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Protein

Urocanate hydratase

Gene

Uroc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O.

Cofactori

NAD+By similarity

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 2 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (Hal), Histidine ammonia-lyase (Hal), Histidine ammonia-lyase (Hal)
  2. Urocanate hydratase (Uroc1)
  3. Probable imidazolonepropionase (Amdhd1)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei204NADBy similarity1
Binding sitei271NADBy similarity1
Binding sitei403NAD; via carbonyl oxygenBy similarity1
Binding sitei594NAD; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi126 – 127NADBy similarity2
Nucleotide bindingi251 – 253NADBy similarity3
Nucleotide bindingi317 – 318NADBy similarity2
Nucleotide bindingi343 – 347NADBy similarity5
Nucleotide bindingi354 – 355NADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processHistidine metabolism
LigandNAD

Enzyme and pathway databases

ReactomeiR-MMU-70921 Histidine catabolism
UniPathwayi
UPA00379;UER00550

Names & Taxonomyi

Protein namesi
Recommended name:
Urocanate hydratase (EC:4.2.1.49)
Short name:
Urocanase
Alternative name(s):
Imidazolonepropionate hydrolase
Gene namesi
Name:Uroc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2385332 Uroc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002073751 – 676Urocanate hydrataseAdd BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534N6-succinyllysineCombined sources1

Proteomic databases

MaxQBiQ8VC12
PaxDbiQ8VC12
PRIDEiQ8VC12

PTM databases

iPTMnetiQ8VC12
PhosphoSitePlusiQ8VC12
SwissPalmiQ8VC12

Expressioni

Gene expression databases

BgeeiENSMUSG00000034456 Expressed in 108 organ(s), highest expression level in left lobe of liver
CleanExiMM_UROC1
ExpressionAtlasiQ8VC12 baseline and differential
GenevisibleiQ8VC12 MM

Interactioni

Protein-protein interaction databases

IntActiQ8VC12, 2 interactors
MINTiQ8VC12
STRINGi10090.ENSMUSP00000040424

Structurei

3D structure databases

ProteinModelPortaliQ8VC12
SMRiQ8VC12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urocanase family.Curated

Phylogenomic databases

eggNOGiENOG410IEG2 Eukaryota
COG2987 LUCA
GeneTreeiENSGT00390000015136
HOGENOMiHOG000237607
HOVERGENiHBG031614
InParanoidiQ8VC12
KOiK01712

Family and domain databases

Gene3Di3.40.50.10730, 1 hit
HAMAPiMF_00577 HutU, 1 hit
InterProiView protein in InterPro
IPR023637 Urocanase
IPR035401 Urocanase_C
IPR038364 Urocanase_central_sf
IPR023636 Urocanase_CS
IPR035400 Urocanase_N
IPR035085 Urocanase_Rossmann-like
IPR036190 Urocanase_sf
PANTHERiPTHR12216 PTHR12216, 1 hit
PfamiView protein in Pfam
PF01175 Urocanase, 1 hit
PF17392 Urocanase_C, 1 hit
PF17391 Urocanase_N, 1 hit
PIRSFiPIRSF001423 Urocanate_hydrat, 1 hit
SUPFAMiSSF111326 SSF111326, 1 hit
TIGRFAMsiTIGR01228 hutU, 1 hit
PROSITEiView protein in PROSITE
PS01233 UROCANASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VC12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLQELCSG LPLRPLPENR GRWAGVPHAP VRTPNLSPEE EQLALRNALR
60 70 80 90 100
YFPPDVQKLL ALEFAQELRQ FGHIYMYRFC PSIEMRAYPI DQYPCRTRAA
110 120 130 140 150
AAIMHMIMNN LDPAVAQFPQ ELVTYGGNGQ VFSNWAQFRL TMSYLSKMTE
160 170 180 190 200
EQTLVMYSGH PLGLFPSSPR APRLVITNGM VIPNYSSRTE YEKLFALGVT
210 220 230 240 250
MYGQMTAGSY CYIGPQGIVH GTVLTVLNAG RRYLGIENLA GKVFVTSGLG
260 270 280 290 300
GMSGAQAKAA AIVGCIGVIA EVDKAALVKR HRQGWLMEVT DSLDRCIARL
310 320 330 340 350
REARKKKEVL SLGYHGNVVD LWERLVHELD TTGELLVDLG SDQTSCHNPF
360 370 380 390 400
NGGYYPVQLS FSEAQSLMSS NPAAFKHLVQ ESLRRHVAAI NRLAQEKFFF
410 420 430 440 450
WDYGNAFLLE AQRAGADVEK KGANKMEFRY PSYVQHIMGD IFSQGFGPFR
460 470 480 490 500
WVCTSGDPQD LAVTDHLATS VLEKAIADGV KASVKLQYMD NIRWIREAAK
510 520 530 540 550
HQLVVGSQAR ILYSDQKGRV AIAVAINQAI ASGKIKAPVV LSRDHHDVSG
560 570 580 590 600
TDSPFRETSN IYDGSAFCAD MAVQNFVGDA CRGATWVALH NGGGVGWGEV
610 620 630 640 650
INGGFGLVLD GTAEAEQKAR MMLSWDVSNG VARRCWSGNP KAYEIICQTM
660 670
QENSGLVVTL PHEVADEQVL QQALRP
Length:676
Mass (Da):74,590
Last modified:July 27, 2011 - v2
Checksum:i097A6CADE3573C64
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UEL5Q3UEL5_MOUSE
Urocanate hydratase
Uroc1
710Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295R → H in AAH22133 (PubMed:15489334).Curated1
Sequence conflicti327H → R in AAH22133 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122521 Genomic DNA No translation available.
AC163346 Genomic DNA No translation available.
BC022133 mRNA Translation: AAH22133.1
CCDSiCCDS39561.1
RefSeqiNP_659189.2, NM_144940.2
UniGeneiMm.335669

Genome annotation databases

EnsembliENSMUST00000046128; ENSMUSP00000040424; ENSMUSG00000034456
GeneIDi243537
KEGGimmu:243537
UCSCiuc009cxc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122521 Genomic DNA No translation available.
AC163346 Genomic DNA No translation available.
BC022133 mRNA Translation: AAH22133.1
CCDSiCCDS39561.1
RefSeqiNP_659189.2, NM_144940.2
UniGeneiMm.335669

3D structure databases

ProteinModelPortaliQ8VC12
SMRiQ8VC12
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VC12, 2 interactors
MINTiQ8VC12
STRINGi10090.ENSMUSP00000040424

PTM databases

iPTMnetiQ8VC12
PhosphoSitePlusiQ8VC12
SwissPalmiQ8VC12

Proteomic databases

MaxQBiQ8VC12
PaxDbiQ8VC12
PRIDEiQ8VC12

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046128; ENSMUSP00000040424; ENSMUSG00000034456
GeneIDi243537
KEGGimmu:243537
UCSCiuc009cxc.2 mouse

Organism-specific databases

CTDi131669
MGIiMGI:2385332 Uroc1

Phylogenomic databases

eggNOGiENOG410IEG2 Eukaryota
COG2987 LUCA
GeneTreeiENSGT00390000015136
HOGENOMiHOG000237607
HOVERGENiHBG031614
InParanoidiQ8VC12
KOiK01712

Enzyme and pathway databases

UniPathwayi
UPA00379;UER00550

ReactomeiR-MMU-70921 Histidine catabolism

Miscellaneous databases

PROiPR:Q8VC12
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034456 Expressed in 108 organ(s), highest expression level in left lobe of liver
CleanExiMM_UROC1
ExpressionAtlasiQ8VC12 baseline and differential
GenevisibleiQ8VC12 MM

Family and domain databases

Gene3Di3.40.50.10730, 1 hit
HAMAPiMF_00577 HutU, 1 hit
InterProiView protein in InterPro
IPR023637 Urocanase
IPR035401 Urocanase_C
IPR038364 Urocanase_central_sf
IPR023636 Urocanase_CS
IPR035400 Urocanase_N
IPR035085 Urocanase_Rossmann-like
IPR036190 Urocanase_sf
PANTHERiPTHR12216 PTHR12216, 1 hit
PfamiView protein in Pfam
PF01175 Urocanase, 1 hit
PF17392 Urocanase_C, 1 hit
PF17391 Urocanase_N, 1 hit
PIRSFiPIRSF001423 Urocanate_hydrat, 1 hit
SUPFAMiSSF111326 SSF111326, 1 hit
TIGRFAMsiTIGR01228 hutU, 1 hit
PROSITEiView protein in PROSITE
PS01233 UROCANASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHUTU_MOUSE
AccessioniPrimary (citable) accession number: Q8VC12
Secondary accession number(s): E9QNN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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