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Protein

Dehydrogenase/reductase SDR family member 9

Gene

Dhrs9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83NADBy similarity1
Binding sitei164SubstrateBy similarity1
Active sitei176Proton acceptorBy similarity1
Binding sitei180NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 58NADBy similarityAdd BLAST25

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: UniProtKB
  • retinol dehydrogenase activity Source: RGD
  • testosterone dehydrogenase (NAD+) activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

ReactomeiR-RNO-2453902 The canonical retinoid cycle in rods (twilight vision)
R-RNO-5365859 RA biosynthesis pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 9 (EC:1.1.-.-)
Alternative name(s):
3-alpha hydroxysteroid dehydrogenase
Short name:
3-alpha-HSD
Short-chain dehydrogenase/reductase retSDR8
Gene namesi
Name:Dhrs9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620655 Dhrs9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075220

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004261921 – 319Dehydrogenase/reductase SDR family member 9Add BLAST299

Proteomic databases

PaxDbiQ8VD48
PRIDEiQ8VD48

PTM databases

iPTMnetiQ8VD48
PhosphoSitePlusiQ8VD48

Expressioni

Tissue specificityi

Highly expressed in epithelium of estrus uterus.1 Publication

Gene expression databases

BgeeiENSRNOG00000058568 Expressed in 8 organ(s), highest expression level in colon
GenevisibleiQ8VD48 RN

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008921

Chemistry databases

BindingDBiQ8VD48

Structurei

3D structure databases

ProteinModelPortaliQ8VD48
SMRiQ8VD48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1610 Eukaryota
ENOG410Y7FK LUCA
GeneTreeiENSGT00920000148940
HOVERGENiHBG005482
InParanoidiQ8VD48
KOiK11149
OMAiLFPKTHY
OrthoDBiEOG091G0LMI
PhylomeDBiQ8VD48

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VD48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLWVLALLF LCAFLWNYKG QLKIADIADK YIFITGCDSG FGNLAARTFD
60 70 80 90 100
RKGFRVIAAC LTESGSEALK AKTSERLHTV LLDVTNPENV KETAQWVKSH
110 120 130 140 150
VGEKGLWGLI NNAGVLGVLA PTDWLTVDDY REPIEVNLFG LINVTLNMLP
160 170 180 190 200
LVKKARGRVI NVSSIGGRLA FGGGGYTPSK YAVEGFNDSL RRDMKAFGVH
210 220 230 240 250
VSCIEPGLFK TGLADPIKTT EKKLAIWKHL SPDIKQQYGE GYIEKSLHRL
260 270 280 290 300
KSSTSSVNLD LSLVVECMDH ALTSLFPKTR YTAGKDAKTF WIPLSHMPAA
310
LQDFLLLKEK VELANPQAV
Length:319
Mass (Da):35,214
Last modified:March 1, 2002 - v1
Checksum:i2EA1B82D3F170B9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337953 mRNA Translation: AAL73225.1
RefSeqiNP_570832.1, NM_130819.1
UniGeneiRn.81185

Genome annotation databases

EnsembliENSRNOT00000080525; ENSRNOP00000069708; ENSRNOG00000058568
GeneIDi170635
KEGGirno:170635
UCSCiRGD:620655 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337953 mRNA Translation: AAL73225.1
RefSeqiNP_570832.1, NM_130819.1
UniGeneiRn.81185

3D structure databases

ProteinModelPortaliQ8VD48
SMRiQ8VD48
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008921

Chemistry databases

BindingDBiQ8VD48
ChEMBLiCHEMBL1075220

PTM databases

iPTMnetiQ8VD48
PhosphoSitePlusiQ8VD48

Proteomic databases

PaxDbiQ8VD48
PRIDEiQ8VD48

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000080525; ENSRNOP00000069708; ENSRNOG00000058568
GeneIDi170635
KEGGirno:170635
UCSCiRGD:620655 rat

Organism-specific databases

CTDi10170
RGDi620655 Dhrs9

Phylogenomic databases

eggNOGiKOG1610 Eukaryota
ENOG410Y7FK LUCA
GeneTreeiENSGT00920000148940
HOVERGENiHBG005482
InParanoidiQ8VD48
KOiK11149
OMAiLFPKTHY
OrthoDBiEOG091G0LMI
PhylomeDBiQ8VD48

Enzyme and pathway databases

ReactomeiR-RNO-2453902 The canonical retinoid cycle in rods (twilight vision)
R-RNO-5365859 RA biosynthesis pathway

Miscellaneous databases

PROiPR:Q8VD48

Gene expression databases

BgeeiENSRNOG00000058568 Expressed in 8 organ(s), highest expression level in colon
GenevisibleiQ8VD48 RN

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHRS9_RAT
AccessioniPrimary (citable) accession number: Q8VD48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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