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Protein

Ankyrin repeat and SOCS box protein 13

Gene

Asb13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 13
Short name:
ASB-13
Gene namesi
Name:Asb13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145525 Asb13

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669501 – 278Ankyrin repeat and SOCS box protein 13Add BLAST278

Proteomic databases

MaxQBiQ8VBX0
PaxDbiQ8VBX0
PRIDEiQ8VBX0

Expressioni

Gene expression databases

BgeeiENSMUSG00000033781 Expressed in 265 organ(s), highest expression level in cerebellar nuclear complex
CleanExiMM_ASB13
GenevisibleiQ8VBX0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046476

Structurei

3D structure databases

ProteinModelPortaliQ8VBX0
SMRiQ8VBX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 47ANK 1Add BLAST30
Repeati51 – 80ANK 2Add BLAST30
Repeati84 – 113ANK 3Add BLAST30
Repeati116 – 145ANK 4Add BLAST30
Repeati149 – 178ANK 5Add BLAST30
Repeati181 – 210ANK 6Add BLAST30
Domaini229 – 278SOCS boxPROSITE-ProRule annotationAdd BLAST50

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150865
HOGENOMiHOG000231513
HOVERGENiHBG001376
InParanoidiQ8VBX0
KOiK10335
OMAiMEAHDCH
OrthoDBiEOG091G0DYR
PhylomeDBiQ8VBX0
TreeFamiTF331945

Family and domain databases

CDDicd00204 ANK, 2 hits
cd03729 SOCS_ASB13, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037334 ASB13_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VBX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPRAGDGCF LGDVGFWVER TPVHEAAQRG ESLQLQQLID SGACVNQVTV
60 70 80 90 100
DSITPLHAAS LQGQAQCVQL LLAAGAQVDA RNIDGSTPLC DACASGSIEC
110 120 130 140 150
VKLLLSYGAK VNPPLYTASP LHEACMSGSS ECVRLLIDVG ANLEAHDCHF
160 170 180 190 200
GTPLHVACAR EHLDCVKVLL NAGANVNAAK LHETALHHAA KVKNVDLIEM
210 220 230 240 250
LIEFGGNIYA RDNRGKKPSD YTWSSSAPAK CFEYYEKTPL SLSQLCRVSL
260 270
RKATGVRGLE KVAKLNIPPR LIDYLSYN
Length:278
Mass (Da):29,896
Last modified:March 1, 2002 - v1
Checksum:i4E59E6C12ED2E094
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403041 mRNA Translation: AAL57360.1
AK078289 mRNA Translation: BAC37207.1
BC018240 mRNA Translation: AAH18240.1
CCDSiCCDS36582.1
RefSeqiNP_840068.1, NM_178283.4
UniGeneiMm.253061

Genome annotation databases

EnsembliENSMUST00000042288; ENSMUSP00000046476; ENSMUSG00000033781
GeneIDi142688
KEGGimmu:142688
UCSCiuc007piz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403041 mRNA Translation: AAL57360.1
AK078289 mRNA Translation: BAC37207.1
BC018240 mRNA Translation: AAH18240.1
CCDSiCCDS36582.1
RefSeqiNP_840068.1, NM_178283.4
UniGeneiMm.253061

3D structure databases

ProteinModelPortaliQ8VBX0
SMRiQ8VBX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046476

Proteomic databases

MaxQBiQ8VBX0
PaxDbiQ8VBX0
PRIDEiQ8VBX0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042288; ENSMUSP00000046476; ENSMUSG00000033781
GeneIDi142688
KEGGimmu:142688
UCSCiuc007piz.2 mouse

Organism-specific databases

CTDi79754
MGIiMGI:2145525 Asb13

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150865
HOGENOMiHOG000231513
HOVERGENiHBG001376
InParanoidiQ8VBX0
KOiK10335
OMAiMEAHDCH
OrthoDBiEOG091G0DYR
PhylomeDBiQ8VBX0
TreeFamiTF331945

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q8VBX0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033781 Expressed in 265 organ(s), highest expression level in cerebellar nuclear complex
CleanExiMM_ASB13
GenevisibleiQ8VBX0 MM

Family and domain databases

CDDicd00204 ANK, 2 hits
cd03729 SOCS_ASB13, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037334 ASB13_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS50225 SOCS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASB13_MOUSE
AccessioniPrimary (citable) accession number: Q8VBX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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