Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein ABHD4

Gene

Abhd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.1 Publication

Caution

Thr-291 is present instead of the conserved His which is expected to be an active site residue.Curated

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: GO_Central
  • lysophospholipase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Protein family/group databases

ESTHERimouse-abhd4 CGI-58_ABHD5_ABHD4
MEROPSiS33.013

Chemistry databases

SwissLipidsiSLP:000001119

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD4Curated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 4Curated
Short name:
Abhydrolase domain-containing protein 4Imported
Alpha/beta-hydrolase 4
Lyso-N-acylphosphatidylethanolamine lipase
Gene namesi
Name:Abhd4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915938 Abhd4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000808651 – 342Protein ABHD4Add BLAST342

Proteomic databases

MaxQBiQ8VD66
PaxDbiQ8VD66
PRIDEiQ8VD66

PTM databases

iPTMnetiQ8VD66
PhosphoSitePlusiQ8VD66

Expressioni

Tissue specificityi

Highest levels in the CNS and in testis, intermediate levels in liver and kidney. Hardly detectable in heart.1 Publication

Gene expression databases

CleanExiMM_ABHD4

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044134

Structurei

3D structure databases

ProteinModelPortaliQ8VD66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 323AB hydrolase-1Sequence analysisAdd BLAST254

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4409 Eukaryota
COG0596 LUCA
HOVERGENiHBG054445
InParanoidiQ8VD66
KOiK13698
PhylomeDBiQ8VD66

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q8VD66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDLEQQPQ GWLSSWLPTW RPTSMSQLKN VEARILQCLQ NKFLARYVSL
60 70 80 90 100
PNQNKIWTVT VSPEQKDRTP LVMVHGFGGG VGLWILNMDS LSARRTLHTF
110 120 130 140 150
DLLGFGRSSR PTFPRDPEGA EDEFVASIET WRETMGIPTM ILLGHSLGGF
160 170 180 190 200
LATSYSIKYP ERVKHLILVD PWGFPLRPTD PSEIRAPPTW VKAVASVLGR
210 220 230 240 250
SNPLAVLRVA GPWGPGLVQR FRPDFKRKFA DFFEDDTISE YIYHCNAQNP
260 270 280 290 300
SGETAFKAMM ESFGWARRPM LERIHLIRKD VPITMIYGAN TWIDTSTGKK
310 320 330 340
VKMQRPDSYV RDMEIEGASH HVYADQPHIF NAVVEEICNS VD
Length:342
Mass (Da):38,861
Last modified:March 1, 2002 - v1
Checksum:i902E8AA7133FFF99
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U7M5Q3U7M5_MOUSE
Protein ABHD4
Abhd4
355Annotation score:
Q8C0M2Q8C0M2_MOUSE
Protein ABHD4
Abhd4
318Annotation score:
A0A0G2JEC8A0A0G2JEC8_MOUSE
Protein ABHD4
Abhd4
189Annotation score:
A0A0G2JGK5A0A0G2JGK5_MOUSE
Protein ABHD4
Abhd4
84Annotation score:
A0A0G2JDM2A0A0G2JDM2_MOUSE
Protein ABHD4
Abhd4
231Annotation score:
A0A0G2JFC7A0A0G2JFC7_MOUSE
Protein ABHD4
Abhd4
91Annotation score:
A0A0G2JE28A0A0G2JE28_MOUSE
Protein ABHD4
Abhd4
56Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049366 mRNA Translation: BAC33711.1
BC017532 mRNA Translation: AAH17532.1
RefSeqiNP_001192110.1, NM_001205181.1
NP_598837.2, NM_134076.2
UniGeneiMm.28771

Genome annotation databases

GeneIDi105501
KEGGimmu:105501
UCSCiuc007tvo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049366 mRNA Translation: BAC33711.1
BC017532 mRNA Translation: AAH17532.1
RefSeqiNP_001192110.1, NM_001205181.1
NP_598837.2, NM_134076.2
UniGeneiMm.28771

3D structure databases

ProteinModelPortaliQ8VD66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044134

Chemistry databases

SwissLipidsiSLP:000001119

Protein family/group databases

ESTHERimouse-abhd4 CGI-58_ABHD5_ABHD4
MEROPSiS33.013

PTM databases

iPTMnetiQ8VD66
PhosphoSitePlusiQ8VD66

Proteomic databases

MaxQBiQ8VD66
PaxDbiQ8VD66
PRIDEiQ8VD66

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi105501
KEGGimmu:105501
UCSCiuc007tvo.2 mouse

Organism-specific databases

CTDi63874
MGIiMGI:1915938 Abhd4

Phylogenomic databases

eggNOGiKOG4409 Eukaryota
COG0596 LUCA
HOVERGENiHBG054445
InParanoidiQ8VD66
KOiK13698
PhylomeDBiQ8VD66

Miscellaneous databases

PROiPR:Q8VD66
SOURCEiSearch...

Gene expression databases

CleanExiMM_ABHD4

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABHD4_MOUSE
AccessioniPrimary (citable) accession number: Q8VD66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again