CCAAT/enhancer-binding protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: ZFIN <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish."
    Liu T.X., Rhodes J., Deng M., Hsu K., Radomska H.S., Kanki J.P., Tenen D.G., Look A.T.
    Exp Hematol 35:230-239(2007) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: ZFINInferred from direct assayⁱ
  • "Interferon regulatory factor 2 binding protein 2b regulates neutrophil <i>versus</i> macrophage fate during zebrafish definitive myelopoiesis."
    Wang L., Gao S., Wang H., Xue C., Liu X., Yuan H., Wang Z., Chen S., Chen Z., de The H., Zhang Y., Zhang W., Zhu J., Zhou J.
    Haematologica 105:325-337(2020) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: ZFINInferred from direct assayⁱ
  • "Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish."
    Liu T.X., Rhodes J., Deng M., Hsu K., Radomska H.S., Kanki J.P., Tenen D.G., Look A.T.
    Exp Hematol 35:230-239(2007) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: ZFINInferred from direct assayⁱ
  • "Interferon regulatory factor 2 binding protein 2b regulates neutrophil <i>versus</i> macrophage fate during zebrafish definitive myelopoiesis."
    Wang L., Gao S., Wang H., Xue C., Liu X., Yuan H., Wang Z., Chen S., Chen Z., de The H., Zhang Y., Zhang W., Zhu J., Zhou J.
    Haematologica 105:325-337(2020) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• definitive hemopoiesis Source: ZFIN <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Sumoylation of CCAAT/enhancer-binding protein alpha is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish."
    Yuan H., Zhang T., Liu X., Deng M., Zhang W., Wen Z., Chen S., Chen Z., de The H., Zhou J., Zhu J.
    Sci Rep 5:9011-9011(2015) [PubMed] [Europe PMC] [Abstract]
• granulocyte differentiation Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish."
    Liu X., Jia X., Yuan H., Ma K., Chen Y., Jin Y., Deng M., Pan W., Chen S., Chen Z., de The H., Zon L.I., Zhou Y., Zhou J., Zhu J.
    J Hematol Oncol 8:15-15(2015) [PubMed] [Europe PMC] [Abstract]
• hematopoietic stem cell migration Source: ZFINInferred from mutant phenotypeⁱ
  • "Dominant-negative C/ebpalpha and polycomb group protein Bmi1 extend short-lived hematopoietic stem/progenitor cell life span and induce lethal dyserythropoiesis."
    Zhou T., Wang L., Zhu K.Y., Dong M., Xu P.F., Chen Y., Chen S.J., Chen Z., Deng M., Liu T.X.
    Blood 118:3842-3852(2011) [PubMed] [Europe PMC] [Abstract]
• hemopoiesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish."
    Liu T.X., Rhodes J., Deng M., Hsu K., Radomska H.S., Kanki J.P., Tenen D.G., Look A.T.
    Exp Hematol 35:230-239(2007) [PubMed] [Europe PMC] [Abstract]
• liver development Source: ZFINInferred from mutant phenotypeⁱ
  • "CCAAT/enhancer-binding protein alpha is required for hepatic outgrowth via the p53 pathway in zebrafish."
    Yuan H., Wen B., Liu X., Gao C., Yang R., Wang L., Chen S., Chen Z., de The H., Zhou J., Zhu J.
    Sci Rep 5:15838-15838(2015) [PubMed] [Europe PMC] [Abstract]
• myeloid cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• myeloid leukocyte differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Cebpalpha is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish."
    Dai Y., Zhu L., Huang Z., Zhou M., Jin W., Liu W., Xu M., Yu T., Zhang Y., Wen Z., Liao W., Zhang W.
    J Genet Genomics 43:593-600(2016) [PubMed] [Europe PMC] [Abstract]
• neutrophil differentiation Source: ZFINInferred from genetic interactionⁱ
  • "Cebpalpha is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish."
    Dai Y., Zhu L., Huang Z., Zhou M., Jin W., Liu W., Xu M., Yu T., Zhang Y., Wen Z., Liao W., Zhang W.
    J Genet Genomics 43:593-600(2016) [PubMed] [Europe PMC] [Abstract]
• primitive hemopoiesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Dominant-negative C/ebpalpha and polycomb group protein Bmi1 extend short-lived hematopoietic stem/progenitor cell life span and induce lethal dyserythropoiesis."
    Zhou T., Wang L., Zhu K.Y., Dong M., Xu P.F., Chen Y., Chen S.J., Chen Z., Deng M., Liu T.X.
    Blood 118:3842-3852(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEQANLYEVA PRPLMTSLVQ NQQNPYIYKD TAGDLSEICE NENSIDISAY 
        60         70         80         90        100
IDPSAFNDEF LADLFHNSSK QEKLKLASGD YDYHHGANGA PGAPQMYGCL 
       110        120        130        140        150
NGYMDSSKLE PIYDSQARMR PVAIKQEPRE EDELGDSMPP TYHHSQHHAP 
       160        170        180        190        200
HLSYLQHQIA HCAQTTMHLQ PGHPTPPPTP VPSPHHQHSH LPGGSMKIGD 
       210        220        230        240        250
RGKSKKHVDK NSTEYRLRRE RNNIAVRKSR DKAKMRNVET QQKVIELSAD 
       260        270        280 
NDRLRKRVEH LTRELETLRG IFRQLPDGSF VKAMGNCA              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ