AAH21506.1
BC027844 mRNA Translation: AAH27844.1 Different initiation.
BC078642 mRNA Translation: AAH78642.1
CCDSiCCDS20995.1 [Q8VDM6-1]
CCDS39841.1 [Q8VDM6-3]
RefSeqiNP_659171.1, NM_144922.2 [Q8VDM6-1]
NP_835190.1, NM_178089.2 [Q8VDM6-3]
XP_006539918.1, XM_006539855.3 [Q8VDM6-2]
XP_006539919.1, XM_006539856.2 [Q8VDM6-2]
UniGeneiMm.254223

3D structure databases

ProteinModelPortaliQ8VDM6
SMRiQ8VDM6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231344, 2 interactors
IntActiQ8VDM6, 4 interactors
MINTiQ8VDM6
STRINGi10090.ENSMUSP00000037268

PTM databases

iPTMnetiQ8VDM6
PhosphoSitePlusiQ8VDM6

Proteomic databases

EPDiQ8VDM6
PaxDbiQ8VDM6
PeptideAtlasiQ8VDM6
PRIDEiQ8VDM6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043765; ENSMUSP00000037268; ENSMUSG00000040725 [Q8VDM6-2]
ENSMUST00000108401; ENSMUSP00000104038; ENSMUSG00000040725 [Q8VDM6-3]
ENSMUST00000206832; ENSMUSP00000146263; ENSMUSG00000040725 [Q8VDM6-1]
GeneIDi232989
KEGGimmu:232989
UCSCiuc009ftu.1 mouse [Q8VDM6-1]
uc009ftw.1 mouse [Q8VDM6-3]

Organism-specific databases

CTDi11100
MGIiMGI:2443517 Hnrnpul1

Phylogenomic databases

eggNOGiKOG2242 Eukaryota
ENOG410XSBV LUCA
GeneTreeiENSGT00390000020210
HOGENOMiHOG000253920
HOVERGENiHBG061101
InParanoidiQ8VDM6
KOiK15047
OrthoDBiEOG091G041T
PhylomeDBiQ8VDM6
TreeFamiTF317301

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:Q8VDM6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040725 Expressed in 274 organ(s), highest expression level in humerus cartilage element
GenevisibleiQ8VDM6 MM

Family and domain databases

CDDicd12884 SPRY_hnRNP, 1 hit
Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR027025 hnRNP_U-like_1
IPR027417 P-loop_NTPase
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR003877 SPRY_dom
IPR035778 SPRY_hnRNP_U
PANTHERiPTHR12381:SF41 PTHR12381:SF41, 1 hit
PfamiView protein in Pfam
PF02037 SAP, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 1 hit
SSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50800 SAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHNRL1_MOUSE
AccessioniPrimary (citable) accession number: Q8VDM6
Secondary accession number(s): Q3U201
, Q3UPB0, Q6AZA7, Q8BY45, Q8K365
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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