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Protein

Receptor expression-enhancing protein 2

Gene

Reep2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity).By similarity

GO - Molecular functioni

  • taste receptor binding Source: MGI

GO - Biological processi

  • endoplasmic reticulum tubular network organization Source: UniProtKB
  • protein transport into membrane raft Source: MGI
  • regulation of intracellular transport Source: UniProtKB
  • sensory perception of bitter taste Source: MGI
  • sensory perception of sweet taste Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor expression-enhancing protein 2
Gene namesi
Name:Reep2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2385070 Reep2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001018241 – 254Receptor expression-enhancing protein 2Add BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei152PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VCD6
PaxDbiQ8VCD6
PRIDEiQ8VCD6

PTM databases

iPTMnetiQ8VCD6
PhosphoSitePlusiQ8VCD6

Expressioni

Gene expression databases

BgeeiENSMUSG00000038555 Expressed in 178 organ(s), highest expression level in cerebellum
CleanExiMM_REEP2
GenevisibleiQ8VCD6 MM

Interactioni

Subunit structurei

Interacts with odorant receptor proteins.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8VCD6, 1 interactor
MINTiQ8VCD6
STRINGi10090.ENSMUSP00000036065

Structurei

3D structure databases

ProteinModelPortaliQ8VCD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1726 Eukaryota
COG5052 LUCA
GeneTreeiENSGT00550000074535
HOGENOMiHOG000007472
HOVERGENiHBG056861
InParanoidiQ8VCD6
KOiK17338
OMAiRTEHSDD
OrthoDBiEOG091G0X58
PhylomeDBiQ8VCD6
TreeFamiTF314177

Family and domain databases

InterProiView protein in InterPro
IPR004345 TB2_DP1_HVA22
PANTHERiPTHR12300 PTHR12300, 1 hit
PfamiView protein in Pfam
PF03134 TB2_DP1_HVA22, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VCD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSWIISRLV VLIFGTLYPA YSSYKAVKTK NVKEYVKWMM YWIVFAFFTT
60 70 80 90 100
AETLTDIILS WFPFYFELKI AFVIWLLSPY TKGSSVLYRK FVHPTLSNKE
110 120 130 140 150
KEIDEYITQA RDKSYETMMR VGKRGLNLAA NAAVTAAAKG QGVLSEKLRS
160 170 180 190 200
FSMQDLTLIR DEDALPLQGP DGRLQPGPVG LLDTIEDLGD EPALSLRSST
210 220 230 240 250
SQPDPRTETS EDDLGDKAPK RTKPIKKVPR AEPPASKTLK TRPKKKSSGG

GDSA
Length:254
Mass (Da):28,437
Last modified:November 23, 2004 - v2
Checksum:i63F9770A04B122AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562230 mRNA Translation: AAT70675.1
BC020184 mRNA Translation: AAH20184.2
CCDSiCCDS29135.1
RefSeqiNP_001191843.1, NM_001204914.1
NP_659114.2, NM_144865.2
UniGeneiMm.293588

Genome annotation databases

EnsembliENSMUST00000043484; ENSMUSP00000036065; ENSMUSG00000038555
GeneIDi225362
KEGGimmu:225362
UCSCiuc008elr.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562230 mRNA Translation: AAT70675.1
BC020184 mRNA Translation: AAH20184.2
CCDSiCCDS29135.1
RefSeqiNP_001191843.1, NM_001204914.1
NP_659114.2, NM_144865.2
UniGeneiMm.293588

3D structure databases

ProteinModelPortaliQ8VCD6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VCD6, 1 interactor
MINTiQ8VCD6
STRINGi10090.ENSMUSP00000036065

PTM databases

iPTMnetiQ8VCD6
PhosphoSitePlusiQ8VCD6

Proteomic databases

MaxQBiQ8VCD6
PaxDbiQ8VCD6
PRIDEiQ8VCD6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043484; ENSMUSP00000036065; ENSMUSG00000038555
GeneIDi225362
KEGGimmu:225362
UCSCiuc008elr.2 mouse

Organism-specific databases

CTDi51308
MGIiMGI:2385070 Reep2

Phylogenomic databases

eggNOGiKOG1726 Eukaryota
COG5052 LUCA
GeneTreeiENSGT00550000074535
HOGENOMiHOG000007472
HOVERGENiHBG056861
InParanoidiQ8VCD6
KOiK17338
OMAiRTEHSDD
OrthoDBiEOG091G0X58
PhylomeDBiQ8VCD6
TreeFamiTF314177

Enzyme and pathway databases

ReactomeiR-MMU-381753 Olfactory Signaling Pathway

Miscellaneous databases

PROiPR:Q8VCD6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038555 Expressed in 178 organ(s), highest expression level in cerebellum
CleanExiMM_REEP2
GenevisibleiQ8VCD6 MM

Family and domain databases

InterProiView protein in InterPro
IPR004345 TB2_DP1_HVA22
PANTHERiPTHR12300 PTHR12300, 1 hit
PfamiView protein in Pfam
PF03134 TB2_DP1_HVA22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREEP2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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