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Protein

Solute carrier family 35 member C2

Gene

Slc35c2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells (By similarity).By similarity

GO - Biological processi

  • fucosylation Source: MGI
  • negative regulation of gene expression Source: MGI
  • positive regulation of Notch signaling pathway Source: MGI
  • protein O-linked fucosylation Source: MGI
  • UDP-glucose transmembrane transport Source: GO_Central

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.7.9.8 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member C2
Alternative name(s):
Ovarian cancer-overexpressed gene 1 protein
Gene namesi
Name:Slc35c2
Synonyms:Ovcov1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385166 Slc35c2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002134001 – 364Solute carrier family 35 member C2Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8VCX2
PaxDbiQ8VCX2
PRIDEiQ8VCX2

PTM databases

iPTMnetiQ8VCX2
PhosphoSitePlusiQ8VCX2

Expressioni

Developmental stagei

Higher expression at embryo stage 7.5 dpc than 11-17 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000017664 Expressed in 287 organ(s), highest expression level in colon
CleanExiMM_SLC35C2
ExpressionAtlasiQ8VCX2 baseline and differential
GenevisibleiQ8VCX2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017808

Structurei

3D structure databases

ProteinModelPortaliQ8VCX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1443 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00510000048078
HOGENOMiHOG000007454
HOVERGENiHBG055852
InParanoidiQ8VCX2
KOiK15280
OMAiHTSNEIT
OrthoDBiEOG091G09SR
PhylomeDBiQ8VCX2
TreeFamiTF314994

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q8VCX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRWALDVAF VWKAALTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM
60 70 80 90 100
LHLAVIFLFS ALSRALVQCS SHKARVVLSW TDYLRRVAPT ALATALDVGL
110 120 130 140 150
SNWSFLYITV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG
160 170 180 190 200
LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQILLQKA DLGLQNPIDT
210 220 230 240 250
MFHLQPLMFL GLFPLFAIFE GLHLSTSEKI FRFQDTGLLL WVLGSLLLGG
260 270 280 290 300
ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
310 320 330 340 350
LGFALCLSGI SLHVALKALH SRGDGGPKPL KSLGSSADLE LLLRSSQQEE
360
EDGEEEYFVT QGQQ
Length:364
Mass (Da):40,302
Last modified:March 1, 2002 - v1
Checksum:i334B742A566FB891
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5GMG7Q5GMG7_MOUSE
Solute carrier family 35 member C2
Slc35c2
163Annotation score:
Q5GMH1Q5GMH1_MOUSE
Solute carrier family 35 member C2
Slc35c2
199Annotation score:
A2A5A3A2A5A3_MOUSE
Solute carrier family 35 member C2
Slc35c2
137Annotation score:
Q5GMG8Q5GMG8_MOUSE
Solute carrier family 35 member C2
Slc35c2
192Annotation score:
Q5GMG9Q5GMG9_MOUSE
Solute carrier family 35 member C2
Slc35c2
196Annotation score:
Q5GMG6Q5GMG6_MOUSE
Solute carrier family 35 member C2
Slc35c2
58Annotation score:
E0CYZ1E0CYZ1_MOUSE
Solute carrier family 35 member C2
Slc35c2
72Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018327 mRNA Translation: AAH18327.1
CCDSiCCDS17074.1
RefSeqiNP_001239502.1, NM_001252573.1
NP_001239503.1, NM_001252574.1
NP_659142.1, NM_144893.2
XP_006499433.1, XM_006499370.3
XP_006499434.1, XM_006499371.3
XP_006499435.1, XM_006499372.3
XP_006499438.1, XM_006499375.3
UniGeneiMm.21184
Mm.488746

Genome annotation databases

EnsembliENSMUST00000017808; ENSMUSP00000017808; ENSMUSG00000017664
ENSMUST00000109298; ENSMUSP00000104921; ENSMUSG00000017664
ENSMUST00000109299; ENSMUSP00000104922; ENSMUSG00000017664
ENSMUST00000109300; ENSMUSP00000104923; ENSMUSG00000017664
GeneIDi228875
KEGGimmu:228875
UCSCiuc008nxd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018327 mRNA Translation: AAH18327.1
CCDSiCCDS17074.1
RefSeqiNP_001239502.1, NM_001252573.1
NP_001239503.1, NM_001252574.1
NP_659142.1, NM_144893.2
XP_006499433.1, XM_006499370.3
XP_006499434.1, XM_006499371.3
XP_006499435.1, XM_006499372.3
XP_006499438.1, XM_006499375.3
UniGeneiMm.21184
Mm.488746

3D structure databases

ProteinModelPortaliQ8VCX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017808

Protein family/group databases

TCDBi2.A.7.9.8 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetiQ8VCX2
PhosphoSitePlusiQ8VCX2

Proteomic databases

MaxQBiQ8VCX2
PaxDbiQ8VCX2
PRIDEiQ8VCX2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017808; ENSMUSP00000017808; ENSMUSG00000017664
ENSMUST00000109298; ENSMUSP00000104921; ENSMUSG00000017664
ENSMUST00000109299; ENSMUSP00000104922; ENSMUSG00000017664
ENSMUST00000109300; ENSMUSP00000104923; ENSMUSG00000017664
GeneIDi228875
KEGGimmu:228875
UCSCiuc008nxd.2 mouse

Organism-specific databases

CTDi51006
MGIiMGI:2385166 Slc35c2

Phylogenomic databases

eggNOGiKOG1443 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00510000048078
HOGENOMiHOG000007454
HOVERGENiHBG055852
InParanoidiQ8VCX2
KOiK15280
OMAiHTSNEIT
OrthoDBiEOG091G09SR
PhylomeDBiQ8VCX2
TreeFamiTF314994

Miscellaneous databases

ChiTaRSiSlc35c2 mouse
PROiPR:Q8VCX2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017664 Expressed in 287 organ(s), highest expression level in colon
CleanExiMM_SLC35C2
ExpressionAtlasiQ8VCX2 baseline and differential
GenevisibleiQ8VCX2 MM

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS35C2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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