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Protein

CRISPR system Cmr subunit Cmr2

Gene

cmr2

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA), formerly called psiRNA (prokaryotic silencing) in this organism. Part of the Cmr ribonucleoprotein complex which has divalent cation-dependent endoribonuclease activity specific for ssRNA complementary to the crRNA (target RNA), generating 5' hydroxy- and 3' phosphate or 2'-3' cyclic phosphate termini. Cmr4 is probably the subunit that cleaves target RNA (PubMed:25280103). Cmr complex does not cleave ssDNA complementary to the crRNA. Cleavage of target RNA is guided by the crRNA; substrate cleavage occurs a fixed distance (14 nt) from the 3' end of the crRNA. In vitro reconstitution shows Cmr1-2 and Cmr5 are not absolutely necessary for target cleavage (PubMed:19945378).3 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi13Manganese 11 Publication1
Metal bindingi14Manganese 11 Publication1
Metal bindingi14Manganese 21 Publication1
Metal bindingi25Manganese 21 Publication1
Metal bindingi448Zinc5 Publications1
Metal bindingi451Zinc5 Publications1
Metal bindingi478Zinc5 Publications1
Metal bindingi481Zinc5 Publications1
Metal bindingi600Manganese 31 Publication1 Publication1
Metal bindingi656Manganese 41 Publication1
Metal bindingi673Manganese 31 Publication1 Publication1
Metal bindingi674Manganese 31 Publication1 Publication1
Metal bindingi694Manganese 41 Publication1
Metal bindingi700Manganese 41 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processAntiviral defense
LigandManganese, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PFUR186497:G1FZR-1161-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CRISPR system Cmr subunit Cmr2
Alternative name(s):
CRISPR-associated protein Cas10/Cmr2, subtype III-B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cmr21 Publication
Ordered Locus Names:PF1129
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri186497 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001013 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi246S → A: No effect on pre-crRNA cleavage. 1 Publication1
Mutagenesisi250S → A: No effect on pre-crRNA cleavage. 1 Publication1
Mutagenesisi600D → N: No effect on pre-crRNA cleavage. 1 Publication1
Mutagenesisi673 – 674DD → NN: No effect on pre-crRNA cleavage. 1 Publication2
Mutagenesisi673D → N: No effect on pre-crRNA cleavage. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004180731 – 871CRISPR system Cmr subunit Cmr2Add BLAST871

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8U1S6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the type III-B Cmr ribonucleoprotein (RNP) complex, an elongated RNP with Cmr2 and Cmr3 as the base, with Cmr4 and Cmr5 forming a helical core along the mature crRNA (39 or 45 nt in length), while the complex is capped by Cmr6 and Cmr1. The 5' end of the crRNA is bound to Cmr2 and Cmr3, while Cmr6 and a Cmr1 subunit (Cmr1-1 or Cmr1-2) cap the 3' end of the crRNA. The target RNA lies antiparallel to the crRNA, with its 5' end near Cmr1 and Cmr6 and its 3' end near Cmr2 and Cmr3; major target cleavage occurs nears the junction of Cmr1/Cmr6 and Cmr4/Cmr, with minor cleavage occurring at 6 nt intervals which coincide with the proposed spacing of Cmr4 subunits (PubMed:24119404, PubMed:25280103). Forms a 1:1 complex with Cmr3 (PubMed:23583914, PubMed:23395183). The Cmr2-Cmr3 complex non-specifically binds ss-target RNA and crRNA (PubMed:23583914). Interacts with Cmr3, Cmr4 and Cmr5 (PubMed:25280103).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
cmr3Q8U1S76EBI-2504936,EBI-2504943

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-54366N

Protein interaction database and analysis system

More...
IntActi
Q8U1S6, 17 interactors

STRING: functional protein association networks

More...
STRINGi
186497.PF1129

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1871
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8U1S6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8U1S6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini592 – 752GGDEFPROSITE-ProRule annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 215Not required for target RNA cleavage1 PublicationAdd BLAST215

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CRISPR system Cmr2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG02666 Archaea
COG1353 LUCA

KEGG Orthology (KO)

More...
KOi
K19076

Identification of Orthologs from Complete Genome Data

More...
OMAi
DLWAGSY

Database of Orthologous Groups

More...
OrthoDBi
POG093Z006S

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.2220, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038242 Cmr2_N
IPR024615 CRISPR-assoc_Cmr2_N
IPR013407 CRISPR-assoc_prot_Cmr2
IPR000160 GGDEF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12469 DUF3692, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02577 cas_TM1794_Cmr2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50887 GGDEF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8U1S6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNIKEKLFV YLHDPPDKAL KIENHEERSK KILSSGNIQY SRTDKVKQAD
60 70 80 90 100
ALSSKTQRFI IRTKENKEPV IDFLGRSSGK YFHVGYPVFI HPISTEIKRY
110 120 130 140 150
ETLEKYIDLG RSNRGERFVN EFLERVSKLE GDVLKEVFED ASNKFKGEES
160 170 180 190 200
KQWAYIWQFY PVKLKEGVKE FAKSELKLKE EEAEKFAEEF VNLPADTRFP
210 220 230 240 250
DHAIWTHLDL TSALSVKDPT LLRIKIVPVQ PFIANSRKQL DLWASSHLLS
260 270 280 290 300
MLMYKALEVI VDKFGPEHVI YPSLRDQPFF LKFYLGENIG DEILVANLPN
310 320 330 340 350
KALAIVSGKE AEKIEEEIKK RIRDFLLQLY REAVDWAVEN GVVKVDRSEK
360 370 380 390 400
DSMLKEAYLK IVREYFTVSI TWVSLSEKED IYQVTENAGL SDEDVKKWLK
410 420 430 440 450
FAEKKENSRV LERIAIYPLL VKILDSLGER KVTEERFEKS EQLKGWKCHV
460 470 480 490 500
CGENLAIFGD MYDHDNLKSL WLDEEPLCPM CLIKRYYPVW IRSKTGQKIR
510 520 530 540 550
FESVVDVALL YKNWRKIFDE KYGKDLVSKA REVSEDFVKD NMLVDSDLYY
560 570 580 590 600
SSTWESGLSK KLKNKKEIDE EKVKEVVDFL NAAYKEIGNP PKYYAILVMD
610 620 630 640 650
GDDMGKVISG EVLGEISTRI HPNIRDYVEI PEAKYYSTPQ VHVAISQALA
660 670 680 690 700
NFSIREVRSV VKDEGLLIYA GGDDVLAILP VDKALEVAYK IRKEFGKSFE
710 720 730 740 750
NGSLLPGWKL SAGILIVHYK HPLYDALEKA RDLLNNKAKN VPGKDTLAIG
760 770 780 790 800
LLKRSGSYYI SLVGWELIRV FYNSELRKKL LEEKGGVGKR FIYHVLREVD
810 820 830 840 850
TWPKVGIDEM LKFEVIRHIR GRNKEETKEL REKIYGEIKD LLEHVRGNNE
860 870
VEKVRGLFTF LKIITDAEVF P
Length:871
Mass (Da):100,984
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i859C2A9DA4490A2B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81253.1

NCBI Reference Sequences

More...
RefSeqi
WP_011012269.1, NC_003413.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL81253; AAL81253; PF1129

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1468998

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfu:PF1129

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|186497.12.peg.1190

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81253.1
RefSeqiWP_011012269.1, NC_003413.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UNGX-ray2.31C215-871[»]
3UR3X-ray2.40C215-871[»]
3W2VX-ray2.60A216-871[»]
3W2WX-ray2.50A216-871[»]
3X1LX-ray2.10A216-871[»]
4DOZX-ray3.10A195-871[»]
4H4KX-ray2.80C215-871[»]
4W8YX-ray3.00A/B1-871[»]
ProteinModelPortaliQ8U1S6
SMRiQ8U1S6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-54366N
IntActiQ8U1S6, 17 interactors
STRINGi186497.PF1129

Proteomic databases

PRIDEiQ8U1S6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL81253; AAL81253; PF1129
GeneIDi1468998
KEGGipfu:PF1129
PATRICifig|186497.12.peg.1190

Phylogenomic databases

eggNOGiarCOG02666 Archaea
COG1353 LUCA
KOiK19076
OMAiDLWAGSY
OrthoDBiPOG093Z006S

Enzyme and pathway databases

BioCyciPFUR186497:G1FZR-1161-MONOMER

Family and domain databases

Gene3Di3.30.70.2220, 2 hits
InterProiView protein in InterPro
IPR038242 Cmr2_N
IPR024615 CRISPR-assoc_Cmr2_N
IPR013407 CRISPR-assoc_prot_Cmr2
IPR000160 GGDEF_dom
PfamiView protein in Pfam
PF12469 DUF3692, 1 hit
TIGRFAMsiTIGR02577 cas_TM1794_Cmr2, 1 hit
PROSITEiView protein in PROSITE
PS50887 GGDEF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMR2_PYRFU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8U1S6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 1, 2002
Last modified: December 5, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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