UniProtKB - Q8VA41 (CAPSD_AQRVA)
Protein
Major inner capsid protein VP3
Gene
S3
Organism
Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
Status
Functioni
Self-assembles to form an icosahedral capsid with a pseudo T=2 symmetry, about 60 nm in diameter, and consisting of 120 VP3 subunits. Displays NTPase, RNA 5'-triphosphatase (RTPase) and RNA helicase activities and probably participates in transcription of the viral genome. Helicase activity might be involved in unwinding or reannealing dsRNA during RNA synthesis. RTPase enzymatic activity represents the first step in RNA capping, which yields a 5'-diphosphorylated plus-strand RNA (By similarity).By similarity
Catalytic activityi
- EC:3.6.4.13
Cofactori
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 113 – 136 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- RNA helicase activity Source: UniProtKB-EC
GO - Biological processi
- 7-methylguanosine mRNA capping Source: UniProtKB-KW
Keywordsi
Molecular function | Helicase, Hydrolase |
Biological process | mRNA capping, mRNA processing |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Major inner capsid protein VP3 (EC:3.6.4.13)Alternative name(s): ATP-dependent DNA helicase VP3 |
Gene namesi | Name:S3 |
Organismi | Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A) |
Taxonomic identifieri | 928295 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Duplornaviricota › Resentoviricetes › Reovirales › Reoviridae › Spinareovirinae › Aquareovirus › |
Virus hosti | Oncorhynchus keta (Chum salmon) (Salmo keta) [TaxID: 8018] |
Subcellular locationi
- Virion Curated
GO - Cellular componenti
- T=2 icosahedral viral capsid Source: UniProtKB-KW
- viral inner capsid Source: UniProtKB-KW
Keywords - Cellular componenti
Capsid protein, Inner capsid protein, T=2 icosahedral capsid protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000404168 | 1 – 1210 | Major inner capsid protein VP3Add BLAST | 1210 |
Interactioni
Subunit structurei
Interacts with VP6.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the reoviridae major inner capsid protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 113 – 136 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Zinc-fingerFamily and domain databases
InterProi | View protein in InterPro IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8VA41-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRTSRNVRA TEVATTAIPP SNAATDTTVD TTVAPTIASA DAAQHASNIS
60 70 80 90 100
SSQLGPAGVS DKVPSSVVTN DGDISVTPIS ENAAQLASSN QPASVIRNPV
110 120 130 140 150
AAATISIVNP SSLRCQQCGA KFSSMTQLAE HVRTEHRTGA GSLVTSPAIN
160 170 180 190 200
QAIESWLLTW EDLRLLAPTI ATDALNKYMG EAVAKAPLLI VEDEGLCTSF
210 220 230 240 250
LASDTISIAG LQREIVGFTW FMETLQMIPA LPEGAVNHPI CHTGWASKDS
260 270 280 290 300
VSRHLDVRLS PPTHGGCFSI HYRTVEGIRQ GHAIQPSYFP CQRPHAGPQV
310 320 330 340 350
RSVQSQDQQV YSVDSGPDPR SRGRYVRFFD NKELFAVAYP GREVLMEANR
360 370 380 390 400
NALFLDESLP DRVGCIGRAQ NVSGDVSAHI DTYELCDDLT LAIREMYHNM
410 420 430 440 450
LFSMHLDPAS VMEIVQDVSQ QLVAASIPFA QTDTILCPWA ASTPTLQLSQ
460 470 480 490 500
VLNLLNVANN TSAALPLIEA AATLIMGITP LRMEPRILSE AIKRVPETTT
510 520 530 540 550
IVPSPTGELT RLLKPLGNDY SAIYRCIAGC LYSGLVQMFI SADAYPDPTQ
560 570 580 590 600
SITSIPAIWK SLIVMLAAPM TTDPHAAVKA FMSMANLLAQ PEPIIIPAPG
610 620 630 640 650
MTQSTPAVQF SHPEVWPPGF VDPTTLDRNR TPLLHALATM IHAHWPQPGV
660 670 680 690 700
IQYGRSRLGS ANLFLPANQL TYPWPTQPLP RITVGPTYDS AMFRWIDSVF
710 720 730 740 750
GFYINVVNSR YVATIVGDTT RRTLTGLMAA LMQVKTMTPF YIERMCPTEV
760 770 780 790 800
AVVGGVTVFP PFQVPITRLD PTQVITNVMV SPRGPPAPCR RSRRSHRYYA
810 820 830 840 850
YAAPIPCQSI PLRLSLLCCV RQTEATLGPS YHYGSAITPM FLSEELFTRN
860 870 880 890 900
QRAVIASEAF VCARSIIAQC VPDGFQVPRP LQDFNQYNAS GSTAADLLKA
910 920 930 940 950
VDDMFKTAFD IDGSLIEGIG LYGDPRVADL SVAYLRQNGA VERVHTAPDS
960 970 980 990 1000
SFLHEAMQVT SQVMVNEPNL WAIARGDIIL AQNATHNNWD PLNPVGLPIF
1010 1020 1030 1040 1050
ARGGPNVHVV GSRGMIIPQP GGLAPMIRDD AGNPQQIEGD WIYPISVLQV
1060 1070 1080 1090 1100
SVANFRDHVW PMIQAGRTRV RIEMGHFLYS IHYHEPFGQI TEAPAIDTWL
1110 1120 1130 1140 1150
AGISPTGIPP FPLSAPIPQI TIPITARRVY FGYCTMNNTG ATFSTLGAAI
1160 1170 1180 1190 1200
QSAWGTDVTI QRNRWPALID PNYIPGQSQL PARVQLYNPL RRYNYRYPSL
1210
KGMLYIPGVE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF418296 Genomic RNA Translation: AAL31498.1 |
RefSeqi | YP_398631.1, NC_007584.1 |
Genome annotation databases
GeneIDi | 3773157 |
KEGGi | vg:3773157 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF418296 Genomic RNA Translation: AAL31498.1 |
RefSeqi | YP_398631.1, NC_007584.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 3773157 |
KEGGi | vg:3773157 |
Family and domain databases
InterProi | View protein in InterPro IPR013087, Znf_C2H2_type |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAPSD_AQRVA | |
Accessioni | Q8VA41Primary (citable) accession number: Q8VA41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 8, 2011 |
Last sequence update: | March 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |