UniProtKB - Q8VDK3 (ELF5_MOUSE)
Protein
ETS-related transcription factor Elf-5
Gene
Elf5
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity). Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter.By similarity2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 161 – 242 | ETSPROSITE-ProRule annotationAdd BLAST | 82 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- cell differentiation Source: GO_Central
- ectodermal cell fate commitment Source: MGI
- ectoderm development Source: MGI
- mammary gland epithelial cell differentiation Source: MGI
- negative regulation of cell differentiation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
- somatic stem cell population maintenance Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: ETS-related transcription factor Elf-5Alternative name(s): E74-like factor 5 |
Gene namesi | Name:Elf5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1335079, Elf5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204093 | 1 – 253 | ETS-related transcription factor Elf-5Add BLAST | 253 |
Proteomic databases
PaxDbi | Q8VDK3 |
PRIDEi | Q8VDK3 |
PTM databases
iPTMneti | Q8VDK3 |
PhosphoSitePlusi | Q8VDK3 |
Expressioni
Tissue specificityi
Expressed in lung, kidney, stomach, brain, ovaries, tongue, bladder and mammary glands.1 Publication
Developmental stagei
In the neonatal stage, and during embryogenesis on days 16, 17 and 19, an expression pattern similar to the adult was observed. In addition at stage 16, expression was detected in small intestine.
Gene expression databases
Bgeei | ENSMUSG00000027186, Expressed in seminal vesicle and 130 other tissues |
ExpressionAtlasi | Q8VDK3, baseline and differential |
Genevisiblei | Q8VDK3, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 199428, 104 interactors |
STRINGi | 10090.ENSMUSP00000028609 |
Miscellaneous databases
RNActi | Q8VDK3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 119 | PNTPROSITE-ProRule annotationAdd BLAST | 87 |
Domaini
The PNT domain acts as a transcriptional activator.1 Publication
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000160980 |
HOGENOMi | CLU_048172_1_0_1 |
InParanoidi | Q8VDK3 |
OMAi | AHGWQEE |
OrthoDBi | 837296at2759 |
PhylomeDBi | Q8VDK3 |
TreeFami | TF318679 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR033069, Elf5 IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849:SF15, PTHR11849:SF15, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8VDK3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLDSVTHSTF LPNASFCDPL MPWTDLFSNE DYYPAFEHQT ACDSYWTSVH
60 70 80 90 100
PEYWTKRHVW EWLQFCCDQY KLDANCISFC HFNISGLQLC SMTQEEFIEA
110 120 130 140 150
AGICGEYLYF ILQNIRSQGY SFFNDAEETK TGIKDYADSS CLKTSGIKSQ
160 170 180 190 200
DCHSRTSLQS SHLWEFVRDL LLSPEENCGI LEWEDREQGI FRVVKSEALA
210 220 230 240 250
KMWGQRKKND RMTYEKLSRA LRYYYKTGIL ERVDRRLVYK FGKNAHGWQE
EKL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2AL22 | A2AL22_MOUSE | ETS-related transcription factor El... | Elf5 | 198 | Annotation score: | ||
A0A668KM45 | A0A668KM45_MOUSE | ETS-related transcription factor El... | Elf5 | 272 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 31 | D → E in AAH21629 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 228 | G → R in AAC79754 (PubMed:9840936).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF049702 mRNA Translation: AAC79754.1 BC021629 mRNA Translation: AAH21629.1 BC012424 mRNA Translation: AAH12424.1 |
CCDSi | CCDS16477.1 |
RefSeqi | NP_001139285.1, NM_001145813.1 NP_034255.2, NM_010125.3 XP_006498768.1, XM_006498705.1 |
Genome annotation databases
Ensembli | ENSMUST00000028609; ENSMUSP00000028609; ENSMUSG00000027186 ENSMUST00000164172; ENSMUSP00000126941; ENSMUSG00000027186 ENSMUST00000171693; ENSMUSP00000131940; ENSMUSG00000027186 |
GeneIDi | 13711 |
KEGGi | mmu:13711 |
UCSCi | uc008liv.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF049702 mRNA Translation: AAC79754.1 BC021629 mRNA Translation: AAH21629.1 BC012424 mRNA Translation: AAH12424.1 |
CCDSi | CCDS16477.1 |
RefSeqi | NP_001139285.1, NM_001145813.1 NP_034255.2, NM_010125.3 XP_006498768.1, XM_006498705.1 |
3D structure databases
SMRi | Q8VDK3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199428, 104 interactors |
STRINGi | 10090.ENSMUSP00000028609 |
PTM databases
iPTMneti | Q8VDK3 |
PhosphoSitePlusi | Q8VDK3 |
Proteomic databases
PaxDbi | Q8VDK3 |
PRIDEi | Q8VDK3 |
Protocols and materials databases
Antibodypediai | 25870, 248 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000028609; ENSMUSP00000028609; ENSMUSG00000027186 ENSMUST00000164172; ENSMUSP00000126941; ENSMUSG00000027186 ENSMUST00000171693; ENSMUSP00000131940; ENSMUSG00000027186 |
GeneIDi | 13711 |
KEGGi | mmu:13711 |
UCSCi | uc008liv.2, mouse |
Organism-specific databases
CTDi | 2001 |
MGIi | MGI:1335079, Elf5 |
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000160980 |
HOGENOMi | CLU_048172_1_0_1 |
InParanoidi | Q8VDK3 |
OMAi | AHGWQEE |
OrthoDBi | 837296at2759 |
PhylomeDBi | Q8VDK3 |
TreeFami | TF318679 |
Miscellaneous databases
BioGRID-ORCSi | 13711, 2 hits in 17 CRISPR screens |
ChiTaRSi | Elf5, mouse |
PROi | PR:Q8VDK3 |
RNActi | Q8VDK3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027186, Expressed in seminal vesicle and 130 other tissues |
ExpressionAtlasi | Q8VDK3, baseline and differential |
Genevisiblei | Q8VDK3, MM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR033069, Elf5 IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849:SF15, PTHR11849:SF15, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ELF5_MOUSE | |
Accessioni | Q8VDK3Primary (citable) accession number: Q8VDK3 Secondary accession number(s): Q921H5, Q9Z2K6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | July 5, 2005 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families