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Protein

Protein EVI2B

Gene

Evi2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EVI2BBy similarity
Alternative name(s):
Ecotropic viral integration site 2B protein
Short name:
EVI-2BBy similarity
CD_antigen: CD361
Gene namesi
Name:Evi2bImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1890682 Evi2b

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 203ExtracellularSequence analysisAdd BLAST180
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 444CytoplasmicSequence analysisAdd BLAST220

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002121424 – 444Protein EVI2BAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei250PhosphothreonineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8VD58
MaxQBiQ8VD58
PaxDbiQ8VD58
PeptideAtlasiQ8VD58
PRIDEiQ8VD58

PTM databases

iPTMnetiQ8VD58
PhosphoSitePlusiQ8VD58

Expressioni

Tissue specificityi

Expressed in myeloid and lymphoid progenitors and increased in mature hematopoietic populations with the highest levels in granulocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000070354 Expressed in 31 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiQ8VD58 baseline and differential
GenevisibleiQ8VD58 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128569

Structurei

3D structure databases

ProteinModelPortaliQ8VD58
SMRiQ8VD58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi121 – 190Pro-richAdd BLAST70

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVU1 Eukaryota
ENOG41118NF LUCA
GeneTreeiENSGT00390000009142
HOGENOMiHOG000285986
HOVERGENiHBG051514
InParanoidiQ8VD58
KOiK16854
OMAiMDPKYFI
OrthoDBiEOG091G0GGD
PhylomeDBiQ8VD58
TreeFamiTF336167

Family and domain databases

InterProiView protein in InterPro
IPR033239 EVI2B
PANTHERiPTHR15384 PTHR15384, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD140898 PD140898, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VD58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFKYLVFIV LCQYLDNTFF SETEAITTEQ QSLSTLITPS LYVTTDSQNT
60 70 80 90 100
AGNALSQTTR FKNISSGQQA SPAQITPEQA TPAVYVSSSP LTYNITRQAE
110 120 130 140 150
SAVNNSLPQT SPSGFTLTNQ PSPSTYNSTG QPPKHLVYTS TQQPPSPAPT
160 170 180 190 200
SSGKPEVEST HNQPTKSTPT IYLQRDTPPP PPPPLTSEPP SGKGTAHKNN
210 220 230 240 250
HNAIAAILIG TIIISMLVAI LMIILWKYLR KPVLNDQNWA GRSPFADGET
260 270 280 290 300
PEMCMDNIRE SEASTKRASV VSLMTWKPSK STLLADDLEV KLFESSEHIN
310 320 330 340 350
DTSNLKTDNV EVQINGLSED SADGSTVGTA VSSDDADLAL PPPLLDLDEN
360 370 380 390 400
LPNKPTVTVV SPLPNDSINP QPSPDGLNQV CEEQHSKIQE PFPPPPDSFN
410 420 430 440
VPLSAGDFIN NQESAHEAQC QEFSTPDLHP DLTDSLPPPP TELL
Length:444
Mass (Da):47,993
Last modified:March 1, 2002 - v1
Checksum:i2BEBB2E4515489BF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
L7N211L7N211_MOUSE
Ecotropic viral integration site 2
Evi2
77Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034440 mRNA Translation: BAC28709.1
AK039968 mRNA Translation: BAE20560.1
AK156127 mRNA Translation: BAE33597.1
AK170476 mRNA Translation: BAE41820.1
AK171686 mRNA Translation: BAE42611.1
AL591174 Genomic DNA Translation: CAI24840.1
BC017548 mRNA Translation: AAH17548.1
CCDSiCCDS25121.1
RefSeqiNP_001070964.1, NM_001077496.1
NP_666135.1, NM_146023.4
UniGeneiMm.439665

Genome annotation databases

EnsembliENSMUST00000170422; ENSMUSP00000128569; ENSMUSG00000070354
ENSMUST00000179322; ENSMUSP00000136153; ENSMUSG00000093938
GeneIDi101488212
216984
KEGGimmu:101488212
mmu:216984
UCSCiuc007kko.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034440 mRNA Translation: BAC28709.1
AK039968 mRNA Translation: BAE20560.1
AK156127 mRNA Translation: BAE33597.1
AK170476 mRNA Translation: BAE41820.1
AK171686 mRNA Translation: BAE42611.1
AL591174 Genomic DNA Translation: CAI24840.1
BC017548 mRNA Translation: AAH17548.1
CCDSiCCDS25121.1
RefSeqiNP_001070964.1, NM_001077496.1
NP_666135.1, NM_146023.4
UniGeneiMm.439665

3D structure databases

ProteinModelPortaliQ8VD58
SMRiQ8VD58
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128569

PTM databases

iPTMnetiQ8VD58
PhosphoSitePlusiQ8VD58

Proteomic databases

EPDiQ8VD58
MaxQBiQ8VD58
PaxDbiQ8VD58
PeptideAtlasiQ8VD58
PRIDEiQ8VD58

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170422; ENSMUSP00000128569; ENSMUSG00000070354
ENSMUST00000179322; ENSMUSP00000136153; ENSMUSG00000093938
GeneIDi101488212
216984
KEGGimmu:101488212
mmu:216984
UCSCiuc007kko.1 mouse

Organism-specific databases

CTDi101488212
2124
MGIiMGI:1890682 Evi2b

Phylogenomic databases

eggNOGiENOG410IVU1 Eukaryota
ENOG41118NF LUCA
GeneTreeiENSGT00390000009142
HOGENOMiHOG000285986
HOVERGENiHBG051514
InParanoidiQ8VD58
KOiK16854
OMAiMDPKYFI
OrthoDBiEOG091G0GGD
PhylomeDBiQ8VD58
TreeFamiTF336167

Miscellaneous databases

PROiPR:Q8VD58
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070354 Expressed in 31 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiQ8VD58 baseline and differential
GenevisibleiQ8VD58 MM

Family and domain databases

InterProiView protein in InterPro
IPR033239 EVI2B
PANTHERiPTHR15384 PTHR15384, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD140898 PD140898, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEVI2B_MOUSE
AccessioniPrimary (citable) accession number: Q8VD58
Secondary accession number(s): Q3U1A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2002
Last modified: October 10, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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