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Protein

Membrane protein

Gene

M

Organism
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane proteinUniRule annotation
Short name:
M proteinUniRule annotation
Alternative name(s):
E1 glycoproteinUniRule annotation
Matrix glycoproteinUniRule annotation
Membrane glycoproteinUniRule annotation
Gene namesi
Name:MUniRule annotation
ORF Names:6
OrganismiBovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
Taxonomic identifieri233264 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000008571 Componenti: Genome

Subcellular locationi

  • Virion membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Host Golgi apparatus membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Note: Largely embedded in the lipid bilayer.UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24Virion surfaceUniRule annotationAdd BLAST24
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Topological domaini46 – 55IntravirionUniRule annotation10
Transmembranei56 – 76HelicalUniRule annotationAdd BLAST21
Topological domaini77 – 84Virion surfaceUniRule annotation8
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Topological domaini106 – 228IntravirionUniRule annotationAdd BLAST123

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001060271 – 230Membrane proteinAdd BLAST230

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the betacoronaviruses M protein family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000NM

Family and domain databases

HAMAPiMF_04202 BETA_CORONA_M, 1 hit
InterProiView protein in InterPro
IPR002574 Corona_M
PfamiView protein in Pfam
PF01635 Corona_M, 1 hit

Sequencei

Sequence statusi: Complete.

Q8V433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVTTPAPV YTWTADEAIK FLKEWNFSLG IILLFITVIL QFGYTSRSMF
60 70 80 90 100
VYVIKMIILW LMWPLTIILT IFNCVYALNN VYLGFSIVFT IVAIIMWIVY
110 120 130 140 150
FVNSIRLFIR TGSWWSFNPE TNNLMCIDMK GRMYVRPIIE DYHTLTVTII
160 170 180 190 200
RGHLYMQGIK LGTGYSLSDL PAYVTVAKVS HLLTYKRGFL DKIGDTSGFA
210 220 230
VYVKSKVGNY RLPSTQKGSG LDTALLRNNI
Length:230
Mass (Da):26,340
Last modified:March 1, 2002 - v1
Checksum:iA35E7858BAC18722
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391542 Genomic RNA Translation: AAL57312.1

Similar proteinsi

Entry informationi

Entry nameiVME1_CVBLU
AccessioniPrimary (citable) accession number: Q8V433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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