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UniProtKB - Q8VBW1 (SC6A8_MOUSE)

Entry version 139 (23 Feb 2022)
Sequence version 1 (01 Mar 2002)
Previous versions | rss
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Protein

Sodium- and chloride-dependent creatine transporter 1

Gene

Slc6a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-71288, Creatine metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium- and chloride-dependent creatine transporter 1
Short name:
CT1
Short name:
Creatine transporter 1
Alternative name(s):
Solute carrier family 6 member 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc6a8
Synonyms:Crt
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2147834, Slc6a8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000019558

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 60CytoplasmicSequence analysisAdd BLAST60
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 87ExtracellularSequence analysis6
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 138CytoplasmicSequence analysisAdd BLAST30
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 230ExtracellularSequence analysisAdd BLAST71
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 269CytoplasmicSequence analysisAdd BLAST18
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Topological domaini291 – 304ExtracellularSequence analysisAdd BLAST14
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 341CytoplasmicSequence analysisAdd BLAST16
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 394ExtracellularSequence analysisAdd BLAST32
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 444CytoplasmicSequence analysisAdd BLAST29
Transmembranei445 – 470HelicalSequence analysisAdd BLAST26
Topological domaini471 – 484ExtracellularSequence analysisAdd BLAST14
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 525CytoplasmicSequence analysisAdd BLAST20
Transmembranei526 – 546HelicalSequence analysisAdd BLAST21
Topological domaini547 – 565ExtracellularSequence analysisAdd BLAST19
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 640CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002147751 – 640Sodium- and chloride-dependent creatine transporter 1Add BLAST640

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi553N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei622PhosphothreonineBy similarity1
Modified residuei625PhosphothreonineCombined sources1
Modified residuei628PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8VBW1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8VBW1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8VBW1

PRoteomics IDEntifications database

More...PRIDEi		Q8VBW1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		255475 [Q8VBW1-1]
255476 [Q8VBW1-2]
255477 [Q8VBW1-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8VBW1, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8VBW1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8VBW1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000019558, Expressed in adult mammalian kidney and 327 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8VBW1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8VBW1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		221964, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q8VBW1, 6 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000033752

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8VBW1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8VBW1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3660, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155869

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8VBW1

Identification of Orthologs from Complete Genome Data

More...OMAi		MLCLMAV

Database of Orthologous Groups

More...OrthoDBi		250396at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8VBW1

TreeFam database of animal gene trees

More...TreeFami		TF343812

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000175, Na/ntran_symport
IPR002984, Na/ntran_symport_creatine
IPR037272, SNS_sf

The PANTHER Classification System

More...PANTHERi		PTHR11616, PTHR11616, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00209, SNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01199, CRTTRANSPORT
PR00176, NANEUSMPORT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF161070, SSF161070, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00610, NA_NEUROTRAN_SYMP_1, 1 hit
PS00754, NA_NEUROTRAN_SYMP_2, 1 hit
PS50267, NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8VBW1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKKSAENGI YSVSGDEKKG PLIVSGPDGA PAKGDGPAGL GAPGGRLAVP 
        60         70         80         90        100
PRETWTRQMD FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV 
       110        120        130        140        150
GGIPIFFLEI SLGQFMKAGS INVWNICPLF KGLGYASMVI VFYCNTYYIM 
       160        170        180        190        200
VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD CVEIFRHEDC ANASLANLTC 
       210        220        230        240        250
DQLADRRSPV IEFWENKVLR LSTGLEVPGA LNWEVTLCLL ACWVLVYFCV 
       260        270        280        290        300
WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL 
       310        320        330        340        350
GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG 
       360        370        380        390        400
TSFFAGFVVF SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP 
       410        420        430        440        450
LWAALFFFML LLLGLDSQFV GVEGFITGLL DLLPASYYFR FQREISVALC 
       460        470        480        490        500
CALCFVIDLS MVTDVSGGKG GMYVFQLFDY YSASGTTLLW QAFWECVVVA 
       510        520        530        540        550
WVYGADRFMD DIACMIGYRP CPWMKWCWSF FTPLVCMGIF IFNIVYYEPL 
       560        570        580        590        600
VYNNTYVYPW WGEAMGWAFA LSSMLCVPLH LLGCLLRAKG TMAERWQHLT 
       610        620        630        640
QPIWGLHHLE YRAQDADVRG LTTLTPVSES SKVVVVESVM
Length:640
Mass (Da):70,999
Last modified:March 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67D3AAAC591EEA0B
GO
Isoform 2 (identifier: Q8VBW1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-469: Missing.

Show »
Length:635
Mass (Da):70,571
Checksum:iFE76B1A95D2F2149
GO
Isoform 3 (identifier: Q8VBW1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-469: Missing.

Show »
Length:632
Mass (Da):70,255
Checksum:i7369D703B507FF24
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6T2E9Q6T2_MOUSE
Sodium- and chloride-dependent crea...
Slc6a8
107Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q151E9Q151_MOUSE
Transporter
Slc6a8
625Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UKB4F6UKB4_MOUSE
Transporter
Slc6a8
576Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7C668F7C668_MOUSE
Sodium- and chloride-dependent crea...
Slc6a8
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012132462 – 469Missing in isoform 3. 1 Publication8
Alternative sequenceiVSP_012133465 – 469Missing in isoform 2. 2 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB077327 mRNA Translation: BAC11857.1
AF459435 mRNA Translation: AAL66354.1
AF459436 Genomic DNA Translation: AAL66355.1
AL805924 Genomic DNA No translation available.
BC024444 mRNA Translation: AAH24444.1
BC049801 mRNA Translation: AAH49801.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30208.1 [Q8VBW1-1]
CCDS53098.1 [Q8VBW1-2]

NCBI Reference Sequences

More...RefSeqi		NP_001136281.1, NM_001142809.1 [Q8VBW1-2]
NP_001136282.1, NM_001142810.1 [Q8VBW1-3]
NP_598748.1, NM_133987.2 [Q8VBW1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000033752; ENSMUSP00000033752; ENSMUSG00000019558 [Q8VBW1-1]
ENSMUST00000114465; ENSMUSP00000110109; ENSMUSG00000019558 [Q8VBW1-2]
ENSMUST00000114467; ENSMUSP00000110111; ENSMUSG00000019558 [Q8VBW1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		102857

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:102857

UCSC genome browser

More...UCSCi		uc009tmf.2, mouse [Q8VBW1-1]
uc009tmg.2, mouse [Q8VBW1-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077327 mRNA Translation: BAC11857.1
AF459435 mRNA Translation: AAL66354.1
AF459436 Genomic DNA Translation: AAL66355.1
AL805924 Genomic DNA No translation available.
BC024444 mRNA Translation: AAH24444.1
BC049801 mRNA Translation: AAH49801.1
CCDSiCCDS30208.1 [Q8VBW1-1]
CCDS53098.1 [Q8VBW1-2]
RefSeqiNP_001136281.1, NM_001142809.1 [Q8VBW1-2]
NP_001136282.1, NM_001142810.1 [Q8VBW1-3]
NP_598748.1, NM_133987.2 [Q8VBW1-1]

3D structure databases

SMRiQ8VBW1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi221964, 6 interactors
IntActiQ8VBW1, 6 interactors
STRINGi10090.ENSMUSP00000033752

PTM databases

GlyGeniQ8VBW1, 3 sites
iPTMnetiQ8VBW1
PhosphoSitePlusiQ8VBW1

Proteomic databases

jPOSTiQ8VBW1
MaxQBiQ8VBW1
PaxDbiQ8VBW1
PRIDEiQ8VBW1
ProteomicsDBi255475 [Q8VBW1-1]
255476 [Q8VBW1-2]
255477 [Q8VBW1-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		102857

Genome annotation databases

EnsembliENSMUST00000033752; ENSMUSP00000033752; ENSMUSG00000019558 [Q8VBW1-1]
ENSMUST00000114465; ENSMUSP00000110109; ENSMUSG00000019558 [Q8VBW1-2]
ENSMUST00000114467; ENSMUSP00000110111; ENSMUSG00000019558 [Q8VBW1-2]
GeneIDi102857
KEGGimmu:102857
UCSCiuc009tmf.2, mouse [Q8VBW1-1]
uc009tmg.2, mouse [Q8VBW1-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6535
MGIiMGI:2147834, Slc6a8
VEuPathDBiHostDB:ENSMUSG00000019558

Phylogenomic databases

eggNOGiKOG3660, Eukaryota
GeneTreeiENSGT00940000155869
InParanoidiQ8VBW1
OMAiMLCLMAV
OrthoDBi250396at2759
PhylomeDBiQ8VBW1
TreeFamiTF343812

Enzyme and pathway databases

ReactomeiR-MMU-71288, Creatine metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		102857, 0 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Slc6a8, mouse

Protein Ontology

More...PROi		PR:Q8VBW1
RNActiQ8VBW1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000019558, Expressed in adult mammalian kidney and 327 other tissues
ExpressionAtlasiQ8VBW1, baseline and differential
GenevisibleiQ8VBW1, MM

Family and domain databases

InterProiView protein in InterPro
IPR000175, Na/ntran_symport
IPR002984, Na/ntran_symport_creatine
IPR037272, SNS_sf
PANTHERiPTHR11616, PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209, SNF, 1 hit
PRINTSiPR01199, CRTTRANSPORT
PR00176, NANEUSMPORT
SUPFAMiSSF161070, SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610, NA_NEUROTRAN_SYMP_1, 1 hit
PS00754, NA_NEUROTRAN_SYMP_2, 1 hit
PS50267, NA_NEUROTRAN_SYMP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC6A8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8VBW1
Secondary accession number(s): A2ALM4
, Q80YC9, Q8K4R3, Q8R1L0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: March 1, 2002
Last modified: February 23, 2022
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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