UniProtKB - Q8VCX2 (S35C2_MOUSE)

BLAST

>sp|Q8VCX2|S35C2_MOUSE Solute carrier family 35 member C2 OS=Mus musculus OX=10090 GN=Slc35c2 PE=1 SV=1
MGRWALDVAFVWKAALTLGLVLLYYCFSIGITFYNKWLTKSFHFPLFMTMLHLAVIFLFS
ALSRALVQCSSHKARVVLSWTDYLRRVAPTALATALDVGLSNWSFLYITVSLYTMTKSSA
VLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQFNVEGFALVLGASFIGGIRW
TLTQILLQKADLGLQNPIDTMFHLQPLMFLGLFPLFAIFEGLHLSTSEKIFRFQDTGLLL
WVLGSLLLGGILAFGLGFSEFLLVSRTSSLTLSIAGIFKEVCTLLLAAHLLGDQISLLNW
LGFALCLSGISLHVALKALHSRGDGGPKPLKSLGSSADLELLLRSSQQEEEDGEEEYFVT
QGQQ

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History
Entry version 115 (12 Sep 2018)
Sequence version 1 (01 Mar 2002)
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Protein

Solute carrier family 35 member C2

Gene

Slc35c2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells (By similarity).By similarity

GO - Biological processⁱ

fucosylation
Source: MGI
Inferred from direct assayⁱ
- 20837470
negative regulation of gene expression
Source: MGI
Inferred from direct assayⁱ
- 20837470
positive regulation of Notch signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 20837470
protein O-linked fucosylation
Source: MGI
Inferred from direct assayⁱ
- 20837470
UDP-glucose transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport

Biological process

Transport

Protein family/group databases

TCDBⁱ	2.A.7.9.8 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.9.8 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 35 member C2 Alternative name(s): Ovarian cancer-overexpressed gene 1 protein
Gene namesⁱ	Name:Slc35c2 Synonyms:Ovcov1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:2385166 Slc35c2

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	14 – 34	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	42 – 62	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	104 – 124	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	136 – 156	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	166 – 186	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	202 – 222	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	238 – 258	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	272 – 292	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	295 – 315	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000213400	1 – 364	Solute carrier family 35 member C2Add BLAST		364

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	102	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	335	PhosphoserineCombined sources	1
Modified residueⁱ	336	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8VCX2
PaxDbⁱ	Q8VCX2
PRIDEⁱ	Q8VCX2

PTM databases

iPTMnetⁱ	Q8VCX2
PhosphoSitePlusⁱ	Q8VCX2

Expressionⁱ

Developmental stageⁱ

Higher expression at embryo stage 7.5 dpc than 11-17 dpc.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000017664 Expressed in 287 organ(s), highest expression level in colon
CleanExⁱ	MM_SLC35C2
ExpressionAtlasⁱ	Q8VCX2 baseline and differential
Genevisibleⁱ	Q8VCX2 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000017808

STRINGⁱ

10090.ENSMUSP00000017808

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8VCX2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TPT transporter family. SLC35C subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1443 Eukaryota COG0697 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048078
HOGENOMⁱ	HOG000007454
HOVERGENⁱ	HBG055852
InParanoidⁱ	Q8VCX2
KEGG Orthology (KO) More...KOⁱ	K15280
OMAⁱ	HTSNEIT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09SR
PhylomeDBⁱ	Q8VCX2
TreeFamⁱ	TF314994

Family and domain databases

InterProⁱ	View protein in InterPro IPR004853 Sugar_P_trans_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03151 TPT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show all Align All

Q8VCX2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGRWALDVAF VWKAALTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM 
        60         70         80         90        100
LHLAVIFLFS ALSRALVQCS SHKARVVLSW TDYLRRVAPT ALATALDVGL 
       110        120        130        140        150
SNWSFLYITV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG 
       160        170        180        190        200
LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQILLQKA DLGLQNPIDT 
       210        220        230        240        250
MFHLQPLMFL GLFPLFAIFE GLHLSTSEKI FRFQDTGLLL WVLGSLLLGG 
       260        270        280        290        300
ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW 
       310        320        330        340        350
LGFALCLSGI SLHVALKALH SRGDGGPKPL KSLGSSADLE LLLRSSQQEE 
       360 
EDGEEEYFVT QGQQ

Length:364

Mass (Da):40,302

Last modified:March 1, 2002 - v1

Checksum:ⁱ334B742A566FB891

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5GMG7	Q5GMG7_MOUSE	Solute carrier family 35 member C2 Solute carrier family 35 member C2	Slc35c2	163	Annotation score:
Q5GMH1	Q5GMH1_MOUSE	Solute carrier family 35 member C2 Solute carrier family 35 member C2	Slc35c2	199	Annotation score:
A2A5A3	A2A5A3_MOUSE	Solute carrier family 35 member C2 Solute carrier family 35 member C2	Slc35c2	137	Annotation score:
Q5GMG8	Q5GMG8_MOUSE	Solute carrier family 35 member C2 Solute carrier family 35 member C2	Slc35c2	192	Annotation score:
Q5GMG9	Q5GMG9_MOUSE	Solute carrier family 35 member C2 Solute carrier family 35 member C2	Slc35c2	196	Annotation score:
Q5GMG6	Q5GMG6_MOUSE	Solute carrier family 35 member C2 Solute carrier family 35 member C2	Slc35c2	58	Annotation score:
E0CYZ1	E0CYZ1_MOUSE	Solute carrier family 35 member C2 Solute carrier family 35 member C2	Slc35c2	72	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC018327 mRNA Translation: AAH18327.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17074.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001239502.1, NM_001252573.1 NP_001239503.1, NM_001252574.1 NP_659142.1, NM_144893.2 XP_006499433.1, XM_006499370.3 XP_006499434.1, XM_006499371.3 XP_006499435.1, XM_006499372.3 XP_006499438.1, XM_006499375.3
UniGeneⁱ	Mm.21184 Mm.488746

Genome annotation databases

Ensemblⁱ	ENSMUST00000017808; ENSMUSP00000017808; ENSMUSG00000017664 ENSMUST00000109298; ENSMUSP00000104921; ENSMUSG00000017664 ENSMUST00000109299; ENSMUSP00000104922; ENSMUSG00000017664 ENSMUST00000109300; ENSMUSP00000104923; ENSMUSG00000017664
GeneIDⁱ	228875
KEGGⁱ	mmu:228875
UCSC genome browser More...UCSCⁱ	uc008nxd.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8VCX2	Slc35c2 protein		MOUSE		364	UniRef100_Q8VCX2
Solute carrier family 35 member C2 (Fragment)		MOUSE		58
Solute carrier family 35 member C2 (Fragment)		MOUSE		163
Solute carrier family 35 member C2 (Fragment)		MOUSE		192
UPI000235B786		MOUSE		250

Protein	Similar proteins		Species	Score	Length	Source
Q8VCX2	Solute carrier family 35 member C2		HUMAN		365	UniRef90_Q9NQQ7
SLC35C2 isoform 1		PANTR		394
Solute carrier family 35 member C2		CAMFR		446
Uncharacterized protein		RHIRO		394
Uncharacterized protein		RHIBE		394
+170

Protein	Similar proteins		Species	Score	Length	Source
Q8VCX2	Solute carrier family 35 member C2		HUMAN		365	UniRef50_Q9NQQ7
SLC35C2 isoform 1		PANTR		394
Solute carrier family 35 member C2		CAMFR		446
Uncharacterized protein		CERAT		394
Uncharacterized protein		PAPAN		394
+229

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC018327 mRNA Translation: AAH18327.1
CCDSⁱ	CCDS17074.1
RefSeqⁱ	NP_001239502.1, NM_001252573.1 NP_001239503.1, NM_001252574.1 NP_659142.1, NM_144893.2 XP_006499433.1, XM_006499370.3 XP_006499434.1, XM_006499371.3 XP_006499435.1, XM_006499372.3 XP_006499438.1, XM_006499375.3
UniGeneⁱ	Mm.21184 Mm.488746

3D structure databases

ProteinModelPortalⁱ	Q8VCX2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000017808

STRINGⁱ

10090.ENSMUSP00000017808

Protein family/group databases

TCDBⁱ	2.A.7.9.8 the drug/metabolite transporter (dmt) superfamily

TCDBⁱ

2.A.7.9.8 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetⁱ	Q8VCX2
PhosphoSitePlusⁱ	Q8VCX2

Proteomic databases

MaxQBⁱ	Q8VCX2
PaxDbⁱ	Q8VCX2
PRIDEⁱ	Q8VCX2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000017808; ENSMUSP00000017808; ENSMUSG00000017664 ENSMUST00000109298; ENSMUSP00000104921; ENSMUSG00000017664 ENSMUST00000109299; ENSMUSP00000104922; ENSMUSG00000017664 ENSMUST00000109300; ENSMUSP00000104923; ENSMUSG00000017664
GeneIDⁱ	228875
KEGGⁱ	mmu:228875
UCSCⁱ	uc008nxd.2 mouse

Organism-specific databases

CTDⁱ	51006
MGIⁱ	MGI:2385166 Slc35c2

Phylogenomic databases

eggNOGⁱ	KOG1443 Eukaryota COG0697 LUCA
GeneTreeⁱ	ENSGT00510000048078
HOGENOMⁱ	HOG000007454
HOVERGENⁱ	HBG055852
InParanoidⁱ	Q8VCX2
KOⁱ	K15280
OMAⁱ	HTSNEIT
OrthoDBⁱ	EOG091G09SR
PhylomeDBⁱ	Q8VCX2
TreeFamⁱ	TF314994

Miscellaneous databases

ChiTaRSⁱ	Slc35c2 mouse
Protein Ontology More...PROⁱ	PR:Q8VCX2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000017664 Expressed in 287 organ(s), highest expression level in colon
CleanExⁱ	MM_SLC35C2
ExpressionAtlasⁱ	Q8VCX2 baseline and differential
Genevisibleⁱ	Q8VCX2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR004853 Sugar_P_trans_dom
Pfamⁱ	View protein in Pfam PF03151 TPT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S35C2_MOUSE
Accessionⁱ	Q8VCX2Primary (citable) accession number: Q8VCX2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
	Last sequence update:	March 1, 2002
	Last modified:	September 12, 2018
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8VCX2 (S35C2_MOUSE)

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Solute carrier family 35 member C2

Slc35c2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Golgi apparatus

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ