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Protein

Tubulin gamma-2 chain

Gene

Tubg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 148GTPSequence analysis7

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: GO_Central
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma-2 chain
Alternative name(s):
Gamma-2-tubulin
Gene namesi
Name:Tubg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144208 Tubg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131S → A: Weak effect possibly due to low expression of this mutant. 1 Publication1
Mutagenesisi131S → D: Phosphomimetic mutant that lead to increased centrosome number. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000484691 – 451Tubulin gamma-2 chainAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131Phosphoserine; by BRSK11 Publication1

Post-translational modificationi

Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VCK3
PaxDbiQ8VCK3
PRIDEiQ8VCK3

2D gel databases

REPRODUCTION-2DPAGEiQ8VCK3

PTM databases

iPTMnetiQ8VCK3
PhosphoSitePlusiQ8VCK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000045007 Expressed in 53 organ(s), highest expression level in submandibular gland primordium
CleanExiMM_TUBG2
ExpressionAtlasiQ8VCK3 baseline and differential
GenevisibleiQ8VCK3 MM

Interactioni

Protein-protein interaction databases

IntActiQ8VCK3, 1 interactor
STRINGi10090.ENSMUSP00000045901

Structurei

3D structure databases

ProteinModelPortaliQ8VCK3
SMRiQ8VCK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1374 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00910000144217
HOGENOMiHOG000165714
HOVERGENiHBG098558
InParanoidiQ8VCK3
KOiK10389
OMAiRRESMFK
OrthoDBiEOG091G08A9
PhylomeDBiQ8VCK3
TreeFamiTF300477

Family and domain databases

CDDicd02188 gamma_tubulin, 1 hit
Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002454 Gamma_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01164 GAMMATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VCK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV
60 70 80 90 100
FFYQADDEHY IPRAVLLDLE PRVIHSILNS SYAKLYNPEN IYLSEHGGGA
110 120 130 140 150
GNNWGRGFSQ GEKIHEDIFD IIDREADGSD SLEGFVLCHS IAGGTGSGLG
160 170 180 190 200
SYLLERLNDR YPKKLVQTYS VFPNQDEMSD VVVQPYNSLL TLKRLTQNAD
210 220 230 240 250
CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST TTLRYPGYMN
260 270 280 290 300
NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP
310 320 330 340 350
KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP
360 370 380 390 400
WGPASIQVAL SRKSPYLPSA HRVSGLMMAN HTSISSLFES SCQQYDKLWK
410 420 430 440 450
RGAFLEQFRK EDIFKDNFEE MHRSREVVQE LIDEYHAATR PDYISWGTQE

Q
Length:451
Mass (Da):51,122
Last modified:March 1, 2002 - v1
Checksum:i1FCC0FF1E04839AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019652 mRNA Translation: AAH19652.1
BC051439 mRNA Translation: AAH51439.1
CCDSiCCDS25452.1
RefSeqiNP_598789.1, NM_134028.2
UniGeneiMm.142348

Genome annotation databases

EnsembliENSMUST00000043654; ENSMUSP00000045901; ENSMUSG00000045007
GeneIDi103768
KEGGimmu:103768
UCSCiuc007lnm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019652 mRNA Translation: AAH19652.1
BC051439 mRNA Translation: AAH51439.1
CCDSiCCDS25452.1
RefSeqiNP_598789.1, NM_134028.2
UniGeneiMm.142348

3D structure databases

ProteinModelPortaliQ8VCK3
SMRiQ8VCK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VCK3, 1 interactor
STRINGi10090.ENSMUSP00000045901

PTM databases

iPTMnetiQ8VCK3
PhosphoSitePlusiQ8VCK3

2D gel databases

REPRODUCTION-2DPAGEiQ8VCK3

Proteomic databases

MaxQBiQ8VCK3
PaxDbiQ8VCK3
PRIDEiQ8VCK3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043654; ENSMUSP00000045901; ENSMUSG00000045007
GeneIDi103768
KEGGimmu:103768
UCSCiuc007lnm.2 mouse

Organism-specific databases

CTDi27175
MGIiMGI:2144208 Tubg2

Phylogenomic databases

eggNOGiKOG1374 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00910000144217
HOGENOMiHOG000165714
HOVERGENiHBG098558
InParanoidiQ8VCK3
KOiK10389
OMAiRRESMFK
OrthoDBiEOG091G08A9
PhylomeDBiQ8VCK3
TreeFamiTF300477

Enzyme and pathway databases

ReactomeiR-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

PROiPR:Q8VCK3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045007 Expressed in 53 organ(s), highest expression level in submandibular gland primordium
CleanExiMM_TUBG2
ExpressionAtlasiQ8VCK3 baseline and differential
GenevisibleiQ8VCK3 MM

Family and domain databases

CDDicd02188 gamma_tubulin, 1 hit
Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002454 Gamma_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01164 GAMMATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBG2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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