Zbtb7c

Functionⁱ

May be a tumor suppressor gene.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	364 – 386	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	392 – 414	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	420 – 442	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	448 – 478	C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST	31

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
nucleic acid binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell proliferation Source: MGI
positive regulation of fat cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 22331133
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 22331133
regulation of RNA polymerase II regulatory region sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 22331133

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 7C Alternative name(s): Zinc finger and BTB domain-containing protein 36
Gene namesⁱ	Name:Zbtb7c Synonyms:Zbtb36
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:2443302 Zbtb7c

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Tumor suppressor

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000337870	1 – 619	Zinc finger and BTB domain-containing protein 7CAdd BLAST		619

Proteomic databases

PaxDbⁱ	Q8VCZ7
PRIDEⁱ	Q8VCZ7

PTM databases

PhosphoSitePlusⁱ	Q8VCZ7

PhosphoSitePlusⁱ

Q8VCZ7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000044646 Expressed in 105 organ(s), highest expression level in indifferent gonad
Genevisibleⁱ	Q8VCZ7 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	228889, 6 interactors
STRINGⁱ	10090.ENSMUSP00000057856

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8VCZ7
SMRⁱ	Q8VCZ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	34 – 101	BTBPROSITE-ProRule annotationAdd BLAST		68

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	125 – 169	Glu-richAdd BLAST	45
Compositional biasⁱ	137 – 209	Asp-richAdd BLAST	73
Compositional biasⁱ	299 – 304	Poly-Pro	6

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	364 – 386	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	392 – 414	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	420 – 442	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	448 – 478	C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST	31

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148950
HOGENOMⁱ	HOG000059674
HOVERGENⁱ	HBG101042
InParanoidⁱ	Q8VCZ7
KEGG Orthology (KO) More...KOⁱ	K10494
OMAⁱ	CIHCNAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03XR
PhylomeDBⁱ	Q8VCZ7
TreeFamⁱ	TF331824

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8VCZ7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MANDIDELIG IPFPNHSSEV LCSLNEQRHA GLLCDVLLVV QEQEYRTHRS 
        60         70         80         90        100
VLAACSKYFK KLFTAGSLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT 
       110        120        130        140        150
ASNVKHILNA ARMLEIQCIV NVCLEIMEPG GSVGEEDDKE EEDEDDDDED 
       160        170        180        190        200
EDDEEEEEEE EEEEEDDPED FADQENLPDP QDITCPQSPS KTDHLTEKDY 
       210        220        230        240        250
SDTPRDFPDS FQPGSPGHLG VIRDFSIESL LRENLYPKAN IPDRRPSLSP 
       260        270        280        290        300
FAPEFFPHLW PGGFGAFAQL PEQPMDSGPL DLVIKNRKIK EEDKEELAPP 
       310        320        330        340        350
PPPPFSSDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGSLFPPW 
       360        370        380        390        400
PLVEERKLKP KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCSICEVR 
       410        420        430        440        450
FTRQDKLKIH MRKHTGERPY LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC 
       460        470        480        490        500
EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG RKPAAWRAAS LLFGPGGPSA 
       510        520        530        540        550
DKAAFVMPPA LGDVGGHLGG TAVCLPGPSP AKHFLASPKG TLSLQELERQ 
       560        570        580        590        600
FEETQMKLFG RAQLEAERNA GGLLALALAE NVAATRPYFP LPDPWAAGLA 
       610 
GLPGLTGLNH VASMSEANN

Length:619

Mass (Da):69,086

Last modified:March 1, 2002 - v1

Checksum:ⁱFC5E6A222BCB5460

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK045522 mRNA Translation: BAC32405.1 BC018187 mRNA Translation: AAH18187.1 BC070424 mRNA Translation: AAH70424.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29349.1
NCBI Reference Sequences More...RefSeqⁱ	NP_663331.1, NM_145356.3 XP_006525800.1, XM_006525737.3
UniGeneⁱ	Mm.159332

Genome annotation databases

Ensemblⁱ	ENSMUST00000058997; ENSMUSP00000057856; ENSMUSG00000044646 ENSMUST00000167921; ENSMUSP00000126808; ENSMUSG00000044646
GeneIDⁱ	207259
KEGGⁱ	mmu:207259
UCSC genome browser More...UCSCⁱ	uc008fqi.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q8VCZ7	Zinc finger and BTB domain-containing protein 7C		HUMAN		619	UniRef90_A1YPR0
Uncharacterized protein		MUSPF		704
zinc finger and BTB domain-containing protein 7C isoform X2		TURTR		665
Uncharacterized protein		RABIT		627
zinc finger and BTB domain-containing protein 7C		PHYCD		622
+123

Protein	Similar proteins		Species	Score	Length	Source
Q8VCZ7	Zinc finger and BTB domain-containing protein 7C		HUMAN		619	UniRef50_A1YPR0
Uncharacterized protein		MUSPF		704
zinc finger and BTB domain-containing protein 7C isoform X2		TURTR		665
Uncharacterized protein		RABIT		627
zinc finger and BTB domain-containing protein 7C		PHYCD		622
+223

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK045522 mRNA Translation: BAC32405.1 BC018187 mRNA Translation: AAH18187.1 BC070424 mRNA Translation: AAH70424.1
CCDSⁱ	CCDS29349.1
RefSeqⁱ	NP_663331.1, NM_145356.3 XP_006525800.1, XM_006525737.3
UniGeneⁱ	Mm.159332

3D structure databases

ProteinModelPortalⁱ	Q8VCZ7
SMRⁱ	Q8VCZ7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	228889, 6 interactors
STRINGⁱ	10090.ENSMUSP00000057856

PTM databases

PhosphoSitePlusⁱ	Q8VCZ7

PhosphoSitePlusⁱ

Q8VCZ7

Proteomic databases

PaxDbⁱ	Q8VCZ7
PRIDEⁱ	Q8VCZ7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000058997; ENSMUSP00000057856; ENSMUSG00000044646 ENSMUST00000167921; ENSMUSP00000126808; ENSMUSG00000044646
GeneIDⁱ	207259
KEGGⁱ	mmu:207259
UCSCⁱ	uc008fqi.1 mouse

Organism-specific databases

CTDⁱ	201501
MGIⁱ	MGI:2443302 Zbtb7c

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00920000148950
HOGENOMⁱ	HOG000059674
HOVERGENⁱ	HBG101042
InParanoidⁱ	Q8VCZ7
KOⁱ	K10494
OMAⁱ	CIHCNAK
OrthoDBⁱ	EOG091G03XR
PhylomeDBⁱ	Q8VCZ7
TreeFamⁱ	TF331824

Miscellaneous databases

ChiTaRSⁱ	Zbtb7c mouse
Protein Ontology More...PROⁱ	PR:Q8VCZ7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000044646 Expressed in 105 organ(s), highest expression level in indifferent gonad
Genevisibleⁱ	Q8VCZ7 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBT7C_MOUSE
Accessionⁱ	Q8VCZ7Primary (citable) accession number: Q8VCZ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
	Last sequence update:	March 1, 2002
	Last modified:	October 10, 2018
	This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8VCZ7 (ZBT7C_MOUSE)

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Zinc finger and BTB domain-containing protein 7C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ