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UniProtKB - Q8VCQ6 (SMS1_MOUSE)

Entry version 161 (25 May 2022)
Sequence version 2 (16 Feb 2004)
Previous versions | rss
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Protein

Phosphatidylcholine:ceramide cholinephosphotransferase 1

Gene

Sgms1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major sphingomyelin synthase at the Golgi apparatus (By similarity).

Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes (By similarity).

Does not use free phosphorylcholine or CDP-choline as donor. Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:22580896, PubMed:16879426) (By similarity).

Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (By similarity).

By similarity2 Publications

(Microbial infection) Contributes to the brain SM production for Japanese encephalitis virus attachment and infection.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Sphingolipid metabolism

This protein is involved in Sphingolipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in Sphingolipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei291By similarity1
Active sitei334By similarity1
Active sitei338By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processApoptosis, Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.8.27, 3474

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1660661, Sphingolipid de novo biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC:2.7.8.271 Publication)
Alternative name(s):
Protein Mob
Sphingomyelin synthase 1
Transmembrane protein 23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sgms1
Synonyms:Tmem23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2444110, Sgms1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000040451

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini331 – 419CytoplasmicSequence analysisAdd BLAST89

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Null mice have hearing impairments with stria vascularis (SV) in these mice exhibiting atrophy and disorganized marginal cells resulting in significantly smaller endocochlear potentials (EPs). These decreased EPs, together with abnormal KCNQ1 expression patterns, increase with age. There is a decrease in plasma, liver, and macrophage sphingomyelin (59%, 45%, and 54%, respectively) and a dramatic increase in glycosphingolipids. No change in ceramide, total cholesterol, phospholipids nor triglycerides levels. Diminished macrophage MAP kinase and NFKB1 activation is observed. Atherosclerosis in SMS1(-/-)/LDLR(-/-) mice is significantly decreased.2 Publications

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523408

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002210691 – 419Phosphatidylcholine:ceramide cholinephosphotransferase 1Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8VCQ6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8VCQ6

PRoteomics IDEntifications database

More...PRIDEi		Q8VCQ6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		261459 [Q8VCQ6-1]
261460 [Q8VCQ6-2]
261461 [Q8VCQ6-3]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8VCQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is widely expressed, isoform 2 shows a more narrow distribution and isoform 3 is detected only in testis and heart.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by TNF-alpha.1 Publication
Induced by TNF-alpha.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000040451, Expressed in brain blood vessel and 308 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8VCQ6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8VCQ6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000117336

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8VCQ6

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8VCQ6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1419
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8VCQ6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8VCQ6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8VCQ6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 76SAMPROSITE-ProRule annotationCuratedAdd BLAST64

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sphingomyelin synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3058, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158306

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027104_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8VCQ6

Identification of Orthologs from Complete Genome Data

More...OMAi		WICWTLS

Database of Orthologous Groups

More...OrthoDBi		599210at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8VCQ6

TreeFam database of animal gene trees

More...TreeFami		TF314547

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR045221, Sphingomyelin_synth-like
IPR025749, Sphingomyelin_synth-like_dom

The PANTHER Classification System

More...PANTHERi		PTHR21290, PTHR21290, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14360, PAP2_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VCQ6-1) [UniParc]FASTAAdd to basket
Also known as: SMS1-alpha

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSARTMKEV VYWSPKKVAD WLLENAMPEY CEPLEHFTGQ DLINLTQEDF 
        60         70         80         90        100
KKPPLYRVSS DNGQRLLDMI ETLKMEHHME AHKNGHANGH LSIGVDIPNP 
       110        120        130        140        150
DGSFSIKTKP NGMPNGFRKE MIKIPMPEPE RSQYPMEWGK TFLAFLYALS 
       160        170        180        190        200
CFVLTTVMIS VVHERVPPKE VQPPLPDTFF DHFNRVQWAF SICEINGMIL 
       210        220        230        240        250
VGLWLFQWLL LKYKSIISRR FFCIVGTLYL YRCITMYVTT LPVPGMHFNC 
       260        270        280        290        300
SPKLFGDWEA QVRRIMKLIA GGGLSITGSH NMCGDYLYSG HTVMLTLTYL 
       310        320        330        340        350
FIKEYSPRRL WWYHWICWLL SVVGIFCILL AHDHYTVDVV VAYYITTRLF 
       360        370        380        390        400
WWYHTMANQQ VLKEASQMNL LARVWWYRPF QYFEKNVQGI VPRSYHWPFP 
       410 
WPVVHLSRQV KYSRLVNDT
Length:419
Mass (Da):49,317
Last modified:February 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i554CC26609F5F345
GO
Isoform 2 (identifier: Q8VCQ6-2) [UniParc]FASTAAdd to basket
Also known as: SMS1-beta

The sequence of this isoform differs from the canonical sequence as follows:
     215-419: Missing.

Show »
Length:214
Mass (Da):24,852
Checksum:iEDFE8073E259AEC4
GO
Isoform 3 (identifier: Q8VCQ6-3) [UniParc]FASTAAdd to basket
Also known as: SMS1-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     215-217: SII → LSP
     218-419: Missing.

Show »
Length:217
Mass (Da):25,149
Checksum:i0CA3256DFE8073E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E3W996E3W996_MOUSE
Phosphatidylcholine:ceramide cholin...
Sgms1
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494BA77A0A494BA77_MOUSE
Phosphatidylcholine:ceramide cholin...
Sgms1
293Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YV54D3YV54_MOUSE
Phosphatidylcholine:ceramide cholin...
Sgms1
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132S → Y in BAC37590 (PubMed:16141072).Curated1
Sequence conflicti406L → I in BAE27428 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050673215 – 419Missing in isoform 2. 2 PublicationsAdd BLAST205
Alternative sequenceiVSP_027225215 – 217SII → LSP in isoform 3. 2 Publications3
Alternative sequenceiVSP_027226218 – 419Missing in isoform 3. 2 PublicationsAdd BLAST202

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY509044 mRNA Translation: AAS90514.1
AK076554 mRNA Translation: BAC36390.1
AK079254 mRNA Translation: BAC37590.1
AK082974 mRNA Translation: BAC38717.1
AK133967 mRNA Translation: BAE21960.1
AK146782 mRNA Translation: BAE27428.1
AK150272 mRNA Translation: BAE29428.1
AK151170 mRNA Translation: BAE30173.1
AK152312 mRNA Translation: BAE31117.1
AK153406 mRNA Translation: BAE31966.1
AK160539 mRNA Translation: BAE35856.1
BC019443 mRNA Translation: AAH19443.2
BC085298 mRNA Translation: AAH85298.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS29750.1 [Q8VCQ6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001161997.1, NM_001168525.1 [Q8VCQ6-1]
NP_001161998.1, NM_001168526.1 [Q8VCQ6-1]
NP_659041.3, NM_144792.4 [Q8VCQ6-1]
XP_006526881.1, XM_006526818.3 [Q8VCQ6-1]
XP_006526882.1, XM_006526819.1 [Q8VCQ6-1]
XP_006526883.1, XM_006526820.3 [Q8VCQ6-1]
XP_011245503.1, XM_011247201.2
XP_011245504.1, XM_011247202.2 [Q8VCQ6-1]
XP_011245505.1, XM_011247203.2 [Q8VCQ6-1]
XP_017173594.1, XM_017318105.1 [Q8VCQ6-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000099514; ENSMUSP00000097114; ENSMUSG00000040451 [Q8VCQ6-1]
ENSMUST00000142618; ENSMUSP00000117336; ENSMUSG00000040451 [Q8VCQ6-1]
ENSMUST00000151289; ENSMUSP00000123395; ENSMUSG00000040451 [Q8VCQ6-1]
ENSMUST00000152340; ENSMUSP00000119869; ENSMUSG00000040451 [Q8VCQ6-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		208449

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:208449

UCSC genome browser

More...UCSCi		uc008hfc.2, mouse [Q8VCQ6-1]
uc008hfh.1, mouse [Q8VCQ6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509044 mRNA Translation: AAS90514.1
AK076554 mRNA Translation: BAC36390.1
AK079254 mRNA Translation: BAC37590.1
AK082974 mRNA Translation: BAC38717.1
AK133967 mRNA Translation: BAE21960.1
AK146782 mRNA Translation: BAE27428.1
AK150272 mRNA Translation: BAE29428.1
AK151170 mRNA Translation: BAE30173.1
AK152312 mRNA Translation: BAE31117.1
AK153406 mRNA Translation: BAE31966.1
AK160539 mRNA Translation: BAE35856.1
BC019443 mRNA Translation: AAH19443.2
BC085298 mRNA Translation: AAH85298.1
CCDSiCCDS29750.1 [Q8VCQ6-1]
RefSeqiNP_001161997.1, NM_001168525.1 [Q8VCQ6-1]
NP_001161998.1, NM_001168526.1 [Q8VCQ6-1]
NP_659041.3, NM_144792.4 [Q8VCQ6-1]
XP_006526881.1, XM_006526818.3 [Q8VCQ6-1]
XP_006526882.1, XM_006526819.1 [Q8VCQ6-1]
XP_006526883.1, XM_006526820.3 [Q8VCQ6-1]
XP_011245503.1, XM_011247201.2
XP_011245504.1, XM_011247202.2 [Q8VCQ6-1]
XP_011245505.1, XM_011247203.2 [Q8VCQ6-1]
XP_017173594.1, XM_017318105.1 [Q8VCQ6-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8CNMR-A1-84[»]
AlphaFoldDBiQ8VCQ6
SMRiQ8VCQ6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000117336

Chemistry databases

BindingDBiQ8VCQ6
ChEMBLiCHEMBL4523408

PTM databases

PhosphoSitePlusiQ8VCQ6

Proteomic databases

MaxQBiQ8VCQ6
PaxDbiQ8VCQ6
PRIDEiQ8VCQ6
ProteomicsDBi261459 [Q8VCQ6-1]
261460 [Q8VCQ6-2]
261461 [Q8VCQ6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27870, 201 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		208449

Genome annotation databases

EnsembliENSMUST00000099514; ENSMUSP00000097114; ENSMUSG00000040451 [Q8VCQ6-1]
ENSMUST00000142618; ENSMUSP00000117336; ENSMUSG00000040451 [Q8VCQ6-1]
ENSMUST00000151289; ENSMUSP00000123395; ENSMUSG00000040451 [Q8VCQ6-1]
ENSMUST00000152340; ENSMUSP00000119869; ENSMUSG00000040451 [Q8VCQ6-3]
GeneIDi208449
KEGGimmu:208449
UCSCiuc008hfc.2, mouse [Q8VCQ6-1]
uc008hfh.1, mouse [Q8VCQ6-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		259230
MGIiMGI:2444110, Sgms1
VEuPathDBiHostDB:ENSMUSG00000040451

Phylogenomic databases

eggNOGiKOG3058, Eukaryota
GeneTreeiENSGT00940000158306
HOGENOMiCLU_027104_1_0_1
InParanoidiQ8VCQ6
OMAiWICWTLS
OrthoDBi599210at2759
PhylomeDBiQ8VCQ6
TreeFamiTF314547

Enzyme and pathway databases

BRENDAi2.7.8.27, 3474
ReactomeiR-MMU-1660661, Sphingolipid de novo biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		208449, 10 hits in 75 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Sgms1, mouse
EvolutionaryTraceiQ8VCQ6

Protein Ontology

More...PROi		PR:Q8VCQ6
RNActiQ8VCQ6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000040451, Expressed in brain blood vessel and 308 other tissues
ExpressionAtlasiQ8VCQ6, baseline and differential
GenevisibleiQ8VCQ6, MM

Family and domain databases

Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR001660, SAM
IPR013761, SAM/pointed_sf
IPR045221, Sphingomyelin_synth-like
IPR025749, Sphingomyelin_synth-like_dom
PANTHERiPTHR21290, PTHR21290, 1 hit
PfamiView protein in Pfam
PF14360, PAP2_C, 1 hit
SUPFAMiSSF47769, SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105, SAM_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMS1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VCQ6
Secondary accession number(s): Q3UIS8
, Q5J3R0, Q8C464, Q8C583, Q8C652
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: February 16, 2004
Last modified: May 25, 2022
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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