UniProtKB - Q8VBU8 (BANP_MOUSE)
Protein BANP
Banp
Functioni
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest and inhibits tumor growth (PubMed:12494467).
6 PublicationsCaution
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 347 | Required for TP53 activation1 Publication | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- identical protein binding Source: MGI
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- chromatin organization Source: UniProtKB-KW
- negative regulation of protein catabolic process Source: GO_Central
- positive regulation of transcription, DNA-templated Source: CACAO
- protein localization to nucleus Source: GO_Central
Keywordsi
Molecular function | Chromatin regulator, Developmental protein, DNA-binding, Repressor |
Biological process | Cell cycle, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-6804759, Regulation of TP53 Activity through Association with Co-factors |
Names & Taxonomyi
Protein namesi | Recommended name: Protein BANPAlternative name(s): Btg3-associated nuclear protein Scaffold/matrix-associated region-1-binding protein |
Gene namesi | Name:Banp Synonyms:Smar1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1889023, Banp |
VEuPathDBi | HostDB:ENSMUSG00000025316 |
Subcellular locationi
Nucleus
- Nucleus 4 Publications
Nucleus
- nuclear body Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 347 | S → A: Impairs TP53 activation. 1 Publication | 1 | |
Mutagenesisi | 348 | S → A: No effect on TP53 activation. 1 Publication | 1 | |
Mutagenesisi | 349 | S → A: No effect on TP53 activation. 1 Publication | 1 | |
Mutagenesisi | 350 | S → A: No effect on TP53 activation. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297911 | 1 – 548 | Protein BANPAdd BLAST | 548 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | PhosphoserineBy similarity | 1 | |
Modified residuei | 98 | PhosphoserineBy similarity | 1 | |
Modified residuei | 108 | PhosphoserineBy similarity | 1 | |
Cross-linki | 141 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 283 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 347 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8VBU8 |
MaxQBi | Q8VBU8 |
PaxDbi | Q8VBU8 |
PeptideAtlasi | Q8VBU8 |
PRIDEi | Q8VBU8 |
ProteomicsDBi | 273537 [Q8VBU8-1] 273538 [Q8VBU8-2] 273539 [Q8VBU8-3] 273540 [Q8VBU8-4] |
PTM databases
iPTMneti | Q8VBU8 |
PhosphoSitePlusi | Q8VBU8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000025316, Expressed in embryonic post-anal tail and 240 other tissues |
ExpressionAtlasi | Q8VBU8, baseline and differential |
Genevisiblei | Q8VBU8, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 207288, 1 interactor |
IntActi | Q8VBU8, 1 interactor |
STRINGi | 10090.ENSMUSP00000132095 |
Miscellaneous databases
RNActi | Q8VBU8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 234 – 330 | BENPROSITE-ProRule annotationAdd BLAST | 97 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 160 – 350 | Interaction with CUX1 and HDAC12 PublicationsAdd BLAST | 191 | |
Regioni | 174 – 206 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 335 – 368 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 350 – 400 | DNA-bindingAdd BLAST | 51 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 65 – 98 | Sequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 189 – 206 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QRIF, Eukaryota |
GeneTreei | ENSGT00390000011116 |
InParanoidi | Q8VBU8 |
OMAi | VSREHTK |
OrthoDBi | 1401911at2759 |
PhylomeDBi | Q8VBU8 |
TreeFami | TF331908 |
Family and domain databases
InterProi | View protein in InterPro IPR042343, BANP IPR018379, BEN_domain |
PANTHERi | PTHR16243, PTHR16243, 1 hit |
Pfami | View protein in Pfam PF10523, BEN, 1 hit |
SMARTi | View protein in SMART SM01025, BEN, 1 hit |
PROSITEi | View protein in PROSITE PS51457, BEN, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMSEQDLADV VQIAVEDLSP DHPVVLENHV VTDDDEPALK RQRLEINCQD
60 70 80 90 100
PSIKSFLYSI NQTICLRLDS IEAKLQALEA TCKSLEEKLD LVTNKQHSPI
110 120 130 140 150
QVPMVAGSPL GATQTCNKVR CVVPQTTVIL NNDRQNAIVA KMEDPLSNRA
160 170 180 190 200
PDSLENIISN AVPGRRQNTI VVKVPGQDDS HNEDGESGSE ASDSVSNCGQ
210 220 230 240 250
PGSQNIGSNV TLITLNSEED YPNGTWLGDE NNPEMRVRCA IIPSDMLHIS
260 270 280 290 300
TNCRTAEKMA LTLLDYLFHR EVQAVSNLSG QGKHGKKQLD PLTIYGIRCH
310 320 330 340 350
LFYKFGITES DWYRIKQSID SKCRTAWRRK QRGQSLAVKS FSRRTPSSSS
360 370 380 390 400
YSASETMMGT PPPTSELQQS QPQALHYALA NAQQVQIHQI GEDGQVQVIP
410 420 430 440 450
QGHLHIAQVP QGEQVQITQD SEGNLQIHHV GQDGQSWGLC QNPIPVSGDS
460 470 480 490 500
VAQANPSQLW PLGGDTLDLP AGNEMIQVLQ GAQLIAVASS DPAATGVDGS
510 520 530 540
PLQGSDIQVQ YVQLAPVSDH TAAAQTAEAL QPTLQPDMQL EHGAIQIQ
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6V6B6 | F6V6B6_MOUSE | Protein BANP | Banp | 321 | Annotation score: | ||
G3UWM0 | G3UWM0_MOUSE | Protein BANP | Banp | 265 | Annotation score: | ||
G3UWN8 | G3UWN8_MOUSE | Protein BANP | Banp | 179 | Annotation score: | ||
G3UYF0 | G3UYF0_MOUSE | Protein BANP | Banp | 126 | Annotation score: | ||
G3UZ43 | G3UZ43_MOUSE | Protein BANP | Banp | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 131 | N → I in AAG16659 (PubMed:10950932).Curated | 1 | |
Sequence conflicti | 147 | S → I in AAG16659 (PubMed:10950932).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027403 | 122 – 160 | Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 39 | |
Alternative sequenceiVSP_027404 | 399 – 401 | Missing in isoform 3. 2 Publications | 3 | |
Alternative sequenceiVSP_027405 | 435 – 476 | Missing in isoform 4. 1 PublicationAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF091234 mRNA Translation: AAC36358.1 AF235503 mRNA Translation: AAG16659.1 AK154088 mRNA Translation: BAE32366.1 BC013339 mRNA Translation: AAH13339.1 BC021650 mRNA Translation: AAH21650.1 BC022168 mRNA Translation: AAH22168.1 BC062641 mRNA Translation: AAH62641.1 |
CCDSi | CCDS40502.1 [Q8VBU8-1] CCDS72176.1 [Q8VBU8-2] CCDS72177.1 [Q8VBU8-3] |
RefSeqi | NP_001103570.1, NM_001110100.2 NP_001272910.1, NM_001285981.1 [Q8VBU8-2] NP_001272912.1, NM_001285983.1 [Q8VBU8-3] NP_058092.2, NM_016812.4 [Q8VBU8-1] XP_011246744.1, XM_011248442.1 [Q8VBU8-4] XP_017168388.1, XM_017312899.1 [Q8VBU8-1] |
Genome annotation databases
Ensembli | ENSMUST00000026354; ENSMUSP00000026354; ENSMUSG00000025316 [Q8VBU8-2] ENSMUST00000093078; ENSMUSP00000090766; ENSMUSG00000025316 [Q8VBU8-3] ENSMUST00000170857; ENSMUSP00000132095; ENSMUSG00000025316 [Q8VBU8-1] ENSMUST00000173254; ENSMUSP00000133783; ENSMUSG00000025316 [Q8VBU8-4] |
GeneIDi | 53325 |
KEGGi | mmu:53325 |
UCSCi | uc009nsg.3, mouse [Q8VBU8-1] uc009nsh.3, mouse [Q8VBU8-3] uc033jih.1, mouse [Q8VBU8-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF091234 mRNA Translation: AAC36358.1 AF235503 mRNA Translation: AAG16659.1 AK154088 mRNA Translation: BAE32366.1 BC013339 mRNA Translation: AAH13339.1 BC021650 mRNA Translation: AAH21650.1 BC022168 mRNA Translation: AAH22168.1 BC062641 mRNA Translation: AAH62641.1 |
CCDSi | CCDS40502.1 [Q8VBU8-1] CCDS72176.1 [Q8VBU8-2] CCDS72177.1 [Q8VBU8-3] |
RefSeqi | NP_001103570.1, NM_001110100.2 NP_001272910.1, NM_001285981.1 [Q8VBU8-2] NP_001272912.1, NM_001285983.1 [Q8VBU8-3] NP_058092.2, NM_016812.4 [Q8VBU8-1] XP_011246744.1, XM_011248442.1 [Q8VBU8-4] XP_017168388.1, XM_017312899.1 [Q8VBU8-1] |
3D structure databases
AlphaFoldDBi | Q8VBU8 |
SMRi | Q8VBU8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207288, 1 interactor |
IntActi | Q8VBU8, 1 interactor |
STRINGi | 10090.ENSMUSP00000132095 |
PTM databases
iPTMneti | Q8VBU8 |
PhosphoSitePlusi | Q8VBU8 |
Proteomic databases
EPDi | Q8VBU8 |
MaxQBi | Q8VBU8 |
PaxDbi | Q8VBU8 |
PeptideAtlasi | Q8VBU8 |
PRIDEi | Q8VBU8 |
ProteomicsDBi | 273537 [Q8VBU8-1] 273538 [Q8VBU8-2] 273539 [Q8VBU8-3] 273540 [Q8VBU8-4] |
Protocols and materials databases
Antibodypediai | 30702, 157 antibodies from 31 providers |
DNASUi | 53325 |
Genome annotation databases
Ensembli | ENSMUST00000026354; ENSMUSP00000026354; ENSMUSG00000025316 [Q8VBU8-2] ENSMUST00000093078; ENSMUSP00000090766; ENSMUSG00000025316 [Q8VBU8-3] ENSMUST00000170857; ENSMUSP00000132095; ENSMUSG00000025316 [Q8VBU8-1] ENSMUST00000173254; ENSMUSP00000133783; ENSMUSG00000025316 [Q8VBU8-4] |
GeneIDi | 53325 |
KEGGi | mmu:53325 |
UCSCi | uc009nsg.3, mouse [Q8VBU8-1] uc009nsh.3, mouse [Q8VBU8-3] uc033jih.1, mouse [Q8VBU8-2] |
Organism-specific databases
CTDi | 54971 |
MGIi | MGI:1889023, Banp |
VEuPathDBi | HostDB:ENSMUSG00000025316 |
Phylogenomic databases
eggNOGi | ENOG502QRIF, Eukaryota |
GeneTreei | ENSGT00390000011116 |
InParanoidi | Q8VBU8 |
OMAi | VSREHTK |
OrthoDBi | 1401911at2759 |
PhylomeDBi | Q8VBU8 |
TreeFami | TF331908 |
Enzyme and pathway databases
Reactomei | R-MMU-6804759, Regulation of TP53 Activity through Association with Co-factors |
Miscellaneous databases
BioGRID-ORCSi | 53325, 18 hits in 59 CRISPR screens |
ChiTaRSi | Banp, mouse |
PROi | PR:Q8VBU8 |
RNActi | Q8VBU8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025316, Expressed in embryonic post-anal tail and 240 other tissues |
ExpressionAtlasi | Q8VBU8, baseline and differential |
Genevisiblei | Q8VBU8, MM |
Family and domain databases
InterProi | View protein in InterPro IPR042343, BANP IPR018379, BEN_domain |
PANTHERi | PTHR16243, PTHR16243, 1 hit |
Pfami | View protein in Pfam PF10523, BEN, 1 hit |
SMARTi | View protein in SMART SM01025, BEN, 1 hit |
PROSITEi | View protein in PROSITE PS51457, BEN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BANP_MOUSE | |
Accessioni | Q8VBU8Primary (citable) accession number: Q8VBU8 Secondary accession number(s): O88973 Q9ES51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | March 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families