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Protein

Multiple PDZ domain protein

Gene

Mpdz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: MGI
  • myelination Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple PDZ domain protein
Alternative name(s):
Multi-PDZ domain protein 1
Gene namesi
Name:Mpdz
Synonyms:Mupp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1343489 Mpdz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176783

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945951 – 2055Multiple PDZ domain proteinAdd BLAST2055

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineBy similarity1
Modified residuei783PhosphoserineBy similarity1
Modified residuei1066PhosphoserineBy similarity1
Modified residuei1158Omega-N-methylarginineCombined sources1
Modified residuei1803PhosphoserineBy similarity1
Modified residuei1809PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8VBX6
PaxDbiQ8VBX6
PRIDEiQ8VBX6

PTM databases

iPTMnetiQ8VBX6
PhosphoSitePlusiQ8VBX6

Expressioni

Tissue specificityi

In the brain, it is strongly expressed in the choroid plexus. Within the hippocampal formation, strongest expression was seen in the soma of CA1-4 pyramidal cells. Expressed in most neocortical regions with the strongest expression in piriform cortex and amygdaloid nuclei but also detected in the subiculum and olfactory bulb. In the cerebellum, the highest level of expression was found in Purkinje cells. Moderately expressed in the granular layer and molecular layer. Expressed in the pontine nuclei, parts of spinal trigeminal nuclei, and the principal sensory trigeminal nuclei of the metencephalon. Expressed in all thalamic and hypothalamic nuclei, and the substantia nigra (at protein level). Ubiquitously expressed.2 Publications

Gene expression databases

BgeeiENSMUSG00000028402 Expressed in 295 organ(s), highest expression level in sciatic nerve
CleanExiMM_MPDZ
ExpressionAtlasiQ8VBX6 baseline and differential
GenevisibleiQ8VBX6 MM

Interactioni

Subunit structurei

Interacts with CLDN5, DLG4, GRIN1, SYNGAP1, CAMK2A and CAMK2B, HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1 and PLEKHA2/TAPP2 (By similarity). Interacts with F11R/JAM, CLDN1, NG2, CXADR, CRB1, MPP4 and MPP5. Interacts with FAT4 (via cytoplasmic domain). Interacts with DLL1 (PubMed:15509766).By similarity8 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201476, 9 interactors
CORUMiQ8VBX6
DIPiDIP-41165N
IntActiQ8VBX6, 9 interactors
MINTiQ8VBX6
STRINGi10090.ENSMUSP00000099894

Structurei

Secondary structure

12055
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8VBX6
SMRiQ8VBX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 63L27PROSITE-ProRule annotationAdd BLAST63
Domaini138 – 225PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini258 – 338PDZ 2PROSITE-ProRule annotationAdd BLAST81
Domaini378 – 464PDZ 3PROSITE-ProRule annotationAdd BLAST87
Domaini546 – 627PDZ 4PROSITE-ProRule annotationAdd BLAST82
Domaini693 – 779PDZ 5PROSITE-ProRule annotationAdd BLAST87
Domaini996 – 1077PDZ 6PROSITE-ProRule annotationAdd BLAST82
Domaini1139 – 1231PDZ 7PROSITE-ProRule annotationAdd BLAST93
Domaini1338 – 1421PDZ 8PROSITE-ProRule annotationAdd BLAST84
Domaini1471 – 1552PDZ 9PROSITE-ProRule annotationAdd BLAST82
Domaini1614 – 1697PDZ 10PROSITE-ProRule annotationAdd BLAST84
Domaini1710 – 1792PDZ 11PROSITE-ProRule annotationAdd BLAST83
Domaini1847 – 1933PDZ 12PROSITE-ProRule annotationAdd BLAST87
Domaini1972 – 2055PDZ 13PROSITE-ProRule annotationAdd BLAST84

Domaini

The PDZ domain 2 mainly binds CAMK2A and CAMK2B. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 10 binds the C-terminal PDZ-binding motif of HTR2C. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1 (By similarity). The PDZ domain 1 binds NG2. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT. The PDZ domain 13 binds CXADR.By similarity2 Publications

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3528 Eukaryota
ENOG4110362 LUCA
GeneTreeiENSGT00760000119017
HOVERGENiHBG080134
InParanoidiQ8VBX6
KOiK06095
TreeFamiTF330709

Family and domain databases

InterProiView protein in InterPro
IPR015132 L27_2
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR032078 MPDZ
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF09045 L27_2, 1 hit
PF16667 MPDZ_u10, 1 hit
PF00595 PDZ, 12 hits
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 13 hits
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 13 hits
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 13 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VBX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLETIDKNRA LQAAERLQSK LKERGDVANE DKLSLLKSVL QSPLFSQILN
60 70 80 90 100
LQTSLQQLKD QVNIATLATA AADHAHTPQF SSAVISNLQS ESLLLSPNHG
110 120 130 140 150
NLEALPGPGA PAVMDGKPTC DELDQLIKNM AQGRHVEIFE LLKPPCGGLG
160 170 180 190 200
FSVVGLRSEN RGELGIFVQE IQEGSVAHRD GRLKETDQIL AINGQVLDQT
210 220 230 240 250
ITHQQAISIL QKAKDTVQLV IARGSLPPVS SPRISRSPSA ASTISAHSNP
260 270 280 290 300
MHWQHVETIE LVNDGSGLGF GIIGGKATGV IVKTILPGGV ADQHGRLCSG
310 320 330 340 350
DHILKIGDTD LAGMSSEQVA QVLRQCGNRV KLMIARGAVE ETPASSSLGI
360 370 380 390 400
TLSSSTSSTS EMRVDASTQK NDESETFDVE LTKNVQGLGI TIAGYIGDKK
410 420 430 440 450
LEPSGIFVKS ITKSSAVEHD GRIQIGDQII AVDGTNLQGF TNQQAVEVLR
460 470 480 490 500
HTGQTVRLTL MRKGASQEAE LTSRGDTAKD VDLPAENCEK DEESLSLKRN
510 520 530 540 550
TSILPIEEEG FPLLSAELEE AEDVQQEAAL LTKWQRIMGI NYEIVVAHVS
560 570 580 590 600
KFSENSGLGI SLEATVGHHF IRSVLPEGPV GHSGKLFSGD ELLEVNGINL
610 620 630 640 650
LGENHQDVVN ILKELPIDVT MVCCRRTVPP IALSEMDSLD INDLELTEKP
660 670 680 690 700
HIDLGEFIGS SETEDPMLAM SDVDQNAEEI QTPLAMWEAG GQSIELEKGS
710 720 730 740 750
RGLGFSILDY QDPIDPANTV IVIRSLVPGG IAEKDGRLFP GDRLMFVNDI
760 770 780 790 800
NLENSTLEEA VEALKGAPSG MVRIGVAKPL PLSPEEGYVS AKEDAFLCSP
810 820 830 840 850
HACKESGLSD KALFRADLAL IDTPDAESIA ESRFESQFSP DNDSVYSTQA
860 870 880 890 900
SIFSLHDGTC SDGMNYGPSL PSSPPKDVTS SSEVVLGLHL SLEELYTQNL
910 920 930 940 950
LQRQHAGSPP TDMRPAPTSG FPISDYTTTN AVEQKYECAN PVAWPHSQLP
960 970 980 990 1000
SSLSTSELAP ALPAVAQKYL TDQSSLASDA ESVNLQSMSQ EAFERTVTIA
1010 1020 1030 1040 1050
KGSSSLGMTV SANKDGLGVI VRSIIHGGAI SRDGRIAVGD CILSINEEST
1060 1070 1080 1090 1100
ISLTNAQARA MLRRHSLIGP DIKITYVPAE HLEEFRVSFG QQAGGIMALD
1110 1120 1130 1140 1150
IFSSYTGRDI PELPEREEGE GEESELQNAA YSSWSQPRRV ELWREPSKSL
1160 1170 1180 1190 1200
GISIVGGRGM GSRLSNGEVM RGIFIKHVLE DSPAGKNGTL KPGDRIIEVD
1210 1220 1230 1240 1250
GMDLRDASHE QAVEAIRKAG NPVVFMVQSI INRPRKSPLP SLPHSLYPKY
1260 1270 1280 1290 1300
SFSSTNPFAD SLQLTTDQAP SQSESETEKP ALCNVPPSSP SVFSEMGSDC
1310 1320 1330 1340 1350
AQPSATAVSE DEDKEDEFGY SWKNIQERYG SLTGQLHVIE LEKGQSGLGL
1360 1370 1380 1390 1400
SLAGNKDRTR MSVFIVGIDP TGAAGRDGRL QIADELLEIN GQILYGRSHQ
1410 1420 1430 1440 1450
NASSIIKCAP SKVKIIFIRN ADAVNQMAVC PGIAADSPSS TSDSPQNKEV
1460 1470 1480 1490 1500
EPCSTTSASA ADLSSLTDVY QLELPKDQGG LGIAICEEDT INGVMIESLT
1510 1520 1530 1540 1550
EHGGAAKDGR LKPGDHILAV DDEVVAGCPV EKFISLLKTA KATVKLTVRA
1560 1570 1580 1590 1600
ENPACPAVPS SAVTVSGERK DNSQTPAVPA PDLEPIPSTS RSSTPAVFAS
1610 1620 1630 1640 1650
DPATCPIIPG CETTIEISKG QTGLGLSIVG GSDTLLGAII IHEVYEEGAA
1660 1670 1680 1690 1700
CKDGRLWAGD QILEVNGIDL RKATHDEAIN VLRQTPQRVR LTLYRDEAPY
1710 1720 1730 1740 1750
KEEDVCDTFT IELQKRPGKG LGLSIVGKRN DTGVFVSDIV KGGIADADGR
1760 1770 1780 1790 1800
LMQGDQILMV NGEDVRHATQ EAVAALLKCS LGAVTLEVGR VKAAPFHSER
1810 1820 1830 1840 1850
RPSQSSQVSE SSLSSFTPPL SGINTSESLE SNSKKNALAS EIQGLRTVEI
1860 1870 1880 1890 1900
KKGPADSLGL SIAGGVGSPL GDVPIFIAMM HPNGVAAQTQ KLRVGDRIVT
1910 1920 1930 1940 1950
ICGTSTDGMT HTQAVNLMKN ASGSIEVQVV AGGDVSVVTG HQQELANPCL
1960 1970 1980 1990 2000
AFTGLTSSSI FPDDLGPPQS KTITLDRGPD GLGFSIVGGY GSPHGDLPIY
2010 2020 2030 2040 2050
VKTVFAKGAA AEDGRLKRGD QIIAVNGQSL EGVTHEEAVA ILKRTKGTVT

LMVLS
Length:2,055
Mass (Da):218,711
Last modified:June 21, 2005 - v2
Checksum:i26EA94B814214B69
GO
Isoform 2 (identifier: Q8VBX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1236-1268: Missing.

Note: No experimental confirmation available.
Show »
Length:2,022
Mass (Da):215,061
Checksum:i1B5D7BF3FFA7B4BA
GO
Isoform 3 (identifier: Q8VBX6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1908: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):15,200
Checksum:i46AF48BDA58C874E
GO
Isoform 4 (identifier: Q8VBX6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1714-1714: Q → QLQ

Note: No experimental confirmation available.
Show »
Length:2,057
Mass (Da):218,953
Checksum:i7861BBC636A9C862
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUX2D3YUX2_MOUSE
Multiple PDZ domain protein
Mpdz
2,056Annotation score:
I7HJS5I7HJS5_MOUSE
Multiple PDZ domain protein
Mpdz
348Annotation score:
A3KG84A3KG84_MOUSE
Multiple PDZ domain protein
Mpdz
495Annotation score:
A3KG83A3KG83_MOUSE
Multiple PDZ domain protein
Mpdz
209Annotation score:
A3KG82A3KG82_MOUSE
Multiple PDZ domain protein
Mpdz
138Annotation score:
F7D0H8F7D0H8_MOUSE
Multiple PDZ domain protein
Mpdz
269Annotation score:
B2RQR2B2RQR2_MOUSE
Mpdz protein
Mpdz
2,069Annotation score:

Sequence cautioni

The sequence BAC27346 differs from that shown. Reason: Frameshift at position 2054.Curated
The sequence BAC34766 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti583S → N in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti588S → N in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti871P → S in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti909 – 910PP → SS in CAA10523 (PubMed:10395806).Curated2
Sequence conflicti914 – 919RPAPTS → KPTPTF in CAA10523 (PubMed:10395806).Curated6
Sequence conflicti932V → G in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti937 – 938EC → QW in CAA10523 (PubMed:10395806).Curated2
Sequence conflicti952S → N in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti956S → F in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti960P → S in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti963P → A in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti967Q → P in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti974 – 975SS → TF in CAA10523 (PubMed:10395806).Curated2
Sequence conflicti984N → T in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti996T → P in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti1532K → N in AAB57835 (PubMed:9192623).Curated1
Sequence conflicti1547T → I in AAB57835 (PubMed:9192623).Curated1
Sequence conflicti1589T → P in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti1616 – 1617EI → GV in AAB57835 (PubMed:9192623).Curated2
Sequence conflicti1691L → V in AAB57835 (PubMed:9192623).Curated1
Sequence conflicti1844G → R in AAB57835 (PubMed:9192623).Curated1
Sequence conflicti1914A → V in AAH61504 (PubMed:15489334).Curated1
Sequence conflicti1968P → S in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti1983 – 1985GFS → SFN in CAA10523 (PubMed:10395806).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti541N → S in strain: DBA/2J and DBA1/J. 1 Publication1
Natural varianti691G → V in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti801H → R in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti859T → A in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti880S → N in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti914R → S in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti977A → V in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti1338V → M in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti1433I → N in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti1767H → N in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0587711 – 1908Missing in isoform 3. 1 PublicationAdd BLAST1908
Alternative sequenceiVSP_0142011236 – 1268Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0142021714Q → QLQ in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131869 mRNA Translation: CAA10523.1
AF326526 mRNA Translation: AAL37372.1
AF326527 mRNA Translation: AAL37373.1
AF326528 mRNA Translation: AAL37374.1
AF326529 mRNA Translation: AAL37375.1
AF326530 mRNA Translation: AAL37376.1
AF326531 mRNA Translation: AAL37377.2
AF326532 mRNA Translation: AAL37378.1
AF326533 mRNA Translation: AAL37379.1
AF326534 mRNA Translation: AAL37380.1
AF326535 mRNA Translation: AAL37381.1
AF326536 mRNA Translation: AAL37382.1
AF326537 mRNA Translation: AAL37383.1
AF326538 mRNA Translation: AAL37384.1
AF326539 mRNA Translation: AAL37385.1
AF326540 mRNA Translation: AAL37386.1
AF326541 mRNA Translation: AAL37387.1
AF326542 mRNA Translation: AAL37388.1
AF326543 mRNA Translation: AAL37389.1
AF326544 mRNA Translation: AAL37390.1
CR352325, AL670939 Genomic DNA Translation: CAI25220.1
AL670939, CR352325 Genomic DNA Translation: CAI25921.1
BC061504 mRNA Translation: AAH61504.1
BC145117 mRNA Translation: AAI45118.1
AF000168 mRNA Translation: AAB57835.1
AK031321 mRNA Translation: BAC27346.1 Frameshift.
AK051782 mRNA Translation: BAC34766.1 Sequence problems.
CCDSiCCDS18292.1 [Q8VBX6-1]
PIRiT30259
RefSeqiNP_001292213.1, NM_001305284.1
NP_001292215.1, NM_001305286.1 [Q8VBX6-2]
NP_034950.2, NM_010820.3 [Q8VBX6-1]
UniGeneiMm.153039

Genome annotation databases

EnsembliENSMUST00000102830; ENSMUSP00000099894; ENSMUSG00000028402 [Q8VBX6-1]
ENSMUST00000107258; ENSMUSP00000102879; ENSMUSG00000028402 [Q8VBX6-2]
GeneIDi17475
KEGGimmu:17475
UCSCiuc008tjw.3 mouse [Q8VBX6-2]
uc008tjx.2 mouse [Q8VBX6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131869 mRNA Translation: CAA10523.1
AF326526 mRNA Translation: AAL37372.1
AF326527 mRNA Translation: AAL37373.1
AF326528 mRNA Translation: AAL37374.1
AF326529 mRNA Translation: AAL37375.1
AF326530 mRNA Translation: AAL37376.1
AF326531 mRNA Translation: AAL37377.2
AF326532 mRNA Translation: AAL37378.1
AF326533 mRNA Translation: AAL37379.1
AF326534 mRNA Translation: AAL37380.1
AF326535 mRNA Translation: AAL37381.1
AF326536 mRNA Translation: AAL37382.1
AF326537 mRNA Translation: AAL37383.1
AF326538 mRNA Translation: AAL37384.1
AF326539 mRNA Translation: AAL37385.1
AF326540 mRNA Translation: AAL37386.1
AF326541 mRNA Translation: AAL37387.1
AF326542 mRNA Translation: AAL37388.1
AF326543 mRNA Translation: AAL37389.1
AF326544 mRNA Translation: AAL37390.1
CR352325, AL670939 Genomic DNA Translation: CAI25220.1
AL670939, CR352325 Genomic DNA Translation: CAI25921.1
BC061504 mRNA Translation: AAH61504.1
BC145117 mRNA Translation: AAI45118.1
AF000168 mRNA Translation: AAB57835.1
AK031321 mRNA Translation: BAC27346.1 Frameshift.
AK051782 mRNA Translation: BAC34766.1 Sequence problems.
CCDSiCCDS18292.1 [Q8VBX6-1]
PIRiT30259
RefSeqiNP_001292213.1, NM_001305284.1
NP_001292215.1, NM_001305286.1 [Q8VBX6-2]
NP_034950.2, NM_010820.3 [Q8VBX6-1]
UniGeneiMm.153039

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XH7X-ray1.65A521-665[»]
ProteinModelPortaliQ8VBX6
SMRiQ8VBX6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201476, 9 interactors
CORUMiQ8VBX6
DIPiDIP-41165N
IntActiQ8VBX6, 9 interactors
MINTiQ8VBX6
STRINGi10090.ENSMUSP00000099894

Chemistry databases

ChEMBLiCHEMBL2176783

PTM databases

iPTMnetiQ8VBX6
PhosphoSitePlusiQ8VBX6

Proteomic databases

EPDiQ8VBX6
PaxDbiQ8VBX6
PRIDEiQ8VBX6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102830; ENSMUSP00000099894; ENSMUSG00000028402 [Q8VBX6-1]
ENSMUST00000107258; ENSMUSP00000102879; ENSMUSG00000028402 [Q8VBX6-2]
GeneIDi17475
KEGGimmu:17475
UCSCiuc008tjw.3 mouse [Q8VBX6-2]
uc008tjx.2 mouse [Q8VBX6-1]

Organism-specific databases

CTDi8777
MGIiMGI:1343489 Mpdz

Phylogenomic databases

eggNOGiKOG3528 Eukaryota
ENOG4110362 LUCA
GeneTreeiENSGT00760000119017
HOVERGENiHBG080134
InParanoidiQ8VBX6
KOiK06095
TreeFamiTF330709

Miscellaneous databases

PROiPR:Q8VBX6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028402 Expressed in 295 organ(s), highest expression level in sciatic nerve
CleanExiMM_MPDZ
ExpressionAtlasiQ8VBX6 baseline and differential
GenevisibleiQ8VBX6 MM

Family and domain databases

InterProiView protein in InterPro
IPR015132 L27_2
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR032078 MPDZ
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF09045 L27_2, 1 hit
PF16667 MPDZ_u10, 1 hit
PF00595 PDZ, 12 hits
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 13 hits
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 13 hits
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMPDZ_MOUSE
AccessioniPrimary (citable) accession number: Q8VBX6
Secondary accession number(s): B7ZNA1
, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: September 12, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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