Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CoB--CoM heterodisulfide reductase iron-sulfur subunit C

Gene

hdrC

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).By similarity

Cofactori

[4Fe-4S] clusterPROSITE-ProRule annotationNote: Binds 2 [4Fe-4S] clusters per subunit.PROSITE-ProRule annotation

Pathwayi: coenzyme M-coenzyme B heterodisulfide reduction

This protein is involved in step 1 of the subpathway that synthesizes coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. CoB--CoM heterodisulfide reductase iron-sulfur subunit A 1 (hdrA1), CoB--CoM heterodisulfide reductase subunit B (hdrB), CoB--CoM heterodisulfide reductase iron-sulfur subunit C (hdrC), CoB--CoM heterodisulfide reductase iron-sulfur subunit A 2 (hdrA2)
This subpathway is part of the pathway coenzyme M-coenzyme B heterodisulfide reduction, which is itself part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide, the pathway coenzyme M-coenzyme B heterodisulfide reduction and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi44Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi47Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi51Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi85Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi88Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi91Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi95Iron-sulfur 1 (4Fe-4S)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processMethanogenesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00647; UER00700

Names & Taxonomyi

Protein namesi
Recommended name:
CoB--CoM heterodisulfide reductase iron-sulfur subunit CCurated (EC:1.8.98.-Curated)
Gene namesi
Name:hdrC
Ordered Locus Names:MK0573
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001500751 – 192CoB--CoM heterodisulfide reductase iron-sulfur subunit CAdd BLAST192

Proteomic databases

PRIDEiQ8TXT7

Interactioni

Subunit structurei

The heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.By similarity

Protein-protein interaction databases

STRINGi190192.MK0573

Structurei

3D structure databases

ProteinModelPortaliQ8TXT7
SMRiQ8TXT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 614Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST30
Domaini75 – 1054Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Belongs to the HdrC family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG00964 Archaea
COG1150 LUCA
HOGENOMiHOG000237015
KOiK03390
OMAiWLCTTCY
OrthoDBiPOG093Z0AYL

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR017680 CoB/CoM_hetero-S_Rdtase_csu
IPR009051 Helical_ferredxn
SUPFAMiSSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR03290 CoB_CoM_SS_C, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 2 hits
PS51379 4FE4S_FER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q8TXT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEPRDTVIR EEDLNPDFLE ELSELVEPVF EEEEVLSVQA CYQCGTCTGS
60 70 80 90 100
CPSGRRTSYR TRLIMRKLQL GLVDEVIKSD ELWMCTTCYT CYERCPRGVK
110 120 130 140 150
IVDAVKAARN LAAKKGYMAK AHRMVAMFVI KTGHAVPIND EIREVRKNIG
160 170 180 190
LDEVPPTTHR YEEALEEVQK LVKINEFDKL IGYDWEEGDL VD
Length:192
Mass (Da):22,022
Last modified:June 1, 2002 - v1
Checksum:i2645D1648F85F4DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM01788.1

Genome annotation databases

EnsemblBacteriaiAAM01788; AAM01788; MK0573
KEGGimka:MK0573
PATRICifig|190192.8.peg.608

Similar proteinsi

Entry informationi

Entry nameiHDRC_METKA
AccessioniPrimary (citable) accession number: Q8TXT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health