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UniProtKB - Q8VBW1 (SC6A8_MOUSE)
Protein
Sodium- and chloride-dependent creatine transporter 1
Gene
Slc6a8
Organism
Mus musculus (Mouse)
Status
Functioni
Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.
GO - Molecular functioni
- choline transmembrane transporter activity Source: MGI
- creatine:sodium symporter activity Source: MGI
- creatine transmembrane transporter activity Source: MGI
GO - Biological processi
- creatine transmembrane transport Source: UniProtKB
- embryonic brain development Source: Ensembl
- neurotransmitter transport Source: InterPro
- nitrogen compound transport Source: MGI
- sodium ion transmembrane transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-MMU-71288, Creatine metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium- and chloride-dependent creatine transporter 1Short name: CT1 Short name: Creatine transporter 1 Alternative name(s): Solute carrier family 6 member 8 |
Gene namesi | Name:Slc6a8 Synonyms:Crt |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2147834, Slc6a8 |
VEuPathDBi | HostDB:ENSMUSG00000019558 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic membrane Source: MGI
Other locations
- glutamatergic synapse Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 60 | CytoplasmicSequence analysisAdd BLAST | 60 | |
Transmembranei | 61 – 81 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 82 – 87 | ExtracellularSequence analysis | 6 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 109 – 138 | CytoplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 139 – 159 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 160 – 230 | ExtracellularSequence analysisAdd BLAST | 71 | |
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 252 – 269 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 270 – 290 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 291 – 304 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 305 – 325 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 326 – 341 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 342 – 362 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 363 – 394 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 395 – 415 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 416 – 444 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 445 – 470 | HelicalSequence analysisAdd BLAST | 26 | |
Topological domaini | 471 – 484 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 485 – 505 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 506 – 525 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 526 – 546 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 547 – 565 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 566 – 586 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 587 – 640 | CytoplasmicSequence analysisAdd BLAST | 54 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000214775 | 1 – 640 | Sodium- and chloride-dependent creatine transporter 1Add BLAST | 640 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 197 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 553 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 622 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 625 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 628 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q8VBW1 |
MaxQBi | Q8VBW1 |
PaxDbi | Q8VBW1 |
PRIDEi | Q8VBW1 |
ProteomicsDBi | 255475 [Q8VBW1-1] 255476 [Q8VBW1-2] 255477 [Q8VBW1-3] |
PTM databases
GlyGeni | Q8VBW1, 3 sites |
iPTMneti | Q8VBW1 |
PhosphoSitePlusi | Q8VBW1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000019558, Expressed in adult mammalian kidney and 327 other tissues |
ExpressionAtlasi | Q8VBW1, baseline and differential |
Genevisiblei | Q8VBW1, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 221964, 6 interactors |
IntActi | Q8VBW1, 6 interactors |
STRINGi | 10090.ENSMUSP00000033752 |
Miscellaneous databases
RNActi | Q8VBW1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | DisorderedSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3660, Eukaryota |
GeneTreei | ENSGT00940000155869 |
InParanoidi | Q8VBW1 |
OMAi | MLCLMAV |
OrthoDBi | 250396at2759 |
PhylomeDBi | Q8VBW1 |
TreeFami | TF343812 |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR002984, Na/ntran_symport_creatine IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR01199, CRTTRANSPORT PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8VBW1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKKSAENGI YSVSGDEKKG PLIVSGPDGA PAKGDGPAGL GAPGGRLAVP
60 70 80 90 100
PRETWTRQMD FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV
110 120 130 140 150
GGIPIFFLEI SLGQFMKAGS INVWNICPLF KGLGYASMVI VFYCNTYYIM
160 170 180 190 200
VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD CVEIFRHEDC ANASLANLTC
210 220 230 240 250
DQLADRRSPV IEFWENKVLR LSTGLEVPGA LNWEVTLCLL ACWVLVYFCV
260 270 280 290 300
WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL
310 320 330 340 350
GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG
360 370 380 390 400
TSFFAGFVVF SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP
410 420 430 440 450
LWAALFFFML LLLGLDSQFV GVEGFITGLL DLLPASYYFR FQREISVALC
460 470 480 490 500
CALCFVIDLS MVTDVSGGKG GMYVFQLFDY YSASGTTLLW QAFWECVVVA
510 520 530 540 550
WVYGADRFMD DIACMIGYRP CPWMKWCWSF FTPLVCMGIF IFNIVYYEPL
560 570 580 590 600
VYNNTYVYPW WGEAMGWAFA LSSMLCVPLH LLGCLLRAKG TMAERWQHLT
610 620 630 640
QPIWGLHHLE YRAQDADVRG LTTLTPVSES SKVVVVESVM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q6T2 | E9Q6T2_MOUSE | Sodium- and chloride-dependent crea... | Slc6a8 | 107 | Annotation score: | ||
E9Q151 | E9Q151_MOUSE | Transporter | Slc6a8 | 625 | Annotation score: | ||
F6UKB4 | F6UKB4_MOUSE | Transporter | Slc6a8 | 576 | Annotation score: | ||
F7C668 | F7C668_MOUSE | Sodium- and chloride-dependent crea... | Slc6a8 | 19 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012132 | 462 – 469 | Missing in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_012133 | 465 – 469 | Missing in isoform 2. 2 Publications | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB077327 mRNA Translation: BAC11857.1 AF459435 mRNA Translation: AAL66354.1 AF459436 Genomic DNA Translation: AAL66355.1 AL805924 Genomic DNA No translation available. BC024444 mRNA Translation: AAH24444.1 BC049801 mRNA Translation: AAH49801.1 |
CCDSi | CCDS30208.1 [Q8VBW1-1] CCDS53098.1 [Q8VBW1-2] |
RefSeqi | NP_001136281.1, NM_001142809.1 [Q8VBW1-2] NP_001136282.1, NM_001142810.1 [Q8VBW1-3] NP_598748.1, NM_133987.2 [Q8VBW1-1] |
Genome annotation databases
Ensembli | ENSMUST00000033752; ENSMUSP00000033752; ENSMUSG00000019558 [Q8VBW1-1] ENSMUST00000114465; ENSMUSP00000110109; ENSMUSG00000019558 [Q8VBW1-2] ENSMUST00000114467; ENSMUSP00000110111; ENSMUSG00000019558 [Q8VBW1-2] |
GeneIDi | 102857 |
KEGGi | mmu:102857 |
UCSCi | uc009tmf.2, mouse [Q8VBW1-1] uc009tmg.2, mouse [Q8VBW1-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB077327 mRNA Translation: BAC11857.1 AF459435 mRNA Translation: AAL66354.1 AF459436 Genomic DNA Translation: AAL66355.1 AL805924 Genomic DNA No translation available. BC024444 mRNA Translation: AAH24444.1 BC049801 mRNA Translation: AAH49801.1 |
CCDSi | CCDS30208.1 [Q8VBW1-1] CCDS53098.1 [Q8VBW1-2] |
RefSeqi | NP_001136281.1, NM_001142809.1 [Q8VBW1-2] NP_001136282.1, NM_001142810.1 [Q8VBW1-3] NP_598748.1, NM_133987.2 [Q8VBW1-1] |
3D structure databases
SMRi | Q8VBW1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 221964, 6 interactors |
IntActi | Q8VBW1, 6 interactors |
STRINGi | 10090.ENSMUSP00000033752 |
PTM databases
GlyGeni | Q8VBW1, 3 sites |
iPTMneti | Q8VBW1 |
PhosphoSitePlusi | Q8VBW1 |
Proteomic databases
jPOSTi | Q8VBW1 |
MaxQBi | Q8VBW1 |
PaxDbi | Q8VBW1 |
PRIDEi | Q8VBW1 |
ProteomicsDBi | 255475 [Q8VBW1-1] 255476 [Q8VBW1-2] 255477 [Q8VBW1-3] |
Protocols and materials databases
DNASUi | 102857 |
Genome annotation databases
Ensembli | ENSMUST00000033752; ENSMUSP00000033752; ENSMUSG00000019558 [Q8VBW1-1] ENSMUST00000114465; ENSMUSP00000110109; ENSMUSG00000019558 [Q8VBW1-2] ENSMUST00000114467; ENSMUSP00000110111; ENSMUSG00000019558 [Q8VBW1-2] |
GeneIDi | 102857 |
KEGGi | mmu:102857 |
UCSCi | uc009tmf.2, mouse [Q8VBW1-1] uc009tmg.2, mouse [Q8VBW1-3] |
Organism-specific databases
CTDi | 6535 |
MGIi | MGI:2147834, Slc6a8 |
VEuPathDBi | HostDB:ENSMUSG00000019558 |
Phylogenomic databases
eggNOGi | KOG3660, Eukaryota |
GeneTreei | ENSGT00940000155869 |
InParanoidi | Q8VBW1 |
OMAi | MLCLMAV |
OrthoDBi | 250396at2759 |
PhylomeDBi | Q8VBW1 |
TreeFami | TF343812 |
Enzyme and pathway databases
Reactomei | R-MMU-71288, Creatine metabolism |
Miscellaneous databases
BioGRID-ORCSi | 102857, 0 hits in 64 CRISPR screens |
ChiTaRSi | Slc6a8, mouse |
PROi | PR:Q8VBW1 |
RNActi | Q8VBW1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019558, Expressed in adult mammalian kidney and 327 other tissues |
ExpressionAtlasi | Q8VBW1, baseline and differential |
Genevisiblei | Q8VBW1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR002984, Na/ntran_symport_creatine IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR01199, CRTTRANSPORT PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SC6A8_MOUSE | |
Accessioni | Q8VBW1Primary (citable) accession number: Q8VBW1 Secondary accession number(s): A2ALM4 Q8R1L0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | March 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families