Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleoprotein

Gene

N

Organism
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NucleoproteinUniRule annotation
Alternative name(s):
Nucleocapsid proteinUniRule annotation
Short name:
NCUniRule annotation
Short name:
Protein NUniRule annotation
Gene namesi
Name:NUniRule annotation
ORF Names:7a
OrganismiBovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
Taxonomic identifieri233264 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000008571 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host endoplasmic reticulum-Golgi intermediate compartment UniRule annotation
  • Host Golgi apparatus UniRule annotation
  • Note: Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001059921 – 448NucleoproteinAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167Phosphoserine; by hostUniRule annotation1
Modified residuei174Phosphothreonine; by hostUniRule annotation1
Modified residuei191Phosphoserine; by hostUniRule annotation1
Modified residuei390Phosphoserine; by hostUniRule annotation1
Modified residuei427Phosphothreonine; by hostUniRule annotation1

Post-translational modificationi

ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.UniRule annotation
Phosphorylated on serine and threonine residues.UniRule annotation

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Interactioni

Subunit structurei

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8V432
SMRiQ8V432
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 194RNA-bindingUniRule annotationAdd BLAST143
Regioni266 – 384DimerizationUniRule annotationAdd BLAST119

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 19Ser-richAdd BLAST19
Compositional biasi191 – 219Ser-richAdd BLAST29

Sequence similaritiesi

Belongs to the betacoronavirus nucleocapsid protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900008T

Family and domain databases

HAMAPiMF_04096 BETA_CORONA_NCAP, 1 hit
InterProiView protein in InterPro
IPR001218 Corona_nucleocap
IPR037179 Nucleocapsid_C
IPR037195 Nucleocapsid_N
PfamiView protein in Pfam
PF00937 Corona_nucleoca, 1 hit
PIRSFiPIRSF003888 Corona_nucleocap, 1 hit
SUPFAMiSSF103068 SSF103068, 1 hit
SSF110304 SSF110304, 1 hit

Sequencei

Sequence statusi: Complete.

Q8V432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFTPGKQSS SRASSGNRSG NGILKWADQS DQSRNVQTRG RRAQSKQTAT
60 70 80 90 100
SQQPSGGNVV PYYSWFSGIT QFQKGKEFEF AEGQGVPIAP GVPATEAKGY
110 120 130 140 150
WYRHNRRSFK TADGNQRQLL PRWYFYYLGT GPHAKDQYGT DIDGVYWVAS
160 170 180 190 200
NQADVNTPAD ILDRDPSSDE AIPTRFPPGT VLPQGYYIEG SGRSAPNSRS
210 220 230 240 250
TSRASSRASS AGSRSRANSG NRTPTSGVTP DMADQIASLV LAKLGKDAAK
260 270 280 290 300
PQQVTKQTAK EIRQKILNKP RQKRSPNKQC TVQQCFGKRG PNQNFGGGEM
310 320 330 340 350
LKLGTSDPQF PILAELAPTA GAFFFGSRLE LAKVQNLSGN LDEPQKDVYE
360 370 380 390 400
LRYNGAIRFD STLSGFETIM KVLNENLNAY QQQDGTMNMS PKPQRQRGQK
410 420 430 440
NGQGENDNIS VAAPKSRVQQ NKIRELTAED ISLLKKMDEP FTEDTSEI
Length:448
Mass (Da):49,285
Last modified:March 1, 2002 - v1
Checksum:iF2B6BB2485D3F8FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391542 Genomic RNA Translation: AAL57313.1

Similar proteinsi

Entry informationi

Entry nameiNCAP_CVBLU
AccessioniPrimary (citable) accession number: Q8V432
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health