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Entry version 121 (02 Dec 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Replication factor C small subunit

Gene

rfcS

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA.2 Publications

Miscellaneous

The intein interrupts the potential ATP-binding site.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PFUR186497:G1FZR-97-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replication factor C small subunit
Short name:
RFC small subunit
Alternative name(s):
Clamp loader small subunit
PfuRFC small subunit
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rfcS
Ordered Locus Names:PF0093
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri186497 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001013 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi785E → A: Decreases the stability of the PCNA-RFC complex and reduces the clamp-loading activity; when associated with A-795; A-796; A-831 and A-835. 1 Publication1
Mutagenesisi795E → A: Decreases the stability of the PCNA-RFC complex and reduces the clamp-loading activity; when associated with A-785; A-796; A-831 and A-835. 1 Publication1
Mutagenesisi796D → A: Decreases the stability of the PCNA-RFC complex and reduces the clamp-loading activity; when associated with A-785; A-795; A-831 and A-835. 1 Publication1
Mutagenesisi831E → A: Decreases the stability of the PCNA-RFC complex and reduces the clamp-loading activity; when associated with A-785; A-795; A-796 and A-835. 1 Publication1
Mutagenesisi835E → A: Decreases the stability of the PCNA-RFC complex and reduces the clamp-loading activity; when associated with A-785; A-795; A-796 and A-831. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000303761 – 59Replication factor C small subunit, 1st partSequence analysisAdd BLAST59
ChainiPRO_000003037760 – 584Pfu RFC inteinSequence analysisAdd BLAST525
ChainiPRO_0000030378585 – 852Replication factor C small subunit, 2nd partSequence analysisAdd BLAST268

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.Curated

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8U4J3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heteromultimer composed of three to four small subunits (RfcS) and one to two large subunits (RfcL).

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
186497.PF0093

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1852
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8U4J3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8U4J3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini183 – 306DOD-type homing endonucleasePROSITE-ProRule annotationAdd BLAST124

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG00469, Archaea
arCOG03154, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015698_0_0_2

Identification of Orthologs from Complete Genome Data

More...
OMAi
DGHADSK

Database of Orthologous Groups

More...
OrthoDBi
37207at2157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.28.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003959, ATPase_AAA_core
IPR008921, DNA_pol3_clamp-load_cplx_C
IPR003586, Hint_dom_C
IPR003587, Hint_dom_N
IPR036844, Hint_dom_sf
IPR027434, Homing_endonucl
IPR006142, INTEIN
IPR030934, Intein_C
IPR004042, Intein_endonuc
IPR006141, Intein_N
IPR004860, LAGLIDADG_2
IPR027417, P-loop_NTPase
IPR013748, Rep_factorC_C
IPR008824, RuvB-like_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004, AAA, 1 hit
PF14528, LAGLIDADG_3, 1 hit
PF08542, Rep_fac_C, 1 hit
PF05496, RuvB_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00379, INTEIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00305, HintC, 1 hit
SM00306, HintN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48019, SSF48019, 1 hit
SSF51294, SSF51294, 1 hit
SSF52540, SSF52540, 2 hits
SSF55608, SSF55608, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01443, intein_Cterm, 1 hit
TIGR01445, intein_Nterm, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50818, INTEIN_C_TER, 1 hit
PS50819, INTEIN_ENDONUCLEASE, 1 hit
PS50817, INTEIN_N_TER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8U4J3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEEIREVKV LEKPWVEKYR PQRLDDIVGQ EHIVKRLKHY VKTGSMPHLL
60 70 80 90 100
FAGPPGVGKC LTGDTKVIAN GQLFELGELV EKLSGGRFGP TPVKGLKVLG
110 120 130 140 150
IDEDGKLREF EVQYVYKDRT DRLIKIKTQL GRELKVTPYH PLLVNRENGE
160 170 180 190 200
IKWIKAEELK PGDKLAIPSF LPLITGENPL AEWLGYFMGS GYAYPSNSVI
210 220 230 240 250
TFTNEDPLIR QRFMELTEKL FPDAKIRERI HADGTPEVYV VSRKAWSLVN
260 270 280 290 300
SISLTLIPRE GWKGIRSFLR AYSDCNGRIE SDAIVLSTDN NDMAQQIAYA
310 320 330 340 350
LASFGIIAKM DGEDVIISGS DNIERFLNEI GFSTQSKLKE AQKLIRKTNV
360 370 380 390 400
RSDGLKINYE LISYVKDRLR LNVNDKRNLS YRNAKELSWE LMKEIYYRLE
410 420 430 440 450
ELERLKKVLS EPILIDWNEV AKKSDEVIEK AKIRAEKLLE YIKGERKPSF
460 470 480 490 500
KEYIEIAKVL GINVERTIEA MKIFAKRYSS YAEIGRKLGT WNFNVKTILE
510 520 530 540 550
SDTVDNVEIL EKIRKIELEL IEEILSDGKL KEGIAYLIFL FQNELYWDEI
560 570 580 590 600
TEVKELRGDF IIYDLHVPGY HNFIAGNMPT VVHNTTAALA LARELFGENW
610 620 630 640 650
RHNFLELNAS DERGINVIRE KVKEFARTKP IGGASFKIIF LDEADALTQD
660 670 680 690 700
AQQALRRTME MFSSNVRFIL SCNYSSKIIE PIQSRCAIFR FRPLRDEDIA
710 720 730 740 750
KRLRYIAENE GLELTEEGLQ AILYIAEGDM RRAINILQAA AALDKKITDE
760 770 780 790 800
NVFMVASRAR PEDIREMMLL ALKGNFLKAR EKLREILLKQ GLSGEDVLVQ
810 820 830 840 850
MHKEVFNLPI EEPKKVLLAD KIGEYNFRLV EGANEIIQLE ALLAQFTLIG

KK
Length:852
Mass (Da):97,793
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4C8B4B945F9946A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL80217.1
AB037375 Genomic DNA Translation: BAB03291.1
AB037375 Genomic DNA Translation: BAB03292.1

NCBI Reference Sequences

More...
RefSeqi
WP_011011205.1, NZ_CP023154.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL80217; AAL80217; PF0093

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41711880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfu:PF0093

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|186497.12.peg.97

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL80217.1
AB037375 Genomic DNA Translation: BAB03291.1
AB037375 Genomic DNA Translation: BAB03292.1
RefSeqiWP_011011205.1, NZ_CP023154.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IQPX-ray2.80A/B/C/D/E/F1-59[»]
A/B/C/D/E/F585-852[»]
SMRiQ8U4J3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi186497.PF0093

Proteomic databases

PRIDEiQ8U4J3

Genome annotation databases

EnsemblBacteriaiAAL80217; AAL80217; PF0093
GeneIDi41711880
KEGGipfu:PF0093
PATRICifig|186497.12.peg.97

Phylogenomic databases

eggNOGiarCOG00469, Archaea
arCOG03154, Archaea
HOGENOMiCLU_015698_0_0_2
OMAiDGHADSK
OrthoDBi37207at2157

Enzyme and pathway databases

BioCyciPFUR186497:G1FZR-97-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ8U4J3

Family and domain databases

Gene3Di3.10.28.10, 1 hit
InterProiView protein in InterPro
IPR003959, ATPase_AAA_core
IPR008921, DNA_pol3_clamp-load_cplx_C
IPR003586, Hint_dom_C
IPR003587, Hint_dom_N
IPR036844, Hint_dom_sf
IPR027434, Homing_endonucl
IPR006142, INTEIN
IPR030934, Intein_C
IPR004042, Intein_endonuc
IPR006141, Intein_N
IPR004860, LAGLIDADG_2
IPR027417, P-loop_NTPase
IPR013748, Rep_factorC_C
IPR008824, RuvB-like_N
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF14528, LAGLIDADG_3, 1 hit
PF08542, Rep_fac_C, 1 hit
PF05496, RuvB_N, 1 hit
PRINTSiPR00379, INTEIN
SMARTiView protein in SMART
SM00305, HintC, 1 hit
SM00306, HintN, 1 hit
SUPFAMiSSF48019, SSF48019, 1 hit
SSF51294, SSF51294, 1 hit
SSF52540, SSF52540, 2 hits
SSF55608, SSF55608, 1 hit
TIGRFAMsiTIGR01443, intein_Cterm, 1 hit
TIGR01445, intein_Nterm, 1 hit
PROSITEiView protein in PROSITE
PS50818, INTEIN_C_TER, 1 hit
PS50819, INTEIN_ENDONUCLEASE, 1 hit
PS50817, INTEIN_N_TER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRFCS_PYRFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8U4J3
Secondary accession number(s): Q9P9H2, Q9P9H3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: June 1, 2002
Last modified: December 2, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Intein-containing proteins
    List of intein-containing protein entries
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