UniProtKB - Q8VCH0 (THIKB_MOUSE)
Protein
3-ketoacyl-CoA thiolase B, peroxisomal
Gene
Acaa1b
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
: fatty acid metabolism Pathwayi
This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 123 | Acyl-thioester intermediateBy similarity | 1 | |
Binding sitei | 249 | Coenzyme ABy similarity | 1 | |
Binding sitei | 252 | Coenzyme ABy similarity | 1 | |
Binding sitei | 276 | Coenzyme A; via carbonyl oxygenBy similarity | 1 | |
Sitei | 377 | Increases nucleophilicity of active site CysBy similarity | 1 | |
Active sitei | 408 | Proton donor/acceptorBy similarity | 1 |
GO - Molecular functioni
- acetyl-CoA C-acetyltransferase activity Source: UniProtKB-EC
- acetyl-CoA C-acyltransferase activity Source: GO_Central
- acetyl-CoA C-myristoyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- fatty acid beta-oxidation Source: GO_Central
- phenylacetate catabolic process Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 2.3.1.16, 3474 |
Reactomei | R-MMU-2046106, alpha-linolenic acid (ALA) metabolism R-MMU-390247, Beta-oxidation of very long chain fatty acids R-MMU-6798695, Neutrophil degranulation R-MMU-9033241, Peroxisomal protein import |
UniPathwayi | UPA00199 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Acaa1b Synonyms:Acaa1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3605455, Acaa1b |
Subcellular locationi
Peroxisome
- Peroxisome By similarity
Mitochondrion
- mitochondrion Source: MGI
Peroxisome
- peroxisome Source: GO_Central
Keywords - Cellular componenti
PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 26 | PeroxisomeBy similarityAdd BLAST | 26 | |
ChainiPRO_0000034069 | 27 – 424 | 3-ketoacyl-CoA thiolase B, peroxisomalAdd BLAST | 398 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 173 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 234 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | Q8VCH0 |
MaxQBi | Q8VCH0 |
PaxDbi | Q8VCH0 |
PeptideAtlasi | Q8VCH0 |
PRIDEi | Q8VCH0 |
PTM databases
CarbonylDBi | Q8VCH0 |
iPTMneti | Q8VCH0 |
PhosphoSitePlusi | Q8VCH0 |
SwissPalmi | Q8VCH0 |
Expressioni
Tissue specificityi
Mainly expressed in liver; weaker levels in kidney, intestine and white adipose tissue.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000010651, Expressed in left lobe of liver and 232 other tissues |
ExpressionAtlasi | Q8VCH0, baseline and differential |
Genevisiblei | Q8VCH0, MM |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
IntActi | Q8VCH0, 5 interactors |
MINTi | Q8VCH0 |
STRINGi | 10090.ENSMUSP00000010795 |
Miscellaneous databases
RNActi | Q8VCH0, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1389, Eukaryota |
GeneTreei | ENSGT01010000222488 |
HOGENOMi | CLU_031026_1_1_1 |
InParanoidi | Q8VCH0 |
OMAi | MNVNRLC |
OrthoDBi | 1129049at2759 |
PhylomeDBi | Q8VCH0 |
TreeFami | TF332308 |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8VCH0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHRLQVVLGH LAGRPESSSA LQAAPCSAGF LQASASDVVV VHGRRTPIGR
60 70 80 90 100
ASRGCFKDTT PDELLSAVLT AVLQDVKLKP EQLGDISVGN VLQPGAGAIM
110 120 130 140 150
ARIAQFLSGI PETVPLSTVN RQCSSGLQAV ANIAGGIRNG SYDIGMACGV
160 170 180 190 200
ESMTLSQRGN HGNISSRLLE NEKARDCLIP MGITSENVAE RFGVSRQKQD
210 220 230 240 250
AFALASQQKA ASAQSRGCFH AEIVPVTTTV LNDKGDKKTI TVSQDEGVRP
260 270 280 290 300
STTMQGLAKL KPAFKDGGST TAGNSSQVSD GAAAVLLARR SKAEELGLPI
310 320 330 340 350
LGVLRSYAVV GVPPDVMGIG PAYAIPAALQ KAGLTVNDID IFEINEAFAS
360 370 380 390 400
QAVYCVEKLG IPAEKVNPLG GAIALGHPLG CTGARQVVTL LNELKRRGRR
410 420
AYGVVSMCIG TGMGAAAVFE YPGN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY273812 mRNA Translation: AAP31669.1 BC019882 mRNA Translation: AAH19882.1 |
CCDSi | CCDS23608.1 |
RefSeqi | NP_666342.1, NM_146230.3 |
Genome annotation databases
Ensembli | ENSMUST00000010795; ENSMUSP00000010795; ENSMUSG00000010651 |
GeneIDi | 235674 |
KEGGi | mmu:235674 |
UCSCi | uc009saj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY273812 mRNA Translation: AAP31669.1 BC019882 mRNA Translation: AAH19882.1 |
CCDSi | CCDS23608.1 |
RefSeqi | NP_666342.1, NM_146230.3 |
3D structure databases
SMRi | Q8VCH0 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8VCH0, 5 interactors |
MINTi | Q8VCH0 |
STRINGi | 10090.ENSMUSP00000010795 |
PTM databases
CarbonylDBi | Q8VCH0 |
iPTMneti | Q8VCH0 |
PhosphoSitePlusi | Q8VCH0 |
SwissPalmi | Q8VCH0 |
Proteomic databases
jPOSTi | Q8VCH0 |
MaxQBi | Q8VCH0 |
PaxDbi | Q8VCH0 |
PeptideAtlasi | Q8VCH0 |
PRIDEi | Q8VCH0 |
Genome annotation databases
Ensembli | ENSMUST00000010795; ENSMUSP00000010795; ENSMUSG00000010651 |
GeneIDi | 235674 |
KEGGi | mmu:235674 |
UCSCi | uc009saj.1, mouse |
Organism-specific databases
CTDi | 235674 |
MGIi | MGI:3605455, Acaa1b |
Phylogenomic databases
eggNOGi | KOG1389, Eukaryota |
GeneTreei | ENSGT01010000222488 |
HOGENOMi | CLU_031026_1_1_1 |
InParanoidi | Q8VCH0 |
OMAi | MNVNRLC |
OrthoDBi | 1129049at2759 |
PhylomeDBi | Q8VCH0 |
TreeFami | TF332308 |
Enzyme and pathway databases
UniPathwayi | UPA00199 |
BRENDAi | 2.3.1.16, 3474 |
Reactomei | R-MMU-2046106, alpha-linolenic acid (ALA) metabolism R-MMU-390247, Beta-oxidation of very long chain fatty acids R-MMU-6798695, Neutrophil degranulation R-MMU-9033241, Peroxisomal protein import |
Miscellaneous databases
BioGRID-ORCSi | 235674, 0 hits in 17 CRISPR screens |
ChiTaRSi | Acaa1b, mouse |
PROi | PR:Q8VCH0 |
RNActi | Q8VCH0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000010651, Expressed in left lobe of liver and 232 other tissues |
ExpressionAtlasi | Q8VCH0, baseline and differential |
Genevisiblei | Q8VCH0, MM |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THIKB_MOUSE | |
Accessioni | Q8VCH0Primary (citable) accession number: Q8VCH0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families