UniProtKB - Q8VDJ3 (VIGLN_MOUSE)
Protein
Vigilin
Gene
Hdlbp
Organism
Mus musculus (Mouse)
Status
Functioni
Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity).By similarity
GO - Molecular functioni
- mRNA binding Source: GO_Central
GO - Biological processi
- cholesterol metabolic process Source: UniProtKB-KW
- lipid transport Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Biological process | Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-8964011, HDL clearance |
Names & Taxonomyi
Protein namesi | Recommended name: VigilinAlternative name(s): High density lipoprotein-binding protein Short name: HDL-binding protein |
Gene namesi | Name:Hdlbp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99256, Hdlbp |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Extracellular region or secreted
- high-density lipoprotein particle Source: UniProtKB-KW
Nucleus
- nucleus Source: GO_Central
Other locations
Keywords - Cellular componenti
Cytoplasm, HDL, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000050132 | 2 – 1268 | VigilinAdd BLAST | 1267 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 8 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 11 | PhosphoserineBy similarity | 1 | |
Modified residuei | 31 | PhosphoserineCombined sources | 1 | |
Modified residuei | 295 | PhosphothreonineSequence analysis | 1 | |
Modified residuei | 296 | PhosphothreonineSequence analysis | 1 | |
Modified residuei | 317 | PhosphoserineBy similarity | 1 | |
Modified residuei | 437 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 645 | PhosphoserineBy similarity | 1 | |
Modified residuei | 991 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1247 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1252 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8VDJ3 |
jPOSTi | Q8VDJ3 |
MaxQBi | Q8VDJ3 |
PaxDbi | Q8VDJ3 |
PRIDEi | Q8VDJ3 |
PTM databases
iPTMneti | Q8VDJ3 |
PhosphoSitePlusi | Q8VDJ3 |
SwissPalmi | Q8VDJ3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034088, Expressed in embryonic post-anal tail and 315 other tissues |
Genevisiblei | Q8VDJ3, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 225750, 17 interactors |
IntActi | Q8VDJ3, 7 interactors |
MINTi | Q8VDJ3 |
STRINGi | 10090.ENSMUSP00000127903 |
Miscellaneous databases
RNActi | Q8VDJ3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 150 – 212 | KH 1PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 222 – 284 | KH 2PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 295 – 357 | KH 3PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 364 – 424 | KH 4PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 435 – 497 | KH 5PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 507 – 570 | KH 6PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 581 – 643 | KH 7PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 653 – 716 | KH 8PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 727 – 790 | KH 9PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 800 – 863 | KH 10PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 873 – 967 | KH 11PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 972 – 1034 | KH 12PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 1052 – 1117 | KH 13PROSITE-ProRule annotationAdd BLAST | 66 | |
Domaini | 1127 – 1190 | KH 14PROSITE-ProRule annotationAdd BLAST | 64 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2208, Eukaryota |
GeneTreei | ENSGT00900000141059 |
HOGENOMi | CLU_008532_0_0_1 |
InParanoidi | Q8VDJ3 |
OMAi | HPFIVGP |
OrthoDBi | 248989at2759 |
PhylomeDBi | Q8VDJ3 |
TreeFami | TF323767 |
Family and domain databases
Gene3Di | 3.30.1370.10, 14 hits |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf |
Pfami | View protein in Pfam PF00013, KH_1, 14 hits |
SMARTi | View protein in SMART SM00322, KH, 14 hits |
SUPFAMi | SSF54791, SSF54791, 14 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 14 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q8VDJ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSVAVLTQE SFAEHRSGLV PQQIKVATLN SEEENDPPTY KDAFPPLPEK
60 70 80 90 100
AACLESAQEP AGAWSNKIRP IKASVITQVF HVPLEERKYK DMNQFGEGEQ
110 120 130 140 150
AKICLEIMQR TGAHLELSLA KDQGLSIMVS GKLDAVMKAR KDIVARLQTQ
160 170 180 190 200
ASATVPIPKE HHRFVIGKNG EKLQDLELKT ATKIQIPRPD DPSNQIKITG
210 220 230 240 250
TKEGIEKARH EVLLISAEQD KRAVERLEVE KAFHPFIAGP YNRLVGEIMQ
260 270 280 290 300
ETGTRINIPP PSVNRTEIVF TGEKEQLAQA VARIKKIYEE KKKKTTTIAV
310 320 330 340 350
EVKKSQHKYV IGPKGNSLQE ILERTGVSVE IPPSDSISET VILRGEPEKL
360 370 380 390 400
GQALTEVYAK ANSFTVSSVS APSWLHRFII GKKGQNLAKI TQQMPKVHIE
410 420 430 440 450
FTEGEDKITL EGPTEDVNVA QEQIEGMVKD LINRMDYVEI NIDHKFHRHL
460 470 480 490 500
IGKSGANINR IKDQYKVSVR IPPDSEKSNL IRIEGDPQGV QQAKRELLEL
510 520 530 540 550
ASRMENERTK DLIIEQRFHR TIIGQKGERI REIRDKFPEV IINFPDPAQK
560 570 580 590 600
SDIVQLRGPK NEVEKCTKYM QKMVADLVEN SYSISVPIFK QFHKNIIGKG
610 620 630 640 650
GANIKKIREE SNTKIDLPAE NSNSETIIIT GKRANCEAAR SRILSIQKDL
660 670 680 690 700
ANIAEVEVSI PAKLHNSLIG TKGRLIRSIM EECGGVHIHF PVEGSGSDTV
710 720 730 740 750
VIRGPSSDVE KAKKQLLHLA EEKQTKSFTV DIRAKPEYHK FLIGKGGGKI
760 770 780 790 800
RKVRDSTGAR IIFPAAEDKD QDLITIIGKE DAVREAQKEL EALIQNLENV
810 820 830 840 850
VEDYMLVDPK HHRHFVIRRG QVLREIAEEY GGVMVSFPRS GTQSDKVTLK
860 870 880 890 900
GAKDCVEAAK KRIQEIIEDL EAQVTVECAI PQKFHRSVMG PKGSRIQQIT
910 920 930 940 950
RDYNVQIKFP DREENPVHSV EPSIQENGDE AGEGREAKET DPGSPRRCDI
960 970 980 990 1000
IIISGRKEKC EAAKEALEAL VPVTIEVEVP FDLHRYIIGQ KGSGIRKMMD
1010 1020 1030 1040 1050
EFEVNIHVPA PELQSDTIAI TGLAANLDRA KAGLLDRVKE LQAEQEDRAL
1060 1070 1080 1090 1100
RSFKLSVTVD PKYHPKIIGR KGAVITQIRL EHEVNIQFPD KDDGNQPQDQ
1110 1120 1130 1140 1150
ITITGYEKNT EAARDAILKI VGELEQMVSE DVPLDHRVHA RIIGARGKAI
1160 1170 1180 1190 1200
RKIMDEFKVD IRFPQSGAPD PNCVTVTGLP ENVEEAIDHI LNLEEEYLAD
1210 1220 1230 1240 1250
VVDSEALQVY MKPPAHEESR APSKGFVVRD APWTSNSSEK APDMSSSEEF
1260
PSFGAQVAPK TLPWGPKR
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WP83 | A0A087WP83_MOUSE | Vigilin | Hdlbp | 1,199 | Annotation score: | ||
A0A087WS92 | A0A087WS92_MOUSE | Vigilin | Hdlbp | 178 | Annotation score: | ||
A0A087WPH2 | A0A087WPH2_MOUSE | Vigilin | Hdlbp | 22 | Annotation score: | ||
A0A087WNQ4 | A0A087WNQ4_MOUSE | Vigilin | Hdlbp | 22 | Annotation score: | ||
A0A087WPC5 | A0A087WPC5_MOUSE | Vigilin | Hdlbp | 141 | Annotation score: | ||
A0A087WQY9 | A0A087WQY9_MOUSE | Vigilin | Hdlbp | 129 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC021765 mRNA Translation: AAH21765.1 BC023806 mRNA Translation: AAH23806.1 BC025648 mRNA Translation: AAH25648.1 BC027779 mRNA Translation: AAH27779.1 BC027788 mRNA Translation: AAH27788.1 BC035301 mRNA Translation: AAH35301.1 |
CCDSi | CCDS15189.1 |
RefSeqi | NP_001288293.1, NM_001301364.1 NP_598569.1, NM_133808.5 XP_006529137.1, XM_006529074.2 XP_006529138.1, XM_006529075.2 XP_006529139.1, XM_006529076.2 XP_006529140.1, XM_006529077.3 |
Genome annotation databases
Ensembli | ENSMUST00000042498; ENSMUSP00000043047; ENSMUSG00000034088 ENSMUST00000170883; ENSMUSP00000127903; ENSMUSG00000034088 |
GeneIDi | 110611 |
KEGGi | mmu:110611 |
UCSCi | uc007cdx.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC021765 mRNA Translation: AAH21765.1 BC023806 mRNA Translation: AAH23806.1 BC025648 mRNA Translation: AAH25648.1 BC027779 mRNA Translation: AAH27779.1 BC027788 mRNA Translation: AAH27788.1 BC035301 mRNA Translation: AAH35301.1 |
CCDSi | CCDS15189.1 |
RefSeqi | NP_001288293.1, NM_001301364.1 NP_598569.1, NM_133808.5 XP_006529137.1, XM_006529074.2 XP_006529138.1, XM_006529075.2 XP_006529139.1, XM_006529076.2 XP_006529140.1, XM_006529077.3 |
3D structure databases
SMRi | Q8VDJ3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 225750, 17 interactors |
IntActi | Q8VDJ3, 7 interactors |
MINTi | Q8VDJ3 |
STRINGi | 10090.ENSMUSP00000127903 |
PTM databases
iPTMneti | Q8VDJ3 |
PhosphoSitePlusi | Q8VDJ3 |
SwissPalmi | Q8VDJ3 |
Proteomic databases
EPDi | Q8VDJ3 |
jPOSTi | Q8VDJ3 |
MaxQBi | Q8VDJ3 |
PaxDbi | Q8VDJ3 |
PRIDEi | Q8VDJ3 |
Protocols and materials databases
Antibodypediai | 1371, 311 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000042498; ENSMUSP00000043047; ENSMUSG00000034088 ENSMUST00000170883; ENSMUSP00000127903; ENSMUSG00000034088 |
GeneIDi | 110611 |
KEGGi | mmu:110611 |
UCSCi | uc007cdx.2, mouse |
Organism-specific databases
CTDi | 3069 |
MGIi | MGI:99256, Hdlbp |
Phylogenomic databases
eggNOGi | KOG2208, Eukaryota |
GeneTreei | ENSGT00900000141059 |
HOGENOMi | CLU_008532_0_0_1 |
InParanoidi | Q8VDJ3 |
OMAi | HPFIVGP |
OrthoDBi | 248989at2759 |
PhylomeDBi | Q8VDJ3 |
TreeFami | TF323767 |
Enzyme and pathway databases
Reactomei | R-MMU-8964011, HDL clearance |
Miscellaneous databases
BioGRID-ORCSi | 110611, 2 hits in 17 CRISPR screens |
ChiTaRSi | Hdlbp, mouse |
PROi | PR:Q8VDJ3 |
RNActi | Q8VDJ3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034088, Expressed in embryonic post-anal tail and 315 other tissues |
Genevisiblei | Q8VDJ3, MM |
Family and domain databases
Gene3Di | 3.30.1370.10, 14 hits |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf |
Pfami | View protein in Pfam PF00013, KH_1, 14 hits |
SMARTi | View protein in SMART SM00322, KH, 14 hits |
SUPFAMi | SSF54791, SSF54791, 14 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 14 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VIGLN_MOUSE | |
Accessioni | Q8VDJ3Primary (citable) accession number: Q8VDJ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot