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Protein

Probable tRNA pseudouridine synthase D

Gene

truD

Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:MK0676
OrganismiMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifieri190192 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus
Proteomesi
  • UP000001826 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001525421 – 400Probable tRNA pseudouridine synthase DAdd BLAST400

Proteomic databases

PRIDEiQ8TXJ7

Interactioni

Protein-protein interaction databases

STRINGi190192.MK0676

Structurei

3D structure databases

ProteinModelPortaliQ8TXJ7
SMRiQ8TXJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 357TRUDUniRule annotationAdd BLAST196

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04252 Archaea
COG0585 LUCA
HOGENOMiHOG000224849
KOiK06176
OMAiLRYERAM
OrthoDBiPOG093Z087N

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 2 hits
PfamiView protein in Pfam
PF01142 TruD, 2 hits
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 2 hits
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

Q8TXJ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKPSRNTYI PLTIVGECPE CREYHRGREC PECGQDLRRP RLRPQFGGRG
60 70 80 90 100
PHTLFYLEKY DWDTMKAVRR IAQALRKHHR HFGIAGMKDK RAVTSQRVTV
110 120 130 140 150
RGVPPGVLAR LRIRDLKIVP MGRARRKLRP GDLWGNRFVI TVRGAKVRRL
160 170 180 190 200
PEALRTVREL GGVPNYYGLQ RFGSRRPVTH VVGKYVVLED WEKAVKTFLT
210 220 230 240 250
LEYPRESPEA LEARRWLKEH WGEFKEALRR FPKFLDYERH ILEHLARHPH
260 270 280 290 300
DYINAFRRLP MWIRRMFVHA YQSYLFNRIL SERIARGLPV HRPVEGDVTQ
310 320 330 340 350
DGLPTVPLPG FRTELSDGPQ GEIEREVLEE EGVRLEDFEI KSMPELSAGG
360 370 380 390 400
DRKPALLRVY GLRAEAIGDD TVRFTFSLPR GGYATTVLRE LLGSEGVYAD
Length:400
Mass (Da):46,488
Last modified:June 1, 2002 - v1
Checksum:i1B1E8E18AD139423
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009439 Genomic DNA Translation: AAM01891.1

Genome annotation databases

EnsemblBacteriaiAAM01891; AAM01891; MK0676
KEGGimka:MK0676
PATRICifig|190192.8.peg.715

Entry informationi

Entry nameiTRUD_METKA
AccessioniPrimary (citable) accession number: Q8TXJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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