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Entry version 118 (07 Oct 2020)
Sequence version 1 (01 Jun 2002)
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Protein
Submitted name:

Putative chitinase

Gene

PF1233

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei555N-acetyl-D-glucosamineCombined sources1
Binding sitei636N-acetyl-D-glucosamineCombined sources1
Binding sitei664N-acetyl-D-glucosamineCombined sources1
Binding sitei679N-acetyl-D-glucosamineCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PFUR186497:G1FZR-1263-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.14, 5243

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM2, Carbohydrate-Binding Module Family 2
CBM5, Carbohydrate-Binding Module Family 5
GH18, Glycoside Hydrolase Family 18

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Putative chitinaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:PF1233Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri186497 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001013 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
186497.PF1233

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8U1H5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8U1H5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni421 – 425N-acetyl-D-glucosamine bindingCombined sources5
Regioni490 – 491N-acetyl-D-glucosamine bindingCombined sources2
Regioni524 – 526N-acetyl-D-glucosamine bindingCombined sources3
Regioni587 – 590N-acetyl-D-glucosamine bindingCombined sources4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG07840, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_385274_0_0_2

KEGG Orthology (KO)

More...
KOi
K01183

Database of Orthologous Groups

More...
OrthoDBi
15793at2157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.290, 1 hit
3.10.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001919, CBD2
IPR008965, CBM2/CBM3_carb-bd_dom_sf
IPR012291, CBM2_carb-bd_dom_sf
IPR011583, Chitinase_II
IPR029070, Chitinase_insertion_sf
IPR001223, Glyco_hydro18_cat
IPR017853, Glycoside_hydrolase_SF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00553, CBM_2, 1 hit
PF00704, Glyco_hydro_18, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00637, CBD_II, 1 hit
SM00636, Glyco_18, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49384, SSF49384, 1 hit
SSF51445, SSF51445, 2 hits
SSF54556, SSF54556, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51173, CBM2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8U1H5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKYLDFINVM TYDYHGAWDP ITGHLAPLYA DPNAPYEDPN IKWNFNVNAS
60 70 80 90 100
IQWYLKHGVN PKQLGLGLPF YGRSFANVPP ENNGLYQPFS GTPAGTWGPA
110 120 130 140 150
YETHGVMDYW DIEEKRASGQ YNYYWDPVAM VPWLYSPSLK IFISYDDKKS
160 170 180 190 200
IGIKVDYALK YNLGGVMVWE ITADRKPGTN SHPLLDTILE HIAQGGGVVP
210 220 230 240 250
TPSPTPTPTP TPTPTPTTTT TTSTPTPTTT TTPSPTTTTT TTTTTTTTST
260 270 280 290 300
TTTPTTTTTP VPVSGSLEVK VNDWGSGAEY DVTLNLDGQY DWTVKVKLAP
310 320 330 340 350
GATVGSFWSA NKQEGNGYVI FTPVSWNKGP TATFGFIVNG PQGDKVEEIT
360 370 380 390 400
LEINGQVIDI WTPTGGTTPT PTTTTTSTPT PSQTPTPTPT PTPTPTPTPT
410 420 430 440 450
LTPTPLPGNA NPIPEHFFAP YIDMSLSVHK PLVEYAKLTG TKYFTLAFIL
460 470 480 490 500
YSSVYNGPAW AGSIPLEKFV DEVRELREIG GEVIIAFGGA VGPYLCQQAS
510 520 530 540 550
TPEQLAEWYI KVIDTYNATY LDFDIEAGID ADKLADALLI VQRERPWVKF
560 570 580 590 600
SFTLPSDPGI GLAGGYGIIE TMAKKGVRVD RVNPMTMDYY WTPSNAENAI
610 620 630 640 650
KVAENVFRQL KQIYPEKSDE EIWKMIGLTP MIGVNDDKSV FTLEDAQQLV
660 670 680 690 700
DWAIQHKIGS LAFWSVDRDH PGPTGEVSPL HRGTNDPDWA FSHVFVKFME
710
AFGYTFSAQT SEASVPT
Length:717
Mass (Da):78,635
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBCB55B9C850E38B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81357.1

NCBI Reference Sequences

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RefSeqi
WP_011012376.1, NZ_CP023154.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL81357; AAL81357; PF1233

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41713038

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfu:PF1233

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|186497.12.peg.1295

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL81357.1
RefSeqiWP_011012376.1, NZ_CP023154.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CWRX-ray1.70A258-358[»]
2CZNNMR-A258-358[»]
2DSKX-ray1.50A/B409-717[»]
3A4WX-ray1.80A/B409-717[»]
3A4XX-ray1.76A/B409-717[»]
3AFBX-ray1.76A/B409-717[»]
SMRiQ8U1H5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi186497.PF1233

Protein family/group databases

CAZyiCBM2, Carbohydrate-Binding Module Family 2
CBM5, Carbohydrate-Binding Module Family 5
GH18, Glycoside Hydrolase Family 18

Genome annotation databases

EnsemblBacteriaiAAL81357; AAL81357; PF1233
GeneIDi41713038
KEGGipfu:PF1233
PATRICifig|186497.12.peg.1295

Phylogenomic databases

eggNOGiarCOG07840, Archaea
HOGENOMiCLU_385274_0_0_2
KOiK01183
OrthoDBi15793at2157

Enzyme and pathway databases

BioCyciPFUR186497:G1FZR-1263-MONOMER
BRENDAi3.2.1.14, 5243

Miscellaneous databases

EvolutionaryTraceiQ8U1H5

Family and domain databases

Gene3Di2.60.40.290, 1 hit
3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR001919, CBD2
IPR008965, CBM2/CBM3_carb-bd_dom_sf
IPR012291, CBM2_carb-bd_dom_sf
IPR011583, Chitinase_II
IPR029070, Chitinase_insertion_sf
IPR001223, Glyco_hydro18_cat
IPR017853, Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00553, CBM_2, 1 hit
PF00704, Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00637, CBD_II, 1 hit
SM00636, Glyco_18, 1 hit
SUPFAMiSSF49384, SSF49384, 1 hit
SSF51445, SSF51445, 2 hits
SSF54556, SSF54556, 1 hit
PROSITEiView protein in PROSITE
PS51173, CBM2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8U1H5_PYRFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8U1H5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: October 7, 2020
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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