UniProtKB - Q8VD07 (Q8VD07_MOUSE)
Protein
Pro-epidermal growth factor
Gene
Egf
Organism
Mus musculus (Mouse)
Status
Functioni
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- growth factor activity Source: UniProtKB-KW
- Wnt-activated receptor activity Source: UniProtKB-UniRule
- Wnt-protein binding Source: UniProtKB-UniRule
GO - Biological processi
- canonical Wnt signaling pathway Source: UniProtKB-UniRule
Keywordsi
Molecular function | Growth factorUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Pro-epidermal growth factorUniRule annotation |
Gene namesi | Name:EgfImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:95290 Egf |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
- receptor complex Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1022 – 1046 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_5004314568 | 26 – 1200 | Pro-epidermal growth factorSequence analysisAdd BLAST | 1175 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 973 ↔ 990 | PROSITE-ProRule annotation | ||
Disulfide bondi | 992 ↔ 1001 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationSAAS annotationInteractioni
Subunit structurei
Interacts with EGFR and promotes EGFR dimerization.
UniRule annotationGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- Wnt-protein binding Source: UniProtKB-UniRule
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 76 – 117 | LDL-receptor class BPROSITE-ProRule annotationAdd BLAST | 42 | |
Repeati | 118 – 159 | LDL-receptor class BPROSITE-ProRule annotationAdd BLAST | 42 | |
Repeati | 160 – 202 | LDL-receptor class BPROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 345 – 385 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Repeati | 472 – 512 | LDL-receptor class BPROSITE-ProRule annotationAdd BLAST | 41 | |
Repeati | 513 – 555 | LDL-receptor class BPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 556 – 598 | LDL-receptor class BPROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 599 – 642 | LDL-receptor class BPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 643 – 685 | LDL-receptor class BPROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 821 – 859 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 860 – 901 | EGF-likeInterPro annotationAdd BLAST | 42 | |
Domaini | 902 – 942 | EGF-likeInterPro annotationAdd BLAST | 41 | |
Domaini | 961 – 1002 | EGF-likeInterPro annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1053 – 1080 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1147 – 1200 | DisorderedSequence analysisAdd BLAST | 54 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotationPhylogenomic databases
eggNOGi | ENOG410IPSY Eukaryota ENOG410ZVIM LUCA |
Family and domain databases
Gene3Di | 2.120.10.30, 2 hits |
InterProi | View protein in InterPro IPR011042 6-blade_b-propeller_TolB-like IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR009030 Growth_fac_rcpt_cys_sf IPR000033 LDLR_classB_rpt IPR016317 Pro-epidermal_GF |
Pfami | View protein in Pfam PF00008 EGF, 1 hit PF07645 EGF_CA, 3 hits PF00058 Ldl_recept_b, 3 hits |
PIRSFi | PIRSF001778 Pro-epidermal_growth_factor, 1 hit |
SMARTi | View protein in SMART SM00181 EGF, 9 hits SM00179 EGF_CA, 8 hits SM00135 LY, 9 hits |
SUPFAMi | SSF57184 SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00010 ASX_HYDROXYL, 3 hits PS00022 EGF_1, 1 hit PS01186 EGF_2, 4 hits PS50026 EGF_3, 5 hits PS01187 EGF_CA, 2 hits PS51120 LDLRB, 8 hits |
i Sequence
Sequence statusi: Complete.
Q8VD07-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPWGRRPTWL LLAFLLVFLK ISILSERSGT CAGPAPFLVF SQGKSISRID
60 70 80 90 100
PDGTNHQQLV VDAGISADMD IHYKKERLYW VDVERQVLLR VFLNGTGLEK
110 120 130 140 150
VCNVERKVSG LAIDWIDDEV LWVDQQNGVI TVTDMTGKNS RVLLSSLKHP
160 170 180 190 200
SNIAVDPIER LMFWSSEVTG SLHRAHLKGV DVKTLLETGG ISVLTLDVLD
210 220 230 240 250
KRLFWVQDSG EGSHAYIHSC DYEGGSVRLI RHQARHSLSS MAFFGDRIFY
260 270 280 290 300
SVLKSKAIWI ANKHTGKDTV RINLHPSFVT PGKLMVVHPR AQPRTEDAAK
310 320 330 340 350
DPDPELLKQR GRPCRFGLCE RDPKSHSSAC AEGYTLSRDR KYCEDVNECA
360 370 380 390 400
TQNHGCTLGC ENTPGSYHCT CPTGFVLLPD GKQCHELVSC PGNVSKCSHG
410 420 430 440 450
CVLTSDGPRC ICPAGSVLGR DGKTCTGCSS PDNGGCSQIC LPLRPGSWEC
460 470 480 490 500
DCFPGYDLQS DRKSCAASGP QPLLLFANSQ DIRHMHFDGT DYKVLLSRQM
510 520 530 540 550
GMVFALDYDP VESKIYFAQT ALKWIERANM DGSQRERLIT EGVDTLEGLA
560 570 580 590 600
LDWIGRRIYW TDSGKSVVGG SDLSGKHHRI IIQERISRPR GIAVHPRARR
610 620 630 640 650
LFWTDVGMSP RIESASLQGS DRVLIASSNL LEPSGITIDY LTDTLYWCDT
660 670 680 690 700
KRSVIEMANL DGSKRRRLIQ NDVGHPFSLA VFEDHLWVSD WAIPSVIRVN
710 720 730 740 750
KRTGQNRVRL QGSMLKPSSL VVVHPLAKPG ADPCLYRNGG CEHICQESLG
760 770 780 790 800
TARCLCREGF VKAWDGKMCL PQDYPILSGE NADLSKEVTS LSNSTQAEVP
810 820 830 840 850
DDDGTESSTL VAEIMVSGMN YEDDCGPGGC GSHARCVSDG ETAECQCLKG
860 870 880 890 900
FARDGNLCSD IDECVLARSD CPSTSSRCIN TEGGYVCRCS EGYEGDGISC
910 920 930 940 950
FDIDECQRGA HNCAENAACT NTEGGYNCTC AGRPSSPGRS CPDSTAPSLL
960 970 980 990 1000
GEDGHHLDRN SYPGCPSSYD GYCLNGGVCM HIESLDSYTC NCVIGYSGDR
1010 1020 1030 1040 1050
CQTRDLRWWE LRHAGYGQKH DIMVVAVCMV ALVLLLLLGM WGTYYYRTRK
1060 1070 1080 1090 1100
QLSNPPKNPC DEPSGSVSSS GPDSSSGAAV ASCPQPWFVV LEKHQDPKNG
1110 1120 1130 1140 1150
SLPADGTNGA VVDAGLSPSL QLGSVHLTSW RQKPHIDGMG TGQSCWIPPS
1160 1170 1180 1190 1200
SDRGPQEIEG NSHLPSYRPV GPEKLHSLQS ANGSCHERAP DLPRQTEPVQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC017681 mRNA Translation: AAH17681.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC017681 mRNA Translation: AAH17681.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Organism-specific databases
MGIi | MGI:95290 Egf |
Phylogenomic databases
eggNOGi | ENOG410IPSY Eukaryota ENOG410ZVIM LUCA |
Miscellaneous databases
ChiTaRSi | Egf mouse |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 2.120.10.30, 2 hits |
InterProi | View protein in InterPro IPR011042 6-blade_b-propeller_TolB-like IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR009030 Growth_fac_rcpt_cys_sf IPR000033 LDLR_classB_rpt IPR016317 Pro-epidermal_GF |
Pfami | View protein in Pfam PF00008 EGF, 1 hit PF07645 EGF_CA, 3 hits PF00058 Ldl_recept_b, 3 hits |
PIRSFi | PIRSF001778 Pro-epidermal_growth_factor, 1 hit |
SMARTi | View protein in SMART SM00181 EGF, 9 hits SM00179 EGF_CA, 8 hits SM00135 LY, 9 hits |
SUPFAMi | SSF57184 SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00010 ASX_HYDROXYL, 3 hits PS00022 EGF_1, 1 hit PS01186 EGF_2, 4 hits PS50026 EGF_3, 5 hits PS01187 EGF_CA, 2 hits PS51120 LDLRB, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8VD07_MOUSE | |
Accessioni | Q8VD07Primary (citable) accession number: Q8VD07 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | October 16, 2019 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |