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UniProtKB - Q8VAK2 (UB403_WSSVS)
Protein
RING finger containing E3 ubiquitin-protein ligase WSV403
Gene
WSV403
Organism
White spot syndrome virus (isolate Shrimp/China/Tongan/1996) (WSSV) (White spot bacilliform virus)
Status
Functioni
Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
1 PublicationCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 329 – 371 | RING-type; atypicalAdd BLAST | 43 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- transferase activity Source: UniProtKB-KW
GO - Biological processi
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
- protein ubiquitination Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Transferase |
Biological process | Host-virus interaction, Modulation of host ubiquitin pathway by viral E3 ligase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: RING finger containing E3 ubiquitin-protein ligase WSV403 (EC:2.3.2.271 Publication)Alternative name(s): RING-type E3 ubiquitin transferase WSV403 |
Gene namesi | ORF Names:WSV403 |
Organismi | White spot syndrome virus (isolate Shrimp/China/Tongan/1996) (WSSV) (White spot bacilliform virus) |
Taxonomic identifieri | 654913 [NCBI] |
Taxonomic lineagei | Viruses › Naldaviricetes › Nimaviridae › Whispovirus › |
Virus hosti | Crustacea [TaxID: 6657] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000397866 | 1 – 641 | RING finger containing E3 ubiquitin-protein ligase WSV403Add BLAST | 641 |
Structurei
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 329 – 371 | RING-type; atypicalAdd BLAST | 43 |
Keywords - Domaini
Zinc-fingerFamily and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR013083, Znf_RING/FYVE/PHD |
i Sequence
Sequence statusi: Complete.
Q8VAK2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVASTPCPGP GPVPTQELLS TNFLEAHKLV VELLLPSYSS DVVYCDSETY
60 70 80 90 100
TKPIPIFGNK SIVSTIGDYV LSNPNEDVSY QMVSSVLEKF PLLFHCTYKT
110 120 130 140 150
NEEDKGIPLW KKLYNKRKFK LLNSLLVHNN KNWTPVPAIP FDRENICDAS
160 170 180 190 200
GRSVLMSEIM STSTFQTICK NNTHYLFDML NMERGKQGGS FLHFFASRKN
210 220 230 240 250
SFTNFENEEM DSHVLSNIAK FICNEKEKLD SFIPANGKIP CPDKTNDEGY
260 270 280 290 300
IPLEIAIMED NYPALLYLVC RYGASWANTY GDHNESLKAF AIRNDAKDCL
310 320 330 340 350
EIIEFISDHY SFNKNVTKEE FVKEKTVECV GCLYDIEDEK RCYKLPCGHF
360 370 380 390 400
MHTFCLSNKC SKANFRCVKC FQTFDDTIFR KCPPTIQWKM GINQTTNHKE
410 420 430 440 450
MDLFNRAFDT YLDFICSYNV KLDKKSKPKH KPENKKVEEE LAKRTAEIEE
460 470 480 490 500
AMKKKEEELT KRTAEIEEAI KKKEEELAKR TAEIEEAMKK KEEEELSKYN
510 520 530 540 550
KIIEKGKRRL NEECVKLRDI STAAINMYKE KVRINGVLLK DSDQELAEAK
560 570 580 590 600
ERLRKILLLE EETKLDRFLF RPKRVEERIF LTKDDETLAF KLALEKKTED
610 620 630 640
IIAKKNNQKG SERRDGEYTI TSHIEKLPQS TALASVCVLN E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF332093 Genomic DNA Translation: AAL33416.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF332093 Genomic DNA Translation: AAL33416.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR013083, Znf_RING/FYVE/PHD |
MobiDBi | Search... |
Entry informationi
Entry namei | UB403_WSSVS | |
Accessioni | Q8VAK2Primary (citable) accession number: Q8VAK2 Secondary accession number(s): Q8VAJ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 5, 2010 |
Last sequence update: | November 11, 2015 | |
Last modified: | September 29, 2021 | |
This is version 65 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways