Nrbf2

Functionⁱ

May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity).By similarity

Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (By similarity). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (PubMed:24849286). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (By similarity). May be involved in autophagosome biogenesis (By similarity). May play a role in neural progenitor cell survival during differentiation (PubMed:18619852).By similarity2 Publications

Involved in the induction of starvation-induced autophagy. Modulates ATG14-linked lipid kinase activity of PIK3C3 and stabilzes PI3K complex I (PI3KC3-C1) assembly (PubMed:24849286). May play a role in neural progenitor cell survival during differentiation (PubMed:18619852).By similarity2 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy
Source: GO_Central
Inferred from mutant phenotypeⁱ
- 24849286
regulation of lipid kinase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24849286
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from sequence orthologyⁱ
- 10786636
response to endoplasmic reticulum stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24849286
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Autophagy, Transcription, Transcription regulation

Biological process

Autophagy, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor-binding factor 2 Short name: NRBF-2
Gene namesⁱ	Name:Nrbf2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:1354950 Nrbf2

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000235817	1 – 287	Nuclear receptor-binding factor 2Add BLAST		287

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	112	PhosphoserineBy similarity		1
Modified residueⁱ	268	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8VCQ3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8VCQ3
PaxDbⁱ	Q8VCQ3
PeptideAtlas More...PeptideAtlasⁱ	Q8VCQ3
PRIDEⁱ	Q8VCQ3

PTM databases

iPTMnetⁱ	Q8VCQ3
PhosphoSitePlusⁱ	Q8VCQ3

Expressionⁱ

Developmental stageⁱ

During embryonic brain development detected in the cerebral cortex at E14; expressed in the walls of the third and fourth ventricles, and in the hippocampus. In the adult brain, predominantly expressed in Purkinje cells of the cerebellum and neurons in the CA3 region of the hippocampus (PubMed:18619852).1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000075000
CleanExⁱ	MM_NRBF2
ExpressionAtlasⁱ	Q8VCQ3 baseline and differential
Genevisibleⁱ	Q8VCQ3 MM

Interactionⁱ

Subunit structureⁱ

Interacts with RRARA, PPARD and PPARG. Interacts with THRB, RARA, RARG and RXRA in the presence of bound ligand (By similarity). Interacts with SCOC (By similarity). Associates with the PI3K complex I (PI3KC3-C1); the direct binding partner in the complex is reported variably as PIK3R4 or ATG14 (PubMed:24849286).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Atg14	Q8CDJ3	7	EBI-2365563,EBI-3506699
Becn1	O88597	5	EBI-2365563,EBI-643716

Show more details

GO - Molecular functionⁱ

ligand-dependent nuclear receptor binding
Source: MGI
Inferred from sequence orthologyⁱ
- 10786636

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	565935, 1 interactor
IntActⁱ	Q8VCQ3, 8 interactors
STRINGⁱ	10090.ENSMUSP00000097254

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	7 – 23	Combined sources	17
Helixⁱ	27 – 45	Combined sources	19
Helixⁱ	51 – 85	Combined sources	35

3D structure databases

ProteinModelPortalⁱ	Q8VCQ3
SMRⁱ	Q8VCQ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q8VCQ3

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	168 – 215	Sequence analysisAdd BLAST		48

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	141 – 145	Nuclear receptor interaction motifBy similarity		5

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IJBN Eukaryota ENOG4111SDN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000984
HOGENOMⁱ	HOG000293418
HOVERGENⁱ	HBG056976
InParanoidⁱ	Q8VCQ3
KEGG Orthology (KO) More...KOⁱ	K21246
OMAⁱ	TWQKFAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FJ8
PhylomeDBⁱ	Q8VCQ3
TreeFamⁱ	TF328627

Family and domain databases

InterProⁱ	View protein in InterPro IPR015056 NRBF2 IPR033393 NRBF2_MIT
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08961 NRBF2, 1 hit PF17169 NRBF2_MIT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8VCQ3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEVMEGPLNL AHQQSRRADR LLAAGKYEEA ISCHRKATTY LSEAMKLTES 
        60         70         80         90        100
EQAHLSLELQ RDSHMKQLLL IQERWKRAKR EERLKAQQST ERDGAPHLQA 
       110        120        130        140        150
PPRPSEDAEG QSPLLSQPYI PSTERRLPEV QGVFDRDPDT LLFLLQQKNE 
       160        170        180        190        200
PSEPCIGSKA PKDDKTIIEE QATKIADLKR HVEFLVAENE RLRKENKQLK 
       210        220        230        240        250
AEKARLLKGT AEKELDVDAD FVEKSELWGL PSHSESAAAS STWQKFAANT 
       260        270        280 
GKAKDIPIPN LPPLDFPSPE LPLMELSEDI LKGFMND

Length:287

Mass (Da):32,501

Last modified:March 1, 2002 - v1

Checksum:ⁱ81B1C0A0CB575D2E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	203	K → E in BAB22375 (PubMed:16141072).Curated		1
Sequence conflictⁱ	245 – 264	KFAAN…NLPPL → SLQLTRGSQGHSNTQPSSS in BAB22375 (PubMed:16141072).CuratedAdd BLAST		20

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK002810 mRNA Translation: BAB22375.1 BC019448 mRNA Translation: AAH19448.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23902.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001031370.1, NM_001036293.2
UniGeneⁱ	Mm.136223

Genome annotation databases

Ensemblⁱ	ENSMUST00000077839; ENSMUSP00000097254; ENSMUSG00000075000 ENSMUST00000229557; ENSMUSP00000155479; ENSMUSG00000115942
GeneIDⁱ	641340
KEGGⁱ	mmu:641340
UCSC genome browser More...UCSCⁱ	uc007flw.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8VCQ3	Nuclear receptor-binding factor 2	)	HUMAN		287
Nuclear receptor binding factor 2 (Fragment)		MUSPF		331
nuclear receptor-binding factor 2 isoform X1		ODORO		288
UPI00076288F1		MARMA		287
Nuclear receptor binding factor 2		RHIRO		287
+50

Protein	Similar proteins		Species	Score	Length
Q8VCQ3	Nuclear receptor-binding factor 2	)	HUMAN		287
Nuclear receptor binding factor 2 (Fragment)		MUSPF		331
nuclear receptor-binding factor 2 isoform X1		ODORO		288
UPI00042AE867		PERMB		287
Putative nuclear receptor-binding factor 2		DESRO		287
+285

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK002810 mRNA Translation: BAB22375.1 BC019448 mRNA Translation: AAH19448.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23902.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001031370.1, NM_001036293.2
UniGeneⁱ	Mm.136223

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CRB	NMR	-	A	4-87	[»]
ProteinModelPortalⁱ	Q8VCQ3
SMRⁱ	Q8VCQ3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	565935, 1 interactor
IntActⁱ	Q8VCQ3, 8 interactors
STRINGⁱ	10090.ENSMUSP00000097254

PTM databases

iPTMnetⁱ	Q8VCQ3
PhosphoSitePlusⁱ	Q8VCQ3

Proteomic databases

EPDⁱ	Q8VCQ3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8VCQ3
PaxDbⁱ	Q8VCQ3
PeptideAtlas More...PeptideAtlasⁱ	Q8VCQ3
PRIDEⁱ	Q8VCQ3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000077839; ENSMUSP00000097254; ENSMUSG00000075000 ENSMUST00000229557; ENSMUSP00000155479; ENSMUSG00000115942
GeneIDⁱ	641340
KEGGⁱ	mmu:641340
UCSC genome browser More...UCSCⁱ	uc007flw.1 mouse

Organism-specific databases

CTDⁱ	29982
MGIⁱ	MGI:1354950 Nrbf2

Phylogenomic databases

eggNOGⁱ	ENOG410IJBN Eukaryota ENOG4111SDN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000984
HOGENOMⁱ	HOG000293418
HOVERGENⁱ	HBG056976
InParanoidⁱ	Q8VCQ3
KEGG Orthology (KO) More...KOⁱ	K21246
OMAⁱ	TWQKFAS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FJ8
PhylomeDBⁱ	Q8VCQ3
TreeFamⁱ	TF328627

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

EvolutionaryTraceⁱ	Q8VCQ3
Protein Ontology More...PROⁱ	PR:Q8VCQ3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000075000
CleanExⁱ	MM_NRBF2
ExpressionAtlasⁱ	Q8VCQ3 baseline and differential
Genevisibleⁱ	Q8VCQ3 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR015056 NRBF2 IPR033393 NRBF2_MIT
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08961 NRBF2, 1 hit PF17169 NRBF2_MIT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NRBF2_MOUSE
Accessionⁱ	Q8VCQ3Primary (citable) accession number: Q8VCQ3 Secondary accession number(s): Q9DCG3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
	Last sequence update:	March 1, 2002
	Last modified:	June 20, 2018
	This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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Supporting data

UniProtKB - Q8VCQ3 (NRBF2_MOUSE)

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Nuclear receptor-binding factor 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Motif

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ