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Protein

Nuclear receptor-binding factor 2

Gene

Nrbf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity).By similarity
Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (By similarity). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (PubMed:24849286). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (By similarity). May be involved in autophagosome biogenesis (By similarity). May play a role in neural progenitor cell survival during differentiation (PubMed:18619852).By similarity2 Publications
Involved in the induction of starvation-induced autophagy. Modulates ATG14-linked lipid kinase activity of PIK3C3 and stabilzes PI3K complex I (PI3KC3-C1) assembly (PubMed:24849286). May play a role in neural progenitor cell survival during differentiation (PubMed:18619852).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • autophagy Source: GO_Central
  • regulation of lipid kinase activity Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: MGI
  • response to endoplasmic reticulum stress Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processAutophagy, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor-binding factor 2
Short name:
NRBF-2
Gene namesi
Name:Nrbf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1354950 Nrbf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002358171 – 287Nuclear receptor-binding factor 2Add BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphoserineBy similarity1
Modified residuei268PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VCQ3
MaxQBiQ8VCQ3
PaxDbiQ8VCQ3
PeptideAtlasiQ8VCQ3
PRIDEiQ8VCQ3

PTM databases

iPTMnetiQ8VCQ3
PhosphoSitePlusiQ8VCQ3

Expressioni

Developmental stagei

During embryonic brain development detected in the cerebral cortex at E14; expressed in the walls of the third and fourth ventricles, and in the hippocampus. In the adult brain, predominantly expressed in Purkinje cells of the cerebellum and neurons in the CA3 region of the hippocampus (PubMed:18619852).1 Publication

Gene expression databases

BgeeiENSMUSG00000075000
CleanExiMM_NRBF2
ExpressionAtlasiQ8VCQ3 baseline and differential
GenevisibleiQ8VCQ3 MM

Interactioni

Subunit structurei

Interacts with RRARA, PPARD and PPARG. Interacts with THRB, RARA, RARG and RXRA in the presence of bound ligand (By similarity). Interacts with SCOC (By similarity). Associates with the PI3K complex I (PI3KC3-C1); the direct binding partner in the complex is reported variably as PIK3R4 or ATG14 (PubMed:24849286).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi565935, 1 interactor
IntActiQ8VCQ3, 8 interactors
STRINGi10090.ENSMUSP00000097254

Structurei

Secondary structure

1287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 23Combined sources17
Helixi27 – 45Combined sources19
Helixi51 – 85Combined sources35

3D structure databases

ProteinModelPortaliQ8VCQ3
SMRiQ8VCQ3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VCQ3

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili168 – 215Sequence analysisAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi141 – 145Nuclear receptor interaction motifBy similarity5

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJBN Eukaryota
ENOG4111SDN LUCA
GeneTreeiENSGT00390000000984
HOGENOMiHOG000293418
HOVERGENiHBG056976
InParanoidiQ8VCQ3
KOiK21246
OMAiTWQKFAS
OrthoDBiEOG091G0FJ8
PhylomeDBiQ8VCQ3
TreeFamiTF328627

Family and domain databases

InterProiView protein in InterPro
IPR015056 NRBF2
IPR033393 NRBF2_MIT
PfamiView protein in Pfam
PF08961 NRBF2, 1 hit
PF17169 NRBF2_MIT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VCQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVMEGPLNL AHQQSRRADR LLAAGKYEEA ISCHRKATTY LSEAMKLTES
60 70 80 90 100
EQAHLSLELQ RDSHMKQLLL IQERWKRAKR EERLKAQQST ERDGAPHLQA
110 120 130 140 150
PPRPSEDAEG QSPLLSQPYI PSTERRLPEV QGVFDRDPDT LLFLLQQKNE
160 170 180 190 200
PSEPCIGSKA PKDDKTIIEE QATKIADLKR HVEFLVAENE RLRKENKQLK
210 220 230 240 250
AEKARLLKGT AEKELDVDAD FVEKSELWGL PSHSESAAAS STWQKFAANT
260 270 280
GKAKDIPIPN LPPLDFPSPE LPLMELSEDI LKGFMND
Length:287
Mass (Da):32,501
Last modified:March 1, 2002 - v1
Checksum:i81B1C0A0CB575D2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203K → E in BAB22375 (PubMed:16141072).Curated1
Sequence conflicti245 – 264KFAAN…NLPPL → SLQLTRGSQGHSNTQPSSS in BAB22375 (PubMed:16141072).CuratedAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002810 mRNA Translation: BAB22375.1
BC019448 mRNA Translation: AAH19448.1
CCDSiCCDS23902.1
RefSeqiNP_001031370.1, NM_001036293.2
UniGeneiMm.136223

Genome annotation databases

EnsembliENSMUST00000077839; ENSMUSP00000097254; ENSMUSG00000075000
ENSMUST00000229557; ENSMUSP00000155479; ENSMUSG00000115942
GeneIDi641340
KEGGimmu:641340
UCSCiuc007flw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNRBF2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCQ3
Secondary accession number(s): Q9DCG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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