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UniProtKB - Q8VCZ7 (ZBT7C_MOUSE)
Protein
Zinc finger and BTB domain-containing protein 7C
Gene
Zbtb7c
Organism
Mus musculus (Mouse)
Status
Functioni
May be a tumor suppressor gene.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 364 – 386 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 478 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 31 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of cell population proliferation Source: MGI
- positive regulation of fat cell differentiation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 7CAlternative name(s): Zinc finger and BTB domain-containing protein 36 |
Gene namesi | Name:Zbtb7c Synonyms:Zbtb36 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443302, Zbtb7c |
VEuPathDBi | HostDB:ENSMUSG00000044646 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337870 | 1 – 619 | Zinc finger and BTB domain-containing protein 7CAdd BLAST | 619 |
Proteomic databases
PaxDbi | Q8VCZ7 |
PRIDEi | Q8VCZ7 |
ProteomicsDBi | 275265 |
PTM databases
iPTMneti | Q8VCZ7 |
PhosphoSitePlusi | Q8VCZ7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000044646, Expressed in stomach and 146 other tissues |
Genevisiblei | Q8VCZ7, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 228889, 7 interactors |
STRINGi | 10090.ENSMUSP00000057856 |
Miscellaneous databases
RNActi | Q8VCZ7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 101 | BTBPROSITE-ProRule annotationAdd BLAST | 68 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 129 – 219 | DisorderedSequence analysisAdd BLAST | 91 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 134 – 176 | Acidic residuesSequence analysisAdd BLAST | 43 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 364 – 386 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 478 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 31 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159814 |
HOGENOMi | CLU_025627_2_0_1 |
InParanoidi | Q8VCZ7 |
OMAi | ENDYSAY |
OrthoDBi | 268859at2759 |
PhylomeDBi | Q8VCZ7 |
TreeFami | TF331824 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q8VCZ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANDIDELIG IPFPNHSSEV LCSLNEQRHA GLLCDVLLVV QEQEYRTHRS
60 70 80 90 100
VLAACSKYFK KLFTAGSLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT
110 120 130 140 150
ASNVKHILNA ARMLEIQCIV NVCLEIMEPG GSVGEEDDKE EEDEDDDDED
160 170 180 190 200
EDDEEEEEEE EEEEEDDPED FADQENLPDP QDITCPQSPS KTDHLTEKDY
210 220 230 240 250
SDTPRDFPDS FQPGSPGHLG VIRDFSIESL LRENLYPKAN IPDRRPSLSP
260 270 280 290 300
FAPEFFPHLW PGGFGAFAQL PEQPMDSGPL DLVIKNRKIK EEDKEELAPP
310 320 330 340 350
PPPPFSSDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGSLFPPW
360 370 380 390 400
PLVEERKLKP KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCSICEVR
410 420 430 440 450
FTRQDKLKIH MRKHTGERPY LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC
460 470 480 490 500
EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG RKPAAWRAAS LLFGPGGPSA
510 520 530 540 550
DKAAFVMPPA LGDVGGHLGG TAVCLPGPSP AKHFLASPKG TLSLQELERQ
560 570 580 590 600
FEETQMKLFG RAQLEAERNA GGLLALALAE NVAATRPYFP LPDPWAAGLA
610
GLPGLTGLNH VASMSEANN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045522 mRNA Translation: BAC32405.1 BC018187 mRNA Translation: AAH18187.1 BC070424 mRNA Translation: AAH70424.1 |
CCDSi | CCDS29349.1 |
RefSeqi | NP_663331.1, NM_145356.3 XP_006525800.1, XM_006525737.3 |
Genome annotation databases
Ensembli | ENSMUST00000058997; ENSMUSP00000057856; ENSMUSG00000044646 ENSMUST00000167921; ENSMUSP00000126808; ENSMUSG00000044646 ENSMUST00000236462; ENSMUSP00000157716; ENSMUSG00000044646 |
GeneIDi | 207259 |
KEGGi | mmu:207259 |
UCSCi | uc008fqi.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045522 mRNA Translation: BAC32405.1 BC018187 mRNA Translation: AAH18187.1 BC070424 mRNA Translation: AAH70424.1 |
CCDSi | CCDS29349.1 |
RefSeqi | NP_663331.1, NM_145356.3 XP_006525800.1, XM_006525737.3 |
3D structure databases
AlphaFoldDBi | Q8VCZ7 |
SMRi | Q8VCZ7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 228889, 7 interactors |
STRINGi | 10090.ENSMUSP00000057856 |
PTM databases
iPTMneti | Q8VCZ7 |
PhosphoSitePlusi | Q8VCZ7 |
Proteomic databases
PaxDbi | Q8VCZ7 |
PRIDEi | Q8VCZ7 |
ProteomicsDBi | 275265 |
Protocols and materials databases
Antibodypediai | 2877, 77 antibodies from 15 providers |
DNASUi | 207259 |
Genome annotation databases
Ensembli | ENSMUST00000058997; ENSMUSP00000057856; ENSMUSG00000044646 ENSMUST00000167921; ENSMUSP00000126808; ENSMUSG00000044646 ENSMUST00000236462; ENSMUSP00000157716; ENSMUSG00000044646 |
GeneIDi | 207259 |
KEGGi | mmu:207259 |
UCSCi | uc008fqi.1, mouse |
Organism-specific databases
CTDi | 201501 |
MGIi | MGI:2443302, Zbtb7c |
VEuPathDBi | HostDB:ENSMUSG00000044646 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159814 |
HOGENOMi | CLU_025627_2_0_1 |
InParanoidi | Q8VCZ7 |
OMAi | ENDYSAY |
OrthoDBi | 268859at2759 |
PhylomeDBi | Q8VCZ7 |
TreeFami | TF331824 |
Miscellaneous databases
BioGRID-ORCSi | 207259, 7 hits in 71 CRISPR screens |
ChiTaRSi | Zbtb7c, mouse |
PROi | PR:Q8VCZ7 |
RNActi | Q8VCZ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000044646, Expressed in stomach and 146 other tissues |
Genevisiblei | Q8VCZ7, MM |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT7C_MOUSE | |
Accessioni | Q8VCZ7Primary (citable) accession number: Q8VCZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot