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Protein

Regulatory factor X-associated protein

Gene

Rfxap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the RFX complex that binds to the X-box of MHC II promoters.By similarity

GO - Molecular functioni

  • DNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory factor X-associated protein
Short name:
RFX-associated protein
Gene namesi
Name:Rfxap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2180854 Rfxap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003002521 – 231Regulatory factor X-associated proteinAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8VCG9
MaxQBiQ8VCG9
PaxDbiQ8VCG9
PRIDEiQ8VCG9

PTM databases

PhosphoSitePlusiQ8VCG9

Expressioni

Gene expression databases

CleanExiMM_RFXAP
ExpressionAtlasiQ8VCG9 baseline and differential

Interactioni

Subunit structurei

RFX consists of at least 3 different subunits; RFXAP, RFX5 and RFX-B/RFXANK; with each subunit representing a separate complementation group. RFX forms cooperative DNA binding complexes with X2BP and CBF/NF-Y. RFX associates with CIITA to form an active transcriptional complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi228427, 1 interactor
STRINGi10090.ENSMUSP00000040917

Structurei

3D structure databases

ProteinModelPortaliQ8VCG9
SMRiQ8VCG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi123 – 138Nuclear localization signalSequence analysisAdd BLAST16

Phylogenomic databases

eggNOGiENOG410IYNY Eukaryota
ENOG4111S79 LUCA
GeneTreeiENSGT00390000006573
HOGENOMiHOG000154106
HOVERGENiHBG073517
InParanoidiQ8VCG9
KOiK08063
PhylomeDBiQ8VCG9

Family and domain databases

Gene3Di1.20.120.1340, 1 hit
InterProiView protein in InterPro
IPR038308 RFXAP_C_sf
IPR029316 RFXAP_RFXANK-bd
PANTHERiPTHR15110 PTHR15110, 1 hit
PfamiView protein in Pfam
PF15289 RFXA_RFXANK_bdg, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VCG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAQAVPEGS GPSTASPRTA PPVTVLVMRQ DEAEADGALR PGLAGSEAAA
60 70 80 90 100
DAEDEAGDDD ADLLDTSDPA GGGESAASPE ELEDEDAEGG GAARRRGSKT
110 120 130 140 150
CTYEGCRETT SQVAKQRKPW MCKKHRNKMY KDKYKKKKSD QALGSGGPSA
160 170 180 190 200
ASTGNVKLEE STDNILSIVK QRTGSFGDRP ARPTLLEQVL NQKRLSLLRS
210 220 230
PEVVQFLQKQ QQLLNQQVLE QRQQHFPGAP V
Length:231
Mass (Da):24,787
Last modified:September 5, 2006 - v2
Checksum:i4BB22676F5A4FA55
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7DBT7F7DBT7_MOUSE
Regulatory factor X-associated prot...
Rfxap
231Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335512 mRNA Translation: AAK38586.1
BC019935 mRNA Translation: AAH19935.2
CCDSiCCDS50907.1
RefSeqiNP_573494.1, NM_133231.2
UniGeneiMm.185735

Genome annotation databases

EnsembliENSMUST00000217267; ENSMUSP00000149458; ENSMUSG00000036615
GeneIDi170767
KEGGimmu:170767
UCSCiuc008pfw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335512 mRNA Translation: AAK38586.1
BC019935 mRNA Translation: AAH19935.2
CCDSiCCDS50907.1
RefSeqiNP_573494.1, NM_133231.2
UniGeneiMm.185735

3D structure databases

ProteinModelPortaliQ8VCG9
SMRiQ8VCG9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228427, 1 interactor
STRINGi10090.ENSMUSP00000040917

PTM databases

PhosphoSitePlusiQ8VCG9

Proteomic databases

EPDiQ8VCG9
MaxQBiQ8VCG9
PaxDbiQ8VCG9
PRIDEiQ8VCG9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000217267; ENSMUSP00000149458; ENSMUSG00000036615
GeneIDi170767
KEGGimmu:170767
UCSCiuc008pfw.1 mouse

Organism-specific databases

CTDi5994
MGIiMGI:2180854 Rfxap

Phylogenomic databases

eggNOGiENOG410IYNY Eukaryota
ENOG4111S79 LUCA
GeneTreeiENSGT00390000006573
HOGENOMiHOG000154106
HOVERGENiHBG073517
InParanoidiQ8VCG9
KOiK08063
PhylomeDBiQ8VCG9

Miscellaneous databases

PROiPR:Q8VCG9
SOURCEiSearch...

Gene expression databases

CleanExiMM_RFXAP
ExpressionAtlasiQ8VCG9 baseline and differential

Family and domain databases

Gene3Di1.20.120.1340, 1 hit
InterProiView protein in InterPro
IPR038308 RFXAP_C_sf
IPR029316 RFXAP_RFXANK-bd
PANTHERiPTHR15110 PTHR15110, 1 hit
PfamiView protein in Pfam
PF15289 RFXA_RFXANK_bdg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRFXAP_MOUSE
AccessioniPrimary (citable) accession number: Q8VCG9
Secondary accession number(s): Q91Y54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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