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Protein

Mediator of RNA polymerase II transcription subunit 17

Gene

Med17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 17
Alternative name(s):
Cofactor required for Sp1 transcriptional activation subunit 6
Short name:
CRSP complex subunit 6
Mediator complex subunit 17
Thyroid hormone receptor-associated protein complex 80 kDa component
Gene namesi
Name:Med17
Synonyms:Crsp6, Trap80
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2182585 Med17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003047001 – 649Mediator of RNA polymerase II transcription subunit 17Add BLAST649

Proteomic databases

EPDiQ8VCD5
MaxQBiQ8VCD5
PaxDbiQ8VCD5
PeptideAtlasiQ8VCD5
PRIDEiQ8VCD5

PTM databases

iPTMnetiQ8VCD5
PhosphoSitePlusiQ8VCD5

Expressioni

Gene expression databases

BgeeiENSMUSG00000031935 Expressed in 267 organ(s), highest expression level in primary oocyte
CleanExiMM_MED17
ExpressionAtlasiQ8VCD5 baseline and differential
GenevisibleiQ8VCD5 MM

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with STAT2 (By similarity). Interacts with GATA1 and PPARG.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RelaQ042074EBI-5744951,EBI-644400

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231602, 4 interactors
ComplexPortaliCPX-3264 Core mediator complex
CORUMiQ8VCD5
DIPiDIP-48407N
IntActiQ8VCD5, 8 interactors
MINTiQ8VCD5
STRINGi10090.ENSMUSP00000034411

Structurei

3D structure databases

ProteinModelPortaliQ8VCD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 17 family.Curated

Phylogenomic databases

eggNOGiKOG4512 Eukaryota
ENOG410XRQ8 LUCA
GeneTreeiENSGT00390000011810
HOGENOMiHOG000008073
HOVERGENiHBG103247
InParanoidiQ8VCD5
KOiK15133
OMAiPHHGTFE
OrthoDBiEOG091G03JX
PhylomeDBiQ8VCD5
TreeFamiTF323615

Family and domain databases

InterProiView protein in InterPro
IPR019313 Mediator_Med17
PANTHERiPTHR13114 PTHR13114, 1 hit
PfamiView protein in Pfam
PF10156 Med17, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q8VCD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGVRAVRIS IESACEKQVQ EVGLDGTETY LQPLSMSQNL ARLAQRIDFS
60 70 80 90 100
QGSGSEEEEA AGPDGDAPDW GGAGADQDDE EGLVKFQPSL WPWDSVRNNL
110 120 130 140 150
RSALTEMCVL YDVLSIVRDK KFMTLDPVSQ DALPPKQSPQ TLQLISKKKS
160 170 180 190 200
LAGAAQILLK GAERLTKSVA ENQENKLQRD FNSELLRLRQ HWKLRKVGDK
210 220 230 240 250
ILGDLSYRSA GSLFPHHGTF EVIKNTDIDL DKKIPEDYCP LDVQIPSDLE
260 270 280 290 300
GSAYIKVSIQ KQAPDIGDLG TVNLFKRPLP KSKPGSPHWQ TKLEAAQNVL
310 320 330 340 350
LCKEIFAQLS REAVQIKSQI PHIVVKNQII SQPFPSLQLS ISLCHSSDDK
360 370 380 390 400
KSQKCAAEKP GQEDHLYVLE HNLHLLIREF HKQTLSSIVM PHPASAPFGH
410 420 430 440 450
KRMRLSGPQA FDKNEINSIQ STEGLLEKII KQAKHIFLRS RTAATIDSLA
460 470 480 490 500
SRIEDPQIQA HWSNINDVYE SSVKVLITSQ GYEQICKSIQ LQLNIGVEQV
510 520 530 540 550
RVVHRDGRVI MLSHQEQELQ DFLLSQMSQH QVHAVQQLAK VMGWQVLSFS
560 570 580 590 600
NHVGLGPIES IGNASAITVA SPSGDYAISV RNGPESGSKI MVQFPRNQCK
610 620 630 640
DLPKSDVLQD SKWSHLRGPF KEVQWNKMEG RNFVYKMELL MSALSPCLL
Length:649
Mass (Da):72,462
Last modified:March 1, 2002 - v1
Checksum:i924D5C2D4150B4B5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SQB3A0A1L1SQB3_MOUSE
Mediator of RNA polymerase II trans...
Med17
199Annotation score:
A0A1L1SV12A0A1L1SV12_MOUSE
Mediator of RNA polymerase II trans...
Med17
211Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti550S → G in BAC30005 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033151 mRNA Translation: BAC28172.1
AK038451 mRNA Translation: BAC30005.1
AK049112 mRNA Translation: BAC33548.1
AK151377 mRNA Translation: BAE30349.1
BC004062 mRNA Translation: AAH04062.1
BC020185 mRNA Translation: AAH20185.1
CCDSiCCDS22834.1
RefSeqiNP_659182.1, NM_144933.1
UniGeneiMm.44151

Genome annotation databases

EnsembliENSMUST00000034411; ENSMUSP00000034411; ENSMUSG00000031935
GeneIDi234959
KEGGimmu:234959
UCSCiuc009ofl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMED17_MOUSE
AccessioniPrimary (citable) accession number: Q8VCD5
Secondary accession number(s): Q8BYS6, Q99KQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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