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Entry version 95 (05 Jun 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Error-prone DNA polymerase 3

Gene

dnaE2-3

Organism
Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
AGRO:ATU6093-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Error-prone DNA polymerase 3UniRule annotation (EC:2.7.7.7UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dnaE2-3UniRule annotation
Ordered Locus Names:Atu6093
ORF Names:AGR_pTi_175
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid pTiC580 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAgrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri176299 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000813 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Plasmid Ti

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001033641 – 1087Error-prone DNA polymerase 3Add BLAST1087

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8U642

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8U642

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-C family. DnaE2 subfamily.UniRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000021783

KEGG Orthology (KO)

More...
KOi
K14162

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVEAREQ

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01902 DNApol_error_prone, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011708 DNA_pol3_alpha_NTPase_dom
IPR040982 DNA_pol3_finger
IPR023073 DNA_pol_error_prone
IPR029460 DNAPol_HHH
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR016195 Pol/histidinol_Pase-like
IPR004805 PolC_alpha

The PANTHER Classification System

More...
PANTHERi
PTHR32294 PTHR32294, 1 hit
PTHR32294:SF4 PTHR32294:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07733 DNA_pol3_alpha, 1 hit
PF17657 DNA_pol3_finger, 1 hit
PF14579 HHH_6, 1 hit
PF02811 PHP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00481 POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF89550 SSF89550, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00594 polc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8U642-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYAELQVTT HFSFLRGASS AQELFETAKA LGIEALGVVD RNSLAGIVRA
60 70 80 90 100
LEASRATGLR LVIGCRLDLA DGMSVLVYPT DRAAYSRLTR LITLGKSRGG
110 120 130 140 150
KNNCLLHWDD VVAYTDGMIG ILVPDLPDDL CGIQLRKMAE LFGDRAYVSL
160 170 180 190 200
CLRRRQNDQL RLHEISNLAT RFKVRTVVTN DVLFHEPGRR QLQDIVTCIR
210 220 230 240 250
TRTTIDEVGF ERERHADRYL KPPEEMERLF PRYRQALART MEIVRRCTFS
260 270 280 290 300
LEELTYQYPE EAIVPGKDAQ ASLEHYVWQC VPDRYPEGLP PDVLKVVRHE
310 320 330 340 350
LDLIRTMKYA PYFLTVFSIV RYARSQGILC QGRGSAANSA VCYILGITSI
360 370 380 390 400
DPSTNDLLFE RFVSQERDEP PDIDVDFEHE RREEVIQWIY RTYTREKAAL
410 420 430 440 450
CATVTRYRAR GAIRDVGKAL GLPEDVIKAL SSGMWSWSEE VCDRNVRELN
460 470 480 490 500
LNPDDRRLVL TLKLAQQLMG APRHLGQHPG GFVLTHDRLD DLVPIEPATM
510 520 530 540 550
KDRQIIEWDK DDVEALKFMK VDILALGMLT CMAKAFDLIR EHKDRDLDLS
560 570 580 590 600
KIEQEDSVTY AMIRKADTLG TFQIESRAQM AMLPRLKPRT FYDLVVQVAI
610 620 630 640 650
VRPGPIQGDM VHPYLRRREG KEAVEYPTPE LEAVLGKTLG VPLFQESAMR
660 670 680 690 700
VAMVCAGFTG GEADQLRKSM ATFKFTGGVS QFKDKLVSGM VRNGYAPEFA
710 720 730 740 750
EKTFSQLEGF GSYGFPESHA ASFALIAYAS SYIKCHYPEA FCAALINSQP
760 770 780 790 800
MGFYAPAQIV GDARAHGVEV RPVCINRSRW DCTLERIGNS DRHAVRLGFR
810 820 830 840 850
QVKGLAVADA ARVVAARMNN AFVSVDDMWR RSGVPSEALV QLAKADAFLP
860 870 880 890 900
SLKLERRDAL WAIKALRDEP LPLFAAAAER EMAAIAEQQE PGVALRQMTD
910 920 930 940 950
GHNVIEDYSH TGLTLRQHPI AFLRKDLSVR NIITCAEAMN SRDGRWVYTA
960 970 980 990 1000
GLVLVRQKPG SAKGVMFITI EDETGPANLV VWPTLFEKRR RAVLGSSMMA
1010 1020 1030 1040 1050
INGRIQREGE VVHLVAQQLF DLSGDLTGLA DRDEEFKLPA GRGDEFAHGS
1060 1070 1080
PGSSDTRDKS KPVVAPRDIF TPDLHIDTLK IKSRNFH
Length:1,087
Mass (Da):122,156
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66C81289A3841EC6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE007871 Genomic DNA Translation: AAK91053.1

Protein sequence database of the Protein Information Resource

More...
PIRi
AC3239

NCBI Reference Sequences

More...
RefSeqi
NP_396612.1, NC_003065.3
WP_010974875.1, NC_003065.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAK91053; AAK91053; Atu6093

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1137416
39518240

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
atu:Atu6093

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|176299.10.peg.5300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007871 Genomic DNA Translation: AAK91053.1
PIRiAC3239
RefSeqiNP_396612.1, NC_003065.3
WP_010974875.1, NC_003065.3

3D structure databases

SMRiQ8U642
ModBaseiSearch...

Proteomic databases

PRIDEiQ8U642

Genome annotation databases

EnsemblBacteriaiAAK91053; AAK91053; Atu6093
GeneIDi1137416
39518240
KEGGiatu:Atu6093
PATRICifig|176299.10.peg.5300

Phylogenomic databases

HOGENOMiHOG000021783
KOiK14162
OMAiHVEAREQ

Enzyme and pathway databases

BioCyciAGRO:ATU6093-MONOMER

Family and domain databases

HAMAPiMF_01902 DNApol_error_prone, 1 hit
InterProiView protein in InterPro
IPR011708 DNA_pol3_alpha_NTPase_dom
IPR040982 DNA_pol3_finger
IPR023073 DNA_pol_error_prone
IPR029460 DNAPol_HHH
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR016195 Pol/histidinol_Pase-like
IPR004805 PolC_alpha
PANTHERiPTHR32294 PTHR32294, 1 hit
PTHR32294:SF4 PTHR32294:SF4, 1 hit
PfamiView protein in Pfam
PF07733 DNA_pol3_alpha, 1 hit
PF17657 DNA_pol3_finger, 1 hit
PF14579 HHH_6, 1 hit
PF02811 PHP, 1 hit
SMARTiView protein in SMART
SM00481 POLIIIAc, 1 hit
SUPFAMiSSF89550 SSF89550, 1 hit
TIGRFAMsiTIGR00594 polc, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNE23_AGRFC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8U642
Secondary accession number(s): Q7D2J1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: June 5, 2019
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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