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UniProtKB - Q8VCX2 (S35C2_MOUSE)
Protein
Solute carrier family 35 member C2
Gene
Slc35c2
Organism
Mus musculus (Mouse)
Status
Functioni
May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells (By similarity).
By similarityGO - Molecular functioni
- antiporter activity Source: GO_Central
GO - Biological processi
- fucosylation Source: MGI
- negative regulation of gene expression Source: MGI
- positive regulation of Notch signaling pathway Source: MGI
- protein O-linked fucosylation Source: MGI
- UDP-glucose transmembrane transport Source: GO_Central
Keywordsi
Biological process | Transport |
Protein family/group databases
TCDBi | 2.A.7.9.8, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 35 member C2Alternative name(s): Ovarian cancer-overexpressed gene 1 protein |
Gene namesi | Name:Slc35c2 Synonyms:Ovcov1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2385166, Slc35c2 |
VEuPathDBi | HostDB:ENSMUSG00000017664 |
Subcellular locationi
Golgi apparatus
- cis-Golgi network membrane By similarity
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
- Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity
Golgi apparatus
- cis-Golgi network Source: MGI
- Golgi apparatus Source: MGI
Nucleus
- nucleoplasm Source: MGI
Other locations
- endoplasmic reticulum-Golgi intermediate compartment Source: MGI
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 14 – 34 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 104 – 124 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 136 – 156 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 202 – 222 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 238 – 258 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 272 – 292 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 295 – 315 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213400 | 1 – 364 | Solute carrier family 35 member C2Add BLAST | 364 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 335 | PhosphoserineCombined sources | 1 | |
Modified residuei | 336 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q8VCX2 |
MaxQBi | Q8VCX2 |
PaxDbi | Q8VCX2 |
PRIDEi | Q8VCX2 |
ProteomicsDBi | 256885 |
PTM databases
GlyGeni | Q8VCX2, 1 site |
iPTMneti | Q8VCX2 |
PhosphoSitePlusi | Q8VCX2 |
Expressioni
Developmental stagei
Higher expression at embryo stage 7.5 dpc than 11-17 dpc.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000017664, Expressed in islet of Langerhans and 309 other tissues |
ExpressionAtlasi | Q8VCX2, baseline and differential |
Genevisiblei | Q8VCX2, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000104923 |
Miscellaneous databases
RNActi | Q8VCX2, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1443, Eukaryota |
GeneTreei | ENSGT00510000048078 |
HOGENOMi | CLU_022332_1_3_1 |
InParanoidi | Q8VCX2 |
OMAi | PVCAAMN |
OrthoDBi | 1337371at2759 |
PhylomeDBi | Q8VCX2 |
TreeFami | TF314994 |
Family and domain databases
InterProi | View protein in InterPro IPR004853, Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151, TPT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q8VCX2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRWALDVAF VWKAALTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM
60 70 80 90 100
LHLAVIFLFS ALSRALVQCS SHKARVVLSW TDYLRRVAPT ALATALDVGL
110 120 130 140 150
SNWSFLYITV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG
160 170 180 190 200
LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQILLQKA DLGLQNPIDT
210 220 230 240 250
MFHLQPLMFL GLFPLFAIFE GLHLSTSEKI FRFQDTGLLL WVLGSLLLGG
260 270 280 290 300
ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
310 320 330 340 350
LGFALCLSGI SLHVALKALH SRGDGGPKPL KSLGSSADLE LLLRSSQQEE
360
EDGEEEYFVT QGQQ
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE0CYZ1 | E0CYZ1_MOUSE | Solute carrier family 35 member C2 | Slc35c2 | 72 | Annotation score: | ||
Q5GMG7 | Q5GMG7_MOUSE | Solute carrier family 35 member C2 | Slc35c2 | 163 | Annotation score: | ||
Q5GMH1 | Q5GMH1_MOUSE | Solute carrier family 35 member C2 | Slc35c2 | 199 | Annotation score: | ||
Q5GMG8 | Q5GMG8_MOUSE | Solute carrier family 35 member C2 | Slc35c2 | 192 | Annotation score: | ||
A2A5A3 | A2A5A3_MOUSE | Solute carrier family 35 member C2 | Slc35c2 | 137 | Annotation score: | ||
Q5GMG6 | Q5GMG6_MOUSE | Solute carrier family 35 member C2 | Slc35c2 | 58 | Annotation score: | ||
Q5GMG9 | Q5GMG9_MOUSE | Solute carrier family 35 member C2 | Slc35c2 | 196 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC018327 mRNA Translation: AAH18327.1 |
CCDSi | CCDS17074.1 |
RefSeqi | NP_001239502.1, NM_001252573.1 NP_001239503.1, NM_001252574.1 NP_659142.1, NM_144893.2 XP_006499433.1, XM_006499370.3 XP_006499434.1, XM_006499371.3 XP_006499435.1, XM_006499372.3 XP_006499438.1, XM_006499375.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC018327 mRNA Translation: AAH18327.1 |
CCDSi | CCDS17074.1 |
RefSeqi | NP_001239502.1, NM_001252573.1 NP_001239503.1, NM_001252574.1 NP_659142.1, NM_144893.2 XP_006499433.1, XM_006499370.3 XP_006499434.1, XM_006499371.3 XP_006499435.1, XM_006499372.3 XP_006499438.1, XM_006499375.3 |
3D structure databases
AlphaFoldDBi | Q8VCX2 |
SMRi | Q8VCX2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000104923 |
Protein family/group databases
TCDBi | 2.A.7.9.8, the drug/metabolite transporter (dmt) superfamily |
PTM databases
GlyGeni | Q8VCX2, 1 site |
iPTMneti | Q8VCX2 |
PhosphoSitePlusi | Q8VCX2 |
Proteomic databases
jPOSTi | Q8VCX2 |
MaxQBi | Q8VCX2 |
PaxDbi | Q8VCX2 |
PRIDEi | Q8VCX2 |
ProteomicsDBi | 256885 |
Protocols and materials databases
Antibodypediai | 53835, 45 antibodies from 14 providers |
DNASUi | 228875 |
Genome annotation databases
Organism-specific databases
CTDi | 51006 |
MGIi | MGI:2385166, Slc35c2 |
VEuPathDBi | HostDB:ENSMUSG00000017664 |
Phylogenomic databases
eggNOGi | KOG1443, Eukaryota |
GeneTreei | ENSGT00510000048078 |
HOGENOMi | CLU_022332_1_3_1 |
InParanoidi | Q8VCX2 |
OMAi | PVCAAMN |
OrthoDBi | 1337371at2759 |
PhylomeDBi | Q8VCX2 |
TreeFami | TF314994 |
Miscellaneous databases
BioGRID-ORCSi | 228875, 4 hits in 71 CRISPR screens |
ChiTaRSi | Slc35c2, mouse |
PROi | PR:Q8VCX2 |
RNActi | Q8VCX2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000017664, Expressed in islet of Langerhans and 309 other tissues |
ExpressionAtlasi | Q8VCX2, baseline and differential |
Genevisiblei | Q8VCX2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004853, Sugar_P_trans_dom |
Pfami | View protein in Pfam PF03151, TPT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S35C2_MOUSE | |
Accessioni | Q8VCX2Primary (citable) accession number: Q8VCX2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families