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Protein

Thioredoxin-related transmembrane protein 1

Gene

Tmx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-related transmembrane protein 1
Alternative name(s):
Thioredoxin domain-containing protein 1
Gene namesi
Name:Tmx1
Synonyms:Txndc, Txndc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1919986 Tmx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 181ExtracellularSequence analysisAdd BLAST155
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 278CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003415427 – 278Thioredoxin-related transmembrane protein 1Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 59Redox-activePROSITE-ProRule annotation
Modified residuei245PhosphoserineCombined sources1
Modified residuei278PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ8VBT0
MaxQBiQ8VBT0
PaxDbiQ8VBT0
PeptideAtlasiQ8VBT0
PRIDEiQ8VBT0

PTM databases

iPTMnetiQ8VBT0
PhosphoSitePlusiQ8VBT0
SwissPalmiQ8VBT0

Expressioni

Gene expression databases

BgeeiENSMUSG00000021072 Expressed in 289 organ(s), highest expression level in pancreas
CleanExiMM_TXNDC1
ExpressionAtlasiQ8VBT0 baseline and differential
GenevisibleiQ8VBT0 MM

Interactioni

Protein-protein interaction databases

BioGridi215541, 1 interactor
IntActiQ8VBT0, 1 interactor
MINTiQ8VBT0
STRINGi10090.ENSMUSP00000021471

Structurei

3D structure databases

ProteinModelPortaliQ8VBT0
SMRiQ8VBT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 132ThioredoxinPROSITE-ProRule annotationAdd BLAST106

Keywords - Domaini

Redox-active center, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0913 Eukaryota
ENOG4111H66 LUCA
GeneTreeiENSGT00390000011580
HOGENOMiHOG000045750
InParanoidiQ8VBT0
OMAiIPSWASY
OrthoDBiEOG091G0MRE
PhylomeDBiQ8VBT0
TreeFamiTF106376

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8VBT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHLGRLMVP LAALVLLLWA VPGAHGRRNN VRVLTDENWT SLLEGEWMIE
60 70 80 90 100
FYAPWCPACQ NLQPEWESFA EWGEDLEVKV AKVDVTEQTG LSGRFIITAL
110 120 130 140 150
PSIYHCKDGE FRRYVGPRTK KDFINFVSDK EWKNIEPISS WFGPSSVLMT
160 170 180 190 200
MMSALFQLSV YIRTSHSYFV HDLGIPAWGS YLVFAFATVL SGLLLGLCMI
210 220 230 240 250
FVADCLCPSK RRKPQQQYAK KTSPEFSQPL KKVEEEQEAD EEDVSEEEAE
260 270
DREGASKATS QSSIRQRCVG LPSATDTS
Length:278
Mass (Da):31,396
Last modified:March 1, 2002 - v1
Checksum:iEB682243008E3333
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6V084F6V084_MOUSE
Thioredoxin-related transmembrane p...
Tmx1
124Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013150 mRNA Translation: BAB28680.3
AK030429 mRNA Translation: BAC26960.1
AK050567 mRNA Translation: BAC34326.1
AK137059 mRNA Translation: BAE23223.1
AK150511 mRNA Translation: BAE29624.1
AK153027 mRNA Translation: BAE31660.1
AK170468 mRNA Translation: BAE41816.1
BC017603 mRNA Translation: AAH17603.1
BC021533 mRNA Translation: AAH21533.1
CCDSiCCDS25958.1
RefSeqiNP_082615.1, NM_028339.1
UniGeneiMm.204670

Genome annotation databases

EnsembliENSMUST00000021471; ENSMUSP00000021471; ENSMUSG00000021072
GeneIDi72736
KEGGimmu:72736
UCSCiuc007ntu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013150 mRNA Translation: BAB28680.3
AK030429 mRNA Translation: BAC26960.1
AK050567 mRNA Translation: BAC34326.1
AK137059 mRNA Translation: BAE23223.1
AK150511 mRNA Translation: BAE29624.1
AK153027 mRNA Translation: BAE31660.1
AK170468 mRNA Translation: BAE41816.1
BC017603 mRNA Translation: AAH17603.1
BC021533 mRNA Translation: AAH21533.1
CCDSiCCDS25958.1
RefSeqiNP_082615.1, NM_028339.1
UniGeneiMm.204670

3D structure databases

ProteinModelPortaliQ8VBT0
SMRiQ8VBT0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215541, 1 interactor
IntActiQ8VBT0, 1 interactor
MINTiQ8VBT0
STRINGi10090.ENSMUSP00000021471

PTM databases

iPTMnetiQ8VBT0
PhosphoSitePlusiQ8VBT0
SwissPalmiQ8VBT0

Proteomic databases

EPDiQ8VBT0
MaxQBiQ8VBT0
PaxDbiQ8VBT0
PeptideAtlasiQ8VBT0
PRIDEiQ8VBT0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021471; ENSMUSP00000021471; ENSMUSG00000021072
GeneIDi72736
KEGGimmu:72736
UCSCiuc007ntu.1 mouse

Organism-specific databases

CTDi81542
MGIiMGI:1919986 Tmx1

Phylogenomic databases

eggNOGiKOG0913 Eukaryota
ENOG4111H66 LUCA
GeneTreeiENSGT00390000011580
HOGENOMiHOG000045750
InParanoidiQ8VBT0
OMAiIPSWASY
OrthoDBiEOG091G0MRE
PhylomeDBiQ8VBT0
TreeFamiTF106376

Miscellaneous databases

ChiTaRSiTmx1 mouse
PROiPR:Q8VBT0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021072 Expressed in 289 organ(s), highest expression level in pancreas
CleanExiMM_TXNDC1
ExpressionAtlasiQ8VBT0 baseline and differential
GenevisibleiQ8VBT0 MM

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMX1_MOUSE
AccessioniPrimary (citable) accession number: Q8VBT0
Secondary accession number(s): Q3UCI8, Q9CSD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2002
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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