Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

COP9 signalosome complex subunit 8

Gene

Cops8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 8
Short name:
SGN8
Short name:
Signalosome subunit 8
Alternative name(s):
COP9 homolog
JAB1-containing signalosome subunit 8
Gene namesi
Name:Cops8
Synonyms:Csn8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915363 Cops8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210081 – 209COP9 signalosome complex subunit 8Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VBV7
MaxQBiQ8VBV7
PaxDbiQ8VBV7
PeptideAtlasiQ8VBV7
PRIDEiQ8VBV7
TopDownProteomicsiQ8VBV7

2D gel databases

REPRODUCTION-2DPAGEiQ8VBV7

PTM databases

iPTMnetiQ8VBV7
PhosphoSitePlusiQ8VBV7

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Expressed in embryonic stem (ES) cells and throughout early embryo development from zygote, preimplantation embryos, to post-implantation embryos. Predominantly expressed in the inner cell mass (ICM) of E3.5 blastocyst and widely expressed in E9.5-day embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000034432 Expressed in 291 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ8VBV7 baseline and differential
GenevisibleiQ8VBV7 MM

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi224368, 10 interactors
CORUMiQ8VBV7
IntActiQ8VBV7, 3 interactors
MINTiQ8VBV7
STRINGi10090.ENSMUSP00000035884

Structurei

3D structure databases

ProteinModelPortaliQ8VBV7
SMRiQ8VBV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 179PCIPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the CSN8 family.Curated

Phylogenomic databases

eggNOGiKOG4414 Eukaryota
ENOG410XW9N LUCA
GeneTreeiENSGT00390000000977
HOGENOMiHOG000253954
HOVERGENiHBG051139
InParanoidiQ8VBV7
KOiK12181
OMAiCETQELE
OrthoDBiEOG091G0O7O
PhylomeDBiQ8VBV7
TreeFamiTF101150

Family and domain databases

InterProiView protein in InterPro
IPR033205 COP9_CSN8
IPR033464 CSN8_PSD8_EIF3K
IPR000717 PCI_dom
PANTHERiPTHR13339 PTHR13339, 1 hit
PfamiView protein in Pfam
PF10075 CSN8_PSD8_EIF3K, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VBV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVAVMADNA FSFRKLLDQC ENQELEAPGG IATPPVYGQL LALYLLQNDM
60 70 80 90 100
NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE
110 120 130 140 150
TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGVLE
160 170 180 190 200
QGWQADSTTR MVLPRKPASG TLDVSLNRFI PLSEPAPVPP IPNEQQLARL

TDYVAFLEN
Length:209
Mass (Da):23,256
Last modified:March 1, 2002 - v1
Checksum:i786226FB7BFAC80E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WPM5A0A087WPM5_MOUSE
COP9 signalosome complex subunit 8
Cops8
80Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193N → M in AAL89689 (PubMed:14636993).Curated1
Sequence conflicti193N → T in AAP13731 (PubMed:14636993).Curated1
Sequence conflicti194 – 195EQ → SR (PubMed:14636993).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF482000 mRNA Translation: AAL89689.1
AF502144 Genomic DNA Translation: AAP13731.1
AK079111 mRNA Translation: BAC37543.1
AK079522 mRNA Translation: BAC37670.1
AK088323 mRNA Translation: BAC40281.1
AK090013 mRNA Translation: BAC41045.1
AK145899 mRNA Translation: BAE26735.1
AK162502 mRNA Translation: BAE36948.1
BC017690 mRNA Translation: AAH17690.1
BC021488 mRNA Translation: AAH21488.1
BC024421 mRNA Translation: AAH24421.1
CCDSiCCDS15153.1
RefSeqiNP_598566.3, NM_133805.3
UniGeneiMm.119177

Genome annotation databases

EnsembliENSMUST00000036153; ENSMUSP00000035884; ENSMUSG00000034432
GeneIDi108679
KEGGimmu:108679
UCSCiuc007bzi.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF482000 mRNA Translation: AAL89689.1
AF502144 Genomic DNA Translation: AAP13731.1
AK079111 mRNA Translation: BAC37543.1
AK079522 mRNA Translation: BAC37670.1
AK088323 mRNA Translation: BAC40281.1
AK090013 mRNA Translation: BAC41045.1
AK145899 mRNA Translation: BAE26735.1
AK162502 mRNA Translation: BAE36948.1
BC017690 mRNA Translation: AAH17690.1
BC021488 mRNA Translation: AAH21488.1
BC024421 mRNA Translation: AAH24421.1
CCDSiCCDS15153.1
RefSeqiNP_598566.3, NM_133805.3
UniGeneiMm.119177

3D structure databases

ProteinModelPortaliQ8VBV7
SMRiQ8VBV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224368, 10 interactors
CORUMiQ8VBV7
IntActiQ8VBV7, 3 interactors
MINTiQ8VBV7
STRINGi10090.ENSMUSP00000035884

PTM databases

iPTMnetiQ8VBV7
PhosphoSitePlusiQ8VBV7

2D gel databases

REPRODUCTION-2DPAGEiQ8VBV7

Proteomic databases

EPDiQ8VBV7
MaxQBiQ8VBV7
PaxDbiQ8VBV7
PeptideAtlasiQ8VBV7
PRIDEiQ8VBV7
TopDownProteomicsiQ8VBV7

Protocols and materials databases

DNASUi108679
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036153; ENSMUSP00000035884; ENSMUSG00000034432
GeneIDi108679
KEGGimmu:108679
UCSCiuc007bzi.1 mouse

Organism-specific databases

CTDi10920
MGIiMGI:1915363 Cops8

Phylogenomic databases

eggNOGiKOG4414 Eukaryota
ENOG410XW9N LUCA
GeneTreeiENSGT00390000000977
HOGENOMiHOG000253954
HOVERGENiHBG051139
InParanoidiQ8VBV7
KOiK12181
OMAiCETQELE
OrthoDBiEOG091G0O7O
PhylomeDBiQ8VBV7
TreeFamiTF101150

Enzyme and pathway databases

ReactomeiR-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Miscellaneous databases

PROiPR:Q8VBV7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034432 Expressed in 291 organ(s), highest expression level in primary oocyte
ExpressionAtlasiQ8VBV7 baseline and differential
GenevisibleiQ8VBV7 MM

Family and domain databases

InterProiView protein in InterPro
IPR033205 COP9_CSN8
IPR033464 CSN8_PSD8_EIF3K
IPR000717 PCI_dom
PANTHERiPTHR13339 PTHR13339, 1 hit
PfamiView protein in Pfam
PF10075 CSN8_PSD8_EIF3K, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSN8_MOUSE
AccessioniPrimary (citable) accession number: Q8VBV7
Secondary accession number(s): Q3TRS9, Q80XF4, Q8R4D2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again