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Protein

Zinc finger and BTB domain-containing protein 7C

Gene

Zbtb7c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a tumor suppressor gene.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri364 – 386C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 478C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 7C
Alternative name(s):
Zinc finger and BTB domain-containing protein 36
Gene namesi
Name:Zbtb7c
Synonyms:Zbtb36
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2443302 Zbtb7c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003378701 – 619Zinc finger and BTB domain-containing protein 7CAdd BLAST619

Proteomic databases

PaxDbiQ8VCZ7
PRIDEiQ8VCZ7

PTM databases

PhosphoSitePlusiQ8VCZ7

Expressioni

Gene expression databases

BgeeiENSMUSG00000044646 Expressed in 105 organ(s), highest expression level in indifferent gonad
GenevisibleiQ8VCZ7 MM

Interactioni

Protein-protein interaction databases

BioGridi228889, 6 interactors
STRINGi10090.ENSMUSP00000057856

Structurei

3D structure databases

ProteinModelPortaliQ8VCZ7
SMRiQ8VCZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 101BTBPROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi125 – 169Glu-richAdd BLAST45
Compositional biasi137 – 209Asp-richAdd BLAST73
Compositional biasi299 – 304Poly-Pro6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri364 – 386C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 478C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148950
HOGENOMiHOG000059674
HOVERGENiHBG101042
InParanoidiQ8VCZ7
KOiK10494
OMAiCIHCNAK
OrthoDBiEOG091G03XR
PhylomeDBiQ8VCZ7
TreeFamiTF331824

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q8VCZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANDIDELIG IPFPNHSSEV LCSLNEQRHA GLLCDVLLVV QEQEYRTHRS
60 70 80 90 100
VLAACSKYFK KLFTAGSLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT
110 120 130 140 150
ASNVKHILNA ARMLEIQCIV NVCLEIMEPG GSVGEEDDKE EEDEDDDDED
160 170 180 190 200
EDDEEEEEEE EEEEEDDPED FADQENLPDP QDITCPQSPS KTDHLTEKDY
210 220 230 240 250
SDTPRDFPDS FQPGSPGHLG VIRDFSIESL LRENLYPKAN IPDRRPSLSP
260 270 280 290 300
FAPEFFPHLW PGGFGAFAQL PEQPMDSGPL DLVIKNRKIK EEDKEELAPP
310 320 330 340 350
PPPPFSSDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGSLFPPW
360 370 380 390 400
PLVEERKLKP KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCSICEVR
410 420 430 440 450
FTRQDKLKIH MRKHTGERPY LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC
460 470 480 490 500
EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG RKPAAWRAAS LLFGPGGPSA
510 520 530 540 550
DKAAFVMPPA LGDVGGHLGG TAVCLPGPSP AKHFLASPKG TLSLQELERQ
560 570 580 590 600
FEETQMKLFG RAQLEAERNA GGLLALALAE NVAATRPYFP LPDPWAAGLA
610
GLPGLTGLNH VASMSEANN
Length:619
Mass (Da):69,086
Last modified:March 1, 2002 - v1
Checksum:iFC5E6A222BCB5460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045522 mRNA Translation: BAC32405.1
BC018187 mRNA Translation: AAH18187.1
BC070424 mRNA Translation: AAH70424.1
CCDSiCCDS29349.1
RefSeqiNP_663331.1, NM_145356.3
XP_006525800.1, XM_006525737.3
UniGeneiMm.159332

Genome annotation databases

EnsembliENSMUST00000058997; ENSMUSP00000057856; ENSMUSG00000044646
ENSMUST00000167921; ENSMUSP00000126808; ENSMUSG00000044646
GeneIDi207259
KEGGimmu:207259
UCSCiuc008fqi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045522 mRNA Translation: BAC32405.1
BC018187 mRNA Translation: AAH18187.1
BC070424 mRNA Translation: AAH70424.1
CCDSiCCDS29349.1
RefSeqiNP_663331.1, NM_145356.3
XP_006525800.1, XM_006525737.3
UniGeneiMm.159332

3D structure databases

ProteinModelPortaliQ8VCZ7
SMRiQ8VCZ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228889, 6 interactors
STRINGi10090.ENSMUSP00000057856

PTM databases

PhosphoSitePlusiQ8VCZ7

Proteomic databases

PaxDbiQ8VCZ7
PRIDEiQ8VCZ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058997; ENSMUSP00000057856; ENSMUSG00000044646
ENSMUST00000167921; ENSMUSP00000126808; ENSMUSG00000044646
GeneIDi207259
KEGGimmu:207259
UCSCiuc008fqi.1 mouse

Organism-specific databases

CTDi201501
MGIiMGI:2443302 Zbtb7c

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148950
HOGENOMiHOG000059674
HOVERGENiHBG101042
InParanoidiQ8VCZ7
KOiK10494
OMAiCIHCNAK
OrthoDBiEOG091G03XR
PhylomeDBiQ8VCZ7
TreeFamiTF331824

Miscellaneous databases

ChiTaRSiZbtb7c mouse
PROiPR:Q8VCZ7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044646 Expressed in 105 organ(s), highest expression level in indifferent gonad
GenevisibleiQ8VCZ7 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT7C_MOUSE
AccessioniPrimary (citable) accession number: Q8VCZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2002
Last modified: October 10, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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