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Protein

U6 snRNA-associated Sm-like protein LSm1

Gene

Lsm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity).By similarity

GO - Molecular functioni

  • mRNA binding Source: MGI
  • pre-mRNA binding Source: MGI
  • RNA binding Source: GO_Central
  • RNA cap binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm1
Gene namesi
Name:Lsm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914457 Lsm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255551 – 133U6 snRNA-associated Sm-like protein LSm1Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineBy similarity1
Modified residuei129PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VC85
MaxQBiQ8VC85
PaxDbiQ8VC85
PRIDEiQ8VC85

2D gel databases

REPRODUCTION-2DPAGEiQ8VC85

PTM databases

iPTMnetiQ8VC85
PhosphoSitePlusiQ8VC85

Expressioni

Gene expression databases

BgeeiENSMUSG00000037296 Expressed in 277 organ(s), highest expression level in renal corpuscle
ExpressionAtlasiQ8VC85 baseline and differential
GenevisibleiQ8VC85 MM

Interactioni

Subunit structurei

Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase (By similarity). LSm subunits form a heteromer with a donut shape (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Eri1Q7TMF23EBI-16026183,EBI-16026214

Protein-protein interaction databases

DIPiDIP-60113N
IntActiQ8VC85, 1 interactor
STRINGi10090.ENSMUSP00000041022

Structurei

3D structure databases

ProteinModelPortaliQ8VC85
SMRiQ8VC85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1782 Eukaryota
ENOG411224Q LUCA
GeneTreeiENSGT00730000111133
HOGENOMiHOG000223544
HOVERGENiHBG027238
InParanoidiQ8VC85
KOiK12620
OMAiFHQTVER
OrthoDBiEOG091G0UEO
PhylomeDBiQ8VC85
TreeFamiTF105846

Family and domain databases

CDDicd01728 LSm1, 1 hit
InterProiView protein in InterPro
IPR034104 Lsm1
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8VC85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYMPGTASL IEDIDKKHLV LLRDGRTLIG FLRSIDQFAN LVLHQTVERI
60 70 80 90 100
HVGKKYGDIP RGIFVVRGEN VVLLGEIDLE KESDTPLQQV SIEEILEEQR
110 120 130
VQQQTRLEAE KLKVQTLKDR GLSIPRADTL DEY
Length:133
Mass (Da):15,236
Last modified:March 1, 2002 - v1
Checksum:i92A34D7205CE036F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GR26A0A1B0GR26_MOUSE
U6 snRNA-associated Sm-like protein...
Lsm1
43Annotation score:
A0A1B0GS83A0A1B0GS83_MOUSE
U6 snRNA-associated Sm-like protein...
Lsm1
21Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021460 mRNA Translation: AAH21460.1
CCDSiCCDS22202.1
RefSeqiNP_080308.1, NM_026032.1
UniGeneiMm.30198

Genome annotation databases

EnsembliENSMUST00000038421; ENSMUSP00000041022; ENSMUSG00000037296
GeneIDi67207
KEGGimmu:67207
UCSCiuc009lgz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021460 mRNA Translation: AAH21460.1
CCDSiCCDS22202.1
RefSeqiNP_080308.1, NM_026032.1
UniGeneiMm.30198

3D structure databases

ProteinModelPortaliQ8VC85
SMRiQ8VC85
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60113N
IntActiQ8VC85, 1 interactor
STRINGi10090.ENSMUSP00000041022

PTM databases

iPTMnetiQ8VC85
PhosphoSitePlusiQ8VC85

2D gel databases

REPRODUCTION-2DPAGEiQ8VC85

Proteomic databases

EPDiQ8VC85
MaxQBiQ8VC85
PaxDbiQ8VC85
PRIDEiQ8VC85

Protocols and materials databases

DNASUi67207
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038421; ENSMUSP00000041022; ENSMUSG00000037296
GeneIDi67207
KEGGimmu:67207
UCSCiuc009lgz.1 mouse

Organism-specific databases

CTDi27257
MGIiMGI:1914457 Lsm1

Phylogenomic databases

eggNOGiKOG1782 Eukaryota
ENOG411224Q LUCA
GeneTreeiENSGT00730000111133
HOGENOMiHOG000223544
HOVERGENiHBG027238
InParanoidiQ8VC85
KOiK12620
OMAiFHQTVER
OrthoDBiEOG091G0UEO
PhylomeDBiQ8VC85
TreeFamiTF105846

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease

Miscellaneous databases

PROiPR:Q8VC85
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037296 Expressed in 277 organ(s), highest expression level in renal corpuscle
ExpressionAtlasiQ8VC85 baseline and differential
GenevisibleiQ8VC85 MM

Family and domain databases

CDDicd01728 LSm1, 1 hit
InterProiView protein in InterPro
IPR034104 Lsm1
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLSM1_MOUSE
AccessioniPrimary (citable) accession number: Q8VC85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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