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Protein

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Gene

Hpgd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).By similarity1 Publication

Catalytic activityi

(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91NAD; via carbonyl oxygenBy similarity1
Binding sitei138SubstrateBy similarity1
Binding sitei148SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 20NADBy similarity9
Nucleotide bindingi36 – 37NADBy similarity2
Nucleotide bindingi63 – 65NADBy similarity3
Nucleotide bindingi151 – 155NADBy similarity5
Nucleotide bindingi186 – 188NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism, Prostaglandin metabolism
LigandNAD

Enzyme and pathway databases

ReactomeiR-MMU-2142700 Synthesis of Lipoxins (LX)
R-MMU-9018676 Biosynthesis of D-series resolvins
R-MMU-9018896 Biosynthesis of E-series 18(S)-resolvins

Names & Taxonomyi

Protein namesi
Recommended name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)] (EC:1.1.1.141)
Short name:
15-PGDH
Alternative name(s):
Prostaglandin dehydrogenase 1
Gene namesi
Name:Hpgd
Synonyms:Pgdh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:108085 Hpgd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002536261 – 26915-hydroxyprostaglandin dehydrogenase [NAD(+)]Add BLAST269

Proteomic databases

MaxQBiQ8VCC1
PaxDbiQ8VCC1
PeptideAtlasiQ8VCC1
PRIDEiQ8VCC1

PTM databases

iPTMnetiQ8VCC1
PhosphoSitePlusiQ8VCC1

Expressioni

Tissue specificityi

Expressed in proximal convoluted tubules of the kidney, where it colocalizes with the prostaglandin transporter SLC22A22 (at protein level) (PubMed:20448048). Expressed in lung, intestine, stomach and liver (PubMed:8950170).2 Publications

Gene expression databases

BgeeiENSMUSG00000031613
CleanExiMM_HPGD
GenevisibleiQ8VCC1 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8VCC1, 1 interactor
MINTiQ8VCC1
STRINGi10090.ENSMUSP00000034026

Structurei

3D structure databases

ProteinModelPortaliQ8VCC1
SMRiQ8VCC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4169 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00920000148965
HOVERGENiHBG107379
InParanoidiQ8VCC1
KOiK00069
OMAiSCEVHYS
OrthoDBiEOG091G0OC9
PhylomeDBiQ8VCC1
TreeFamiTF324093

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VCC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVNGKVALV TGAAQGIGKA FAEALLLHGA KVALVDWNLE AGVKCKAALD
60 70 80 90 100
EQFEPQKTLF VQCDVADQKQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW
110 120 130 140 150
EQTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINMSSLA GLMPVAQQPV
160 170 180 190 200
YCASKHGIIG FTRSAAMAAN LMKSGVRLNV ICPGFVDTPI LESIEKEENM
210 220 230 240 250
GQYIEYKDQI KAMMKFYGVL HPSTIANGLI NLIEDDALNG AIMKITASKG
260
IHFQDYDISP LLVKAPLTS
Length:269
Mass (Da):29,181
Last modified:March 1, 2002 - v1
Checksum:i10E879A7E31A8E34
GO

Sequence cautioni

The sequence AAB41825 differs from that shown. Reason: Frameshift at position 267.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113S → G in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti153A → S in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti205E → G in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti224T → A in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti231N → D in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti241A → P in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti246T → S in AAB41825 (PubMed:8950170).Curated1
Sequence conflicti249K → E in AAB41825 (PubMed:8950170).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44389 mRNA Translation: AAB41825.1 Frameshift.
AK146038 mRNA Translation: BAE26850.1
BC021157 mRNA Translation: AAH21157.1
CCDSiCCDS40341.1
RefSeqiNP_032304.2, NM_008278.2
UniGeneiMm.18832

Genome annotation databases

EnsembliENSMUST00000034026; ENSMUSP00000034026; ENSMUSG00000031613
GeneIDi15446
KEGGimmu:15446
UCSCiuc009lso.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPGDH_MOUSE
AccessioniPrimary (citable) accession number: Q8VCC1
Secondary accession number(s): Q61106
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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