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Protein

C-type lectin domain family 4 member K

Gene

Cd207

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.2 Publications

GO - Molecular functioni

  • carbohydrate binding Source: MGI

GO - Biological processi

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)

Protein family/group databases

UniLectiniQ8VBX4

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member K
Alternative name(s):
Langerin
CD_antigen: CD207
Gene namesi
Name:Cd207
Synonyms:Clec4k
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2180021 Cd207

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini63 – 331ExtracellularSequence analysisAdd BLAST269

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236941 – 331C-type lectin domain family 4 member KAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi226 ↔ 322PROSITE-ProRule annotation
Disulfide bondi298 ↔ 314PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8VBX4
PaxDbiQ8VBX4
PRIDEiQ8VBX4

PTM databases

iPTMnetiQ8VBX4
PhosphoSitePlusiQ8VBX4

Expressioni

Tissue specificityi

Expressed by Langerhans cells. Expressed in dendritic cells and by scattered cells in lymph nodes and spleen. Also detected in some non-lymphoid tissues such as lung, liver and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000034783 Expressed in 23 organ(s), highest expression level in lymph node
CleanExiMM_CD207
GenevisibleiQ8VBX4 MM

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040746

Structurei

Secondary structure

1331
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8VBX4
SMRiQ8VBX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 323C-type lectinPROSITE-ProRule annotationAdd BLAST119

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili106 – 197Sequence analysisAdd BLAST92

Domaini

The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.By similarity

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00930000150891
HOGENOMiHOG000064516
HOVERGENiHBG073250
InParanoidiQ8VBX4
KOiK06561
OMAiTWYSAEQ
OrthoDBiEOG091G0GQS
PhylomeDBiQ8VBX4
TreeFamiTF333341

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VBX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEAEMKEEA PEAHFTVDKQ NISLWPREPP PKQDLSPVLR KPLCICVAFT
60 70 80 90 100
CLALVLVTSI VLQAVFYPRL MGKILDVKSD AQMLKGRVDN ISTLGSDLKT
110 120 130 140 150
ERGRVDDAEV QMQIVNTTLK RVRSQILSLE TSMKIANDQL QILTMSWGEV
160 170 180 190 200
DSLSAKIPEL KRDLDKASAL NTKVQGLQNS LENVNKLLKQ QSDILEMVAR
210 220 230 240 250
GWKYFSGNFY YFSRTPKTWY SAEQFCISRK AHLTSVSSES EQKFLYKAAD
260 270 280 290 300
GIPHWIGLTK AGSEGDWYWV DQTSFNKEQS RRFWIPGEPN NAGNNEHCAN
310 320 330
IRVSALKCWN DGPCDNTFLF ICKRPYVQTT E
Length:331
Mass (Da):37,621
Last modified:March 1, 2002 - v1
Checksum:i3DFCFDB322CAB7E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105V → A in AAL83701 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302711 mRNA Translation: CAC82936.1
AY026050 mRNA Translation: AAK01952.1
AY078415 mRNA Translation: AAL83701.1
AK142731 mRNA Translation: BAE25177.1
CCDSiCCDS39534.1
RefSeqiNP_659192.2, NM_144943.3
UniGeneiMm.136079

Genome annotation databases

EnsembliENSMUST00000037882; ENSMUSP00000040746; ENSMUSG00000034783
GeneIDi246278
KEGGimmu:246278
UCSCiuc009cnw.2 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Langerin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302711 mRNA Translation: CAC82936.1
AY026050 mRNA Translation: AAK01952.1
AY078415 mRNA Translation: AAL83701.1
AK142731 mRNA Translation: BAE25177.1
CCDSiCCDS39534.1
RefSeqiNP_659192.2, NM_144943.3
UniGeneiMm.136079

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5K8YX-ray2.40A/B194-331[»]
5M62X-ray1.70A/B194-331[»]
ProteinModelPortaliQ8VBX4
SMRiQ8VBX4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040746

Protein family/group databases

UniLectiniQ8VBX4

PTM databases

iPTMnetiQ8VBX4
PhosphoSitePlusiQ8VBX4

Proteomic databases

MaxQBiQ8VBX4
PaxDbiQ8VBX4
PRIDEiQ8VBX4

Protocols and materials databases

DNASUi246278
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037882; ENSMUSP00000040746; ENSMUSG00000034783
GeneIDi246278
KEGGimmu:246278
UCSCiuc009cnw.2 mouse

Organism-specific databases

CTDi50489
MGIiMGI:2180021 Cd207

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00930000150891
HOGENOMiHOG000064516
HOVERGENiHBG073250
InParanoidiQ8VBX4
KOiK06561
OMAiTWYSAEQ
OrthoDBiEOG091G0GQS
PhylomeDBiQ8VBX4
TreeFamiTF333341

Enzyme and pathway databases

ReactomeiR-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)

Miscellaneous databases

PROiPR:Q8VBX4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034783 Expressed in 23 organ(s), highest expression level in lymph node
CleanExiMM_CD207
GenevisibleiQ8VBX4 MM

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLC4K_MOUSE
AccessioniPrimary (citable) accession number: Q8VBX4
Secondary accession number(s): Q8R442
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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