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Entry version 157 (07 Apr 2021)
Sequence version 2 (21 Jun 2005)
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Protein

Multiple PDZ domain protein

Gene

Mpdz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (By similarity). Promotes clustering of HT2RC at the cell surface (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: MGI
  • myelination Source: MGI

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multiple PDZ domain protein
Alternative name(s):
Multi-PDZ domain protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mpdz
Synonyms:Mupp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1343489, Mpdz

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse, Synaptosome, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2176783

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945951 – 2055Multiple PDZ domain proteinAdd BLAST2055

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei231PhosphoserineBy similarity1
Modified residuei783PhosphoserineBy similarity1
Modified residuei1066PhosphoserineBy similarity1
Modified residuei1158Omega-N-methylarginineCombined sources1
Modified residuei1803PhosphoserineBy similarity1
Modified residuei1809PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8VBX6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8VBX6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8VBX6

PRoteomics IDEntifications database

More...
PRIDEi
Q8VBX6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
252603 [Q8VBX6-1]
252604 [Q8VBX6-2]
252605 [Q8VBX6-3]
252606 [Q8VBX6-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8VBX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8VBX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the brain, it is strongly expressed in the choroid plexus. Within the hippocampal formation, strongest expression was seen in the soma of CA1-4 pyramidal cells. Expressed in most neocortical regions with the strongest expression in piriform cortex and amygdaloid nuclei but also detected in the subiculum and olfactory bulb. In the cerebellum, the highest level of expression was found in Purkinje cells. Moderately expressed in the granular layer and molecular layer. Expressed in the pontine nuclei, parts of spinal trigeminal nuclei, and the principal sensory trigeminal nuclei of the metencephalon. Expressed in all thalamic and hypothalamic nuclei, and the substantia nigra (at protein level). Ubiquitously expressed.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at the outer limiting membrane of the retina at 3 months of age.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028402, Expressed in sciatic nerve and 306 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8VBX6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8VBX6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CLDN5, DLG4, GRIN1, SYNGAP1, CAMK2A and CAMK2B, HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1 and PLEKHA2/TAPP2 (By similarity).

Interacts with F11R/JAM, CLDN1, NG2, CXADR, CRB1, MPP4 and MPP5.

Interacts with FAT4 (via cytoplasmic domain).

Interacts with DLL1 (PubMed:15509766).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
201476, 15 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8VBX6

Database of interacting proteins

More...
DIPi
DIP-41165N

Protein interaction database and analysis system

More...
IntActi
Q8VBX6, 10 interactors

Molecular INTeraction database

More...
MINTi
Q8VBX6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099894

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8VBX6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12055
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8VBX6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 63L27PROSITE-ProRule annotationAdd BLAST63
Domaini138 – 225PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini258 – 338PDZ 2PROSITE-ProRule annotationAdd BLAST81
Domaini378 – 464PDZ 3PROSITE-ProRule annotationAdd BLAST87
Domaini546 – 627PDZ 4PROSITE-ProRule annotationAdd BLAST82
Domaini693 – 779PDZ 5PROSITE-ProRule annotationAdd BLAST87
Domaini996 – 1077PDZ 6PROSITE-ProRule annotationAdd BLAST82
Domaini1139 – 1231PDZ 7PROSITE-ProRule annotationAdd BLAST93
Domaini1338 – 1421PDZ 8PROSITE-ProRule annotationAdd BLAST84
Domaini1471 – 1552PDZ 9PROSITE-ProRule annotationAdd BLAST82
Domaini1614 – 1697PDZ 10PROSITE-ProRule annotationAdd BLAST84
Domaini1710 – 1792PDZ 11PROSITE-ProRule annotationAdd BLAST83
Domaini1847 – 1933PDZ 12PROSITE-ProRule annotationAdd BLAST87
Domaini1972 – 2055PDZ 13PROSITE-ProRule annotationAdd BLAST84

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain 2 mainly binds CAMK2A and CAMK2B. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 10 binds the C-terminal PDZ-binding motif of HTR2C. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1 (By similarity). The PDZ domain 1 binds NG2. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT. The PDZ domain 13 binds CXADR.By similarity2 Publications

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3528, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155586

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002378_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8VBX6

Identification of Orthologs from Complete Genome Data

More...
OMAi
GTPHING

Database of Orthologous Groups

More...
OrthoDBi
1419918at2759

TreeFam database of animal gene trees

More...
TreeFami
TF330709

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 13 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015132, L27_2
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR032078, MPDZ
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09045, L27_2, 1 hit
PF16667, MPDZ_u10, 1 hit
PF00595, PDZ, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00569, L27, 1 hit
SM00228, PDZ, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101288, SSF101288, 1 hit
SSF50156, SSF50156, 13 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51022, L27, 1 hit
PS50106, PDZ, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VBX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLETIDKNRA LQAAERLQSK LKERGDVANE DKLSLLKSVL QSPLFSQILN
60 70 80 90 100
LQTSLQQLKD QVNIATLATA AADHAHTPQF SSAVISNLQS ESLLLSPNHG
110 120 130 140 150
NLEALPGPGA PAVMDGKPTC DELDQLIKNM AQGRHVEIFE LLKPPCGGLG
160 170 180 190 200
FSVVGLRSEN RGELGIFVQE IQEGSVAHRD GRLKETDQIL AINGQVLDQT
210 220 230 240 250
ITHQQAISIL QKAKDTVQLV IARGSLPPVS SPRISRSPSA ASTISAHSNP
260 270 280 290 300
MHWQHVETIE LVNDGSGLGF GIIGGKATGV IVKTILPGGV ADQHGRLCSG
310 320 330 340 350
DHILKIGDTD LAGMSSEQVA QVLRQCGNRV KLMIARGAVE ETPASSSLGI
360 370 380 390 400
TLSSSTSSTS EMRVDASTQK NDESETFDVE LTKNVQGLGI TIAGYIGDKK
410 420 430 440 450
LEPSGIFVKS ITKSSAVEHD GRIQIGDQII AVDGTNLQGF TNQQAVEVLR
460 470 480 490 500
HTGQTVRLTL MRKGASQEAE LTSRGDTAKD VDLPAENCEK DEESLSLKRN
510 520 530 540 550
TSILPIEEEG FPLLSAELEE AEDVQQEAAL LTKWQRIMGI NYEIVVAHVS
560 570 580 590 600
KFSENSGLGI SLEATVGHHF IRSVLPEGPV GHSGKLFSGD ELLEVNGINL
610 620 630 640 650
LGENHQDVVN ILKELPIDVT MVCCRRTVPP IALSEMDSLD INDLELTEKP
660 670 680 690 700
HIDLGEFIGS SETEDPMLAM SDVDQNAEEI QTPLAMWEAG GQSIELEKGS
710 720 730 740 750
RGLGFSILDY QDPIDPANTV IVIRSLVPGG IAEKDGRLFP GDRLMFVNDI
760 770 780 790 800
NLENSTLEEA VEALKGAPSG MVRIGVAKPL PLSPEEGYVS AKEDAFLCSP
810 820 830 840 850
HACKESGLSD KALFRADLAL IDTPDAESIA ESRFESQFSP DNDSVYSTQA
860 870 880 890 900
SIFSLHDGTC SDGMNYGPSL PSSPPKDVTS SSEVVLGLHL SLEELYTQNL
910 920 930 940 950
LQRQHAGSPP TDMRPAPTSG FPISDYTTTN AVEQKYECAN PVAWPHSQLP
960 970 980 990 1000
SSLSTSELAP ALPAVAQKYL TDQSSLASDA ESVNLQSMSQ EAFERTVTIA
1010 1020 1030 1040 1050
KGSSSLGMTV SANKDGLGVI VRSIIHGGAI SRDGRIAVGD CILSINEEST
1060 1070 1080 1090 1100
ISLTNAQARA MLRRHSLIGP DIKITYVPAE HLEEFRVSFG QQAGGIMALD
1110 1120 1130 1140 1150
IFSSYTGRDI PELPEREEGE GEESELQNAA YSSWSQPRRV ELWREPSKSL
1160 1170 1180 1190 1200
GISIVGGRGM GSRLSNGEVM RGIFIKHVLE DSPAGKNGTL KPGDRIIEVD
1210 1220 1230 1240 1250
GMDLRDASHE QAVEAIRKAG NPVVFMVQSI INRPRKSPLP SLPHSLYPKY
1260 1270 1280 1290 1300
SFSSTNPFAD SLQLTTDQAP SQSESETEKP ALCNVPPSSP SVFSEMGSDC
1310 1320 1330 1340 1350
AQPSATAVSE DEDKEDEFGY SWKNIQERYG SLTGQLHVIE LEKGQSGLGL
1360 1370 1380 1390 1400
SLAGNKDRTR MSVFIVGIDP TGAAGRDGRL QIADELLEIN GQILYGRSHQ
1410 1420 1430 1440 1450
NASSIIKCAP SKVKIIFIRN ADAVNQMAVC PGIAADSPSS TSDSPQNKEV
1460 1470 1480 1490 1500
EPCSTTSASA ADLSSLTDVY QLELPKDQGG LGIAICEEDT INGVMIESLT
1510 1520 1530 1540 1550
EHGGAAKDGR LKPGDHILAV DDEVVAGCPV EKFISLLKTA KATVKLTVRA
1560 1570 1580 1590 1600
ENPACPAVPS SAVTVSGERK DNSQTPAVPA PDLEPIPSTS RSSTPAVFAS
1610 1620 1630 1640 1650
DPATCPIIPG CETTIEISKG QTGLGLSIVG GSDTLLGAII IHEVYEEGAA
1660 1670 1680 1690 1700
CKDGRLWAGD QILEVNGIDL RKATHDEAIN VLRQTPQRVR LTLYRDEAPY
1710 1720 1730 1740 1750
KEEDVCDTFT IELQKRPGKG LGLSIVGKRN DTGVFVSDIV KGGIADADGR
1760 1770 1780 1790 1800
LMQGDQILMV NGEDVRHATQ EAVAALLKCS LGAVTLEVGR VKAAPFHSER
1810 1820 1830 1840 1850
RPSQSSQVSE SSLSSFTPPL SGINTSESLE SNSKKNALAS EIQGLRTVEI
1860 1870 1880 1890 1900
KKGPADSLGL SIAGGVGSPL GDVPIFIAMM HPNGVAAQTQ KLRVGDRIVT
1910 1920 1930 1940 1950
ICGTSTDGMT HTQAVNLMKN ASGSIEVQVV AGGDVSVVTG HQQELANPCL
1960 1970 1980 1990 2000
AFTGLTSSSI FPDDLGPPQS KTITLDRGPD GLGFSIVGGY GSPHGDLPIY
2010 2020 2030 2040 2050
VKTVFAKGAA AEDGRLKRGD QIIAVNGQSL EGVTHEEAVA ILKRTKGTVT

LMVLS
Length:2,055
Mass (Da):218,711
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26EA94B814214B69
GO
Isoform 2 (identifier: Q8VBX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1236-1268: Missing.

Show »
Length:2,022
Mass (Da):215,061
Checksum:i1B5D7BF3FFA7B4BA
GO
Isoform 3 (identifier: Q8VBX6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1908: Missing.

Show »
Length:147
Mass (Da):15,200
Checksum:i46AF48BDA58C874E
GO
Isoform 4 (identifier: Q8VBX6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1714-1714: Q → QLQ

Show »
Length:2,057
Mass (Da):218,953
Checksum:i7861BBC636A9C862
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RQR2B2RQR2_MOUSE
Mpdz protein
Mpdz
2,069Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YUX2D3YUX2_MOUSE
Multiple PDZ domain protein
Mpdz
2,056Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KG84A3KG84_MOUSE
Multiple PDZ domain protein
Mpdz
495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KG83A3KG83_MOUSE
Multiple PDZ domain protein
Mpdz
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7D0H8F7D0H8_MOUSE
Multiple PDZ domain protein
Mpdz
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I7HJS5I7HJS5_MOUSE
Multiple PDZ domain protein
Mpdz
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KG82A3KG82_MOUSE
Multiple PDZ domain protein
Mpdz
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC27346 differs from that shown. Reason: Frameshift.Curated
The sequence BAC34766 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti583S → N in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti588S → N in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti871P → S in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti909 – 910PP → SS in CAA10523 (PubMed:10395806).Curated2
Sequence conflicti914 – 919RPAPTS → KPTPTF in CAA10523 (PubMed:10395806).Curated6
Sequence conflicti932V → G in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti937 – 938EC → QW in CAA10523 (PubMed:10395806).Curated2
Sequence conflicti952S → N in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti956S → F in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti960P → S in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti963P → A in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti967Q → P in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti974 – 975SS → TF in CAA10523 (PubMed:10395806).Curated2
Sequence conflicti984N → T in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti996T → P in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti1532K → N in AAB57835 (PubMed:9192623).Curated1
Sequence conflicti1547T → I in AAB57835 (PubMed:9192623).Curated1
Sequence conflicti1589T → P in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti1616 – 1617EI → GV in AAB57835 (PubMed:9192623).Curated2
Sequence conflicti1691L → V in AAB57835 (PubMed:9192623).Curated1
Sequence conflicti1844G → R in AAB57835 (PubMed:9192623).Curated1
Sequence conflicti1914A → V in AAH61504 (PubMed:15489334).Curated1
Sequence conflicti1968P → S in CAA10523 (PubMed:10395806).Curated1
Sequence conflicti1983 – 1985GFS → SFN in CAA10523 (PubMed:10395806).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti541N → S in strain: DBA/2J and DBA1/J. 1 Publication1
Natural varianti691G → V in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti801H → R in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti859T → A in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti880S → N in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti914R → S in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti977A → V in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti1338V → M in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti1433I → N in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1
Natural varianti1767H → N in strain: DBA/2J, DBA1/J, CE/J, A/HeJ, BALB/cJ, C57Br/cdJ, C57L/J, WSP2 and 129/J. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0587711 – 1908Missing in isoform 3. 1 PublicationAdd BLAST1908
Alternative sequenceiVSP_0142011236 – 1268Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0142021714Q → QLQ in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ131869 mRNA Translation: CAA10523.1
AF326526 mRNA Translation: AAL37372.1
AF326527 mRNA Translation: AAL37373.1
AF326528 mRNA Translation: AAL37374.1
AF326529 mRNA Translation: AAL37375.1
AF326530 mRNA Translation: AAL37376.1
AF326531 mRNA Translation: AAL37377.2
AF326532 mRNA Translation: AAL37378.1
AF326533 mRNA Translation: AAL37379.1
AF326534 mRNA Translation: AAL37380.1
AF326535 mRNA Translation: AAL37381.1
AF326536 mRNA Translation: AAL37382.1
AF326537 mRNA Translation: AAL37383.1
AF326538 mRNA Translation: AAL37384.1
AF326539 mRNA Translation: AAL37385.1
AF326540 mRNA Translation: AAL37386.1
AF326541 mRNA Translation: AAL37387.1
AF326542 mRNA Translation: AAL37388.1
AF326543 mRNA Translation: AAL37389.1
AF326544 mRNA Translation: AAL37390.1
AL670939 Genomic DNA No translation available.
CR352325 Genomic DNA No translation available.
BC061504 mRNA Translation: AAH61504.1
BC145117 mRNA Translation: AAI45118.1
AF000168 mRNA Translation: AAB57835.1
AK031321 mRNA Translation: BAC27346.1 Frameshift.
AK051782 mRNA Translation: BAC34766.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18292.1 [Q8VBX6-1]
CCDS89767.1 [Q8VBX6-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T30259

NCBI Reference Sequences

More...
RefSeqi
NP_001292213.1, NM_001305284.1
NP_001292215.1, NM_001305286.1 [Q8VBX6-2]
NP_034950.2, NM_010820.3 [Q8VBX6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000102830; ENSMUSP00000099894; ENSMUSG00000028402 [Q8VBX6-1]
ENSMUST00000107258; ENSMUSP00000102879; ENSMUSG00000028402 [Q8VBX6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
17475

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17475

UCSC genome browser

More...
UCSCi
uc008tjw.3, mouse [Q8VBX6-2]
uc008tjx.2, mouse [Q8VBX6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131869 mRNA Translation: CAA10523.1
AF326526 mRNA Translation: AAL37372.1
AF326527 mRNA Translation: AAL37373.1
AF326528 mRNA Translation: AAL37374.1
AF326529 mRNA Translation: AAL37375.1
AF326530 mRNA Translation: AAL37376.1
AF326531 mRNA Translation: AAL37377.2
AF326532 mRNA Translation: AAL37378.1
AF326533 mRNA Translation: AAL37379.1
AF326534 mRNA Translation: AAL37380.1
AF326535 mRNA Translation: AAL37381.1
AF326536 mRNA Translation: AAL37382.1
AF326537 mRNA Translation: AAL37383.1
AF326538 mRNA Translation: AAL37384.1
AF326539 mRNA Translation: AAL37385.1
AF326540 mRNA Translation: AAL37386.1
AF326541 mRNA Translation: AAL37387.1
AF326542 mRNA Translation: AAL37388.1
AF326543 mRNA Translation: AAL37389.1
AF326544 mRNA Translation: AAL37390.1
AL670939 Genomic DNA No translation available.
CR352325 Genomic DNA No translation available.
BC061504 mRNA Translation: AAH61504.1
BC145117 mRNA Translation: AAI45118.1
AF000168 mRNA Translation: AAB57835.1
AK031321 mRNA Translation: BAC27346.1 Frameshift.
AK051782 mRNA Translation: BAC34766.1 Sequence problems.
CCDSiCCDS18292.1 [Q8VBX6-1]
CCDS89767.1 [Q8VBX6-2]
PIRiT30259
RefSeqiNP_001292213.1, NM_001305284.1
NP_001292215.1, NM_001305286.1 [Q8VBX6-2]
NP_034950.2, NM_010820.3 [Q8VBX6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XH7X-ray1.65A521-665[»]
SMRiQ8VBX6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi201476, 15 interactors
CORUMiQ8VBX6
DIPiDIP-41165N
IntActiQ8VBX6, 10 interactors
MINTiQ8VBX6
STRINGi10090.ENSMUSP00000099894

Chemistry databases

ChEMBLiCHEMBL2176783

PTM databases

iPTMnetiQ8VBX6
PhosphoSitePlusiQ8VBX6

Proteomic databases

EPDiQ8VBX6
jPOSTiQ8VBX6
PaxDbiQ8VBX6
PRIDEiQ8VBX6
ProteomicsDBi252603 [Q8VBX6-1]
252604 [Q8VBX6-2]
252605 [Q8VBX6-3]
252606 [Q8VBX6-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4615, 82 antibodies

Genome annotation databases

EnsembliENSMUST00000102830; ENSMUSP00000099894; ENSMUSG00000028402 [Q8VBX6-1]
ENSMUST00000107258; ENSMUSP00000102879; ENSMUSG00000028402 [Q8VBX6-2]
GeneIDi17475
KEGGimmu:17475
UCSCiuc008tjw.3, mouse [Q8VBX6-2]
uc008tjx.2, mouse [Q8VBX6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8777
MGIiMGI:1343489, Mpdz

Phylogenomic databases

eggNOGiKOG3528, Eukaryota
GeneTreeiENSGT00940000155586
HOGENOMiCLU_002378_0_0_1
InParanoidiQ8VBX6
OMAiGTPHING
OrthoDBi1419918at2759
TreeFamiTF330709

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
17475, 0 hits in 47 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mpdz, mouse

Protein Ontology

More...
PROi
PR:Q8VBX6
RNActiQ8VBX6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028402, Expressed in sciatic nerve and 306 other tissues
ExpressionAtlasiQ8VBX6, baseline and differential
GenevisibleiQ8VBX6, MM

Family and domain databases

Gene3Di2.30.42.10, 13 hits
InterProiView protein in InterPro
IPR015132, L27_2
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR032078, MPDZ
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF09045, L27_2, 1 hit
PF16667, MPDZ_u10, 1 hit
PF00595, PDZ, 13 hits
SMARTiView protein in SMART
SM00569, L27, 1 hit
SM00228, PDZ, 13 hits
SUPFAMiSSF101288, SSF101288, 1 hit
SSF50156, SSF50156, 13 hits
PROSITEiView protein in PROSITE
PS51022, L27, 1 hit
PS50106, PDZ, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPDZ_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VBX6
Secondary accession number(s): B7ZNA1
, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: April 7, 2021
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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