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Entry version 134 (12 Aug 2020)
Sequence version 1 (01 Mar 2002)
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Protein

Zinc finger CCHC domain-containing protein 18

Gene

Zcchc18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri346 – 363CCHC-typeAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 18Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zcchc18Imported
Synonyms:Sizn2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914245, Zcchc18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003953621 – 393Zinc finger CCHC domain-containing protein 18Add BLAST393

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8VD24

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VD24

PRoteomics IDEntifications database

More...
PRIDEi
Q8VD24

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VD24

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VD24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031428, Expressed in ventromedial nucleus of hypothalamus and 241 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VD24, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033804

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8VD24, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VD24

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZCCHC12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri346 – 363CCHC-typeAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RU0T, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01000000214513

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_686127_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VD24

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSEPIME

Database of Orthologous Groups

More...
OrthoDBi
697027at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8VD24

TreeFam database of animal gene trees

More...
TreeFami
TF335054

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026523, PNMA

The PANTHER Classification System

More...
PANTHERi
PTHR23095, PTHR23095, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14893, PNMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8VD24-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLLARMGN SRRQNAAFMP FAHSMLRALG RSLGPLIANI AERNIQSFSG
60 70 80 90 100
RAELGPGEET FENWLSQVHE VLPDWPMSEE EKIKRLMRTL RGPAREAMRL
110 120 130 140 150
FQADNPNLNV AEFLRAMKLL FGASESSITA HGKFLSTLQA QGEKPSLYVI
160 170 180 190 200
RLEVQLQNAI QAGVLPQSEA NRTRLHQLLV GAELSRELRT KLKGLLQMHA
210 220 230 240 250
HNEQENLPDF LELIRMIREE EDWDETFLRN KRPRRSETVM ERAASPVVFQ
260 270 280 290 300
GSLPIVIGSA DCNVIEIDDS QDDSDEDVIL VEPEDPPLSS PGASSLRGTA
310 320 330 340 350
STQEEMLIIE SPDDFDEESP STSSGSGQRN NGPGDLGRTR KRKYPIRCPH
360 370 380 390
CGEEGHAKET CDNTSNKGQV FENLIVTLQE LTHMERPKPS VPY
Length:393
Mass (Da):43,975
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD2DEA24596452AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti255I → M in BAB23950 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY650116 mRNA Translation: AAT67149.1
AK005317 mRNA Translation: BAB23950.1
AK075607 mRNA Translation: BAC35854.1
AK134856 mRNA Translation: BAE22314.1
AL672008 Genomic DNA No translation available.
CH466616 Genomic DNA Translation: EDL23889.1
CH466616 Genomic DNA Translation: EDL23890.1
BC017627 mRNA Translation: AAH17627.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30427.1

NCBI Reference Sequences

More...
RefSeqi
NP_001030586.1, NM_001035509.1
NP_001030587.1, NM_001035510.1
NP_080169.2, NM_025893.2
XP_006528657.1, XM_006528594.1
XP_011246059.1, XM_011247757.2
XP_017174097.1, XM_017318608.1
XP_017174098.1, XM_017318609.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000033804; ENSMUSP00000033804; ENSMUSG00000031428
ENSMUST00000101227; ENSMUSP00000098788; ENSMUSG00000031428
ENSMUST00000113067; ENSMUSP00000108690; ENSMUSG00000031428

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66995

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:66995

UCSC genome browser

More...
UCSCi
uc009ujk.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY650116 mRNA Translation: AAT67149.1
AK005317 mRNA Translation: BAB23950.1
AK075607 mRNA Translation: BAC35854.1
AK134856 mRNA Translation: BAE22314.1
AL672008 Genomic DNA No translation available.
CH466616 Genomic DNA Translation: EDL23889.1
CH466616 Genomic DNA Translation: EDL23890.1
BC017627 mRNA Translation: AAH17627.1
CCDSiCCDS30427.1
RefSeqiNP_001030586.1, NM_001035509.1
NP_001030587.1, NM_001035510.1
NP_080169.2, NM_025893.2
XP_006528657.1, XM_006528594.1
XP_011246059.1, XM_011247757.2
XP_017174097.1, XM_017318608.1
XP_017174098.1, XM_017318609.1

3D structure databases

SMRiQ8VD24
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033804

PTM databases

iPTMnetiQ8VD24
PhosphoSitePlusiQ8VD24

Proteomic databases

MaxQBiQ8VD24
PaxDbiQ8VD24
PRIDEiQ8VD24

Genome annotation databases

EnsembliENSMUST00000033804; ENSMUSP00000033804; ENSMUSG00000031428
ENSMUST00000101227; ENSMUSP00000098788; ENSMUSG00000031428
ENSMUST00000113067; ENSMUSP00000108690; ENSMUSG00000031428
GeneIDi66995
KEGGimmu:66995
UCSCiuc009ujk.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
644353
MGIiMGI:1914245, Zcchc18

Phylogenomic databases

eggNOGiENOG502RU0T, Eukaryota
GeneTreeiENSGT01000000214513
HOGENOMiCLU_686127_0_0_1
InParanoidiQ8VD24
OMAiRSEPIME
OrthoDBi697027at2759
PhylomeDBiQ8VD24
TreeFamiTF335054

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
66995, 2 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Zcchc18, mouse

Protein Ontology

More...
PROi
PR:Q8VD24
RNActiQ8VD24, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031428, Expressed in ventromedial nucleus of hypothalamus and 241 other tissues
GenevisibleiQ8VD24, MM

Family and domain databases

InterProiView protein in InterPro
IPR026523, PNMA
PANTHERiPTHR23095, PTHR23095, 1 hit
PfamiView protein in Pfam
PF14893, PNMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZCC18_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VD24
Secondary accession number(s): Q9DB17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 1, 2002
Last modified: August 12, 2020
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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