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Protein

UBX domain-containing protein 4

Gene

Ubxn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.By similarity

GO - Biological processi

Keywordsi

Biological processUnfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 4
Alternative name(s):
Erasin
UBX domain-containing protein 2
Gene namesi
Name:Ubxn4
Synonyms:Ubxd2, Ubxdc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915062 Ubxn4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 411CytoplasmicSequence analysisAdd BLAST411
Intramembranei412 – 432Sequence analysisAdd BLAST21
Topological domaini433 – 506CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002110281 – 506UBX domain-containing protein 4Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei487PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VCH8
MaxQBiQ8VCH8
PaxDbiQ8VCH8
PeptideAtlasiQ8VCH8
PRIDEiQ8VCH8

PTM databases

iPTMnetiQ8VCH8
PhosphoSitePlusiQ8VCH8
SwissPalmiQ8VCH8

Expressioni

Tissue specificityi

Expressed in many tissues, including brain, heart, kidney, liver, muscle and spleen (at protein level).1 Publication

Interactioni

Subunit structurei

Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027592

Structurei

Secondary structure

1506
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8VCH8
SMRiQ8VCH8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VCH8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini313 – 391UBXPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 199Interaction with UBQLN1By similarityAdd BLAST199

Domaini

The UBX domain is required for interaction with VCP.By similarity
The intramembrane domain also contains the signal for ER targeting.By similarity

Phylogenomic databases

eggNOGiKOG2507 Eukaryota
ENOG410ZR21 LUCA
HOGENOMiHOG000007283
HOVERGENiHBG056020
InParanoidiQ8VCH8
PhylomeDBiQ8VCH8
TreeFamiTF317466

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00166 UBX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8VCH8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLWFQGAIPA AIASAKRSGA VFVVFVAGDD EQSIQMAASW EDEKVTQASS
60 70 80 90 100
NNFVAIKIDT KSEACLQFSQ IYPVVCVPSS FFIGDSGIPL EVIAGSVSAD
110 120 130 140 150
ELVTRIHKVQ QMHSSKGEAS VTNDNQSESS VSTPSASFEP DVCENPESKN
160 170 180 190 200
TELCETPATS DIKSDTATGG ECTGHDSHSQ EPHGCSNQRP AEDLTVRVER
210 220 230 240 250
LTKKLEERRE EKRKEEAQRE IKKEIERRKT GKEMLDYKRK QEEELTKRML
260 270 280 290 300
EERSREKAED RAARERIKQQ IALDRAERAA RFAKTKEAEA AKAAALLTKQ
310 320 330 340 350
AGTEVKREST ARDRSTIARI QFRLPDGSSF TNQFPSDAPL EEARQFAAQT
360 370 380 390 400
VGNTYGNFSL ATMFPRREFT REDYKRRLLD LELAPSASVV LLPAGRPATS
410 420 430 440 450
IVHSSSGDIW TLLGTVLYPF LAIWRLISNF LFSNPPPAQT SARATSTEPS
460 470 480 490 500
NSASSSKSEK REPVRKRMLE KRGEDFKKEG KIYRLRTQDD GEDENNTWNG

NSTQQM
Length:506
Mass (Da):56,472
Last modified:March 1, 2002 - v1
Checksum:iDD9CCC380F29C80F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J078A0A0R4J078_MOUSE
UBX domain containing 2, isoform CR...
Ubxn4 Ubxd2, mCG_20043
506Annotation score:
A0A087WSK5A0A087WSK5_MOUSE
UBX domain-containing protein 4
Ubxn4
88Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65C → R in BAC35906 (PubMed:16141072).Curated1
Sequence conflicti162I → T in BAE28143 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075716 mRNA Translation: BAC35906.1
AK147795 mRNA Translation: BAE28143.1
BC019795 mRNA Translation: AAH19795.1
CCDSiCCDS15251.1
RefSeqiNP_080666.2, NM_026390.2
UniGeneiMm.293321

Genome annotation databases

GeneIDi67812
KEGGimmu:67812
UCSCiuc007cll.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075716 mRNA Translation: BAC35906.1
AK147795 mRNA Translation: BAE28143.1
BC019795 mRNA Translation: AAH19795.1
CCDSiCCDS15251.1
RefSeqiNP_080666.2, NM_026390.2
UniGeneiMm.293321

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DZKNMR-A312-409[»]
ProteinModelPortaliQ8VCH8
SMRiQ8VCH8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027592

PTM databases

iPTMnetiQ8VCH8
PhosphoSitePlusiQ8VCH8
SwissPalmiQ8VCH8

Proteomic databases

EPDiQ8VCH8
MaxQBiQ8VCH8
PaxDbiQ8VCH8
PeptideAtlasiQ8VCH8
PRIDEiQ8VCH8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi67812
KEGGimmu:67812
UCSCiuc007cll.1 mouse

Organism-specific databases

CTDi23190
MGIiMGI:1915062 Ubxn4

Phylogenomic databases

eggNOGiKOG2507 Eukaryota
ENOG410ZR21 LUCA
HOGENOMiHOG000007283
HOVERGENiHBG056020
InParanoidiQ8VCH8
PhylomeDBiQ8VCH8
TreeFamiTF317466

Miscellaneous databases

ChiTaRSiUbxn4 mouse
EvolutionaryTraceiQ8VCH8
PROiPR:Q8VCH8
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00166 UBX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBXN4_MOUSE
AccessioniPrimary (citable) accession number: Q8VCH8
Secondary accession number(s): Q3UGR4, Q8BW17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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