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Protein

CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1

Gene

hdrA1

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).By similarity

Cofactori

Protein has several cofactor binding sites:
  • [4Fe-4S] clusterPROSITE-ProRule annotationNote: Binds 4 [4Fe-4S] clusters per subunit.PROSITE-ProRule annotation
  • FADBy similarity

Pathwayi: coenzyme M-coenzyme B heterodisulfide reduction

This protein is involved in step 1 of the subpathway that synthesizes coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1 (hdrA1), CoB--CoM heterodisulfide reductase subunit B (hdrB), CoB--CoM heterodisulfide reductase iron-sulfur subunit C (hdrC), CoB--CoM heterodisulfide reductase iron-sulfur subunit A 2 (hdrA2)
This subpathway is part of the pathway coenzyme M-coenzyme B heterodisulfide reduction, which is itself part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide, the pathway coenzyme M-coenzyme B heterodisulfide reduction and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi249Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi252Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi255Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi259Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi296Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi299Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi302Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi306Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi593Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi596Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi599Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi603Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi626Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi629Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi632Iron-sulfur 4 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi636Iron-sulfur 3 (4Fe-4S)PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi153 – 176FADSequence analysisAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processMethanogenesis
Ligand4Fe-4S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00647; UER00700

Names & Taxonomyi

Protein namesi
Recommended name:
CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1Curated (EC:1.8.98.-Curated)
Gene namesi
Name:hdrA1
Synonyms:hdrA_1
Ordered Locus Names:MK0249
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001500581 – 669CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1Add BLAST669

Proteomic databases

PRIDEiQ8TYP4

Interactioni

Subunit structurei

The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.By similarity

Protein-protein interaction databases

STRINGi190192.MK0249

Structurei

3D structure databases

ProteinModelPortaliQ8TYP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini239 – 2704Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST32
Domaini287 – 3184Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST32
Domaini584 – 6134Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd BLAST30
Domaini617 – 6464Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Belongs to the HdrA family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG02235 Archaea
COG1148 LUCA
HOGENOMiHOG000230698
KOiK03388
OMAiCTPKIHE
OrthoDBiPOG093Z04QZ

Family and domain databases

InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
PfamiView protein in Pfam
PF12838 Fer4_7, 1 hit
PF13187 Fer4_9, 1 hit
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 4 hits
PS51379 4FE4S_FER_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q8TYP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKDDVRIG VFVCHCGVNI KASVDVEEVV EYAKKLPGVV YATDYPFFCA
60 70 80 90 100
DPGQEIIQEA IKEHDLDRVV VAACTPKIHE NTFRNCVKEA GLSPYYMEMV
110 120 130 140 150
NIREHCSFVH MQEPEKATEK AKDLIRAAVE RAKRLEDVPT KEVEVENSVL
160 170 180 190 200
IIGGGIAGIQ AALDLADQGF KVYLVEKEPT IGGNMARLAK TFPTDDCAMU
210 220 230 240 250
ILAPKMVQVG NHPNIEMITY AEVKDVDGYI GNFEVTIEKK PRYVDEDACT
260 270 280 290 300
GCGVCAEVCP IEVPNEFDLG IGTRKAIYVP FPQAMPLVYT IDMEHCIQCG
310 320 330 340 350
LCEEACPQDP PAIDFDQEPE EIRLKVGTII VATGYEEFDA SKLEEYGYGK
360 370 380 390 400
YDNVITTLEL ERMINPAGPT EGHVIRPSDG KEPHRIVFIH CVGSRCPGKE
410 420 430 440 450
EKGEAYCSRI CCMFILKNAQ LIKQHEPDAE VYCCYMDVRA FGKGYEEYYE
460 470 480 490 500
RAQKQFGVRF IRGRPAEIVE DPETKNLIVR VEDTLTGEPM EIEADLVVLG
510 520 530 540 550
CGLVAPEETY SKLADILGID RSPDGFFKEL HPKLEPVSTK VRGVQIAGVA
560 570 580 590 600
QGPKDIPDTV AQAKGAASEA SIPMSQGKVE IELITATVDE DVCGGCGACA
610 620 630 640 650
QVCPFDAIEM VEKDGKRVAE VQDVACQGCG QCAAACPSGA MQLRYYRDEQ
660
LMPQIEALLA EALEEEEEE
Length:669
Mass (Da):73,742
Last modified:February 26, 2008 - v3
Checksum:iC2D8D120157026E5
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei200SelenocysteineCurated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM01466.1

Genome annotation databases

EnsemblBacteriaiAAM01466; AAM01466; MK0249
KEGGimka:MK0249
PATRICifig|190192.8.peg.251

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiHDRA1_METKA
AccessioniPrimary (citable) accession number: Q8TYP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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