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Protein

Ribonuclease H

Gene

rnhA

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Magnesium 1UniRule annotation1
Metal bindingi9Magnesium 2UniRule annotation1
Metal bindingi47Magnesium 1UniRule annotation1
Metal bindingi69Magnesium 1UniRule annotation1
Metal bindingi133Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciAGRO:ATU0776-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HUniRule annotation
Gene namesi
Name:rnhAUniRule annotation
Ordered Locus Names:Atu0776
ORF Names:AGR_C_1417
OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Taxonomic identifieri176299 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
Proteomesi
  • UP000000813 Componenti: Chromosome circular

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001953621 – 146Ribonuclease HAdd BLAST146

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi176299.Atu0776

Structurei

3D structure databases

ProteinModelPortaliQ8UHA7
SMRiQ8UHA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 141RNase HUniRule annotationAdd BLAST141

Sequence similaritiesi

Belongs to the RNase H family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UMW Bacteria
COG0328 LUCA
HOGENOMiHOG000040465
KOiK03469
OMAiMQEIEIF

Family and domain databases

CDDicd09278 RNase_HI_prokaryote_like, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00042 RNase_H, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
IPR022892 RNaseHI
PfamiView protein in Pfam
PF00075 RNase_H, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50879 RNASE_H, 1 hit

Sequencei

Sequence statusi: Complete.

Q8UHA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKHVDIFTDG ACSGNPGPGG WGAVLRYGET EKELSGGEAD TTNNRMELLA
60 70 80 90 100
AISALNALKS PCEVDLYTDS AYVKDGITKW IFGWKKKGWK TADNKPVKNV
110 120 130 140
ELWQALEAAQ ERHKVTLHWV KGHAGHPENE RADELARKGM EPFKRR
Length:146
Mass (Da):16,261
Last modified:June 1, 2002 - v1
Checksum:iCA90796A79057155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA Translation: AAK86585.1
PIRiAB2672
H97453
RefSeqiNP_353800.1, NC_003062.2
WP_003511799.1, NC_003062.2

Genome annotation databases

EnsemblBacteriaiAAK86585; AAK86585; Atu0776
GeneIDi1132814
31900165
KEGGiatu:Atu0776
PATRICifig|176299.10.peg.776

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007869 Genomic DNA Translation: AAK86585.1
PIRiAB2672
H97453
RefSeqiNP_353800.1, NC_003062.2
WP_003511799.1, NC_003062.2

3D structure databases

ProteinModelPortaliQ8UHA7
SMRiQ8UHA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176299.Atu0776

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK86585; AAK86585; Atu0776
GeneIDi1132814
31900165
KEGGiatu:Atu0776
PATRICifig|176299.10.peg.776

Phylogenomic databases

eggNOGiENOG4108UMW Bacteria
COG0328 LUCA
HOGENOMiHOG000040465
KOiK03469
OMAiMQEIEIF

Enzyme and pathway databases

BioCyciAGRO:ATU0776-MONOMER

Family and domain databases

CDDicd09278 RNase_HI_prokaryote_like, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00042 RNase_H, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
IPR022892 RNaseHI
PfamiView protein in Pfam
PF00075 RNase_H, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50879 RNASE_H, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNH_AGRFC
AccessioniPrimary (citable) accession number: Q8UHA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: June 1, 2002
Last modified: October 10, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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