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Protein

Telomerase Cajal body protein 1

Gene

Wrap53

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (By similarity). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (By similarity). In addition, also controls telomerase holoenzyme complex localization to Cajal body (By similarity). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (By similarity). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (By similarity). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (By similarity). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, RNA-binding
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Telomerase Cajal body protein 1By similarity
Alternative name(s):
WD repeat-containing protein 79By similarity
WD40 repeat-containing protein antisense to TP53 gene homologBy similarity
Gene namesi
Name:Wrap53Imported
Synonyms:Tcab1By similarity, Wdr79By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2384933 Wrap53

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426971 – 532Telomerase Cajal body protein 1Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineBy similarity1
Modified residuei61PhosphoserineBy similarity1
Modified residuei83PhosphoserineBy similarity1
Modified residuei474PhosphothreonineBy similarity1
Modified residuei476PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at Ser-61 by ATM in response to DNA damage, promoting its interaction with histone H2AX/H2AFX and localization to sites of DNA double-strand breaks.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VC51
MaxQBiQ8VC51
PaxDbiQ8VC51
PeptideAtlasiQ8VC51
PRIDEiQ8VC51

PTM databases

iPTMnetiQ8VC51
PhosphoSitePlusiQ8VC51

Expressioni

Gene expression databases

BgeeiENSMUSG00000041346 Expressed in 189 organ(s), highest expression level in bone marrow
CleanExiMM_WDR79
ExpressionAtlasiQ8VC51 baseline and differential
GenevisibleiQ8VC51 MM

Interactioni

Subunit structurei

Component of the telomerase holoenzyme complex composed of one molecule of TERT, one molecule of WRAP53/TCAB1, two molecules of H/ACA ribonucleoprotein complex subunits DKC1, NOP10, NHP2 and GAR1, and a telomerase RNA template component (TERC). The telomerase holoenzyme complex is associated with TEP1, SMG6/EST1A and POT1. Interacts with the chaperonin-containing T-complex (TRiC) complex; which mediates the folding of WRAP53/TCAB1. Interacts with COIL. Interacts with SMN1. Interacts with RNF8. Interacts with histone H2AX/H2AFX.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047825

Structurei

3D structure databases

ProteinModelPortaliQ8VC51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati151 – 190WD 1Sequence analysisAdd BLAST40
Repeati206 – 251WD 2Sequence analysisAdd BLAST46
Repeati256 – 297WD 3Sequence analysisAdd BLAST42
Repeati307 – 348WD 4Sequence analysisAdd BLAST42
Repeati349 – 389WD 5Sequence analysisAdd BLAST41
Repeati395 – 434WD 6Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the TCAB1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2919 Eukaryota
ENOG410XS4K LUCA
GeneTreeiENSGT00390000010169
HOGENOMiHOG000030352
HOVERGENiHBG098609
InParanoidiQ8VC51
OMAiVSCIREN
OrthoDBiEOG091G0FP1
PhylomeDBiQ8VC51
TreeFamiTF315169

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VC51-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTSEERLLA PDSLPPDLAP APVPQGSPAE KNTDFEPVPP PCGGDDQPQL
60 70 80 90 100
ATDPVASLVV SQELQQGDSV PLEVEFNTSS ELSPGIEEQD VSEHASLPGE
110 120 130 140 150
ETNLPELESG EATEGVSEER AEVDEGDTFW TYSFSQVPRY LSGSWSEFST
160 170 180 190 200
RSENFLKGCK WAPDGSCILT NSADNVLRIY NLPPELYSEQ EQVDYAEMVP
210 220 230 240 250
VLRMVEGDTI YDYCWYSLMS STQPDTSYVA SSSRENPIHI WDAFTGELRA
260 270 280 290 300
SFRAYNHLDE LTAAHSLCFS PDGSQLFCGF NRTVRVFSTS RPGRDCEVRA
310 320 330 340 350
TFAKKQGQSG IISCIAFSPS QPLYACGSYG RTIGLYAWDD GSPLALLGGH
360 370 380 390 400
QGGITHLCFH PDGNLFFSGA RKDAELLCWD LRQPGHLLWS LSREVTTNQR
410 420 430 440 450
IYFDLDPSGQ FLVSGNTSGV VSVWDISGAL SDDSKLEPVV TFLPQKDCTN
460 470 480 490 500
GVSLHPTLPL LATASGQRVF PEPTNSGDEG ELELELPLLS LCHAHPECQL
510 520 530
QLWWCGGGPD PSSPVDDQDE KGQRRTEAVG MS
Length:532
Mass (Da):58,151
Last modified:March 1, 2002 - v1
Checksum:i928FE02E7D74D235
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I7HJ86I7HJ86_MOUSE
Telomerase Cajal body protein 1
Wrap53 Wdr79, RP23-56I20.3-003
170Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731687 Genomic DNA Translation: CAI52013.1
BC021790 mRNA Translation: AAH21790.1
BC069868 mRNA Translation: AAH69868.1
CCDSiCCDS24897.1
RefSeqiNP_659073.1, NM_144824.2
UniGeneiMm.31586

Genome annotation databases

EnsembliENSMUST00000048139; ENSMUSP00000047825; ENSMUSG00000041346
GeneIDi216853
KEGGimmu:216853
UCSCiuc007jqj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731687 Genomic DNA Translation: CAI52013.1
BC021790 mRNA Translation: AAH21790.1
BC069868 mRNA Translation: AAH69868.1
CCDSiCCDS24897.1
RefSeqiNP_659073.1, NM_144824.2
UniGeneiMm.31586

3D structure databases

ProteinModelPortaliQ8VC51
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047825

PTM databases

iPTMnetiQ8VC51
PhosphoSitePlusiQ8VC51

Proteomic databases

EPDiQ8VC51
MaxQBiQ8VC51
PaxDbiQ8VC51
PeptideAtlasiQ8VC51
PRIDEiQ8VC51

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048139; ENSMUSP00000047825; ENSMUSG00000041346
GeneIDi216853
KEGGimmu:216853
UCSCiuc007jqj.1 mouse

Organism-specific databases

CTDi55135
MGIiMGI:2384933 Wrap53

Phylogenomic databases

eggNOGiKOG2919 Eukaryota
ENOG410XS4K LUCA
GeneTreeiENSGT00390000010169
HOGENOMiHOG000030352
HOVERGENiHBG098609
InParanoidiQ8VC51
OMAiVSCIREN
OrthoDBiEOG091G0FP1
PhylomeDBiQ8VC51
TreeFamiTF315169

Miscellaneous databases

PROiPR:Q8VC51
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041346 Expressed in 189 organ(s), highest expression level in bone marrow
CleanExiMM_WDR79
ExpressionAtlasiQ8VC51 baseline and differential
GenevisibleiQ8VC51 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCAB1_MOUSE
AccessioniPrimary (citable) accession number: Q8VC51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2002
Last modified: October 10, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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