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Protein

Beta-taxilin

Gene

Txlnb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes motor nerve regeneration. May be involved in intracellular vesicle traffic (By similarity).By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-taxilin
Alternative name(s):
Muscle-derived protein 77
Gene namesi
Name:Txlnb
Synonyms:Mdp77
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2671945 Txlnb

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001894241 – 685Beta-taxilinAdd BLAST685

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei477PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VBT1
PaxDbiQ8VBT1
PeptideAtlasiQ8VBT1
PRIDEiQ8VBT1

PTM databases

iPTMnetiQ8VBT1
PhosphoSitePlusiQ8VBT1

Expressioni

Tissue specificityi

Specifically expressed in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000039891 Expressed in 124 organ(s), highest expression level in interventricular septum
CleanExiMM_TXLNB
GenevisibleiQ8VBT1 MM

Interactioni

Subunit structurei

Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a preference for STX1A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8VBT1, 2 interactors
MINTiQ8VBT1
STRINGi10090.ENSMUSP00000044936

Structurei

3D structure databases

ProteinModelPortaliQ8VBT1
SMRiQ8VBT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili138 – 354Sequence analysisAdd BLAST217
Coiled coili381 – 470Sequence analysisAdd BLAST90

Sequence similaritiesi

Belongs to the taxilin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1850 Eukaryota
ENOG410XQH1 LUCA
GeneTreeiENSGT00390000001482
HOGENOMiHOG000231384
HOVERGENiHBG104385
InParanoidiQ8VBT1
OMAiTAFMIIH
OrthoDBiEOG091G0GVB
PhylomeDBiQ8VBT1
TreeFamiTF318595

Family and domain databases

InterProiView protein in InterPro
IPR026183 Taxilin_fam
PANTHERiPTHR16127 PTHR16127, 1 hit
PfamiView protein in Pfam
PF09728 Taxilin, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VBT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEINHPDQLS VEHPTPPGDS SSLNQNGPGK QDGERCSTSG QAPEQEGSLH
60 70 80 90 100
PEKGAHDVAE ELSRQLEDII STYGSAASPR GKESTSETKE QPPNTEAPDN
110 120 130 140 150
EDVDYEETTE EIDREPTAPE EPAAAKEPVS NKEQKLEKKI LKGLGKEANL
160 170 180 190 200
LMQNLNKLQA PEEKLDFLFK KYTELLDEHR TEQKKLKLLL KQQAQTQREK
210 220 230 240 250
DQLQSEHNRA VLARSKLESL CRELQRHNKT LKEETLQRAR EEEEKRKEIT
260 270 280 290 300
SHFQTTLTDI QTQIEQQSER NMKLCQENTE LAEKLKSIID QYELREEHLD
310 320 330 340 350
KIFKHRELQQ KLVDAKLEEA QELMQEAEER HRREKEYLLN QAAEWKLQAK
360 370 380 390 400
VLKEQETVLQ AQLTLYSGRF EEFQSTLTKS NEVFATFKQE MDKTTKKMKK
410 420 430 440 450
LEKDTATWKA RFENCNKALL DMIEEKALRA KEYECFVMKI QRLENLCRAL
460 470 480 490 500
QEERKELYKK IREAKMSEKE DQVQRTSEEE PEPSVSENEE VDAEEANSFQ
510 520 530 540 550
KAVENLATAF TILHHPEFTP DQPTERQLAV NGPQSGSDVT HQHPETARLN
560 570 580 590 600
HPSLPADSGS PRPPVGAQAV AEGVCEATPA PTASCTPAEA ELQSQGLPAE
610 620 630 640 650
NTPGPKPHKP EANTSGQAPL SPAQGSLSVV EAKYDISPSP ESEGDSAVVP
660 670 680
GCESREQPPP EVTDIPVGPS TGLPREPDAC LNGVD
Length:685
Mass (Da):77,207
Last modified:November 9, 2004 - v2
Checksum:i4EC5F4F2EAE03895
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80 – 85RGKEST → EEGDA in AAL33909 (PubMed:11805063).Curated6
Sequence conflicti313 – 314VD → AY in BAC39238 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF422244 mRNA Translation: AAL33909.1
AF422245 mRNA Translation: AAL33910.1
AK084639 mRNA Translation: BAC39238.2
AK137442 mRNA Translation: BAE23352.1
BC141023 mRNA Translation: AAI41024.1
CCDSiCCDS35851.1
RefSeqiNP_619534.2, NM_138628.3
UniGeneiMm.283493

Genome annotation databases

EnsembliENSMUST00000037964; ENSMUSP00000044936; ENSMUSG00000039891
GeneIDi378431
KEGGimmu:378431
UCSCiuc007elv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF422244 mRNA Translation: AAL33909.1
AF422245 mRNA Translation: AAL33910.1
AK084639 mRNA Translation: BAC39238.2
AK137442 mRNA Translation: BAE23352.1
BC141023 mRNA Translation: AAI41024.1
CCDSiCCDS35851.1
RefSeqiNP_619534.2, NM_138628.3
UniGeneiMm.283493

3D structure databases

ProteinModelPortaliQ8VBT1
SMRiQ8VBT1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VBT1, 2 interactors
MINTiQ8VBT1
STRINGi10090.ENSMUSP00000044936

PTM databases

iPTMnetiQ8VBT1
PhosphoSitePlusiQ8VBT1

Proteomic databases

MaxQBiQ8VBT1
PaxDbiQ8VBT1
PeptideAtlasiQ8VBT1
PRIDEiQ8VBT1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037964; ENSMUSP00000044936; ENSMUSG00000039891
GeneIDi378431
KEGGimmu:378431
UCSCiuc007elv.1 mouse

Organism-specific databases

CTDi167838
MGIiMGI:2671945 Txlnb

Phylogenomic databases

eggNOGiKOG1850 Eukaryota
ENOG410XQH1 LUCA
GeneTreeiENSGT00390000001482
HOGENOMiHOG000231384
HOVERGENiHBG104385
InParanoidiQ8VBT1
OMAiTAFMIIH
OrthoDBiEOG091G0GVB
PhylomeDBiQ8VBT1
TreeFamiTF318595

Miscellaneous databases

PROiPR:Q8VBT1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039891 Expressed in 124 organ(s), highest expression level in interventricular septum
CleanExiMM_TXLNB
GenevisibleiQ8VBT1 MM

Family and domain databases

InterProiView protein in InterPro
IPR026183 Taxilin_fam
PANTHERiPTHR16127 PTHR16127, 1 hit
PfamiView protein in Pfam
PF09728 Taxilin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXLNB_MOUSE
AccessioniPrimary (citable) accession number: Q8VBT1
Secondary accession number(s): B2RU93, Q3UVB8, Q8BUK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 9, 2004
Last modified: September 12, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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