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Entry version 133 (22 Apr 2020)
Sequence version 2 (21 Aug 2007)
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Protein

PH-interacting protein

Gene

Phip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PH-interacting protein
Short name:
PHIP
Alternative name(s):
IRS-1 PH domain-binding protein
Neuronal differentiation-related protein
Short name:
NDRP
WD repeat-containing protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Phip
Synonyms:Ndrp, Phip1, Wdr11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1932404 Phip

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002977581 – 1821PH-interacting proteinAdd BLAST1821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei136PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki421Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei641PhosphoserineBy similarity1
Modified residuei659PhosphoserineBy similarity1
Modified residuei674PhosphoserineBy similarity1
Modified residuei677PhosphoserineBy similarity1
Modified residuei683PhosphoserineBy similarity1
Modified residuei692PhosphoserineBy similarity1
Modified residuei879PhosphoserineBy similarity1
Modified residuei880PhosphoserineBy similarity1
Modified residuei881PhosphoserineBy similarity1
Modified residuei911PhosphoserineBy similarity1
Modified residuei1281PhosphoserineCombined sources1
Modified residuei1283PhosphoserineCombined sources1
Modified residuei1296PhosphoserineBy similarity1
Modified residuei1315PhosphoserineCombined sources1
Modified residuei1359PhosphothreonineBy similarity1
Modified residuei1405PhosphoserineBy similarity1
Cross-linki1470Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki1470Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1479PhosphoserineBy similarity1
Modified residuei1497N6-acetyllysineBy similarity1
Modified residuei1525PhosphoserineBy similarity1
Modified residuei1533N6-acetyllysineCombined sources1
Modified residuei1560PhosphoserineBy similarity1
Cross-linki1644Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1651PhosphoserineBy similarity1
Cross-linki1670Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1762PhosphoserineBy similarity1
Modified residuei1783PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8VDD9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8VDD9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8VDD9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VDD9

PRoteomics IDEntifications database

More...
PRIDEi
Q8VDD9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VDD9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VDD9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with most abundant expression detected in pancreatic islets, brain and skeletal muscle. Predominantly expressed in developing and regenerating neurons. Expressed in adult brain (granular layer of the olfactorium bulb, hippocampus, dentate gyrus and cerebellum internal granular layer). Expressed in the CA3 region of adult hippocampus, adult and fetal retina, perinatal dorsal root ganglion and embryonal olfactory epithelia (at protein level).3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at highest levels at 17.5 dpc in the neural layer of the retina and olfactory epithelia.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In motor neurons after injury.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via bromo domain) with acetylated lysine residues on histone H1.4, histone H3 and H4 (in vitro) (By similarity).

Interacts with IRS1 and IRS2.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8VDD9, 6 interactors

Molecular INTeraction database

More...
MINTi
Q8VDD9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000034787

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8VDD9 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati181 – 222WD 1Add BLAST42
Repeati224 – 262WD 2Add BLAST39
Repeati265 – 310WD 3Add BLAST46
Repeati319 – 360WD 4Add BLAST42
Repeati363 – 402WD 5Add BLAST40
Repeati422 – 461WD 6Add BLAST40
Repeati464 – 504WD 7Add BLAST41
Repeati512 – 551WD 8Add BLAST40
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1176 – 1246Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1333 – 1403Bromo 2PROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni924 – 1129Mediates interaction with IRS11 PublicationAdd BLAST206

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi867 – 923Lys-richAdd BLAST57
Compositional biasi1752 – 1758Poly-Glu7

Keywords - Domaini

Bromodomain, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0644 Eukaryota
ENOG410YCD8 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VDD9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8VDD9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 2 hits
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR028738 PHIP
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR16266:SF4 PTHR16266:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 2 hits
PF00400 WD40, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 2 hits
SM00320 WD40, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 2 hits
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 2 hits
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8VDD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRERKGLSE LRSELYFLIA RFLEDGPCQQ AAQVLIREVA EKELLPRRTD
60 70 80 90 100
WTGKEHPRTY QNLVKYYRHL APDHLLQICH RLGPLLEQEI PQSVPGVQTL
110 120 130 140 150
LGAGRQSLLR TNKSCKHVVW KGSALAALHC GRPPESPVNY GSPPSIADTL
160 170 180 190 200
FSRKLNGKYR LERLVPTAVY QHMKMHKRIL GHLSSVYCVT FDRTGRRIFT
210 220 230 240 250
GSDDCLVKIW ATDDGRLLAT LRGHAAEISD MAVNYENTMI AAGSCDKMIR
260 270 280 290 300
VWCLRTCAPL AVLQGHSASI TSLQFSPLCS GSKRYLSSTG ADGTICFWLW
310 320 330 340 350
DAGTLKINPR PTKFTERPRP GVQMICSSFS AGGMFLATGS TDHIIRVYFF
360 370 380 390 400
GSGQPEKISE LEFHTDKVDS IQFSNTSNRF VSGSRDGTAR IWQFKRREWK
410 420 430 440 450
SILLDMATRP AGQNLQGIED KITKMKVTMV AWDRHDNTVI TAVNNMTLKV
460 470 480 490 500
WNSYTGQLIH VLMGHEDEVF VLEPHPFDPR VLFSAGHDGN VIVWDLARGV
510 520 530 540 550
KVRSYFNMIE GQGHGAVFDC KCSPDGQHFA CTDSHGHLLI FGFGSSSKYD
560 570 580 590 600
KIADQMFFHS DYRPLIRDAN NFVLDEQTQQ APHLMPPPFL VDVDGNPHPS
610 620 630 640 650
RYQRLVPGRE NCREEQLIPQ MGVTSSGLNQ VLSQQANQDI SPLDSMIQRL
660 670 680 690 700
QQEQDLRRSG EAGVSNASRV NRGSVSSTSE VHSPPNIGLR RSGQIEGVRQ
710 720 730 740 750
MHSNAPRSEI ATERDLVAWS RRVVVPELSA GVASRQEEWR TAKGEEEIKS
760 770 780 790 800
YRSEEKRKHL TVAKENKILT VSKNHAHEHF LDLGDSKKQQ ANQHNYRTRS
810 820 830 840 850
ALEETPRPLE ELENGTSSSD EGEVLAVSGG TSEEEERAWH SDGSSSDYSS
860 870 880 890 900
DYSDWTADAG INLQPPKKVP KHKTKKPESS SDEEEESENQ KQKHIKKERK
910 920 930 940 950
KANEEKDGPT SPKKKKPKER KQKRLAVGEL TENGLTLEEW LPSAWITDTL
960 970 980 990 1000
PRRCPFVPQM GDEVYYFRQG HEAYVEMARK NKIYSINPKK QPWHKMELRE
1010 1020 1030 1040 1050
QELMKIVGIK YEVGLPTLCC LKLAFLDPDT GKLTGGSFTM KYHDMPDVID
1060 1070 1080 1090 1100
FLVLRQQFDD AKYRPWNIGD RFRSVIDDAW WFGTIESQEP LQPEYPDSLF
1110 1120 1130 1140 1150
QCYNVCWDNG DTEKMSPWDM ELIPNNAVFP EELGTSVPLT DVECRSLIYK
1160 1170 1180 1190 1200
PLDGEWGANP RDEECERIVG GINQLMTLDI ASAFVAPVDL QAYPMYCTVV
1210 1220 1230 1240 1250
AYPTDLSTIK QRLENRFYRR FSSLMWEVRY IEHNTRTFNE PGSPIVKSAK
1260 1270 1280 1290 1300
FVTDLLLHFI KDQTCYNIIP LYNSMKKKVL SDSEEEEKDA DVPGTSTRKR
1310 1320 1330 1340 1350
KDHQPRRRLR NRAQSYDIQA WKKQCQELLN LIFQCEDSEP FRQPVDLLEY
1360 1370 1380 1390 1400
PDYRDIIDTP MDFATVRETL EAGNYESPME LCKDVRLIFS NFKAYTPSKR
1410 1420 1430 1440 1450
SRIYSMSLRL SAFFEEHISS VLSDYKSALR FHKRNTISKK RKKRNRSSSL
1460 1470 1480 1490 1500
SSSAASSPER KKRILKPQLK SEVSTSPFSI PTRSVLPRHN AAQMNGKPES
1510 1520 1530 1540 1550
SSVVRTRSNR VAVDPVVTEQ PSTSSATKAF VSKTNTSAMP GKAMLENSVR
1560 1570 1580 1590 1600
HSKALSTLSS PDPLTFSHAT KNNSAKENME KEKPVKRKMK SSVFSKASPL
1610 1620 1630 1640 1650
PKSAAVIEQG ECKNNVLIPG TIQVNGHGGQ PSKLVKRGPG RKPKVEVNTS
1660 1670 1680 1690 1700
SGEVTHKKRG RKPKNLQCAK QENSEQNNMH PIRADVLPSS TCNFLSETNA
1710 1720 1730 1740 1750
VKEDLLQKKS RGGRKPKRKM KTHNLDSELI VPTNVKVLRR SNRKKTDDPI
1760 1770 1780 1790 1800
DEEEEFEELK GSEPHMRTRN QGRRTAFYNE DDSEEEQRQL LFEDTSLTFG
1810 1820
TSSRGRVRKL TEKAKANLIG W
Length:1,821
Mass (Da):206,726
Last modified:August 21, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92E8DF0833F60FFA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VQ93F8VQ93_MOUSE
PH-interacting protein
Phip
1,821Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WR26A0A087WR26_MOUSE
PH-interacting protein
Phip
360Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WPP7A0A087WPP7_MOUSE
PH-interacting protein
Phip
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WP89A0A087WP89_MOUSE
PH-interacting protein
Phip
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG45146 differs from that shown. Intron retention. This sequence is incomplete at the 5' end and extensively differs from that shown.Curated
The sequence AAH49950 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB16299 differs from that shown. Intron retention. This sequence is incomplete at the 3' end and extensively differs from that shown.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti672R → G in AAH49950 (PubMed:15489334).Curated1
Sequence conflicti1065P → R in BAE36779 (PubMed:16141072).Curated1
Sequence conflicti1065P → R in AAG45146 (PubMed:11018022).Curated1
Sequence conflicti1155E → D in AAG45146 (PubMed:11018022).Curated1
Sequence conflicti1392F → S in BAE36779 (PubMed:16141072).Curated1
Sequence conflicti1392F → S in AAG45146 (PubMed:11018022).Curated1
Sequence conflicti1776A → T in AAG45146 (PubMed:11018022).Curated1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ303103 mRNA Translation: CAC83119.1
AB049460 mRNA Translation: BAB16299.1 Sequence problems.
BC049950 mRNA Translation: AAH49950.1 Different termination.
AK162189 mRNA Translation: BAE36779.1
AF310251 mRNA Translation: AAG45146.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS40706.1

Genome annotation databases

UCSC genome browser

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UCSCi
uc009qvw.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303103 mRNA Translation: CAC83119.1
AB049460 mRNA Translation: BAB16299.1 Sequence problems.
BC049950 mRNA Translation: AAH49950.1 Different termination.
AK162189 mRNA Translation: BAE36779.1
AF310251 mRNA Translation: AAG45146.1 Sequence problems.
CCDSiCCDS40706.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8VDD9, 6 interactors
MINTiQ8VDD9
STRINGi10090.ENSMUSP00000034787

PTM databases

iPTMnetiQ8VDD9
PhosphoSitePlusiQ8VDD9

Proteomic databases

EPDiQ8VDD9
jPOSTiQ8VDD9
MaxQBiQ8VDD9
PaxDbiQ8VDD9
PRIDEiQ8VDD9

Genome annotation databases

UCSCiuc009qvw.1 mouse

Organism-specific databases

MGIiMGI:1932404 Phip

Phylogenomic databases

eggNOGiKOG0644 Eukaryota
ENOG410YCD8 LUCA
InParanoidiQ8VDD9
PhylomeDBiQ8VDD9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Phip mouse

Protein Ontology

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PROi
PR:Q8VDD9
RNActiQ8VDD9 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

Gene3Di1.20.920.10, 2 hits
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR028738 PHIP
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR16266:SF4 PTHR16266:SF4, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF00400 WD40, 5 hits
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SM00320 WD40, 8 hits
SUPFAMiSSF47370 SSF47370, 2 hits
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 2 hits
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHIP_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VDD9
Secondary accession number(s): Q3TS96
, Q80VI6, Q9EPY1, Q9ESL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: April 22, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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