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Protein

Ubiquitin-associated domain-containing protein 1

Gene

Ubac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-associated domain-containing protein 1
Short name:
UBA domain-containing protein 1
Alternative name(s):
E3 ubiquitin-protein ligase subunit KPC2
Kip1 ubiquitination-promoting complex protein 2
Gene namesi
Name:Ubac1
Synonyms:Kpc2, Ubadc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1920995 Ubac1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002504501 – 409Ubiquitin-associated domain-containing protein 1Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8VDI7
MaxQBiQ8VDI7
PaxDbiQ8VDI7
PeptideAtlasiQ8VDI7
PRIDEiQ8VDI7

PTM databases

iPTMnetiQ8VDI7
PhosphoSitePlusiQ8VDI7

Expressioni

Gene expression databases

BgeeiENSMUSG00000036352 Expressed in 293 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
CleanExiMM_UBAC1
ExpressionAtlasiQ8VDI7 baseline and differential
GenevisibleiQ8VDI7 MM

Interactioni

Subunit structurei

Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123 via its N-terminal domain. Interacts with the proteasome via its N-terminal domain (By similarity).By similarity

Protein-protein interaction databases

BioGridi221128, 2 interactors
STRINGi10090.ENSMUSP00000040220

Structurei

3D structure databases

ProteinModelPortaliQ8VDI7
SMRiQ8VDI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 98Ubiquitin-likeAdd BLAST85
Domaini187 – 231UBA 1PROSITE-ProRule annotationAdd BLAST45
Domaini292 – 332UBA 2PROSITE-ProRule annotationAdd BLAST41
Domaini357 – 396STI1Add BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHU5 Eukaryota
ENOG410Y2UN LUCA
GeneTreeiENSGT00390000014658
HOGENOMiHOG000231457
HOVERGENiHBG053148
InParanoidiQ8VDI7
KOiK12174
OMAiVTHHKLI
OrthoDBiEOG091G05QY
PhylomeDBiQ8VDI7
TreeFamiTF324579

Family and domain databases

InterProiView protein in InterPro
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00627 UBA, 2 hits
SMARTiView protein in SMART
SM00727 STI1, 1 hit
SM00165 UBA, 2 hits
SUPFAMiSSF46934 SSF46934, 2 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8VDI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFVQEEKIFA GKVLRLHICA ADGAEWLEEA TEDTSVEKLK ESCLKHGAHG
60 70 80 90 100
SLEDPKNVTH HKLIHAASER VLSDSKTILE ENIQDQDVLL LIKKRVPSPL
110 120 130 140 150
PKMADVSAEE KKKQEQKAPD KDAILRATAN LPACSTDRTA VQTTMRDFQT
160 170 180 190 200
ELRKILVSLI EVAQKLLALN PDAVELFKKA NAMLDEDEDE RVDETALRQL
210 220 230 240 250
TEMGFPESRA SKALRLNHMS VPQAMEWLIE HSEDPAIDTP LPGHAAQAGA
260 270 280 290 300
SAAATTSSTS SEAAVGTSVE DEESRDELTE IFKKIRRKKE FRADARAVIS
310 320 330 340 350
LMEMGFDEKE VIDALRVNNN QQNAACEWLL GDRKPSPEEL DQGIDPNSPL
360 370 380 390 400
FQAILDNPVV QLGLTNPKTL LAFEDMLENP LNSTQWMNDP ETGPVMLQIS

RIFQTLNRT
Length:409
Mass (Da):45,531
Last modified:October 3, 2006 - v2
Checksum:i7CE7C9ACC5975231
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Z1E7F6Z1E7_MOUSE
Ubiquitin-associated domain-contain...
Ubac1
184Annotation score:
F6UMH9F6UMH9_MOUSE
Ubiquitin-associated domain-contain...
Ubac1
260Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti252A → G in strain: Czech II. 1 Publication1
Natural varianti269V → A in strain: Czech II. 1 Publication1
Natural varianti274S → T in strain: Czech II. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157857 mRNA Translation: BAE34235.1
BC021811 mRNA Translation: AAH21811.1
CCDSiCCDS15795.1
RefSeqiNP_598596.2, NM_133835.2
UniGeneiMm.247824

Genome annotation databases

EnsembliENSMUST00000036509; ENSMUSP00000040220; ENSMUSG00000036352
GeneIDi98766
KEGGimmu:98766
UCSCiuc008itz.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157857 mRNA Translation: BAE34235.1
BC021811 mRNA Translation: AAH21811.1
CCDSiCCDS15795.1
RefSeqiNP_598596.2, NM_133835.2
UniGeneiMm.247824

3D structure databases

ProteinModelPortaliQ8VDI7
SMRiQ8VDI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221128, 2 interactors
STRINGi10090.ENSMUSP00000040220

PTM databases

iPTMnetiQ8VDI7
PhosphoSitePlusiQ8VDI7

Proteomic databases

EPDiQ8VDI7
MaxQBiQ8VDI7
PaxDbiQ8VDI7
PeptideAtlasiQ8VDI7
PRIDEiQ8VDI7

Protocols and materials databases

DNASUi98766
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036509; ENSMUSP00000040220; ENSMUSG00000036352
GeneIDi98766
KEGGimmu:98766
UCSCiuc008itz.2 mouse

Organism-specific databases

CTDi10422
MGIiMGI:1920995 Ubac1

Phylogenomic databases

eggNOGiENOG410IHU5 Eukaryota
ENOG410Y2UN LUCA
GeneTreeiENSGT00390000014658
HOGENOMiHOG000231457
HOVERGENiHBG053148
InParanoidiQ8VDI7
KOiK12174
OMAiVTHHKLI
OrthoDBiEOG091G05QY
PhylomeDBiQ8VDI7
TreeFamiTF324579

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiUbac1 mouse
PROiPR:Q8VDI7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036352 Expressed in 293 organ(s), highest expression level in fetal liver hematopoietic progenitor cell
CleanExiMM_UBAC1
ExpressionAtlasiQ8VDI7 baseline and differential
GenevisibleiQ8VDI7 MM

Family and domain databases

InterProiView protein in InterPro
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00627 UBA, 2 hits
SMARTiView protein in SMART
SM00727 STI1, 1 hit
SM00165 UBA, 2 hits
SUPFAMiSSF46934 SSF46934, 2 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiUBAC1_MOUSE
AccessioniPrimary (citable) accession number: Q8VDI7
Secondary accession number(s): Q3TZH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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