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Protein

Grancalcin

Gene

Gca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.1 Publication

Miscellaneous

This protein has been shown to bind calcium with high affinity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi105 – 1161PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi135 – 1462PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Grancalcin
Gene namesi
Name:Gca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1918521 Gca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Not essential for normal resistance to microbial infections. Grancalcin-deficient neutrophils exhibit decreased adhesion to fibronectin, and a strongly reduced number of focal adhesion complexes.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737221 – 220GrancalcinAdd BLAST220

Proteomic databases

MaxQBiQ8VC88
PaxDbiQ8VC88
PeptideAtlasiQ8VC88
PRIDEiQ8VC88

2D gel databases

REPRODUCTION-2DPAGEiIPI00308789

PTM databases

PhosphoSitePlusiQ8VC88

Expressioni

Gene expression databases

BgeeiENSMUSG00000026893 Expressed in 230 organ(s), highest expression level in brain
CleanExiMM_GCA
GenevisibleiQ8VC88 MM

Interactioni

Subunit structurei

Homodimer. Interacts with SRI and LCP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028257

Structurei

3D structure databases

ProteinModelPortaliQ8VC88
SMRiQ8VC88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 86EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini92 – 127EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini122 – 157EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini158 – 193EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
ENOG410YKQK LUCA
GeneTreeiENSGT00620000087734
HOGENOMiHOG000231982
HOVERGENiHBG004492
InParanoidiQ8VC88
OMAiKCLTQSG
OrthoDBiEOG091G0ISY
PhylomeDBiQ8VC88
TreeFamiTF314682

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q8VC88-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYPGYGGAF GNFSGQIPGM QMQMGQPMPG AGPNMFSGGY PGYLGYSDSY
60 70 80 90 100
SPADDSMWTY FTAVAGQDGE VDAEELQRCL TQSGISGTYA PFSLETCRIM
110 120 130 140 150
IAMLDRDYTG KMGFNEFKEL WAALNAWKQN FMTIDQDQSG TVEHHELSQA
160 170 180 190 200
IALMGYRLSP QTLAAIVRRY SKNGRIFFDD YVACCVKLRA LTDFFRRRDH
210 220
LQQGIVNFMY EDFLQGTMTI
Length:220
Mass (Da):24,663
Last modified:March 1, 2002 - v1
Checksum:i694DCA7D6ADF8279
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187 – 188KL → NV in AAM66720 (PubMed:12529388).Curated2
Sequence conflicti217T → P in BAC32686 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518325 mRNA Translation: AAM66720.1
AB088388 mRNA Translation: BAC07231.1
AK033740 mRNA Translation: BAC28458.1
AK046347 mRNA Translation: BAC32686.1
AK049317 mRNA Translation: BAC33679.1
AK050540 mRNA Translation: BAC34315.1
AK078915 mRNA Translation: BAC37457.1
BC021450 mRNA Translation: AAH21450.1
CCDSiCCDS16069.1
RefSeqiNP_663498.1, NM_145523.3
UniGeneiMm.219877

Genome annotation databases

EnsembliENSMUST00000028257; ENSMUSP00000028257; ENSMUSG00000026893
GeneIDi227960
KEGGimmu:227960
UCSCiuc008jvp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518325 mRNA Translation: AAM66720.1
AB088388 mRNA Translation: BAC07231.1
AK033740 mRNA Translation: BAC28458.1
AK046347 mRNA Translation: BAC32686.1
AK049317 mRNA Translation: BAC33679.1
AK050540 mRNA Translation: BAC34315.1
AK078915 mRNA Translation: BAC37457.1
BC021450 mRNA Translation: AAH21450.1
CCDSiCCDS16069.1
RefSeqiNP_663498.1, NM_145523.3
UniGeneiMm.219877

3D structure databases

ProteinModelPortaliQ8VC88
SMRiQ8VC88
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028257

PTM databases

PhosphoSitePlusiQ8VC88

2D gel databases

REPRODUCTION-2DPAGEiIPI00308789

Proteomic databases

MaxQBiQ8VC88
PaxDbiQ8VC88
PeptideAtlasiQ8VC88
PRIDEiQ8VC88

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028257; ENSMUSP00000028257; ENSMUSG00000026893
GeneIDi227960
KEGGimmu:227960
UCSCiuc008jvp.1 mouse

Organism-specific databases

CTDi25801
MGIiMGI:1918521 Gca

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
ENOG410YKQK LUCA
GeneTreeiENSGT00620000087734
HOGENOMiHOG000231982
HOVERGENiHBG004492
InParanoidiQ8VC88
OMAiKCLTQSG
OrthoDBiEOG091G0ISY
PhylomeDBiQ8VC88
TreeFamiTF314682

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:Q8VC88
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026893 Expressed in 230 organ(s), highest expression level in brain
CleanExiMM_GCA
GenevisibleiQ8VC88 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGRAN_MOUSE
AccessioniPrimary (citable) accession number: Q8VC88
Secondary accession number(s): Q8BL53, Q8K3Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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