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Protein

THAP domain-containing protein 7

Gene

Thap7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 93THAP-typePROSITE-ProRule annotationAdd BLAST93

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 7
Gene namesi
Name:Thap7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1916259 Thap7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686491 – 309THAP domain-containing protein 7Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineBy similarity1
Modified residuei210PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VCZ3
PRIDEiQ8VCZ3

PTM databases

PhosphoSitePlusiQ8VCZ3

Expressioni

Gene expression databases

BgeeiENSMUSG00000022760 Expressed in 287 organ(s), highest expression level in primary oocyte
CleanExiMM_THAP7
GenevisibleiQ8VCZ3 MM

Interactioni

Subunit structurei

Interacts with HDAC3 and nuclear hormone receptor corepressors.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213170, 1 interactor
IntActiQ8VCZ3, 1 interactor
STRINGi10090.ENSMUSP00000097701

Structurei

3D structure databases

ProteinModelPortaliQ8VCZ3
SMRiQ8VCZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi229 – 232HCFC1-binding motif (HBM)By similarity4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 93THAP-typePROSITE-ProRule annotationAdd BLAST93

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IVKX Eukaryota
ENOG410YA1P LUCA
GeneTreeiENSGT00730000111394
HOGENOMiHOG000264238
HOVERGENiHBG056757
InParanoidiQ8VCZ3
OMAiYPPGPPD
OrthoDBiEOG091G0FJ7
PhylomeDBiQ8VCZ3
TreeFamiTF335838

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR026519 THAP7
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR23080:SF14 PTHR23080:SF14, 1 hit
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8VCZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRHCSAAGC CTRDTRETRN RGISFHRLPK KDNPRRGLWL ANCQRLDPSG
60 70 80 90 100
QGLWDPTSEY IYFCSKHFEE NCFELVGISG YHRLKEGAVP TIFESFSKLR
110 120 130 140 150
RTAKTKGHGY PPGLPDVSRL RRCRKRCSER QGPTTPFSPP PRADIICFPV
160 170 180 190 200
EEASAPATLP ASPAVRLDPG LNSPFSDLLG PLGAQADEAG CSTQPSPEQH
210 220 230 240 250
PSPLEPQPAS PSAYMLRLPP PAGAYIQNEH SYQVGSALLW KRRAEAALDA
260 270 280 290 300
LDKTQRQLQA CKRREQRLRL RLTKLQQERA REKRAQADAR QTLKDHVQDF

AMQLSSSMA
Length:309
Mass (Da):34,593
Last modified:March 1, 2002 - v1
Checksum:iD952896B87CC5F00
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P7J4A0A338P7J4_MOUSE
THAP domain-containing protein 7
Thap7
190Annotation score:
A0A338P6A2A0A338P6A2_MOUSE
THAP domain-containing protein 7
Thap7
178Annotation score:
A0A338P6L2A0A338P6L2_MOUSE
THAP domain-containing protein 7
Thap7
91Annotation score:
A0A338P6Q1A0A338P6Q1_MOUSE
THAP domain-containing protein 7
Thap7
67Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018221 mRNA Translation: AAH18221.1
CCDSiCCDS28004.1
RefSeqiNP_081185.1, NM_026909.2
XP_006522574.1, XM_006522511.3
UniGeneiMm.10174

Genome annotation databases

EnsembliENSMUST00000100125; ENSMUSP00000097701; ENSMUSG00000022760
ENSMUST00000231548; ENSMUSP00000156168; ENSMUSG00000022760
GeneIDi69009
KEGGimmu:69009
UCSCiuc007yld.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018221 mRNA Translation: AAH18221.1
CCDSiCCDS28004.1
RefSeqiNP_081185.1, NM_026909.2
XP_006522574.1, XM_006522511.3
UniGeneiMm.10174

3D structure databases

ProteinModelPortaliQ8VCZ3
SMRiQ8VCZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213170, 1 interactor
IntActiQ8VCZ3, 1 interactor
STRINGi10090.ENSMUSP00000097701

PTM databases

PhosphoSitePlusiQ8VCZ3

Proteomic databases

PaxDbiQ8VCZ3
PRIDEiQ8VCZ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100125; ENSMUSP00000097701; ENSMUSG00000022760
ENSMUST00000231548; ENSMUSP00000156168; ENSMUSG00000022760
GeneIDi69009
KEGGimmu:69009
UCSCiuc007yld.1 mouse

Organism-specific databases

CTDi80764
MGIiMGI:1916259 Thap7

Phylogenomic databases

eggNOGiENOG410IVKX Eukaryota
ENOG410YA1P LUCA
GeneTreeiENSGT00730000111394
HOGENOMiHOG000264238
HOVERGENiHBG056757
InParanoidiQ8VCZ3
OMAiYPPGPPD
OrthoDBiEOG091G0FJ7
PhylomeDBiQ8VCZ3
TreeFamiTF335838

Miscellaneous databases

PROiPR:Q8VCZ3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022760 Expressed in 287 organ(s), highest expression level in primary oocyte
CleanExiMM_THAP7
GenevisibleiQ8VCZ3 MM

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR026519 THAP7
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR23080:SF14 PTHR23080:SF14, 1 hit
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHAP7_MOUSE
AccessioniPrimary (citable) accession number: Q8VCZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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