UniProtKB - Q8VCD5 (MED17_MOUSE)
Mediator of RNA polymerase II transcription subunit 17
Med17
Functioni
GO - Molecular functioni
- nuclear receptor transcription coactivator activity Source: MGI
- thyroid hormone receptor binding Source: MGI
- transcription coactivator activity Source: MGI
- transcription coregulator activity Source: MGI
- ubiquitin protein ligase activity Source: Ensembl
GO - Biological processi
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- protein ubiquitination Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- stem cell population maintenance Source: MGI
- transcription initiation from RNA polymerase II promoter Source: MGI
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-212436 Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 17Alternative name(s): Cofactor required for Sp1 transcriptional activation subunit 6 Short name: CRSP complex subunit 6 Mediator complex subunit 17 Thyroid hormone receptor-associated protein complex 80 kDa component |
Gene namesi | Name:Med17 Synonyms:Crsp6, Trap80 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2182585 Med17 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- core mediator complex Source: GO_Central
- mediator complex Source: MGI
- nucleoplasm Source: Reactome
- nucleus Source: MGI
Other locations
- transcription factor complex Source: MGI
- ubiquitin ligase complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304700 | 1 – 649 | Mediator of RNA polymerase II transcription subunit 17Add BLAST | 649 |
Proteomic databases
EPDi | Q8VCD5 |
MaxQBi | Q8VCD5 |
PaxDbi | Q8VCD5 |
PeptideAtlasi | Q8VCD5 |
PRIDEi | Q8VCD5 |
PTM databases
iPTMneti | Q8VCD5 |
PhosphoSitePlusi | Q8VCD5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031935 Expressed in 267 organ(s), highest expression level in primary oocyte |
ExpressionAtlasi | Q8VCD5 baseline and differential |
Genevisiblei | Q8VCD5 MM |
Interactioni
Subunit structurei
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
Interacts with STAT2 (By similarity).
Interacts with GATA1 and PPARG.
By similarity2 PublicationsBinary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Q04207 | 4 | EBI-5744951,EBI-644400 |
GO - Molecular functioni
- thyroid hormone receptor binding Source: MGI
Protein-protein interaction databases
BioGridi | 231602, 5 interactors |
ComplexPortali | CPX-3264 Core mediator complex |
CORUMi | Q8VCD5 |
DIPi | DIP-48407N |
IntActi | Q8VCD5, 9 interactors |
MINTi | Q8VCD5 |
STRINGi | 10090.ENSMUSP00000034411 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4512 Eukaryota ENOG410XRQ8 LUCA |
GeneTreei | ENSGT00390000011810 |
HOGENOMi | HOG000008073 |
InParanoidi | Q8VCD5 |
KOi | K15133 |
OMAi | CQIYQHQ |
OrthoDBi | 1128763at2759 |
PhylomeDBi | Q8VCD5 |
TreeFami | TF323615 |
Family and domain databases
InterProi | View protein in InterPro IPR019313 Mediator_Med17 |
PANTHERi | PTHR13114 PTHR13114, 1 hit |
Pfami | View protein in Pfam PF10156 Med17, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSGVRAVRIS IESACEKQVQ EVGLDGTETY LQPLSMSQNL ARLAQRIDFS
60 70 80 90 100
QGSGSEEEEA AGPDGDAPDW GGAGADQDDE EGLVKFQPSL WPWDSVRNNL
110 120 130 140 150
RSALTEMCVL YDVLSIVRDK KFMTLDPVSQ DALPPKQSPQ TLQLISKKKS
160 170 180 190 200
LAGAAQILLK GAERLTKSVA ENQENKLQRD FNSELLRLRQ HWKLRKVGDK
210 220 230 240 250
ILGDLSYRSA GSLFPHHGTF EVIKNTDIDL DKKIPEDYCP LDVQIPSDLE
260 270 280 290 300
GSAYIKVSIQ KQAPDIGDLG TVNLFKRPLP KSKPGSPHWQ TKLEAAQNVL
310 320 330 340 350
LCKEIFAQLS REAVQIKSQI PHIVVKNQII SQPFPSLQLS ISLCHSSDDK
360 370 380 390 400
KSQKCAAEKP GQEDHLYVLE HNLHLLIREF HKQTLSSIVM PHPASAPFGH
410 420 430 440 450
KRMRLSGPQA FDKNEINSIQ STEGLLEKII KQAKHIFLRS RTAATIDSLA
460 470 480 490 500
SRIEDPQIQA HWSNINDVYE SSVKVLITSQ GYEQICKSIQ LQLNIGVEQV
510 520 530 540 550
RVVHRDGRVI MLSHQEQELQ DFLLSQMSQH QVHAVQQLAK VMGWQVLSFS
560 570 580 590 600
NHVGLGPIES IGNASAITVA SPSGDYAISV RNGPESGSKI MVQFPRNQCK
610 620 630 640
DLPKSDVLQD SKWSHLRGPF KEVQWNKMEG RNFVYKMELL MSALSPCLL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1SV12 | A0A1L1SV12_MOUSE | Mediator of RNA polymerase II trans... | Med17 | 211 | Annotation score: | ||
A0A1L1SQB3 | A0A1L1SQB3_MOUSE | Mediator of RNA polymerase II trans... | Med17 | 199 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 550 | S → G in BAC30005 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK033151 mRNA Translation: BAC28172.1 AK038451 mRNA Translation: BAC30005.1 AK049112 mRNA Translation: BAC33548.1 AK151377 mRNA Translation: BAE30349.1 BC004062 mRNA Translation: AAH04062.1 BC020185 mRNA Translation: AAH20185.1 |
CCDSi | CCDS22834.1 |
RefSeqi | NP_659182.1, NM_144933.1 |
Genome annotation databases
Ensembli | ENSMUST00000034411; ENSMUSP00000034411; ENSMUSG00000031935 |
GeneIDi | 234959 |
KEGGi | mmu:234959 |
UCSCi | uc009ofl.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK033151 mRNA Translation: BAC28172.1 AK038451 mRNA Translation: BAC30005.1 AK049112 mRNA Translation: BAC33548.1 AK151377 mRNA Translation: BAE30349.1 BC004062 mRNA Translation: AAH04062.1 BC020185 mRNA Translation: AAH20185.1 |
CCDSi | CCDS22834.1 |
RefSeqi | NP_659182.1, NM_144933.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 231602, 5 interactors |
ComplexPortali | CPX-3264 Core mediator complex |
CORUMi | Q8VCD5 |
DIPi | DIP-48407N |
IntActi | Q8VCD5, 9 interactors |
MINTi | Q8VCD5 |
STRINGi | 10090.ENSMUSP00000034411 |
PTM databases
iPTMneti | Q8VCD5 |
PhosphoSitePlusi | Q8VCD5 |
Proteomic databases
EPDi | Q8VCD5 |
MaxQBi | Q8VCD5 |
PaxDbi | Q8VCD5 |
PeptideAtlasi | Q8VCD5 |
PRIDEi | Q8VCD5 |
Genome annotation databases
Ensembli | ENSMUST00000034411; ENSMUSP00000034411; ENSMUSG00000031935 |
GeneIDi | 234959 |
KEGGi | mmu:234959 |
UCSCi | uc009ofl.1 mouse |
Organism-specific databases
CTDi | 9440 |
MGIi | MGI:2182585 Med17 |
Phylogenomic databases
eggNOGi | KOG4512 Eukaryota ENOG410XRQ8 LUCA |
GeneTreei | ENSGT00390000011810 |
HOGENOMi | HOG000008073 |
InParanoidi | Q8VCD5 |
KOi | K15133 |
OMAi | CQIYQHQ |
OrthoDBi | 1128763at2759 |
PhylomeDBi | Q8VCD5 |
TreeFami | TF323615 |
Enzyme and pathway databases
Reactomei | R-MMU-212436 Generic Transcription Pathway |
Miscellaneous databases
ChiTaRSi | Med17 mouse |
PROi | PR:Q8VCD5 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031935 Expressed in 267 organ(s), highest expression level in primary oocyte |
ExpressionAtlasi | Q8VCD5 baseline and differential |
Genevisiblei | Q8VCD5 MM |
Family and domain databases
InterProi | View protein in InterPro IPR019313 Mediator_Med17 |
PANTHERi | PTHR13114 PTHR13114, 1 hit |
Pfami | View protein in Pfam PF10156 Med17, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MED17_MOUSE | |
Accessioni | Q8VCD5Primary (citable) accession number: Q8VCD5 Secondary accession number(s): Q8BYS6, Q99KQ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | March 1, 2002 | |
Last modified: | October 16, 2019 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot