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Protein

U3 small nucleolar RNA-associated protein 6 homolog

Gene

Utp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.By similarity

GO - Molecular functioni

  • snoRNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processrRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 6 homolog
Alternative name(s):
Multiple hat domains protein
Gene namesi
Name:Utp6
Synonyms:Mhat
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2445193 Utp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002394661 – 597U3 small nucleolar RNA-associated protein 6 homologAdd BLAST597

Proteomic databases

EPDiQ8VCY6
MaxQBiQ8VCY6
PaxDbiQ8VCY6
PeptideAtlasiQ8VCY6
PRIDEiQ8VCY6

PTM databases

iPTMnetiQ8VCY6
PhosphoSitePlusiQ8VCY6

Expressioni

Gene expression databases

BgeeiENSMUSG00000035575 Expressed in 274 organ(s), highest expression level in blood
GenevisibleiQ8VCY6 MM

Interactioni

Protein-protein interaction databases

BioGridi229829, 3 interactors
IntActiQ8VCY6, 1 interactor
STRINGi10090.ENSMUSP00000046643

Structurei

3D structure databases

ProteinModelPortaliQ8VCY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati121 – 153HAT 1Add BLAST33
Repeati156 – 188HAT 2Add BLAST33
Repeati304 – 335HAT 3Add BLAST32
Repeati488 – 520HAT 4Add BLAST33
Repeati524 – 557HAT 5Add BLAST34

Sequence similaritiesi

Belongs to the UTP6 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2396 Eukaryota
COG5191 LUCA
GeneTreeiENSGT00390000016493
HOGENOMiHOG000285956
HOVERGENiHBG051886
InParanoidiQ8VCY6
KOiK14557
OMAiLSHVAFC
OrthoDBiEOG091G09F4
PhylomeDBiQ8VCY6
TreeFamiTF323957

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR011990 TPR-like_helical_dom_sf
IPR013949 Utp6
PfamiView protein in Pfam
PF08640 U3_assoc_6, 1 hit
SMARTiView protein in SMART
SM00386 HAT, 6 hits
SUPFAMiSSF48452 SSF48452, 2 hits

Sequencei

Sequence statusi: Complete.

Q8VCY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEIIQERIE DRIPELEQLE RIGLFSHAEI KAIIKKASDL EYKIHRRTLL
60 70 80 90 100
KEDFINYVQY EINLLELIQR RRARIKYSFK KDEIEYSMVH RVQGVFGRAS
110 120 130 140 150
AKWKDDVQLW LSYIVFCKKW GTKTHLSKIF SAMLAIHSNK PALWIMAAKW
160 170 180 190 200
EMEDRLSSES ARQLFLRALR FHPECPKLYQ EYFRMELMHA EKLRKEKQEF
210 220 230 240 250
EKAAMDMGDF DHPEEILKGE LARIIYKNSI SKIKGAEFHV SLLAIAQLFD
260 270 280 290 300
FAKDLQKEIY DDLQALHTDD PLTWDYVARR ELEIESQPGE EQPVSKQAKA
310 320 330 340 350
VEMGRREERC CAVYEEAVKA LPTEAMWKCY ITFCLERFSK KTSSVPLRGQ
360 370 380 390 400
RLERTMLAFR KAHELKLLSE VQYKQWIDLL LRQDLFKEAL QVAEAGTELF
410 420 430 440 450
KDSVTMWQTK LQVLIDSKSP DVEMRFEEAF AHLKPQVCLP LWISWAEWSE
460 470 480 490 500
SAKSQEDTEA IFKKAIIAVT GASSVTLKEK YLDWAYRSGG YKKARAVFKS
510 520 530 540 550
LQESRPFSVE FFRKMMQFEK EQEPCKMVNL REYYERALRE FGTSDSDLWM
560 570 580 590
DYIKEELNHP FGKPENCGQI YWRAMKMLQG QSAELFVAKH AMHQAGH
Length:597
Mass (Da):70,429
Last modified:March 1, 2002 - v1
Checksum:iAC8D5282DA3C1C0E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti524P → S in AAO15383 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334387 mRNA Translation: AAO15383.1
AK029151 mRNA Translation: BAC26328.1
AK084976 mRNA Translation: BAC39327.1
AL591113 Genomic DNA No translation available.
BC018250 mRNA Translation: AAH18250.1
BC024850 mRNA Translation: AAH24850.1
BC023920 mRNA Translation: AAH23920.1
CCDSiCCDS25124.1
RefSeqiNP_659075.1, NM_144826.3
UniGeneiMm.274961

Genome annotation databases

EnsembliENSMUST00000043152; ENSMUSP00000046643; ENSMUSG00000035575
ENSMUST00000108241; ENSMUSP00000103876; ENSMUSG00000035575
GeneIDi216987
KEGGimmu:216987
UCSCiuc007klb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334387 mRNA Translation: AAO15383.1
AK029151 mRNA Translation: BAC26328.1
AK084976 mRNA Translation: BAC39327.1
AL591113 Genomic DNA No translation available.
BC018250 mRNA Translation: AAH18250.1
BC024850 mRNA Translation: AAH24850.1
BC023920 mRNA Translation: AAH23920.1
CCDSiCCDS25124.1
RefSeqiNP_659075.1, NM_144826.3
UniGeneiMm.274961

3D structure databases

ProteinModelPortaliQ8VCY6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229829, 3 interactors
IntActiQ8VCY6, 1 interactor
STRINGi10090.ENSMUSP00000046643

PTM databases

iPTMnetiQ8VCY6
PhosphoSitePlusiQ8VCY6

Proteomic databases

EPDiQ8VCY6
MaxQBiQ8VCY6
PaxDbiQ8VCY6
PeptideAtlasiQ8VCY6
PRIDEiQ8VCY6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043152; ENSMUSP00000046643; ENSMUSG00000035575
ENSMUST00000108241; ENSMUSP00000103876; ENSMUSG00000035575
GeneIDi216987
KEGGimmu:216987
UCSCiuc007klb.1 mouse

Organism-specific databases

CTDi55813
MGIiMGI:2445193 Utp6

Phylogenomic databases

eggNOGiKOG2396 Eukaryota
COG5191 LUCA
GeneTreeiENSGT00390000016493
HOGENOMiHOG000285956
HOVERGENiHBG051886
InParanoidiQ8VCY6
KOiK14557
OMAiLSHVAFC
OrthoDBiEOG091G09F4
PhylomeDBiQ8VCY6
TreeFamiTF323957

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiUtp6 mouse
PROiPR:Q8VCY6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035575 Expressed in 274 organ(s), highest expression level in blood
GenevisibleiQ8VCY6 MM

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR003107 HAT
IPR011990 TPR-like_helical_dom_sf
IPR013949 Utp6
PfamiView protein in Pfam
PF08640 U3_assoc_6, 1 hit
SMARTiView protein in SMART
SM00386 HAT, 6 hits
SUPFAMiSSF48452 SSF48452, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiUTP6_MOUSE
AccessioniPrimary (citable) accession number: Q8VCY6
Secondary accession number(s): Q8CH76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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