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UniProtKB - Q8VDI7 (UBAC1_MOUSE)
Protein
Ubiquitin-associated domain-containing protein 1
Gene
Ubac1
Organism
Mus musculus (Mouse)
Status
Functioni
Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (By similarity).
By similarity: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- protein ubiquitination Source: UniProtKB-UniPathway
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-associated domain-containing protein 1Short name: UBA domain-containing protein 1 Alternative name(s): E3 ubiquitin-protein ligase subunit KPC2 Kip1 ubiquitination-promoting complex protein 2 |
Gene namesi | Name:Ubac1 Synonyms:Kpc2, Ubadc1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1920995, Ubac1 |
VEuPathDBi | HostDB:ENSMUSG00000036352 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- cytosol Source: MGI
Golgi apparatus
- Golgi apparatus Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000250450 | 1 – 409 | Ubiquitin-associated domain-containing protein 1Add BLAST | 409 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q8VDI7 |
MaxQBi | Q8VDI7 |
PaxDbi | Q8VDI7 |
PeptideAtlasi | Q8VDI7 |
PRIDEi | Q8VDI7 |
ProteomicsDBi | 297780 |
PTM databases
iPTMneti | Q8VDI7 |
PhosphoSitePlusi | Q8VDI7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000036352, Expressed in fetal liver hematopoietic progenitor cell and 316 other tissues |
ExpressionAtlasi | Q8VDI7, baseline and differential |
Genevisiblei | Q8VDI7, MM |
Interactioni
Subunit structurei
Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2.
Interacts with RNF123 via its N-terminal domain.
Interacts with the proteasome via its N-terminal domain (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 221128, 7 interactors |
STRINGi | 10090.ENSMUSP00000040220 |
Miscellaneous databases
RNActi | Q8VDI7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 98 | Ubiquitin-likeAdd BLAST | 85 | |
Domaini | 187 – 231 | UBA 1PROSITE-ProRule annotationAdd BLAST | 45 | |
Domaini | 292 – 332 | UBA 2PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 357 – 396 | STI1Add BLAST | 40 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 101 – 122 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 239 – 273 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 105 – 122 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 250 – 267 | Polar residuesSequence analysisAdd BLAST | 18 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QQQ6, Eukaryota |
GeneTreei | ENSGT00390000014658 |
HOGENOMi | CLU_035938_0_0_1 |
InParanoidi | Q8VDI7 |
OMAi | RCLKHHV |
OrthoDBi | 1163759at2759 |
PhylomeDBi | Q8VDI7 |
TreeFami | TF324579 |
Family and domain databases
CDDi | cd14303, UBA1_KPC2, 1 hit cd14304, UBA2_KPC2, 1 hit |
InterProi | View protein in InterPro IPR006636, STI1_HS-bd IPR015940, UBA IPR009060, UBA-like_sf IPR041926, UBA1_UBAC1 IPR041927, UBA2_UBAC1 IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00627, UBA, 2 hits |
SMARTi | View protein in SMART SM00727, STI1, 1 hit SM00165, UBA, 2 hits |
SUPFAMi | SSF46934, SSF46934, 2 hits SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50030, UBA, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8VDI7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFVQEEKIFA GKVLRLHICA ADGAEWLEEA TEDTSVEKLK ESCLKHGAHG
60 70 80 90 100
SLEDPKNVTH HKLIHAASER VLSDSKTILE ENIQDQDVLL LIKKRVPSPL
110 120 130 140 150
PKMADVSAEE KKKQEQKAPD KDAILRATAN LPACSTDRTA VQTTMRDFQT
160 170 180 190 200
ELRKILVSLI EVAQKLLALN PDAVELFKKA NAMLDEDEDE RVDETALRQL
210 220 230 240 250
TEMGFPESRA SKALRLNHMS VPQAMEWLIE HSEDPAIDTP LPGHAAQAGA
260 270 280 290 300
SAAATTSSTS SEAAVGTSVE DEESRDELTE IFKKIRRKKE FRADARAVIS
310 320 330 340 350
LMEMGFDEKE VIDALRVNNN QQNAACEWLL GDRKPSPEEL DQGIDPNSPL
360 370 380 390 400
FQAILDNPVV QLGLTNPKTL LAFEDMLENP LNSTQWMNDP ETGPVMLQIS
RIFQTLNRT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6Z1E7 | F6Z1E7_MOUSE | Ubiquitin-associated domain-contain... | Ubac1 | 184 | Annotation score: | ||
F6UMH9 | F6UMH9_MOUSE | Ubiquitin-associated domain-contain... | Ubac1 | 260 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 252 | A → G in strain: Czech II. 1 Publication | 1 | |
Natural varianti | 269 | V → A in strain: Czech II. 1 Publication | 1 | |
Natural varianti | 274 | S → T in strain: Czech II. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK157857 mRNA Translation: BAE34235.1 BC021811 mRNA Translation: AAH21811.1 |
CCDSi | CCDS15795.1 |
RefSeqi | NP_598596.2, NM_133835.2 |
Genome annotation databases
Ensembli | ENSMUST00000036509; ENSMUSP00000040220; ENSMUSG00000036352 |
GeneIDi | 98766 |
KEGGi | mmu:98766 |
UCSCi | uc008itz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK157857 mRNA Translation: BAE34235.1 BC021811 mRNA Translation: AAH21811.1 |
CCDSi | CCDS15795.1 |
RefSeqi | NP_598596.2, NM_133835.2 |
3D structure databases
SMRi | Q8VDI7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 221128, 7 interactors |
STRINGi | 10090.ENSMUSP00000040220 |
PTM databases
iPTMneti | Q8VDI7 |
PhosphoSitePlusi | Q8VDI7 |
Proteomic databases
EPDi | Q8VDI7 |
MaxQBi | Q8VDI7 |
PaxDbi | Q8VDI7 |
PeptideAtlasi | Q8VDI7 |
PRIDEi | Q8VDI7 |
ProteomicsDBi | 297780 |
Protocols and materials databases
Antibodypediai | 18666, 198 antibodies from 28 providers |
DNASUi | 98766 |
Genome annotation databases
Ensembli | ENSMUST00000036509; ENSMUSP00000040220; ENSMUSG00000036352 |
GeneIDi | 98766 |
KEGGi | mmu:98766 |
UCSCi | uc008itz.2, mouse |
Organism-specific databases
CTDi | 10422 |
MGIi | MGI:1920995, Ubac1 |
VEuPathDBi | HostDB:ENSMUSG00000036352 |
Phylogenomic databases
eggNOGi | ENOG502QQQ6, Eukaryota |
GeneTreei | ENSGT00390000014658 |
HOGENOMi | CLU_035938_0_0_1 |
InParanoidi | Q8VDI7 |
OMAi | RCLKHHV |
OrthoDBi | 1163759at2759 |
PhylomeDBi | Q8VDI7 |
TreeFami | TF324579 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 98766, 2 hits in 66 CRISPR screens |
ChiTaRSi | Ubac1, mouse |
PROi | PR:Q8VDI7 |
RNActi | Q8VDI7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036352, Expressed in fetal liver hematopoietic progenitor cell and 316 other tissues |
ExpressionAtlasi | Q8VDI7, baseline and differential |
Genevisiblei | Q8VDI7, MM |
Family and domain databases
CDDi | cd14303, UBA1_KPC2, 1 hit cd14304, UBA2_KPC2, 1 hit |
InterProi | View protein in InterPro IPR006636, STI1_HS-bd IPR015940, UBA IPR009060, UBA-like_sf IPR041926, UBA1_UBAC1 IPR041927, UBA2_UBAC1 IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00627, UBA, 2 hits |
SMARTi | View protein in SMART SM00727, STI1, 1 hit SM00165, UBA, 2 hits |
SUPFAMi | SSF46934, SSF46934, 2 hits SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50030, UBA, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | UBAC1_MOUSE | |
Accessioni | Q8VDI7Primary (citable) accession number: Q8VDI7 Secondary accession number(s): Q3TZH3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | October 3, 2006 | |
Last modified: | February 23, 2022 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways